PLAZA diatoms 1.0 gene overview : FBgn0260945

Gene: FBgn0260945 (Drosophila melanogaster)

Overview

Gene Identifier: FBgn0260945
Transcript Identifier: FBtr0300561
Gene Type: Coding gene
Location: 3L : 12785337-12804444 : negative

Family Information

Homologous gene family: HOM02SEM000001
(5917 genes in 26 species)
specific family

Descriptions

gene_descr: Autophagy-related 1

Identifiers

Type	Value
pid	FBpp0289788
Uniprot	Q8MQJ7
RefSeq_mRNA	NM_001169962.2
EMBL	AE014296
EMBL	AY129445

Toolbox

Biological Process

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0035096	IMP	Genome Project	larval midgut cell programmed cell death
GO:0035096	IMP	Gene Ontology	larval midgut cell programmed cell death	1 2
GO:0006914	IMP, IGI	Genome Project	autophagy
GO:0006914	IMP, IGI	Gene Ontology	autophagy	1 2 3 4 5 6 7 8 9
GO:0010906	IMP	Genome Project	regulation of glucose metabolic process
GO:2000331	IMP	Genome Project	regulation of terminal button organization
GO:2000331	IMP	Gene Ontology	regulation of terminal button organization	10
GO:0006468	IMP NAS	Genome Project	protein phosphorylation
GO:0006468	IMP NAS	Gene Ontology	protein phosphorylation	11 12
GO:0061723	IMP	Genome Project	glycophagy
GO:0061723	IMP	Gene Ontology	glycophagy	13
GO:0045819	IMP	Genome Project	positive regulation of glycogen catabolic process
GO:0045819	IMP	Gene Ontology	positive regulation of glycogen catabolic process	13
GO:0010506	IMP, IGI	Genome Project	regulation of autophagy
GO:0010506	IMP, IGI	Gene Ontology	regulation of autophagy	14 15 16
GO:0010508	IMP	Genome Project	positive regulation of autophagy
GO:0010508	IMP	Gene Ontology	positive regulation of autophagy	17 18 19 20
GO:0006897	IMP	Genome Project	endocytosis
GO:0006897	IMP	Gene Ontology	endocytosis	21
GO:0035069	IMP	Genome Project	larval midgut histolysis
GO:0035069	IMP	Gene Ontology	larval midgut histolysis	20 22
GO:0014067	IMP	Genome Project	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014067	IMP	Gene Ontology	negative regulation of phosphatidylinositol 3-kinase signaling	20
GO:0046777	IMP	Genome Project	protein autophosphorylation
GO:0046777	IMP	Gene Ontology	protein autophosphorylation	23
GO:0045850	IMP	Genome Project	positive regulation of nurse cell apoptotic process
GO:0045850	IMP	Gene Ontology	positive regulation of nurse cell apoptotic process	24
GO:0045476	IMP	Genome Project	nurse cell apoptotic process
GO:0045476	IMP	Gene Ontology	nurse cell apoptotic process	25
GO:0034599	IDA, IMP	Genome Project	cellular response to oxidative stress
GO:0034599	IDA, IMP	Gene Ontology	cellular response to oxidative stress	19
GO:0006979	IGI	Genome Project	response to oxidative stress
GO:0006979	IGI	Gene Ontology	response to oxidative stress	19
GO:0009267	IMP	Genome Project	cellular response to starvation
GO:0009267	IMP	Gene Ontology	cellular response to starvation	19
GO:0050804	IMP	Genome Project	modulation of chemical synaptic transmission
GO:0050804	IMP	Gene Ontology	modulation of chemical synaptic transmission	26
GO:0008088	IMP	Genome Project	axo-dendritic transport
GO:0008088	IMP	Gene Ontology	axo-dendritic transport	26 27
GO:0051124	IMP	Genome Project	synaptic growth at neuromuscular junction
GO:0051124	IMP	Gene Ontology	synaptic growth at neuromuscular junction	26
GO:0050808	IMP	Genome Project	synapse organization
GO:0050808	IMP	Gene Ontology	synapse organization	26
GO:0001558	IMP	Genome Project	regulation of cell growth
GO:0001558	IMP	Gene Ontology	regulation of cell growth	28
GO:0032007	IMP	Genome Project	negative regulation of TOR signaling
GO:0032007	IMP	Gene Ontology	negative regulation of TOR signaling	28
GO:0016236	IMP	Genome Project	macroautophagy
GO:0016236	IMP	Gene Ontology	macroautophagy	3
GO:0006909	IEA	PLAZA Integrative Orthology	phagocytosis	WBGene00006786
GO:0061709	IEA	PLAZA Integrative Orthology	reticulophagy	YGL180W
GO:0048870	IEA	PLAZA Integrative Orthology	cell motility	WBGene00006786
GO:0022411	IEA	PLAZA Integrative Orthology	cellular component disassembly	SPCC63.08c
GO:0007568	IEA	PLAZA Integrative Orthology	aging	WBGene00006786
GO:0006996	IEA	PLAZA Integrative Orthology	organelle organization	SPCC63.08c
GO:0061387	IEA	PLAZA Integrative Orthology	regulation of extent of cell growth	WBGene00006786
