Gene: ENSG00000254647 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000254647
Transcript Identifier
ENST00000381330
Gene Type
Coding gene
Location
11 : 2159852-2160971 : negative

Family Information

Homologous gene family
HOM02SEM037247
(2 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
insulin

Identifiers

Type Value
pidENSP00000370731
HGNC6081
UniprotP01308
UniprotI3WAC9
EMBLCH471158
EMBLJQ951950

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000252
IDA
Genome Projectnegative regulation of feeding behavior
GO:2000252
IDA
Gene Ontologynegative regulation of feeding behavior1
GO:1902176
NAS
Genome Projectnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176
NAS
Gene Ontologynegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway2
GO:1900182
IDA
Genome Projectpositive regulation of protein localization to nucleus
GO:1900182
IDA
Gene Ontologypositive regulation of protein localization to nucleus3
GO:0097756
NAS
Genome Projectnegative regulation of blood vessel diameter
GO:0097756
NAS
Gene Ontologynegative regulation of blood vessel diameter4
GO:0097755
NAS
Genome Projectpositive regulation of blood vessel diameter
GO:0097755
NAS
Gene Ontologypositive regulation of blood vessel diameter5
GO:0090336
TAS
Genome Projectpositive regulation of brown fat cell differentiation
GO:0090336
TAS
Gene Ontologypositive regulation of brown fat cell differentiation6
GO:0090277
TAS
Genome Projectpositive regulation of peptide hormone secretion
GO:0090277
TAS
Gene Ontologypositive regulation of peptide hormone secretion6
GO:0060267
IDA
Genome Projectpositive regulation of respiratory burst
GO:0060267
IDA
Gene Ontologypositive regulation of respiratory burst7
GO:0060266
IDA
Genome Projectnegative regulation of respiratory burst involved in inflammatory response
GO:0060266
IDA
Gene Ontologynegative regulation of respiratory burst involved in inflammatory response8
GO:0055089
IMP
Genome Projectfatty acid homeostasis
GO:0055089
IMP
Gene Ontologyfatty acid homeostasis9
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051897
IDA
Gene Ontologypositive regulation of protein kinase B signaling10
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IDA
Gene Ontologypositive regulation of NF-kappaB transcription factor activity11
GO:0051000
NAS
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051000
NAS
Gene Ontologypositive regulation of nitric-oxide synthase activity12
GO:0050995
IMP
NAS
Genome Projectnegative regulation of lipid catabolic process
GO:0050995
IMP
NAS
Gene Ontologynegative regulation of lipid catabolic process13 14
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050715
IDA
Genome Projectpositive regulation of cytokine secretion
GO:0050715
IDA
Gene Ontologypositive regulation of cytokine secretion15
GO:0050709
IDA
Genome Projectnegative regulation of protein secretion
GO:0050709
IDA
Gene Ontologynegative regulation of protein secretion16
GO:0050708
IDA
Genome Projectregulation of protein secretion
GO:0050708
IDA
Gene Ontologyregulation of protein secretion17
GO:0046889
NAS
Genome Projectpositive regulation of lipid biosynthetic process
GO:0046889
NAS
Gene Ontologypositive regulation of lipid biosynthetic process13
GO:0046631
IDA
Genome Projectalpha-beta T cell activation
GO:0046631
IDA
Gene Ontologyalpha-beta T cell activation18
GO:0046628
IDA
Genome Projectpositive regulation of insulin receptor signaling pathway
GO:0046628
IDA
Gene Ontologypositive regulation of insulin receptor signaling pathway19
GO:0046326
IDA
Genome Projectpositive regulation of glucose import
GO:0046326
IDA
Gene Ontologypositive regulation of glucose import20 21
GO:0045922
IMP
Genome Projectnegative regulation of fatty acid metabolic process
GO:0045922
IMP
Gene Ontologynegative regulation of fatty acid metabolic process9
GO:0045861
IMP
Genome Projectnegative regulation of proteolysis
GO:0045861
IMP
Gene Ontologynegative regulation of proteolysis22
GO:0045840
IDA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045840
IDA
Gene Ontologypositive regulation of mitotic nuclear division10 23
GO:0045821
IDA, IMP
Genome Projectpositive regulation of glycolytic process
GO:0045821
IDA, IMP
Gene Ontologypositive regulation of glycolytic process19 24
GO:0045818
IMP
Genome Projectnegative regulation of glycogen catabolic process
GO:0045818
IMP
Gene Ontologynegative regulation of glycogen catabolic process24
GO:0045740
IDA
Genome Projectpositive regulation of DNA replication
GO:0045725
IDA
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0045725
IDA
Gene Ontologypositive regulation of glycogen biosynthetic process25
GO:0045721
NAS
Genome Projectnegative regulation of gluconeogenesis
GO:0045721
NAS
Gene Ontologynegative regulation of gluconeogenesis13
GO:0045597
NAS
Genome Projectpositive regulation of cell differentiation
GO:0045597
NAS
Gene Ontologypositive regulation of cell differentiation13
GO:0045429
NAS
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0044267
TAS
Gene Ontologycellular protein metabolic process
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0043410
IDA
Gene Ontologypositive regulation of MAPK cascade3 10
GO:0042593
IMP
Genome Projectglucose homeostasis
GO:0042593
IMP
Gene Ontologyglucose homeostasis24
GO:0042177
IDA
Genome Projectnegative regulation of protein catabolic process
GO:0042177
IDA
Gene Ontologynegative regulation of protein catabolic process26
GO:0042060
IDA
Genome Projectwound healing
GO:0042060
IDA
Gene Ontologywound healing27
GO:0033861
IDA
Genome Projectnegative regulation of NAD(P)H oxidase activity
GO:0033861
IDA
Gene Ontologynegative regulation of NAD(P)H oxidase activity8
GO:0032880
IDA
Genome Projectregulation of protein localization
GO:0032880
IDA
Gene Ontologyregulation of protein localization20
GO:0032460
IDA
Genome Projectnegative regulation of protein oligomerization
GO:0032460
IDA
Gene Ontologynegative regulation of protein oligomerization28
GO:0032270
IMP
Genome Projectpositive regulation of cellular protein metabolic process
GO:0032270
IMP
Gene Ontologypositive regulation of cellular protein metabolic process22
GO:0032148
IDA
Genome Projectactivation of protein kinase B activity
GO:0032148
IDA
Gene Ontologyactivation of protein kinase B activity29
GO:0031954
ISS
Genome Projectpositive regulation of protein autophosphorylation
GO:0031954
ISS
Gene Ontologypositive regulation of protein autophosphorylation30
GO:0030335
ISS
Genome Projectpositive regulation of cell migration
GO:0030335
ISS
Gene Ontologypositive regulation of cell migration31
GO:0030307
NAS
Genome Projectpositive regulation of cell growth
GO:0030307
NAS
Gene Ontologypositive regulation of cell growth13
GO:0022898
IDA
Genome Projectregulation of transmembrane transporter activity
GO:0022898
IDA
Gene Ontologyregulation of transmembrane transporter activity20
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014068
IDA
Gene Ontologypositive regulation of phosphatidylinositol 3-kinase signaling19
GO:0010628
IGI
Genome Projectpositive regulation of gene expression
GO:0010628
IGI
Gene Ontologypositive regulation of gene expression32
GO:0008286
IDA
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008286
IDA
TAS
Gene Ontologyinsulin receptor signaling pathway3
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008284
IDA
Gene Ontologypositive regulation of cell proliferation19 25
GO:0007267
IC
Genome Projectcell-cell signaling
GO:0007267
IC
Gene Ontologycell-cell signaling33
GO:0007186
IDA
Genome ProjectG protein-coupled receptor signaling pathway
GO:0007186
IDA
Gene OntologyG protein-coupled receptor signaling pathway7
GO:0006953
IDA
Genome Projectacute-phase response
GO:0006953
IDA
Gene Ontologyacute-phase response16
GO:0006888
TAS
Genome ProjectER to Golgi vesicle-mediated transport
GO:0006888
TAS
Gene OntologyER to Golgi vesicle-mediated transport
GO:0006521
IMP
Genome Projectregulation of cellular amino acid metabolic process
GO:0006521
IMP
Gene Ontologyregulation of cellular amino acid metabolic process22
GO:0006355
NAS
Genome Projectregulation of transcription, DNA-templated
GO:0006355
NAS
Gene Ontologyregulation of transcription, DNA-templated34
GO:0006006
IEA
Genome Projectglucose metabolic process
GO:0002674
IDA
Genome Projectnegative regulation of acute inflammatory response
GO:0002674
IDA
Gene Ontologynegative regulation of acute inflammatory response8
GO:0000165
IDA
Genome ProjectMAPK cascade
GO:1990535
IGI
Gene Ontologyneuron projection maintenance35
GO:1903427
IGI
Gene Ontologynegative regulation of reactive oxygen species biosynthetic process35
GO:1903076
IGI
Gene Ontologyregulation of protein localization to plasma membrane35
GO:1902952
IGI
Gene Ontologypositive regulation of dendritic spine maintenance35
GO:1900273
TAS
Gene Ontologypositive regulation of long-term synaptic potentiation35
GO:0050890
TAS
Gene Ontologycognition35
GO:0048167
TAS
Gene Ontologyregulation of synaptic plasticity35
GO:0010750
IMP
Gene Ontologypositive regulation of nitric oxide mediated signal transduction20

