Gene: ENSG00000274229 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000274229
Transcript Identifier
ENST00000615473
Gene Type
Coding gene
Location
CHR_HSCHR17_7_CTG4 : 2387193-2431287 : positive

Family Information

Homologous gene family
HOM02SEM008595
(10 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM010834
(6 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
suppressor of cytokine signaling 7

Identifiers

Type Value
pidENSP00000480736
HGNC29846
UniprotO14512
RefSeq_mRNANM_014598.3
EMBLAB005216
EMBLAC115992
EMBLAC124789
EMBLBC128607

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046426
IBA
Genome Projectnegative regulation of JAK-STAT cascade
GO:0045444
IEA
Genome Projectfat cell differentiation
GO:0040008
IEA
Genome Projectregulation of growth
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0021942
IEA
Genome Projectradial glia guided migration of Purkinje cell
GO:0021819
IEA
Genome Projectlayer formation in cerebral cortex
GO:0019221
IBA
Genome Projectcytokine-mediated signaling pathway
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0008286
IEA
Genome Projectinsulin receptor signaling pathway
GO:0008150
ND
Genome Projectbiological_process
GO:0008150
ND
Gene Ontologybiological_process
GO:0006469
IBA
Genome Projectnegative regulation of protein kinase activity
GO:0006508
IEA
PLAZA Integrative Orthologyproteolysis ENSG00000170677
GO:0010647
IEA
PLAZA Integrative Orthologypositive regulation of cell communication FBgn0033266
GO:0023056
IEA
PLAZA Integrative Orthologypositive regulation of signaling FBgn0033266
GO:0048010
IEA
PLAZA Integrative Orthologyvascular endothelial growth factor receptor signaling pathway FBgn0030869
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress ENSG00000170677
GO:0044248
IEA
PLAZA Integrative Orthologycellular catabolic process ENSG00000170677
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction FBgn0033266
GO:0006952
IEA
PLAZA Integrative Orthologydefense response ENSG00000170677
GO:0031929
IEA
PLAZA Integrative OrthologyTOR signaling FBgn0030869
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process ENSG00000170677
GO:0030163
IEA
PLAZA Integrative Orthologyprotein catabolic process ENSG00000170677
GO:1903432
IEA
PLAZA Integrative Orthologyregulation of TORC1 signaling FBgn0030869
GO:1904263
IEA
PLAZA Integrative Orthologypositive regulation of TORC1 signaling FBgn0030869
GO:0038127
IEA
PLAZA Integrative OrthologyERBB signaling pathway FBgn0033266
GO:0038202
IEA
PLAZA Integrative OrthologyTORC1 signaling FBgn0030869
GO:0032006
IEA
PLAZA Integrative Orthologyregulation of TOR signaling FBgn0030869
GO:0010498
IEA
PLAZA Integrative Orthologyproteasomal protein catabolic process ENSG00000170677
GO:0032008
IEA
PLAZA Integrative Orthologypositive regulation of TOR signaling FBgn0030869
GO:0051603
IEA
PLAZA Integrative Orthologyproteolysis involved in cellular protein catabolic process ENSG00000170677
GO:0044265
IEA
PLAZA Integrative Orthologycellular macromolecule catabolic process ENSG00000170677
GO:0048522
IEA
PLAZA Integrative Orthologypositive regulation of cellular process FBgn0033266
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus FBgn0033266
GO:0048518
IEA
PLAZA Integrative Orthologypositive regulation of biological process FBgn0033266
GO:0043687
IEA
PLAZA Integrative Orthologypost-translational protein modification ENSG00000170677
GO:1902533
IEA
PLAZA Integrative Orthologypositive regulation of intracellular signal transduction FBgn0030869
GO:0042058
IEA
PLAZA Integrative Orthologyregulation of epidermal growth factor receptor signaling pathway FBgn0033266
GO:0044257
IEA
PLAZA Integrative Orthologycellular protein catabolic process ENSG00000170677
GO:0045742
IEA
PLAZA Integrative Orthologypositive regulation of epidermal growth factor receptor signaling pathway FBgn0033266
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process ENSG00000170677
GO:0007173
IEA
PLAZA Integrative Orthologyepidermal growth factor receptor signaling pathway FBgn0033266
GO:1901186
IEA
PLAZA Integrative Orthologypositive regulation of ERBB signaling pathway FBgn0033266
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process ENSG00000170677
GO:0009057
IEA
PLAZA Integrative Orthologymacromolecule catabolic process ENSG00000170677
GO:1901184
IEA
PLAZA Integrative Orthologyregulation of ERBB signaling pathway FBgn0033266

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0017124
NAS
Genome ProjectSH3 domain binding
GO:0017124
NAS
Gene OntologySH3 domain binding1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2
GO:0004860
IBA
Genome Projectprotein kinase inhibitor activity
GO:0008092
IEA
PLAZA Integrative Orthologycytoskeletal protein binding FBgn0030869
GO:0017022
IEA
PLAZA Integrative Orthologymyosin binding FBgn0030869

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol
GO:0005737
IBA
Genome Projectcytoplasm
GO:0005634
IEA
Genome Projectnucleus
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000170677
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part ENSG00000170677
GO:0001772
IEA
PLAZA Integrative Orthologyimmunological synapse ENSG00000170677

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000980SH2 domain
IPR001496SOCS box domain
IPR028423Suppressor of cytokine signalling 7

No MapMan annotations defined for this gene.
KeggID Description
K04699SOCS6_7; suppressor of cytokine signaling 6/7
No chloroplast target sequence found.