GO:0061024	IEA	PLAZA Integrative Orthology	membrane organization	ENSG00000177169
GO:0033036	IEA	PLAZA Integrative Orthology	macromolecule localization	YGL180W
GO:0018210	IEA	PLAZA Integrative Orthology	peptidyl-threonine modification	ENSG00000177169
GO:0050770	IEA	PLAZA Integrative Orthology	regulation of axonogenesis	WBGene00006786
GO:0048588	IEA	PLAZA Integrative Orthology	developmental cell growth	WBGene00006786
GO:0032989	IEA	PLAZA Integrative Orthology	cellular component morphogenesis	WBGene00006786
GO:0007548	IEA	PLAZA Integrative Orthology	sex differentiation	WBGene00006786
GO:0048858	IEA	PLAZA Integrative Orthology	cell projection morphogenesis	WBGene00006786
GO:0048699	IEA	PLAZA Integrative Orthology	generation of neurons	ENSG00000177169
GO:0008361	IEA	PLAZA Integrative Orthology	regulation of cell size	WBGene00006786
GO:0090598	IEA	PLAZA Integrative Orthology	male anatomical structure morphogenesis	WBGene00006786
GO:0007033	IEA	PLAZA Integrative Orthology	vacuole organization	YGL180W
GO:0032990	IEA	PLAZA Integrative Orthology	cell part morphogenesis	WBGene00006786
GO:0018209	IEA	PLAZA Integrative Orthology	peptidyl-serine modification	ENSG00000177169
GO:0044419	IEA	PLAZA Integrative Orthology	interspecies interaction between organisms	ENSG00000083290
GO:0018107	IEA	PLAZA Integrative Orthology	peptidyl-threonine phosphorylation	ENSG00000177169
GO:0050767	IEA	PLAZA Integrative Orthology	regulation of neurogenesis	WBGene00006786
GO:0018105	IEA	PLAZA Integrative Orthology	peptidyl-serine phosphorylation	ENSG00000177169
GO:0032879	IEA	PLAZA Integrative Orthology	regulation of localization	WBGene00006786
GO:0000422	IEA	PLAZA Integrative Orthology	autophagy of mitochondrion	SPCC63.08c
GO:0044403	IEA	PLAZA Integrative Orthology	symbiont process	ENSG00000083290
GO:0043277	IEA	PLAZA Integrative Orthology	apoptotic cell clearance	WBGene00006786
GO:0032880	IEA	PLAZA Integrative Orthology	regulation of protein localization	WBGene00006786
GO:0030182	IEA	PLAZA Integrative Orthology	neuron differentiation	ENSG00000177169
GO:0044804	IEA	PLAZA Integrative Orthology	autophagy of nucleus	YGL180W
GO:0044805	IEA	PLAZA Integrative Orthology	late nucleophagy	YGL180W
GO:0010975	IEA	PLAZA Integrative Orthology	regulation of neuron projection development	WBGene00006786
GO:0072665	IEA	PLAZA Integrative Orthology	protein localization to vacuole	YGL180W
GO:0046661	IEA	PLAZA Integrative Orthology	male sex differentiation	WBGene00006786
GO:0044087	IEA	PLAZA Integrative Orthology	regulation of cellular component biogenesis	ENSG00000177169
GO:0051960	IEA	PLAZA Integrative Orthology	regulation of nervous system development	WBGene00006786
GO:0018193	IEA	PLAZA Integrative Orthology	peptidyl-amino acid modification	ENSG00000177169
GO:0022603	IEA	PLAZA Integrative Orthology	regulation of anatomical structure morphogenesis	WBGene00006786
GO:0002164	IEA	PLAZA Integrative Orthology	larval development	WBGene00006786
GO:0042330	IEA	PLAZA Integrative Orthology	taxis	WBGene00006786
GO:0060560	IEA	PLAZA Integrative Orthology	developmental growth involved in morphogenesis	WBGene00006786
GO:0120039	IEA	PLAZA Integrative Orthology	plasma membrane bounded cell projection morphogenesis	WBGene00006786
GO:0070925	IEA	PLAZA Integrative Orthology	organelle assembly	YGL180W
GO:0022604	IEA	PLAZA Integrative Orthology	regulation of cell morphogenesis	WBGene00006786
GO:0120036	IEA	PLAZA Integrative Orthology	plasma membrane bounded cell projection organization	ENSG00000177169
GO:0120035	IEA	PLAZA Integrative Orthology	regulation of plasma membrane bounded cell projection organization	WBGene00006786
GO:2000026	IEA	PLAZA Integrative Orthology	regulation of multicellular organismal development	WBGene00006786
GO:0032258	IEA	PLAZA Integrative Orthology	protein localization by the Cvt pathway	YGL180W
GO:0032535	IEA	PLAZA Integrative Orthology	regulation of cellular component size	WBGene00006786
GO:0010769	IEA	PLAZA Integrative Orthology	regulation of cell morphogenesis involved in differentiation	WBGene00006786
GO:0051674	IEA	PLAZA Integrative Orthology	localization of cell	WBGene00006786
GO:0030516	IEA	PLAZA Integrative Orthology	regulation of axon extension	WBGene00006786
GO:0075071	IEA	PLAZA Integrative Orthology	autophagy involved in symbiotic interaction	ENSG00000083290
