Gene: ENSG00000274638 (Homo sapiens)

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Gene Identifier
ENSG00000274638
Transcript Identifier
ENST00000613825
Gene Type
Coding gene
Location
CHR_HSCHR19LRC_LRC_I_CTG3_1 : 950002-980884 : positive

Family Information

Homologous gene family
HOM02SEM000951
(50 genes in 5 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
NACHT, LRR and PYD domains-containing protein 2

Identifiers

Type Value
pidENSP00000483963
UniprotQ9NX02
RefSeq_mRNANM_017852.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0050718
IDA
Gene Ontologypositive regulation of interleukin-1 beta secretion1
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:0032088
IGI
Gene Ontologynegative regulation of NF-kappaB transcription factor activity2
GO:0032610
IEA
PLAZA Integrative Orthologyinterleukin-1 alpha production ENSG00000276780
GO:0031400
IEA
PLAZA Integrative Orthologynegative regulation of protein modification process ENSG00000142405
GO:0050703
IEA
PLAZA Integrative Orthologyinterleukin-1 alpha secretion ENSG00000276780
GO:0050705
IEA
PLAZA Integrative Orthologyregulation of interleukin-1 alpha secretion ENSG00000276780
GO:0032730
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-1 alpha production ENSG00000276780
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process ENSG00000277776
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium ENSG00000277776
GO:0002674
IEA
PLAZA Integrative Orthologynegative regulation of acute inflammatory response ENSG00000162711
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction ENSG00000158077
GO:0002673
IEA
PLAZA Integrative Orthologyregulation of acute inflammatory response ENSG00000162711
GO:0002792
IEA
PLAZA Integrative Orthologynegative regulation of peptide secretion ENSG00000277776
GO:0042089
IEA
PLAZA Integrative Orthologycytokine biosynthetic process ENSG00000142405
GO:0050829
IEA
PLAZA Integrative Orthologydefense response to Gram-negative bacterium ENSG00000276780
GO:0050709
IEA
PLAZA Integrative Orthologynegative regulation of protein secretion ENSG00000277776
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process ENSG00000158077
GO:0072604
IEA
PLAZA Integrative Orthologyinterleukin-6 secretion ENSG00000276780
GO:0072606
IEA
PLAZA Integrative Orthologyinterleukin-8 secretion ENSG00000276780
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process ENSG00000276230
GO:0010955
IEA
PLAZA Integrative Orthologynegative regulation of protein processing ENSG00000277776
GO:0001568
IEA
PLAZA Integrative Orthologyblood vessel development ENSG00000276230
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction ENSG00000142405
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus ENSG00000277776
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction ENSG00000158077
GO:0002534
IEA
PLAZA Integrative Orthologycytokine production involved in inflammatory response ENSG00000277776
GO:0051346
IEA
PLAZA Integrative Orthologynegative regulation of hydrolase activity ENSG00000277776
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus ENSG00000277776
GO:0051224
IEA
PLAZA Integrative Orthologynegative regulation of protein transport ENSG00000277776
GO:0002532
IEA
PLAZA Integrative Orthologyproduction of molecular mediator involved in inflammatory response ENSG00000277776
GO:0006468
IEA
PLAZA Integrative Orthologyprotein phosphorylation ENSG00000142405
GO:0045345
IEA
PLAZA Integrative Orthologypositive regulation of MHC class I biosynthetic process ENSG00000142405
GO:0006464
IEA
PLAZA Integrative Orthologycellular protein modification process ENSG00000142405
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development ENSG00000276230
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000179709
GO:0032635
IEA
PLAZA Integrative Orthologyinterleukin-6 production ENSG00000142405
GO:0032755
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-6 production ENSG00000276780
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis ENSG00000091592
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization ENSG00000091592
GO:0045341
IEA
PLAZA Integrative OrthologyMHC class I biosynthetic process ENSG00000142405
GO:0045343
IEA
PLAZA Integrative Orthologyregulation of MHC class I biosynthetic process ENSG00000142405
GO:0048731
IEA
PLAZA Integrative Orthologysystem development ENSG00000276230
GO:0032637
IEA
