Gene: FBgn0003444 (Drosophila melanogaster)

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Gene Identifier
FBgn0003444
Transcript Identifier
FBtr0078129
Gene Type
Coding gene
Location
2L : 277826-281514 : positive

Family Information

Homologous gene family
HOM02SEM002618
(27 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM019986
(2 genes in 2 species)
specific family

Descriptions

gene_descr
smoothened

Identifiers

Type Value
pidFBpp0077788
UniprotP91682
UniprotQ86PA9
RefSeq_mRNANM_078719.4
EMBLAE014134
EMBLAF030334
EMBLBT003246
EMBLBT053691
EMBLU87613

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002385
IMP
Genome Projectmucosal immune response
GO:0002385
IMP
Gene Ontologymucosal immune response1
GO:0045746
IGI
Genome Projectnegative regulation of Notch signaling pathway
GO:0045746
IGI
Gene Ontologynegative regulation of Notch signaling pathway2
GO:0042981
IGI
Genome Projectregulation of apoptotic process
GO:0042981
IGI
Gene Ontologyregulation of apoptotic process3
GO:0007193
IMP
Genome Projectadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007193
IMP
Gene Ontologyadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway4
GO:0048592
IMP
Genome Projecteye morphogenesis
GO:0048592
IMP
Gene Ontologyeye morphogenesis5
GO:0035019
IMP
Genome Projectsomatic stem cell population maintenance
GO:0035019
IMP
Gene Ontologysomatic stem cell population maintenance6
GO:0030707
IMP
Genome Projectovarian follicle cell development
GO:0030707
IMP, IGI
Gene Ontologyovarian follicle cell development6 7
GO:2000134
IMP
Genome Projectnegative regulation of G1/S transition of mitotic cell cycle
GO:2000134
IMP
Gene Ontologynegative regulation of G1/S transition of mitotic cell cycle8
GO:0007224
IMP
NAS
Genome Projectsmoothened signaling pathway
GO:0007224
IMP
NAS
Gene Ontologysmoothened signaling pathway9 10 11
GO:0007455
IGI
Genome Projecteye-antennal disc morphogenesis
GO:0007455
IGI
Gene Ontologyeye-antennal disc morphogenesis12
GO:0048100
TAS
Genome Projectwing disc anterior/posterior pattern formation
GO:0048100
TAS
Gene Ontologywing disc anterior/posterior pattern formation10
GO:0007346
IMP
Genome Projectregulation of mitotic cell cycle
GO:0007346
IMP
Gene Ontologyregulation of mitotic cell cycle13
GO:0007165
ISS
Genome Projectsignal transduction
GO:0007165
ISS
Gene Ontologysignal transduction14
GO:0001746
IMP
Genome ProjectBolwig's organ morphogenesis
GO:0001746
IMP
Gene OntologyBolwig's organ morphogenesis15
GO:0048099
TAS
Genome Projectanterior/posterior lineage restriction, imaginal disc
GO:0048099
TAS
Gene Ontologyanterior/posterior lineage restriction, imaginal disc16
GO:0007350
IMP
Genome Projectblastoderm segmentation
GO:0007350
IMP
Gene Ontologyblastoderm segmentation17
GO:1904263
IMP, IGI
Gene Ontologypositive regulation of TORC1 signaling18
GO:1903078
IDA
Gene Ontologypositive regulation of protein localization to plasma membrane19
GO:2000026
IEA
PLAZA Homology (enrichment)regulation of multicellular organismal development HOM02SEM002618
GO:0035567
IEA
PLAZA Homology (enrichment)non-canonical Wnt signaling pathway HOM02SEM002618
GO:0051239
IEA
PLAZA Homology (enrichment)regulation of multicellular organismal process HOM02SEM002618
GO:0001655
IEA
PLAZA Integrative Orthologyurogenital system development ENSG00000128602
GO:0198738
IEA
PLAZA Homology (enrichment)cell-cell signaling by wnt HOM02SEM002618
GO:0060070
IEA
PLAZA Homology (enrichment)canonical Wnt signaling pathway HOM02SEM002618
GO:0072001
IEA
PLAZA Integrative Orthologyrenal system development ENSG00000128602
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus ENSG00000128602
GO:0048699
IEA
PLAZA Homology (enrichment)generation of neurons HOM02SEM002618
GO:0007399
IEA
PLAZA Homology (enrichment)nervous system development HOM02SEM002618
GO:0071840
IEA
PLAZA Homology (enrichment)cellular component organization or biogenesis HOM02SEM002618
GO:0016043
IEA
PLAZA Homology (enrichment)cellular component organization HOM02SEM002618
GO:0042221
IEA
PLAZA Homology (enrichment)response to chemical HOM02SEM002618
GO:0007267
IEA
PLAZA Homology (enrichment)cell-cell signaling HOM02SEM002618
GO:1905114
IEA
PLAZA Homology (enrichment)cell surface receptor signaling pathway involved in cell-cell signaling HOM02SEM002618
GO:0030182
IEA
PLAZA Homology (enrichment)neuron differentiation HOM02SEM002618
GO:0016055
IEA
PLAZA Homology (enrichment)Wnt signaling pathway HOM02SEM002618
GO:0051606
IEA
PLAZA Integrative Orthologydetection of stimulus ENSG00000128602
GO:0050793
IEA
PLAZA Homology (enrichment)regulation of developmental process HOM02SEM002618
GO:0060248
IEA
PLAZA Integrative Orthologydetection of cell density by contact stimulus involved in contact inhibition ENSG00000128602
GO:0060246
IEA
PLAZA Integrative Orthologydetection of cell density by contact stimulus ENSG00000128602
GO:0022008
IEA
PLAZA Homology (enrichment)neurogenesis HOM02SEM002618
GO:0009595
IEA
PLAZA Integrative Orthologydetection of biotic stimulus ENSG00000128602
GO:0060245
IEA
PLAZA Integrative Orthologydetection of cell density ENSG00000128602
GO:0060242
IEA
PLAZA Integrative Orthologycontact inhibition ENSG00000128602