GO:0007005	IEA	PLAZA Integrative Orthology	mitochondrion organization	SPCC63.08c
GO:0048666	IEA	PLAZA Integrative Orthology	neuron development	ENSG00000177169
GO:0048667	IEA	PLAZA Integrative Orthology	cell morphogenesis involved in neuron differentiation	WBGene00006786
GO:0043254	IEA	PLAZA Integrative Orthology	regulation of protein complex assembly	ENSG00000177169
GO:0031175	IEA	PLAZA Integrative Orthology	neuron projection development	ENSG00000177169
GO:0040024	IEA	PLAZA Integrative Orthology	dauer larval development	WBGene00006786
GO:0043933	IEA	PLAZA Integrative Orthology	protein-containing complex subunit organization	ENSG00000177169
GO:0016237	IEA	PLAZA Integrative Orthology	lysosomal microautophagy	YGL180W
GO:0016477	IEA	PLAZA Integrative Orthology	cell migration	WBGene00006786
GO:0031333	IEA	PLAZA Integrative Orthology	negative regulation of protein complex assembly	ENSG00000177169
GO:0034727	IEA	PLAZA Integrative Orthology	piecemeal microautophagy of the nucleus	YGL180W
GO:0006935	IEA	PLAZA Integrative Orthology	chemotaxis	WBGene00006786
GO:0000045	IEA	PLAZA Integrative Orthology	autophagosome assembly	YGL180W
GO:0045664	IEA	PLAZA Integrative Orthology	regulation of neuron differentiation	WBGene00006786
GO:0048812	IEA	PLAZA Integrative Orthology	neuron projection morphogenesis	WBGene00006786
GO:0040011	IEA	PLAZA Integrative Orthology	locomotion	WBGene00006786
GO:0040014	IEA	PLAZA Integrative Orthology	regulation of multicellular organism growth	WBGene00006786
GO:0035264	IEA	PLAZA Integrative Orthology	multicellular organism growth	WBGene00006786
GO:0034613	IEA	PLAZA Integrative Orthology	cellular protein localization	YGL180W
GO:0033365	IEA	PLAZA Integrative Orthology	protein localization to organelle	YGL180W
GO:0031344	IEA	PLAZA Integrative Orthology	regulation of cell projection organization	WBGene00006786
GO:0016241	IEA	PLAZA Integrative Orthology	regulation of macroautophagy	ENSG00000177169
GO:1990138	IEA	PLAZA Integrative Orthology	neuron projection extension	WBGene00006786
GO:0075044	IEA	PLAZA Integrative Orthology	autophagy of host cells involved in interaction with symbiont	ENSG00000083290
GO:0061726	IEA	PLAZA Integrative Orthology	mitochondrion disassembly	SPCC63.08c
GO:0045138	IEA	PLAZA Integrative Orthology	nematode male tail tip morphogenesis	WBGene00006786
GO:0090066	IEA	PLAZA Integrative Orthology	regulation of anatomical structure size	WBGene00006786
GO:0000902	IEA	PLAZA Integrative Orthology	cell morphogenesis	WBGene00006786
GO:1905037	IEA	PLAZA Integrative Orthology	autophagosome organization	YGL180W
GO:0000904	IEA	PLAZA Integrative Orthology	cell morphogenesis involved in differentiation	WBGene00006786
GO:0065003	IEA	PLAZA Integrative Orthology	protein-containing complex assembly	ENSG00000177169
GO:0061564	IEA	PLAZA Integrative Orthology	axon development	WBGene00006786
GO:0051129	IEA	PLAZA Integrative Orthology	negative regulation of cellular component organization	ENSG00000177169
GO:0010259	IEA	PLAZA Integrative Orthology	multicellular organism aging	WBGene00006786
GO:0007409	IEA	PLAZA Integrative Orthology	axonogenesis	WBGene00006786
GO:0002119	IEA	PLAZA Integrative Orthology	nematode larval development	WBGene00006786
GO:0097485	IEA	PLAZA Integrative Orthology	neuron projection guidance	WBGene00006786
GO:0048638	IEA	PLAZA Integrative Orthology	regulation of developmental growth	WBGene00006786
GO:0022008	IEA	PLAZA Integrative Orthology	neurogenesis	ENSG00000177169
GO:0007411	IEA	PLAZA Integrative Orthology	axon guidance	WBGene00006786
GO:1903008	IEA	PLAZA Integrative Orthology	organelle disassembly	SPCC63.08c
GO:0008104	IEA	PLAZA Integrative Orthology	protein localization	YGL180W
GO:0030030	IEA	PLAZA Integrative Orthology	cell projection organization	ENSG00000177169
GO:0008340	IEA	PLAZA Integrative Orthology	determination of adult lifespan	WBGene00006786
GO:0009792	IEA	PLAZA Integrative Orthology	embryo development ending in birth or egg hatching	WBGene00006786
GO:0070727	IEA	PLAZA Integrative Orthology	cellular macromolecule localization	YGL180W
GO:0009790	IEA	PLAZA Integrative Orthology	embryo development	WBGene00006786
GO:0060729	IMP	Gene Ontology	intestinal epithelial structure maintenance	9

