Gene: FBgn0260945 (Drosophila melanogaster)

Overview top

Gene Identifier
FBgn0260945
Transcript Identifier
FBtr0300561
Gene Type
Coding gene
Location
3L : 12785337-12804444 : negative

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family

Descriptions

gene_descr
Autophagy-related 1

Identifiers

Type Value
pidFBpp0289788
UniprotQ8MQJ7
RefSeq_mRNANM_001169962.2
EMBLAE014296
EMBLAY129445

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0035096
IMP
Genome Projectlarval midgut cell programmed cell death
GO:0035096
IMP
Gene Ontologylarval midgut cell programmed cell death1 2
GO:0006914
IMP, IGI
Genome Projectautophagy
GO:0006914
IMP, IGI
Gene Ontologyautophagy1 2 3 4 5 6 7 8 9
GO:0010906
IMP
Genome Projectregulation of glucose metabolic process
GO:2000331
IMP
Genome Projectregulation of terminal button organization
GO:2000331
IMP
Gene Ontologyregulation of terminal button organization10
GO:0006468
IMP
NAS
Genome Projectprotein phosphorylation
GO:0006468
IMP
NAS
Gene Ontologyprotein phosphorylation11 12
GO:0061723
IMP
Genome Projectglycophagy
GO:0061723
IMP
Gene Ontologyglycophagy13
GO:0045819
IMP
Genome Projectpositive regulation of glycogen catabolic process
GO:0045819
IMP
Gene Ontologypositive regulation of glycogen catabolic process13
GO:0010506
IMP, IGI
Genome Projectregulation of autophagy
GO:0010506
IMP, IGI
Gene Ontologyregulation of autophagy14 15 16
GO:0010508
IMP
Genome Projectpositive regulation of autophagy
GO:0010508
IMP
Gene Ontologypositive regulation of autophagy17 18 19 20
GO:0006897
IMP
Genome Projectendocytosis
GO:0006897
IMP
Gene Ontologyendocytosis21
GO:0035069
IMP
Genome Projectlarval midgut histolysis
GO:0035069
IMP
Gene Ontologylarval midgut histolysis20 22
GO:0014067
IMP
Genome Projectnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0014067
IMP
Gene Ontologynegative regulation of phosphatidylinositol 3-kinase signaling20
GO:0046777
IMP
Genome Projectprotein autophosphorylation
GO:0046777
IMP
Gene Ontologyprotein autophosphorylation23
GO:0045850
IMP
Genome Projectpositive regulation of nurse cell apoptotic process
GO:0045850
IMP
Gene Ontologypositive regulation of nurse cell apoptotic process24
GO:0045476
IMP
Genome Projectnurse cell apoptotic process
GO:0045476
IMP
Gene Ontologynurse cell apoptotic process25
GO:0034599
IDA, IMP
Genome Projectcellular response to oxidative stress
GO:0034599
IDA, IMP
Gene Ontologycellular response to oxidative stress19
GO:0006979
IGI
Genome Projectresponse to oxidative stress
GO:0006979
IGI
Gene Ontologyresponse to oxidative stress19
GO:0009267
IMP
Genome Projectcellular response to starvation
GO:0009267
IMP
Gene Ontologycellular response to starvation19
GO:0050804
IMP
Genome Projectmodulation of chemical synaptic transmission
GO:0050804
IMP
Gene Ontologymodulation of chemical synaptic transmission26
GO:0008088
IMP
Genome Projectaxo-dendritic transport
GO:0008088
IMP
Gene Ontologyaxo-dendritic transport26 27
GO:0051124
IMP
Genome Projectsynaptic growth at neuromuscular junction
GO:0051124
IMP
Gene Ontologysynaptic growth at neuromuscular junction26
GO:0050808
IMP
Genome Projectsynapse organization
GO:0050808
IMP
Gene Ontologysynapse organization26
GO:0001558
IMP
Genome Projectregulation of cell growth
GO:0001558
IMP
Gene Ontologyregulation of cell growth28
GO:0032007
IMP
Genome Projectnegative regulation of TOR signaling
GO:0032007
IMP
Gene Ontologynegative regulation of TOR signaling28
GO:0016236
IMP
Genome Projectmacroautophagy
GO:0016236
IMP
Gene Ontologymacroautophagy3
GO:0006909
IEA
PLAZA Integrative Orthologyphagocytosis WBGene00006786
GO:0061709
IEA
PLAZA Integrative Orthologyreticulophagy YGL180W
GO:0048870
IEA
PLAZA Integrative Orthologycell motility WBGene00006786
GO:0022411
IEA
PLAZA Integrative Orthologycellular component disassembly SPCC63.08c
GO:0007568
IEA
PLAZA Integrative Orthologyaging WBGene00006786
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization SPCC63.08c
GO:0061387
IEA