PLAZA Integrative Orthologyinterleukin-8 production ENSG00000276780
GO:0032757
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-8 production ENSG00000276780
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression ENSG00000277776
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism ENSG00000276780
GO:0042742
IEA
PLAZA Integrative Orthologydefense response to bacterium ENSG00000276780
GO:0038061
IEA
PLAZA Integrative OrthologyNIK/NF-kappaB signaling ENSG00000142405
GO:1904784
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex assembly ENSG00000091592
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process ENSG00000158077
GO:0070646
IEA
PLAZA Integrative Orthologyprotein modification by small protein removal ENSG00000162711
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus ENSG00000277776
GO:0070647
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation or removal ENSG00000162711
GO:0006919
IEA
PLAZA Integrative Orthologyactivation of cysteine-type endopeptidase activity involved in apoptotic process ENSG00000091592
GO:0035239
IEA
PLAZA Integrative Orthologytube morphogenesis ENSG00000276230
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound ENSG00000277776
GO:1901701
IEA
PLAZA Integrative Orthologycellular response to oxygen-containing compound ENSG00000277776
GO:0022603
IEA
PLAZA Integrative Orthologyregulation of anatomical structure morphogenesis ENSG00000276230
GO:0046777
IEA
PLAZA Integrative Orthologyprotein autophosphorylation ENSG00000142405
GO:0022607
IEA
PLAZA Integrative Orthologycellular component assembly ENSG00000091592
GO:0036211
IEA
PLAZA Integrative Orthologyprotein modification process ENSG00000142405
GO:0032496
IEA
PLAZA Integrative Orthologyresponse to lipopolysaccharide ENSG00000277776
GO:0051716
IEA
PLAZA Integrative Orthologycellular response to stimulus ENSG00000277776
GO:0042326
IEA
PLAZA Integrative Orthologynegative regulation of phosphorylation ENSG00000142405
GO:0042325
IEA
PLAZA Integrative Orthologyregulation of phosphorylation ENSG00000142405
GO:0006796
IEA
PLAZA Integrative Orthologyphosphate-containing compound metabolic process ENSG00000142405
GO:0043412
IEA
PLAZA Integrative Orthologymacromolecule modification ENSG00000142405
GO:0006793
IEA
PLAZA Integrative Orthologyphosphorus metabolic process ENSG00000142405
GO:0016579
IEA
PLAZA Integrative Orthologyprotein deubiquitination ENSG00000162711
GO:0032269
IEA
PLAZA Integrative Orthologynegative regulation of cellular protein metabolic process ENSG00000277776
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000277776
GO:2000778
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-6 secretion ENSG00000276780
GO:0001525
IEA
PLAZA Integrative Orthologyangiogenesis ENSG00000276230
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance ENSG00000277776
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism ENSG00000277776
GO:0051259
IEA
PLAZA Integrative Orthologyprotein complex oligomerization ENSG00000162711
GO:0016485
IEA
PLAZA Integrative Orthologyprotein processing ENSG00000277776
GO:0050727
IEA
PLAZA Integrative Orthologyregulation of inflammatory response ENSG00000277776
GO:0070555
IEA
PLAZA Integrative Orthologyresponse to interleukin-1 ENSG00000277776
GO:0002526
IEA
PLAZA Integrative Orthologyacute inflammatory response ENSG00000162711
GO:0043086
IEA
PLAZA Integrative Orthologynegative regulation of catalytic activity ENSG00000277776
GO:0032715
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-6 production ENSG00000142405
GO:1900426
IEA
PLAZA Integrative Orthologypositive regulation of defense response to bacterium ENSG00000276780
GO:1900424
IEA
PLAZA Integrative Orthologyregulation of defense response to bacterium ENSG00000276780
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000142405
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction ENSG00000142405
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process ENSG00000277776
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis ENSG00000276230
GO:0050728
IEA
PLAZA Integrative Orthologynegative regulation of inflammatory response ENSG00000277776
GO:0045936
IEA
PLAZA Integrative Orthologynegative regulation of phosphate metabolic process ENSG00000142405
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance ENSG00000277776
GO:0050710
IEA
PLAZA Integrative Orthologynegative regulation of cytokine secretion ENSG00000277776