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding36 37 38 39 40
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding41 42 43 44
GO:0005179
IMP
NAS, IC
Genome Projecthormone activity
GO:0005179
IMP
NAS, IC
Gene Ontologyhormone activity24 45 46
GO:0005159
IPI
Genome Projectinsulin-like growth factor receptor binding
GO:0005159
IPI
Gene Ontologyinsulin-like growth factor receptor binding47
GO:0005158
IDA, IPI
Genome Projectinsulin receptor binding
GO:0005158
IDA, IPI
Gene Ontologyinsulin receptor binding33 45 47
GO:0002020
IPI
Genome Projectprotease binding
GO:0002020
IPI
Gene Ontologyprotease binding48

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0034774
TAS
Genome Projectsecretory granule lumen
GO:0034774
TAS
Gene Ontologysecretory granule lumen
GO:0033116
TAS
Genome Projectendoplasmic reticulum-Golgi intermediate compartment membrane
GO:0033116
TAS
Gene Ontologyendoplasmic reticulum-Golgi intermediate compartment membrane
GO:0031904
TAS
Genome Projectendosome lumen
GO:0031904
TAS
Gene Ontologyendosome lumen
GO:0030133
TAS
Genome Projecttransport vesicle
GO:0030133
TAS
Gene Ontologytransport vesicle
GO:0005796
TAS
Genome ProjectGolgi lumen
GO:0005796
TAS
Gene OntologyGolgi lumen
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005788
TAS
Gene Ontologyendoplasmic reticulum lumen
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space45
GO:0005576
TAS, IC
Genome Projectextracellular region
GO:0005576
TAS, IC
Gene Ontologyextracellular region33
GO:0000139
TAS
Genome ProjectGolgi membrane
GO:0000139
TAS
Gene OntologyGolgi membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004825Insulin
IPR016179Insulin-like
IPR022352Insulin family
IPR022353Insulin, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K04526INS; insulin
No chloroplast target sequence found.