Molecular Function

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005515	IPI	Genome Project	protein binding
GO:0005515	IPI	Gene Ontology	protein binding	29
GO:0032182	IPI	Genome Project	ubiquitin-like protein binding
GO:0032182	IPI	Gene Ontology	ubiquitin-like protein binding	30
GO:0004674	IMP	Genome Project	protein serine/threonine kinase activity
GO:0004674	IDA, IMP	Gene Ontology	protein serine/threonine kinase activity	23 27 31
GO:0004672	IDA, IMP NAS	Genome Project	protein kinase activity
GO:0004672	NAS	Gene Ontology	protein kinase activity	11
GO:0005524	IEA	Genome Project	ATP binding
GO:0019899	IEA	PLAZA Integrative Orthology	enzyme binding	ENSG00000177169
GO:0042802	IEA	PLAZA Integrative Orthology	identical protein binding	ENSG00000177169
GO:0017016	IEA	PLAZA Integrative Orthology	Ras GTPase binding	ENSG00000177169
GO:0017137	IEA	PLAZA Integrative Orthology	Rab GTPase binding	ENSG00000177169
GO:0031267	IEA	PLAZA Integrative Orthology	small GTPase binding	ENSG00000177169
GO:0044877	IEA	PLAZA Integrative Orthology	protein-containing complex binding	ENSG00000177169
GO:0051020	IEA	PLAZA Integrative Orthology	GTPase binding	ENSG00000177169