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction ENSG00000142405
GO:0051248
IEA
PLAZA Integrative Orthologynegative regulation of protein metabolic process ENSG00000277776
GO:0050711
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-1 secretion ENSG00000277776
GO:0050713
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-1 beta secretion ENSG00000277776
GO:0051241
IEA
PLAZA Integrative Orthologynegative regulation of multicellular organismal process ENSG00000277776
GO:0032606
IEA
PLAZA Integrative Orthologytype I interferon production ENSG00000160505
GO:0048514
IEA
PLAZA Integrative Orthologyblood vessel morphogenesis ENSG00000276230
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress ENSG00000277776
GO:0050717
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-1 alpha secretion ENSG00000276780
GO:0008063
IEA
PLAZA Integrative OrthologyToll signaling pathway ENSG00000142405
GO:0010563
IEA
PLAZA Integrative Orthologynegative regulation of phosphorus metabolic process ENSG00000142405
GO:0071345
IEA
PLAZA Integrative Orthologycellular response to cytokine stimulus ENSG00000277776
GO:0071347
IEA
PLAZA Integrative Orthologycellular response to interleukin-1 ENSG00000277776
GO:0071222
IEA
PLAZA Integrative Orthologycellular response to lipopolysaccharide ENSG00000277776
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation ENSG00000158077
GO:0007166
IEA
PLAZA Integrative Orthologycell surface receptor signaling pathway ENSG00000142405
GO:0045751
IEA
PLAZA Integrative Orthologynegative regulation of Toll signaling pathway ENSG00000142405
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process ENSG00000158077
GO:0035295
IEA
PLAZA Integrative Orthologytube development ENSG00000276230
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis ENSG00000158077
GO:0007165
IEA
PLAZA Integrative Orthologysignal transduction ENSG00000142405
GO:0050896
IEA
PLAZA Integrative Orthologyresponse to stimulus ENSG00000277776
GO:0016310
IEA
PLAZA Integrative Orthologyphosphorylation ENSG00000142405
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process ENSG00000142405
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus ENSG00000277776
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process ENSG00000142405
GO:0032103
IEA
PLAZA Integrative Orthologypositive regulation of response to external stimulus ENSG00000276780
GO:0032102
IEA
PLAZA Integrative Orthologynegative regulation of response to external stimulus ENSG00000277776
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus ENSG00000277776
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus ENSG00000277776
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus ENSG00000142405
GO:1901566
IEA
PLAZA Integrative Orthologyorganonitrogen compound biosynthetic process ENSG00000142405
GO:1902533
IEA
PLAZA Integrative Orthologypositive regulation of intracellular signal transduction ENSG00000142405
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation ENSG00000158077
GO:1902532
IEA
PLAZA Integrative Orthologynegative regulation of intracellular signal transduction ENSG00000142405
GO:0045861
IEA
PLAZA Integrative Orthologynegative regulation of proteolysis ENSG00000277776
GO:1905245
IEA
PLAZA Integrative Orthologyregulation of aspartic-type peptidase activity ENSG00000277776
GO:1905246
IEA
PLAZA Integrative Orthologynegative regulation of aspartic-type peptidase activity ENSG00000277776
GO:1902531
IEA
PLAZA Integrative Orthologyregulation of intracellular signal transduction ENSG00000142405
GO:0007154
IEA
PLAZA Integrative Orthologycell communication ENSG00000142405
GO:1904950
IEA
PLAZA Integrative Orthologynegative regulation of establishment of protein localization ENSG00000277776
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development ENSG00000276230
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus ENSG00000277776
GO:0032479
IEA
PLAZA Integrative Orthologyregulation of type I interferon production ENSG00000160505
GO:0034097
IEA
PLAZA Integrative Orthologyresponse to cytokine ENSG00000277776
GO:0010466
IEA
PLAZA Integrative Orthologynegative regulation of peptidase activity ENSG00000277776
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction ENSG00000158077
GO:0051174
IEA
PLAZA Integrative Orthologyregulation of phosphorus metabolic process ENSG00000142405
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical ENSG00000277776