PLAZA Integrative Orthologyregulation of extent of cell growth WBGene00006786
GO:0061024
IEA
PLAZA Integrative Orthologymembrane organization ENSG00000177169
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization YGL180W
GO:0018210
IEA
PLAZA Integrative Orthologypeptidyl-threonine modification ENSG00000177169
GO:0050770
IEA
PLAZA Integrative Orthologyregulation of axonogenesis WBGene00006786
GO:0048588
IEA
PLAZA Integrative Orthologydevelopmental cell growth WBGene00006786
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis WBGene00006786
GO:0007548
IEA
PLAZA Integrative Orthologysex differentiation WBGene00006786
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis WBGene00006786
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons ENSG00000177169
GO:0008361
IEA
PLAZA Integrative Orthologyregulation of cell size WBGene00006786
GO:0090598
IEA
PLAZA Integrative Orthologymale anatomical structure morphogenesis WBGene00006786
GO:0007033
IEA
PLAZA Integrative Orthologyvacuole organization YGL180W
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis WBGene00006786
GO:0018209
IEA
PLAZA Integrative Orthologypeptidyl-serine modification ENSG00000177169
GO:0044419
IEA
PLAZA Integrative Orthologyinterspecies interaction between organisms ENSG00000083290
GO:0018107
IEA
PLAZA Integrative Orthologypeptidyl-threonine phosphorylation ENSG00000177169
GO:0050767
IEA
PLAZA Integrative Orthologyregulation of neurogenesis WBGene00006786
GO:0018105
IEA
PLAZA Integrative Orthologypeptidyl-serine phosphorylation ENSG00000177169
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization WBGene00006786
GO:0000422
IEA
PLAZA Integrative Orthologyautophagy of mitochondrion SPCC63.08c
GO:0044403
IEA
PLAZA Integrative Orthologysymbiont process ENSG00000083290
GO:0043277
IEA
PLAZA Integrative Orthologyapoptotic cell clearance WBGene00006786
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization WBGene00006786
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation ENSG00000177169
GO:0044804
IEA
PLAZA Integrative Orthologyautophagy of nucleus YGL180W
GO:0044805
IEA
PLAZA Integrative Orthologylate nucleophagy YGL180W
GO:0010975
IEA
PLAZA Integrative Orthologyregulation of neuron projection development WBGene00006786
GO:0072665
IEA
PLAZA Integrative Orthologyprotein localization to vacuole YGL180W
GO:0046661
IEA
PLAZA Integrative Orthologymale sex differentiation WBGene00006786
GO:0044087
IEA
PLAZA Integrative Orthologyregulation of cellular component biogenesis ENSG00000177169
GO:0051960
IEA
PLAZA Integrative Orthologyregulation of nervous system development WBGene00006786
GO:0018193
IEA
PLAZA Integrative Orthologypeptidyl-amino acid modification ENSG00000177169
GO:0022603
IEA
PLAZA Integrative Orthologyregulation of anatomical structure morphogenesis WBGene00006786
GO:0002164
IEA
PLAZA Integrative Orthologylarval development WBGene00006786
GO:0042330
IEA
PLAZA Integrative Orthologytaxis WBGene00006786
GO:0060560
IEA
PLAZA Integrative Orthologydevelopmental growth involved in morphogenesis WBGene00006786
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis WBGene00006786
GO:0070925
IEA
PLAZA Integrative Orthologyorganelle assembly YGL180W
GO:0022604
IEA
PLAZA Integrative Orthologyregulation of cell morphogenesis WBGene00006786
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization ENSG00000177169
GO:0120035
IEA
PLAZA Integrative Orthologyregulation of plasma membrane bounded cell projection organization WBGene00006786
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development WBGene00006786
GO:0032258
IEA
PLAZA Integrative Orthologyprotein localization by the Cvt pathway YGL180W
GO:0032535
IEA
PLAZA Integrative Orthologyregulation of cellular component size WBGene00006786
GO:0010769
IEA
PLAZA Integrative Orthologyregulation of cell morphogenesis involved in differentiation WBGene00006786
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell WBGene00006786
GO:0030516
IEA