Cellular Component

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:1990316	IDA	Genome Project	Atg1/ULK1 kinase complex
GO:1990316	IDA	Gene Ontology	Atg1/ULK1 kinase complex	5 8 32
GO:0098805	IEA	PLAZA Integrative Orthology	whole membrane	SPCC63.08c
GO:0019898	IEA	PLAZA Integrative Orthology	extrinsic component of membrane	ENSG00000177169
GO:0055037	IEA	PLAZA Integrative Orthology	recycling endosome	ENSG00000177169
GO:0012505	IEA	PLAZA Integrative Orthology	endomembrane system	ENSG00000177169
GO:0016020	IEA	PLAZA Integrative Orthology	membrane	SPCC63.08c
GO:0031090	IEA	PLAZA Integrative Orthology	organelle membrane	SPCC63.08c
GO:0044425	IEA	PLAZA Integrative Orthology	membrane part	ENSG00000177169
GO:0044422	IEA	PLAZA Integrative Orthology	organelle part	SPCC63.08c
GO:0005783	IEA	PLAZA Integrative Orthology	endoplasmic reticulum	ENSG00000177169
GO:0000407	IEA	PLAZA Integrative Orthology	phagophore assembly site	SPCC63.08c
GO:0044429	IEA	PLAZA Integrative Orthology	mitochondrial part	ENSG00000177169
GO:0097708	IEA	PLAZA Integrative Orthology	intracellular vesicle	ENSG00000177169
GO:0031410	IEA	PLAZA Integrative Orthology	cytoplasmic vesicle	ENSG00000177169
GO:0005768	IEA	PLAZA Integrative Orthology	endosome	ENSG00000177169
GO:0005776	IEA	PLAZA Integrative Orthology	autophagosome	AT3G61960
GO:0042995	IEA	PLAZA Integrative Orthology	cell projection	WBGene00006786
GO:0005773	IEA	PLAZA Integrative Orthology	vacuole	SPCC63.08c
GO:0005774	IEA	PLAZA Integrative Orthology	vacuolar membrane	SPCC63.08c
GO:1903349	IEA	PLAZA Integrative Orthology	omegasome membrane	ENSG00000177169
GO:0098827	IEA	PLAZA Integrative Orthology	endoplasmic reticulum subcompartment	ENSG00000177169
GO:0097458	IEA	PLAZA Integrative Orthology	neuron part	WBGene00006786
GO:1990462	IEA	PLAZA Integrative Orthology	omegasome	ENSG00000177169
GO:0000421	IEA	PLAZA Integrative Orthology	autophagosome membrane	YGL180W
GO:0000306	IEA	PLAZA Integrative Orthology	extrinsic component of vacuolar membrane	ENSG00000177169
GO:0120025	IEA	PLAZA Integrative Orthology	plasma membrane bounded cell projection	WBGene00006786
GO:0031312	IEA	PLAZA Integrative Orthology	extrinsic component of organelle membrane	ENSG00000177169
GO:0005829	IEA	PLAZA Integrative Orthology	cytosol	SPCC63.08c
GO:0005789	IEA	PLAZA Integrative Orthology	endoplasmic reticulum membrane	ENSG00000177169
GO:0043025	IEA	PLAZA Integrative Orthology	neuronal cell body	WBGene00006786
GO:0120095	IEA	PLAZA Integrative Orthology	vacuole-isolation membrane contact site	YGL180W
GO:0097635	IEA	PLAZA Integrative Orthology	extrinsic component of autophagosome membrane	ENSG00000177169
GO:0005739	IEA	PLAZA Integrative Orthology	mitochondrion	ENSG00000177169
GO:0042175	IEA	PLAZA Integrative Orthology	nuclear outer membrane-endoplasmic reticulum membrane network	ENSG00000177169
GO:0044232	IEA	PLAZA Integrative Orthology	organelle membrane contact site	YGL180W
GO:0097632	IEA	PLAZA Integrative Orthology	extrinsic component of phagophore assembly site membrane	ENSG00000177169