GO:0042226
IEA
PLAZA Integrative Orthologyinterleukin-6 biosynthetic process ENSG00000142405
GO:0042107
IEA
PLAZA Integrative Orthologycytokine metabolic process ENSG00000142405
GO:0031953
IEA
PLAZA Integrative Orthologynegative regulation of protein autophosphorylation ENSG00000142405
GO:0031952
IEA
PLAZA Integrative Orthologyregulation of protein autophosphorylation ENSG00000142405
GO:0071219
IEA
PLAZA Integrative Orthologycellular response to molecule of bacterial origin ENSG00000277776
GO:0051604
IEA
PLAZA Integrative Orthologyprotein maturation ENSG00000277776
GO:0031399
IEA
PLAZA Integrative Orthologyregulation of protein modification process ENSG00000142405
GO:0071216
IEA
PLAZA Integrative Orthologycellular response to biotic stimulus ENSG00000277776
GO:0051606
IEA
PLAZA Integrative Orthologydetection of stimulus ENSG00000162711
GO:0002833
IEA
PLAZA Integrative Orthologypositive regulation of response to biotic stimulus ENSG00000276780
GO:0044085
IEA
PLAZA Integrative Orthologycellular component biogenesis ENSG00000091592
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus ENSG00000276780
GO:0051048
IEA
PLAZA Integrative Orthologynegative regulation of secretion ENSG00000277776
GO:0051051
IEA
PLAZA Integrative Orthologynegative regulation of transport ENSG00000277776
GO:0009595
IEA
PLAZA Integrative Orthologydetection of biotic stimulus ENSG00000162711
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process ENSG00000277776
GO:0070613
IEA
PLAZA Integrative Orthologyregulation of protein processing ENSG00000277776
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process ENSG00000277776
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development ENSG00000276230
GO:0001818
IEA
PLAZA Integrative Orthologynegative regulation of cytokine production ENSG00000277776
GO:0032650
IEA
PLAZA Integrative Orthologyregulation of interleukin-1 alpha production ENSG00000276780
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000142405
GO:0072358
IEA
PLAZA Integrative Orthologycardiovascular system development ENSG00000276230
GO:0072359
IEA
PLAZA Integrative Orthologycirculatory system development ENSG00000276230
GO:0001933
IEA
PLAZA Integrative Orthologynegative regulation of protein phosphorylation ENSG00000142405
GO:0001932
IEA
PLAZA Integrative Orthologyregulation of protein phosphorylation ENSG00000142405
GO:0010647
IEA
PLAZA Integrative Orthologypositive regulation of cell communication ENSG00000142405
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000142405
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process ENSG00000142405
GO:1903318
IEA
PLAZA Integrative Orthologynegative regulation of protein maturation ENSG00000277776
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress ENSG00000277776
GO:1903317
IEA
PLAZA Integrative Orthologyregulation of protein maturation ENSG00000277776
GO:0007249
IEA
PLAZA Integrative OrthologyI-kappaB kinase/NF-kappaB signaling ENSG00000142405
GO:0006952
IEA
PLAZA Integrative Orthologydefense response ENSG00000277776
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization ENSG00000091592
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid ENSG00000277776
GO:0019220
IEA
PLAZA Integrative Orthologyregulation of phosphate metabolic process ENSG00000142405
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid ENSG00000277776
GO:0043124
IEA
PLAZA Integrative Orthologynegative regulation of I-kappaB kinase/NF-kappaB signaling ENSG00000142405
GO:0042036
IEA
PLAZA Integrative Orthologynegative regulation of cytokine biosynthetic process ENSG00000142405
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis ENSG00000276230
GO:0042035
IEA
PLAZA Integrative Orthologyregulation of cytokine biosynthetic process ENSG00000142405
GO:0043122
IEA
PLAZA Integrative Orthologyregulation of I-kappaB kinase/NF-kappaB signaling ENSG00000142405
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process ENSG00000142405
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process ENSG00000142405
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process ENSG00000277776
GO:0032677
IEA
PLAZA Integrative Orthologyregulation of interleukin-8 production ENSG00000276780
GO:0031348
IEA
PLAZA Integrative Orthologynegative regulation of defense response ENSG00000277776
GO:2000484
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-8 secretion ENSG00000276780