PLAZA Integrative Orthologyregulation of axon extension WBGene00006786
GO:0075071
IEA
PLAZA Integrative Orthologyautophagy involved in symbiotic interaction ENSG00000083290
GO:0007005
IEA
PLAZA Integrative Orthologymitochondrion organization SPCC63.08c
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development ENSG00000177169
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation WBGene00006786
GO:0043254
IEA
PLAZA Integrative Orthologyregulation of protein complex assembly ENSG00000177169
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development ENSG00000177169
GO:0040024
IEA
PLAZA Integrative Orthologydauer larval development WBGene00006786
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization ENSG00000177169
GO:0016237
IEA
PLAZA Integrative Orthologylysosomal microautophagy YGL180W
GO:0016477
IEA
PLAZA Integrative Orthologycell migration WBGene00006786
GO:0031333
IEA
PLAZA Integrative Orthologynegative regulation of protein complex assembly ENSG00000177169
GO:0034727
IEA
PLAZA Integrative Orthologypiecemeal microautophagy of the nucleus YGL180W
GO:0006935
IEA
PLAZA Integrative Orthologychemotaxis WBGene00006786
GO:0000045
IEA
PLAZA Integrative Orthologyautophagosome assembly YGL180W
GO:0045664
IEA
PLAZA Integrative Orthologyregulation of neuron differentiation WBGene00006786
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis WBGene00006786
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion WBGene00006786
GO:0040014
IEA
PLAZA Integrative Orthologyregulation of multicellular organism growth WBGene00006786
GO:0035264
IEA
PLAZA Integrative Orthologymulticellular organism growth WBGene00006786
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization YGL180W
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle YGL180W
GO:0031344
IEA
PLAZA Integrative Orthologyregulation of cell projection organization WBGene00006786
GO:0016241
IEA
PLAZA Integrative Orthologyregulation of macroautophagy ENSG00000177169
GO:1990138
IEA
PLAZA Integrative Orthologyneuron projection extension WBGene00006786
GO:0075044
IEA
PLAZA Integrative Orthologyautophagy of host cells involved in interaction with symbiont ENSG00000083290
GO:0061726
IEA
PLAZA Integrative Orthologymitochondrion disassembly SPCC63.08c
GO:0045138
IEA
PLAZA Integrative Orthologynematode male tail tip morphogenesis WBGene00006786
GO:0090066
IEA
PLAZA Integrative Orthologyregulation of anatomical structure size WBGene00006786
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis WBGene00006786
GO:1905037
IEA
PLAZA Integrative Orthologyautophagosome organization YGL180W
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation WBGene00006786
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly ENSG00000177169
GO:0061564
IEA
PLAZA Integrative Orthologyaxon development WBGene00006786
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization ENSG00000177169
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging WBGene00006786
GO:0007409
IEA
PLAZA Integrative Orthologyaxonogenesis WBGene00006786
GO:0002119
IEA
PLAZA Integrative Orthologynematode larval development WBGene00006786
GO:0097485
IEA
PLAZA Integrative Orthologyneuron projection guidance WBGene00006786
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth WBGene00006786
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis ENSG00000177169
GO:0007411
IEA
PLAZA Integrative Orthologyaxon guidance WBGene00006786
GO:1903008
IEA
PLAZA Integrative Orthologyorganelle disassembly SPCC63.08c
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization YGL180W
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization ENSG00000177169
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan WBGene00006786
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00006786
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization YGL180W
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00006786
GO:0060729
IMP
Gene Ontologyintestinal epithelial structure maintenance9

