Gene: ENSG00000253729 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000253729
Transcript Identifier
ENST00000314191
Gene Type
Coding gene
Location
8 : 47774173-47960126 : negative

Family Information

Homologous gene family
HOM02SEM000244
(122 genes in 26 species)
specific family

Descriptions

gene_descr
protein kinase, DNA-activated, catalytic polypeptide

Identifiers

Type Value
pidENSP00000313420
HGNC9413
UniprotP78527
RefSeq_mRNANM_006904.6

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001229
IEA
Genome Projectnegative regulation of response to gamma radiation
GO:2000773
IEA
Genome Projectnegative regulation of cellular senescence
GO:0097681
TAS
Genome Projectdouble-strand break repair via alternative nonhomologous end joining
GO:0097681
TAS
Gene Ontologydouble-strand break repair via alternative nonhomologous end joining1
GO:0072431
IMP
Genome Projectsignal transduction involved in mitotic G1 DNA damage checkpoint
GO:0072431
IMP
Gene Ontologysignal transduction involved in mitotic G1 DNA damage checkpoint2
GO:0048660
IMP
Genome Projectregulation of smooth muscle cell proliferation
GO:0048660
IMP
Gene Ontologyregulation of smooth muscle cell proliferation3
GO:0048639
IEA
Genome Projectpositive regulation of developmental growth
GO:0048538
IEA
Genome Projectthymus development
GO:0048536
IEA
Genome Projectspleen development
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048146
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0045944
IMP
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IMP
Gene Ontologypositive regulation of transcription by RNA polymerase II4
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043066
IMP
Gene Ontologynegative regulation of apoptotic process5
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0042752
ISS
Genome Projectregulation of circadian rhythm
GO:0042752
ISS
Gene Ontologyregulation of circadian rhythm
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0033153
IEA
Genome ProjectT cell receptor V(D)J recombination
GO:0033152
IEA
Genome Projectimmunoglobulin V(D)J recombination
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0032869
IMP
Genome Projectcellular response to insulin stimulus
GO:0032869
IMP
Gene Ontologycellular response to insulin stimulus4
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032481
TAS
Gene Ontologypositive regulation of type I interferon production
GO:0031648
IEA
Genome Projectprotein destabilization
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018105
IDA
Gene Ontologypeptidyl-serine phosphorylation4 6
GO:0016567
TAS
Genome Projectprotein ubiquitination
GO:0016567
TAS
Gene Ontologyprotein ubiquitination
GO:0016233
IMP
Genome Projecttelomere capping
GO:0016233
IMP
Gene Ontologytelomere capping1
GO:0014823
IEA
Genome Projectresponse to activity
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008283
IMP
Genome Projectcell proliferation
GO:0008283
IMP
Gene Ontologycell proliferation1
GO:0007507
IEA
Genome Projectheart development
GO:0007420
IEA
Genome Projectbrain development
GO:0006468
IMP
Genome Projectprotein phosphorylation
GO:0006468
IMP
Gene Ontologyprotein phosphorylation7
GO:0006464
TAS
Genome Projectcellular protein modification process
GO:0006464
TAS
Gene Ontologycellular protein modification process8
GO:0006303
TAS
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0006303
TAS
Gene Ontologydouble-strand break repair via nonhomologous end joining
GO:0006302
IMP
Genome Projectdouble-strand break repair
GO:0006302
IMP
Gene Ontologydouble-strand break repair1
GO:0002684
IEA
Genome Projectpositive regulation of immune system process
GO:0002638
IEA
Genome Projectnegative regulation of immunoglobulin production
GO:0002360
IEA
Genome ProjectT cell lineage commitment
GO:0002328
IEA
Genome Projectpro-B cell differentiation
GO:0002326
IEA
Genome ProjectB cell lineage commitment
GO:0001933
ISS
Genome Projectnegative regulation of protein phosphorylation
GO:0001933
ISS
Gene Ontologynegative regulation of protein phosphorylation
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0002218
IDA
Gene Ontologyactivation of innate immune response9

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0019904
IPI
Gene Ontologyprotein domain specific binding7
GO:0019899
IEA
Genome Projectenzyme binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding4
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 7 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26
GO:0004677
IDA
Genome ProjectDNA-dependent protein kinase activity
GO:0004677
IDA
Gene OntologyDNA-dependent protein kinase activity6
GO:0004674
IDA
TAS
Genome Projectprotein serine/threonine kinase activity
GO:0004674
IDA
TAS
Gene Ontologyprotein serine/threonine kinase activity4 5
GO:0004672
IDA, IMP
Genome Projectprotein kinase activity
GO:0004672
IDA, IMP
Gene Ontologyprotein kinase activity7 8
GO:0003723
IDA
Genome ProjectRNA binding
GO:0003723
Gene OntologyRNA binding27 28
GO:0003690
IDA
Genome Projectdouble-stranded DNA binding
GO:0003690
IDA
Gene Ontologydouble-stranded DNA binding7

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070419
IDA
Genome Projectnonhomologous end joining complex
GO:0070419
IDA
Gene Ontologynonhomologous end joining complex24 29
GO:0032993
IDA
Genome Projectprotein-DNA complex
GO:0032993
IDA
Gene Ontologyprotein-DNA complex7
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane30
GO:0005958
IDA
Genome ProjectDNA-dependent protein kinase-DNA ligase 4 complex
GO:0005958
IDA
Gene OntologyDNA-dependent protein kinase-DNA ligase 4 complex6
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005730
IEA
Genome Projectnucleolus
GO:0005730
IDA
Gene Ontologynucleolus31
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005667
IDA
Gene Ontologytranscription factor complex4
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus7
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0000784
Gene Ontologynuclear chromosome, telomeric region32
GO:0032991
IMP
Gene Ontologyprotein-containing complex7

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151PIK-related kinase, FAT
IPR003152FATC domain
IPR011009Protein kinase-like domain superfamily
IPR011989Armadillo-like helical
IPR011990Tetratricopeptide-like helical domain superfamily
IPR012582NUC194
IPR014009PIK-related kinase
IPR016024Armadillo-type fold
IPR018936Phosphatidylinositol 3/4-kinase, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K06642PRKDC; DNA-dependent protein kinase catalytic subunit
No chloroplast target sequence found.