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response ENSG00000277776
GO:0032675
IEA
PLAZA Integrative Orthologyregulation of interleukin-6 production ENSG00000142405
GO:0023052
IEA
PLAZA Integrative Orthologysignaling ENSG00000142405
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000142405
GO:0023056
IEA
PLAZA Integrative Orthologypositive regulation of signaling ENSG00000142405
GO:0031349
IEA
PLAZA Integrative Orthologypositive regulation of defense response ENSG00000276780
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000142405
GO:0008592
IEA
PLAZA Integrative Orthologyregulation of Toll signaling pathway ENSG00000142405
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly ENSG00000091592
GO:1903531
IEA
PLAZA Integrative Orthologynegative regulation of secretion by cell ENSG00000277776
GO:0051402
IEA
PLAZA Integrative Orthologyneuron apoptotic process ENSG00000091592
GO:0001944
IEA
PLAZA Integrative Orthologyvasculature development ENSG00000276230
GO:0006954
IEA
PLAZA Integrative Orthologyinflammatory response ENSG00000277776
GO:0002237
IEA
PLAZA Integrative Orthologyresponse to molecule of bacterial origin ENSG00000277776
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process ENSG00000276230
GO:0051092
IEA
PLAZA Integrative Orthologypositive regulation of NF-kappaB transcription factor activity ENSG00000162711
GO:1900015
IEA
PLAZA Integrative Orthologyregulation of cytokine production involved in inflammatory response ENSG00000277776
GO:0051091
IEA
PLAZA Integrative Orthologypositive regulation of DNA-binding transcription factor activity ENSG00000162711
GO:1900016
IEA
PLAZA Integrative Orthologynegative regulation of cytokine production involved in inflammatory response ENSG00000277776
GO:1901223
IEA
PLAZA Integrative Orthologynegative regulation of NIK/NF-kappaB signaling ENSG00000162711
GO:0045765
IEA
PLAZA Integrative Orthologyregulation of angiogenesis ENSG00000276230
GO:1901224
IEA
PLAZA Integrative Orthologypositive regulation of NIK/NF-kappaB signaling ENSG00000142405
GO:0032691
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-1 beta production ENSG00000277776
GO:1901342
IEA
PLAZA Integrative Orthologyregulation of vasculature development ENSG00000276230
GO:0032692
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-1 production ENSG00000277776
GO:1901222
IEA
PLAZA Integrative Orthologyregulation of NIK/NF-kappaB signaling ENSG00000142405
GO:0043902
IEA
PLAZA Integrative Orthologypositive regulation of multi-organism process ENSG00000276780
GO:2000482
IEA
PLAZA Integrative Orthologyregulation of interleukin-8 secretion ENSG00000276780
GO:0045408
IEA
PLAZA Integrative Orthologyregulation of interleukin-6 biosynthetic process ENSG00000142405
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process ENSG00000276780
GO:0045409
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-6 biosynthetic process ENSG00000142405

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032090
IPI
Gene OntologyPyrin domain binding1
GO:0005515
IPI
Gene Ontologyprotein binding1 3
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000277776
GO:0030554
IEA
PLAZA Integrative Orthologyadenyl nucleotide binding ENSG00000091592
GO:0017111
IEA
PLAZA Integrative Orthologynucleoside-triphosphatase activity ENSG00000276780
GO:0016818
IEA
PLAZA Integrative Orthologyhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ENSG00000276780
GO:0016817
IEA
PLAZA Integrative Orthologyhydrolase activity, acting on acid anhydrides ENSG00000276780
GO:0043168
IEA
PLAZA Integrative Orthologyanion binding ENSG00000091592
GO:0043167
IEA
PLAZA Integrative Orthologyion binding ENSG00000091592
GO:0004866
IEA
PLAZA Integrative Orthologyendopeptidase inhibitor activity ENSG00000277776
GO:0008428
IEA
PLAZA Integrative Orthologyribonuclease inhibitor activity ENSG00000276230
GO:0004857
IEA
PLAZA Integrative Orthologyenzyme inhibitor activity ENSG00000276230
GO:0098772
IEA
PLAZA Integrative Orthologymolecular function regulator ENSG00000276230
GO:1901265
IEA
PLAZA Integrative Orthologynucleoside phosphate binding ENSG00000091592
GO:0061135
IEA
PLAZA Integrative Orthologyendopeptidase regulator activity ENSG00000277776
GO:0061134
IEA
PLAZA Integrative Orthologypeptidase regulator activity ENSG00000277776
GO:0016462
IEA
PLAZA Integrative Orthologypyrophosphatase activity ENSG00000276780
GO:0003824
