Gene: FBgn0261988 (Drosophila melanogaster)

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Gene Identifier
FBgn0261988
Transcript Identifier
FBtr0334555
Gene Type
Coding gene
Location
3R : 31433837-31456466 : positive

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
G protein-coupled receptor kinase 2

Identifiers

Type Value
pidFBpp0306622
UniprotP32866
RefSeq_mRNANM_001276214.1
EMBLAE014297
EMBLAF004674
EMBLAY051949
EMBLBT031258
EMBLM80494

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IMP
ISS
NAS
Genome Projectprotein phosphorylation
GO:0006468
IMP
NAS
Gene Ontologyprotein phosphorylation1 2
GO:0003384
IMP
Genome Projectapical constriction involved in gastrulation
GO:0003384
IMP
Gene Ontologyapical constriction involved in gastrulation3
GO:0045879
IGI
Genome Projectnegative regulation of smoothened signaling pathway
GO:0045879
IGI
Gene Ontologynegative regulation of smoothened signaling pathway4
GO:0043950
IGI
Genome Projectpositive regulation of cAMP-mediated signaling
GO:0043950
IGI
Gene Ontologypositive regulation of cAMP-mediated signaling4
GO:0002805
IMP
Genome Projectregulation of antimicrobial peptide biosynthetic process
GO:0002805
IMP
Gene Ontologyregulation of antimicrobial peptide biosynthetic process5
GO:0008592
IGI
Genome Projectregulation of Toll signaling pathway
GO:0008592
IGI
Gene Ontologyregulation of Toll signaling pathway5
GO:0050830
IMP
Genome Projectdefense response to Gram-positive bacterium
GO:0050830
IMP
Gene Ontologydefense response to Gram-positive bacterium5
GO:0008589
IDA
Genome Projectregulation of smoothened signaling pathway
GO:0008589
IDA
Gene Ontologyregulation of smoothened signaling pathway6
GO:0007474
IMP
Genome Projectimaginal disc-derived wing vein specification
GO:0007474
IMP
Gene Ontologyimaginal disc-derived wing vein specification6
GO:0007224
IMP
Genome Projectsmoothened signaling pathway
GO:0007224
IMP
Gene Ontologysmoothened signaling pathway7
GO:0048601
IMP
Genome Projectoocyte morphogenesis
GO:0048601
IMP
Gene Ontologyoocyte morphogenesis8
GO:0007165
ISS
Genome Projectsignal transduction
GO:0012501
IEA
PLAZA Integrative Orthologyprogrammed cell death ENSG00000198873
GO:0043066
IEA
PLAZA Integrative Orthologynegative regulation of apoptotic process ENSG00000198873
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000125388
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000198873
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle ENSG00000198873
GO:0007602
IEA
PLAZA Integrative Orthologyphototransduction ENSG00000114124
GO:0009583
IEA
PLAZA Integrative Orthologydetection of light stimulus ENSG00000114124
GO:0009582
IEA
PLAZA Integrative Orthologydetection of abiotic stimulus ENSG00000114124
GO:0009584
IEA
PLAZA Integrative Orthologydetection of visible light ENSG00000114124
GO:0009581
IEA
PLAZA Integrative Orthologydetection of external stimulus ENSG00000114124
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation ENSG00000114124
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport ENSG00000125388
GO:0009416
IEA
PLAZA Integrative Orthologyresponse to light stimulus ENSG00000114124
GO:0060548
IEA
PLAZA Integrative Orthologynegative regulation of cell death ENSG00000198873
GO:0008284
IEA
PLAZA Integrative Orthologypositive regulation of cell proliferation ENSG00000198873
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation ENSG00000198873
GO:0031623
IEA
PLAZA Integrative Orthologyreceptor internalization ENSG00000125388
GO:0104004
IEA
PLAZA Integrative Orthologycellular response to environmental stimulus ENSG00000114124
GO:0010941
IEA
PLAZA Integrative Orthologyregulation of cell death ENSG00000198873
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000125388
GO:0071482
IEA
PLAZA Integrative Orthologycellular response to light stimulus ENSG00000114124
GO:0006898
IEA
PLAZA Integrative Orthologyreceptor-mediated endocytosis ENSG00000125388
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000125388
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis ENSG00000125388
GO:0008277
IEA
PLAZA Integrative Orthologyregulation of G protein-coupled receptor signaling pathway ENSG00000114124
GO:0007188
IEA
PLAZA Integrative Orthologyadenylate cyclase-modulating G protein-coupled receptor signaling pathway ENSG00000198873
GO:0042981
IEA
PLAZA Integrative Orthologyregulation of apoptotic process ENSG00000198873
GO:0007187
IEA
PLAZA Integrative OrthologyG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ENSG00000198873
GO:0043112
IEA
PLAZA Integrative Orthologyreceptor metabolic process ENSG00000125388
GO:0007186
IEA
PLAZA Integrative OrthologyG protein-coupled receptor signaling pathway ENSG00000114124
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle ENSG00000198873
GO:0016056
IEA
PLAZA Integrative Orthologyrhodopsin mediated signaling pathway ENSG00000114124
GO:0071214
IEA
PLAZA Integrative Orthologycellular response to abiotic stimulus ENSG00000114124
GO:0051606
IEA
PLAZA Integrative Orthologydetection of stimulus ENSG00000114124
GO:0098657
IEA
PLAZA Integrative Orthologyimport into cell ENSG00000125388
GO:0008219
IEA
PLAZA Integrative Orthologycell death ENSG00000198873
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus ENSG00000114124
GO:0007603
IEA
PLAZA Integrative Orthologyphototransduction, visible light ENSG00000114124
GO:0022400
IEA
PLAZA Integrative Orthologyregulation of rhodopsin mediated signaling pathway ENSG00000114124
GO:0007217
IEA
PLAZA Integrative Orthologytachykinin receptor signaling pathway ENSG00000198873
GO:0043069
IEA
PLAZA Integrative Orthologynegative regulation of programmed cell death ENSG00000198873
GO:0043067
IEA
PLAZA Integrative Orthologyregulation of programmed cell death ENSG00000198873
GO:0046777
IEA
PLAZA Integrative Orthologyprotein autophosphorylation ENSG00000114124
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation ENSG00000114124