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding29
GO:0032182
IPI
Genome Projectubiquitin-like protein binding
GO:0032182
IPI
Gene Ontologyubiquitin-like protein binding30
GO:0004674
IMP
Genome Projectprotein serine/threonine kinase activity
GO:0004674
IDA, IMP
Gene Ontologyprotein serine/threonine kinase activity23 27 31
GO:0004672
IDA, IMP
NAS
Genome Projectprotein kinase activity
GO:0004672
NAS
Gene Ontologyprotein kinase activity11
GO:0005524
IEA
Genome ProjectATP binding
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000177169
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding ENSG00000177169
GO:0017016
IEA
PLAZA Integrative OrthologyRas GTPase binding ENSG00000177169
GO:0017137
IEA
PLAZA Integrative OrthologyRab GTPase binding ENSG00000177169
GO:0031267
IEA
PLAZA Integrative Orthologysmall GTPase binding ENSG00000177169
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding ENSG00000177169
GO:0051020
IEA
PLAZA Integrative OrthologyGTPase binding ENSG00000177169

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990316
IDA
Genome ProjectAtg1/ULK1 kinase complex
GO:1990316
IDA
Gene OntologyAtg1/ULK1 kinase complex5 8 32
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane SPCC63.08c
GO:0019898
IEA
PLAZA Integrative Orthologyextrinsic component of membrane ENSG00000177169
GO:0055037
IEA
PLAZA Integrative Orthologyrecycling endosome ENSG00000177169
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000177169
GO:0016020
IEA
PLAZA Integrative Orthologymembrane SPCC63.08c
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane SPCC63.08c
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000177169
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part SPCC63.08c
GO:0005783
IEA
PLAZA Integrative Orthologyendoplasmic reticulum ENSG00000177169
GO:0000407
IEA
PLAZA Integrative Orthologyphagophore assembly site SPCC63.08c
GO:0044429
IEA
PLAZA Integrative Orthologymitochondrial part ENSG00000177169
GO:0097708
IEA
PLAZA Integrative Orthologyintracellular vesicle ENSG00000177169
GO:0031410
IEA
PLAZA Integrative Orthologycytoplasmic vesicle ENSG00000177169
GO:0005768
IEA
PLAZA Integrative Orthologyendosome ENSG00000177169
GO:0005776
IEA
PLAZA Integrative Orthologyautophagosome AT3G61960
GO:0042995
IEA
PLAZA Integrative Orthologycell projection WBGene00006786
GO:0005773
IEA
PLAZA Integrative Orthologyvacuole SPCC63.08c
GO:0005774
IEA
PLAZA Integrative Orthologyvacuolar membrane SPCC63.08c
GO:1903349
IEA
PLAZA Integrative Orthologyomegasome membrane ENSG00000177169
GO:0098827
IEA
PLAZA Integrative Orthologyendoplasmic reticulum subcompartment ENSG00000177169
GO:0097458
IEA
PLAZA Integrative Orthologyneuron part WBGene00006786
GO:1990462
IEA
PLAZA Integrative Orthologyomegasome ENSG00000177169
GO:0000421
IEA
PLAZA Integrative Orthologyautophagosome membrane YGL180W
GO:0000306
IEA
PLAZA Integrative Orthologyextrinsic component of vacuolar membrane ENSG00000177169
GO:0120025
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection WBGene00006786
GO:0031312
IEA
PLAZA Integrative Orthologyextrinsic component of organelle membrane ENSG00000177169
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPCC63.08c
GO:0005789
IEA
PLAZA Integrative Orthologyendoplasmic reticulum membrane ENSG00000177169
GO:0043025
IEA