IEA
PLAZA Integrative Orthologycatalytic activity ENSG00000276780
GO:0089720
IEA
PLAZA Integrative Orthologycaspase binding ENSG00000277776
GO:0030414
IEA
PLAZA Integrative Orthologypeptidase inhibitor activity ENSG00000277776
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding ENSG00000091592
GO:0003723
IEA
PLAZA Integrative OrthologyRNA binding ENSG00000179873
GO:0036094
IEA
PLAZA Integrative Orthologysmall molecule binding ENSG00000091592
GO:0016787
IEA
PLAZA Integrative Orthologyhydrolase activity ENSG00000276780
GO:0017076
IEA
PLAZA Integrative Orthologypurine nucleotide binding ENSG00000091592
GO:0005539
IEA
PLAZA Integrative Orthologyglycosaminoglycan binding ENSG00000162711
GO:0097159
IEA
PLAZA Integrative Orthologyorganic cyclic compound binding ENSG00000179873
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding ENSG00000162711
GO:0005524
IEA
PLAZA Integrative OrthologyATP binding ENSG00000091592
GO:0002020
IEA
PLAZA Integrative Orthologyprotease binding ENSG00000277776
GO:0019955
IEA
PLAZA Integrative Orthologycytokine binding ENSG00000277776
GO:0019828
IEA
PLAZA Integrative Orthologyaspartic-type endopeptidase inhibitor activity ENSG00000277776
GO:0019966
IEA
PLAZA Integrative Orthologyinterleukin-1 binding ENSG00000277776
GO:0003924
IEA
PLAZA Integrative OrthologyGTPase activity ENSG00000276780
GO:0035639
IEA
PLAZA Integrative Orthologypurine ribonucleoside triphosphate binding ENSG00000091592
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding ENSG00000091592
GO:0019838
IEA
PLAZA Integrative Orthologygrowth factor binding ENSG00000277776
GO:0030234
IEA
PLAZA Integrative Orthologyenzyme regulator activity ENSG00000276230
GO:0003676
IEA
PLAZA Integrative Orthologynucleic acid binding ENSG00000179873
GO:0000166
IEA
PLAZA Integrative Orthologynucleotide binding ENSG00000091592
GO:1901363
IEA
PLAZA Integrative Orthologyheterocyclic compound binding ENSG00000179873
GO:0042834
IEA
PLAZA Integrative Orthologypeptidoglycan binding ENSG00000162711
GO:0032555
IEA
PLAZA Integrative Orthologypurine ribonucleotide binding ENSG00000091592
GO:0032553
IEA
PLAZA Integrative Orthologyribonucleotide binding ENSG00000091592
GO:0032559
IEA
PLAZA Integrative Orthologyadenyl ribonucleotide binding ENSG00000091592
GO:0016887
IEA
PLAZA Integrative OrthologyATPase activity ENSG00000276780

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000784
IDA
Gene Ontologynuclear chromosome, telomeric region4
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle
GO:0005829
IDA
Gene Ontologycytosol
GO:0005794
IDA
Gene OntologyGolgi apparatus
GO:0005737
IDA
Gene Ontologycytoplasm1
GO:0019897
IEA
PLAZA Integrative Orthologyextrinsic component of plasma membrane ENSG00000276780
GO:0019898
IEA
PLAZA Integrative Orthologyextrinsic component of membrane ENSG00000276780
GO:0016020
IEA
PLAZA Integrative Orthologymembrane ENSG00000276780
GO:0061702
IEA
PLAZA Integrative Orthologyinflammasome complex ENSG00000091592
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000276230
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000276230
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000276230
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000276230
GO:0072559
IEA
PLAZA Integrative OrthologyNLRP3 inflammasome complex ENSG00000162711
GO:0072558
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex ENSG00000091592
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000276780
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000276230
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000276230
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery ENSG00000276780
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000276230
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000276230
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part ENSG00000276780
GO:0032311
IEA
PLAZA Integrative Orthologyangiogenin-PRI complex ENSG00000276230
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane ENSG00000276780
GO:0044445
IEA
PLAZA Integrative Orthologycytosolic part ENSG00000091592
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000276230

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
No InterPro domains detected for this gene.
No MapMan annotations defined for this gene.
KeggID Description
K19409NLRP2; NACHT, LRR and PYD domains-containing protein 2
No chloroplast target sequence found.