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
IEA
Genome ProjectATP binding
GO:0004674
NAS
Genome Projectprotein serine/threonine kinase activity
GO:0004674
NAS
Gene Ontologyprotein serine/threonine kinase activity1
GO:0004703
IMP
ISS
Genome ProjectG protein-coupled receptor kinase activity
GO:0004703
IMP
Gene OntologyG protein-coupled receptor kinase activity8
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000198873
GO:0005543
IEA
PLAZA Integrative Orthologyphospholipid binding ENSG00000198873
GO:0019900
IEA
PLAZA Integrative Orthologykinase binding ENSG00000198873
GO:0047696
IEA
PLAZA Integrative Orthologybeta-adrenergic receptor kinase activity ENSG00000198055
GO:0050254
IEA
PLAZA Integrative Orthologyrhodopsin kinase activity ENSG00000114124
GO:0008289
IEA
PLAZA Integrative Orthologylipid binding ENSG00000198873
GO:0005515
IEA
PLAZA Integrative Orthologyprotein binding ENSG00000198055
GO:0005080
IEA
PLAZA Integrative Orthologyprotein kinase C binding ENSG00000198873
GO:0019901
IEA
PLAZA Integrative Orthologyprotein kinase binding ENSG00000198873

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane8 9
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm8
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000198873
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000198873
GO:0031965
IEA
PLAZA Integrative Orthologynuclear membrane ENSG00000198873
GO:0031967
IEA
PLAZA Integrative Orthologyorganelle envelope ENSG00000198873
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000114124
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000114124
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000114124
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000198873
GO:0031975
IEA
PLAZA Integrative Orthologyenvelope ENSG00000198873
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000198873
GO:0031253
IEA
PLAZA Integrative Orthologycell projection membrane ENSG00000114124
GO:0005929
IEA
PLAZA Integrative Orthologycilium ENSG00000114124
GO:0044463
IEA
PLAZA Integrative Orthologycell projection part ENSG00000114124
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000198873
GO:0042995
IEA
PLAZA Integrative Orthologycell projection ENSG00000114124
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part ENSG00000114124
GO:0043005
IEA
PLAZA Integrative Orthologyneuron projection ENSG00000114124
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000198873
GO:0044451
IEA
PLAZA Integrative Orthologynucleoplasm part ENSG00000198873
GO:0097733
IEA
PLAZA Integrative Orthologyphotoreceptor cell cilium ENSG00000114124
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle ENSG00000114124
GO:0097458
IEA
PLAZA Integrative Orthologyneuron part ENSG00000114124
GO:0097730
IEA
PLAZA Integrative Orthologynon-motile cilium ENSG00000114124
GO:0097731
IEA
PLAZA Integrative Orthology9+0 non-motile cilium ENSG00000114124
GO:0005634
IEA
PLAZA Integrative Orthologynucleus ENSG00000198873
GO:0005635
IEA
PLAZA Integrative Orthologynuclear envelope ENSG00000198873
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000198873
GO:0097381
IEA
PLAZA Integrative Orthologyphotoreceptor disc membrane ENSG00000114124
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part ENSG00000198873
GO:0098590
IEA
PLAZA Integrative Orthologyplasma membrane region ENSG00000114124
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000198873
GO:0120025
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection ENSG00000114124
GO:0060170
IEA
PLAZA Integrative Orthologyciliary membrane ENSG00000114124
GO:0005829
IEA
PLAZA Integrative Orthologycytosol ENSG00000198873
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle ENSG00000198873
GO:0044441
IEA
PLAZA Integrative Orthologyciliary part ENSG00000114124
GO:0001750
IEA
PLAZA Integrative Orthologyphotoreceptor outer segment ENSG00000114124
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000114124
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle ENSG00000114124
GO:0016607
IEA
PLAZA Integrative Orthologynuclear speck ENSG00000198873
GO:0120038
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection part ENSG00000114124
GO:0016604
IEA
PLAZA Integrative Orthologynuclear body ENSG00000198873
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle ENSG00000198873

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000239GPCR kinase
IPR000719Protein kinase domain
IPR000961AGC-kinase, C-terminal
IPR011009Protein kinase-like domain superfamily
IPR016137RGS domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.
KeggID Description
K08291GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]
No chloroplast target sequence found.