PLAZA Integrative Orthologyneuronal cell body WBGene00006786
GO:0120095
IEA
PLAZA Integrative Orthologyvacuole-isolation membrane contact site YGL180W
GO:0097635
IEA
PLAZA Integrative Orthologyextrinsic component of autophagosome membrane ENSG00000177169
GO:0005739
IEA
PLAZA Integrative Orthologymitochondrion ENSG00000177169
GO:0042175
IEA
PLAZA Integrative Orthologynuclear outer membrane-endoplasmic reticulum membrane network ENSG00000177169
GO:0044232
IEA
PLAZA Integrative Orthologyorganelle membrane contact site YGL180W
GO:0097632
IEA
PLAZA Integrative Orthologyextrinsic component of phagophore assembly site membrane ENSG00000177169
GO:0031966
IEA
PLAZA Integrative Orthologymitochondrial membrane ENSG00000177169
GO:0031968
IEA
PLAZA Integrative Orthologyorganelle outer membrane ENSG00000177169
GO:0031967
IEA
PLAZA Integrative Orthologyorganelle envelope ENSG00000177169
GO:0061908
IEA
PLAZA Integrative Orthologyphagophore YGL180W
GO:0000322
IEA
PLAZA Integrative Orthologystorage vacuole SPCC63.08c
GO:0000323
IEA
PLAZA Integrative Orthologylytic vacuole SPCC63.08c
GO:0005740
IEA
PLAZA Integrative Orthologymitochondrial envelope ENSG00000177169
GO:0000324
IEA
PLAZA Integrative Orthologyfungal-type vacuole SPCC63.08c
GO:0005741
IEA
PLAZA Integrative Orthologymitochondrial outer membrane ENSG00000177169
GO:0000329
IEA
PLAZA Integrative Orthologyfungal-type vacuole membrane SPCC63.08c
GO:0034045
IEA
PLAZA Integrative Orthologyphagophore assembly site membrane ENSG00000083290
GO:0019867
IEA
PLAZA Integrative Orthologyouter membrane ENSG00000177169
GO:0031975
IEA
PLAZA Integrative Orthologyenvelope ENSG00000177169
GO:0097629
IEA
PLAZA Integrative Orthologyextrinsic component of omegasome membrane ENSG00000177169
GO:0043005
IEA
PLAZA Integrative Orthologyneuron projection WBGene00006786
GO:0036477
IEA
PLAZA Integrative Orthologysomatodendritic compartment WBGene00006786
GO:0031984
IEA
PLAZA Integrative Orthologyorganelle subcompartment ENSG00000177169
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000177169
GO:0044297
IEA
PLAZA Integrative Orthologycell body WBGene00006786
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle SPCC63.08c
GO:0005634
IEA
PLAZA Integrative Orthologynucleus SPCC63.08c
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part SPCC63.08c
GO:0030424
IEA
PLAZA Integrative Orthologyaxon WBGene00006786
GO:0032045
IEA
PLAZA Integrative Orthologyguanyl-nucleotide exchange factor complex ENSG00000177169
GO:0098852
IEA
PLAZA Integrative Orthologylytic vacuole membrane SPCC63.08c
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle SPCC63.08c
GO:0044437
IEA
PLAZA Integrative Orthologyvacuolar part SPCC63.08c
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle SPCC63.08c
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle SPCC63.08c
GO:0044432
IEA
PLAZA Integrative Orthologyendoplasmic reticulum part ENSG00000177169
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle SPCC63.08c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamily
IPR017184Serine/threonine-protein kinase Unc-51
IPR017441Protein kinase, ATP binding site
IPR022708Serine/threonine-protein kinase, C-terminal

No MapMan annotations defined for this gene.
KeggID Description
K08269ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
No chloroplast target sequence found.