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding11 20 21
GO:0004930
ISS
TAS
Genome ProjectG protein-coupled receptor activity
GO:0004888
ISS
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005102
IEA
PLAZA Integrative Orthologysignaling receptor binding ENSG00000128602
GO:0017147
IEA
PLAZA Homology (enrichment)Wnt-protein binding HOM02SEM002618
GO:0005113
IEA
PLAZA Integrative Orthologypatched binding ENSG00000128602
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding ENSG00000128602
GO:0042813
IEA
PLAZA Homology (enrichment)Wnt-activated receptor activity HOM02SEM002618

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030424
IDA
Genome Projectaxon
GO:0030424
IDA
Gene Ontologyaxon22
GO:0030425
IDA
Genome Projectdendrite
GO:0030425
IDA
Gene Ontologydendrite22
GO:0005929
IDA
Genome Projectcilium
GO:0005929
IDA
Gene Ontologycilium22
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043025
IDA
Gene Ontologyneuronal cell body22
GO:0005768
TAS
Genome Projectendosome
GO:0005768
TAS
Gene Ontologyendosome23
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane23
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0005887
IDA
Gene Ontologyintegral component of plasma membrane24
GO:0016021
ISS
TAS
Genome Projectintegral component of membrane
GO:0016021
ISS
Gene Ontologyintegral component of membrane14 25
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane ENSG00000128602
GO:0045121
IEA
PLAZA Integrative Orthologymembrane raft ENSG00000128602
GO:0012506
IEA
PLAZA Integrative Orthologyvesicle membrane ENSG00000128602
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000128602
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000128602
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000128602
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000128602
GO:0031253
IEA
PLAZA Integrative Orthologycell projection membrane ENSG00000128602
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000128602
GO:0097542
IEA
PLAZA Integrative Orthologyciliary tip ENSG00000128602
GO:0044853
IEA
PLAZA Integrative Orthologyplasma membrane raft ENSG00000128602
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000128602
GO:0098589
IEA
PLAZA Integrative Orthologymembrane region ENSG00000128602
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle ENSG00000128602
GO:0030659
IEA
PLAZA Integrative Orthologycytoplasmic vesicle membrane ENSG00000128602
GO:0030139
IEA
PLAZA Integrative Orthologyendocytic vesicle ENSG00000128602
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000128602
GO:0098590
IEA
PLAZA Integrative Orthologyplasma membrane region ENSG00000128602
GO:0030666
IEA
PLAZA Integrative Orthologyendocytic vesicle membrane ENSG00000128602
GO:0098857
IEA
PLAZA Integrative Orthologymembrane microdomain ENSG00000128602
GO:0060170
IEA
PLAZA Integrative Orthologyciliary membrane ENSG00000128602
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000128602
GO:0044441
IEA
PLAZA Integrative Orthologyciliary part ENSG00000128602
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle ENSG00000128602
GO:0005901
IEA
PLAZA Integrative Orthologycaveola ENSG00000128602
GO:0044433
IEA
PLAZA Integrative Orthologycytoplasmic vesicle part ENSG00000128602
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000128602
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000128602

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000539Frizzled/Smoothened, transmembrane domain
IPR015526Frizzled/secreted frizzled-related protein
IPR017981GPCR, family 2-like
IPR020067Frizzled domain
IPR026544Smoothened

No MapMan annotations defined for this gene.
KeggID Description
K06226SMO; smoothened
No chloroplast target sequence found.