GO:0031966	IEA	PLAZA Integrative Orthology	mitochondrial membrane	ENSG00000177169
GO:0031968	IEA	PLAZA Integrative Orthology	organelle outer membrane	ENSG00000177169
GO:0031967	IEA	PLAZA Integrative Orthology	organelle envelope	ENSG00000177169
GO:0061908	IEA	PLAZA Integrative Orthology	phagophore	YGL180W
GO:0000322	IEA	PLAZA Integrative Orthology	storage vacuole	SPCC63.08c
GO:0000323	IEA	PLAZA Integrative Orthology	lytic vacuole	SPCC63.08c
GO:0005740	IEA	PLAZA Integrative Orthology	mitochondrial envelope	ENSG00000177169
GO:0000324	IEA	PLAZA Integrative Orthology	fungal-type vacuole	SPCC63.08c
GO:0005741	IEA	PLAZA Integrative Orthology	mitochondrial outer membrane	ENSG00000177169
GO:0000329	IEA	PLAZA Integrative Orthology	fungal-type vacuole membrane	SPCC63.08c
GO:0034045	IEA	PLAZA Integrative Orthology	phagophore assembly site membrane	ENSG00000083290
GO:0019867	IEA	PLAZA Integrative Orthology	outer membrane	ENSG00000177169
GO:0031975	IEA	PLAZA Integrative Orthology	envelope	ENSG00000177169
GO:0097629	IEA	PLAZA Integrative Orthology	extrinsic component of omegasome membrane	ENSG00000177169
GO:0043005	IEA	PLAZA Integrative Orthology	neuron projection	WBGene00006786
GO:0036477	IEA	PLAZA Integrative Orthology	somatodendritic compartment	WBGene00006786
GO:0031984	IEA	PLAZA Integrative Orthology	organelle subcompartment	ENSG00000177169
GO:0031982	IEA	PLAZA Integrative Orthology	vesicle	ENSG00000177169
GO:0044297	IEA	PLAZA Integrative Orthology	cell body	WBGene00006786
GO:0098588	IEA	PLAZA Integrative Orthology	bounding membrane of organelle	SPCC63.08c
GO:0005634	IEA	PLAZA Integrative Orthology	nucleus	SPCC63.08c
GO:0044446	IEA	PLAZA Integrative Orthology	intracellular organelle part	SPCC63.08c
GO:0030424	IEA	PLAZA Integrative Orthology	axon	WBGene00006786
GO:0032045	IEA	PLAZA Integrative Orthology	guanyl-nucleotide exchange factor complex	ENSG00000177169
GO:0098852	IEA	PLAZA Integrative Orthology	lytic vacuole membrane	SPCC63.08c
GO:0043231	IEA	PLAZA Integrative Orthology	intracellular membrane-bounded organelle	SPCC63.08c
GO:0044437	IEA	PLAZA Integrative Orthology	vacuolar part	SPCC63.08c
GO:0043227	IEA	PLAZA Integrative Orthology	membrane-bounded organelle	SPCC63.08c
GO:0043226	IEA	PLAZA Integrative Orthology	organelle	SPCC63.08c
GO:0044432	IEA	PLAZA Integrative Orthology	endoplasmic reticulum part	ENSG00000177169
GO:0043229	IEA	PLAZA Integrative Orthology	intracellular organelle	SPCC63.08c

Color Legend

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR017184	Serine/threonine-protein kinase Unc-51
IPR017441	Protein kinase, ATP binding site
IPR022708	Serine/threonine-protein kinase, C-terminal

No MapMan annotations defined for this gene.

KeggID	Description
K08269	ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]

No chloroplast target sequence found.

Gene: FBgn0260945 (Drosophila melanogaster)

Overview

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Descriptions

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Biological Process

Molecular Function

Cellular Component

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