Gene: ENSG00000245848 (Homo sapiens)

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Gene Identifier
ENSG00000245848
Transcript Identifier
ENST00000498907
Gene Type
Coding gene
Location
19 : 33301338-33302414 : negative

Family Information

Homologous gene family
HOM02SEM019137
(4 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
CCAAT/enhancer binding protein (C/EBP), alpha

Identifiers

Type Value
pidENSP00000427514
HGNC1833
UniprotP49715
RefSeq_mRNANM_001285829.1
RefSeq_mRNANM_001287424.1
RefSeq_mRNANM_001287435.1
RefSeq_mRNANM_004364.4
EMBLAC008738
EMBLBC027902
EMBLEU048234
EMBLU34070
EMBLY11525

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0071356
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0055088
ISS
Genome Projectlipid homeostasis
GO:0055088
ISS
Gene Ontologylipid homeostasis
GO:0050873
IEA
Genome Projectbrown fat cell differentiation
GO:0050872
IEA
Genome Projectwhite fat cell differentiation
GO:0048839
IEA
Genome Projectinner ear development
GO:0048469
IEA
Genome Projectcell maturation
GO:0045945
IDA
Genome Projectpositive regulation of transcription by RNA polymerase III
GO:0045945
IDA
Gene Ontologypositive regulation of transcription by RNA polymerase III1
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA, IMP
Gene Ontologypositive regulation of transcription by RNA polymerase II2 3 4
GO:0045892
ISS
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
ISS
Gene Ontologynegative regulation of transcription, DNA-templated
GO:0045736
TAS
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045736
TAS
Gene Ontologynegative regulation of cyclin-dependent protein serine/threonine kinase activity5
GO:0045669
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045600
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0045444
ISS
Genome Projectfat cell differentiation
GO:0045444
ISS
Gene Ontologyfat cell differentiation
GO:0042593
ISS
Genome Projectglucose homeostasis
GO:0042593
ISS
Gene Ontologyglucose homeostasis
GO:0032436
TAS
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
TAS
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process5
GO:0030851
ISS
Genome Projectgranulocyte differentiation
GO:0030851
ISS
Gene Ontologygranulocyte differentiation
GO:0030324
ISS
Genome Projectlung development
GO:0030324
ISS
Gene Ontologylung development
GO:0030225
IEA
Genome Projectmacrophage differentiation
GO:0030099
NAS
Genome Projectmyeloid cell differentiation
GO:0030099
NAS
Gene Ontologymyeloid cell differentiation6
GO:0019221
NAS
Genome Projectcytokine-mediated signaling pathway
GO:0019221
NAS
Gene Ontologycytokine-mediated signaling pathway6
GO:0016032
IEA
Genome Projectviral process
GO:0008285
IDA
ISS
Genome Projectnegative regulation of cell proliferation
GO:0008285
IDA
ISS
Gene Ontologynegative regulation of cell proliferation7
GO:0008203
IEA
Genome Projectcholesterol metabolic process
GO:0007219
IEA
Genome ProjectNotch signaling pathway
GO:0007005
IEA
Genome Projectmitochondrion organization
GO:0006366
TAS
Genome Projecttranscription by RNA polymerase II
GO:0006366
TAS
Gene Ontologytranscription by RNA polymerase II8
GO:0006351
IDA
NAS
Genome Projecttranscription, DNA-templated
GO:0006351
IDA
NAS
Gene Ontologytranscription, DNA-templated6 9
GO:0006091
TAS
Genome Projectgeneration of precursor metabolites and energy
GO:0006091
TAS
Gene Ontologygeneration of precursor metabolites and energy8
GO:0001892
IEA
Genome Projectembryonic placenta development
GO:0001889
ISS
Genome Projectliver development
GO:0001889
ISS
Gene Ontologyliver development
GO:0000122
IEA
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000050
IEA
Genome Projecturea cycle
GO:0050729
ISS
Gene Ontologypositive regulation of inflammatory response
GO:0043032
ISS
Gene Ontologypositive regulation of macrophage activation
GO:0044070
IEA
PLAZA Integrative Orthologyregulation of anion transport ENSG00000172216
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development ENSG00000172216
GO:0012501
IEA
PLAZA Integrative Orthologyprogrammed cell death ENSG00000172216
GO:0034976
IEA
PLAZA Integrative Orthologyresponse to endoplasmic reticulum stress ENSG00000172216
GO:0002526
IEA
PLAZA Integrative Orthologyacute inflammatory response ENSG00000172216
GO:0070059
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ENSG00000172216
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000172216
GO:0010966
IEA
PLAZA Integrative Orthologyregulation of phosphate transport ENSG00000172216
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization ENSG00000172216
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000172216
GO:0009888
IEA
PLAZA Integrative Orthologytissue development ENSG00000172216
GO:1990440
IEA
PLAZA Integrative Orthologypositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ENSG00000172216
GO:0006953
IEA
PLAZA Integrative Orthologyacute-phase response ENSG00000172216
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000172216
GO:1903793
IEA
PLAZA Integrative Orthologypositive regulation of anion transport ENSG00000172216
GO:0042089
IEA
PLAZA Homology (enrichment)cytokine biosynthetic process HOM02SEM019137
GO:0036003
IEA
PLAZA Integrative Orthologypositive regulation of transcription from RNA polymerase II promoter in response to stress ENSG00000172216
GO:0043618
IEA
PLAZA Integrative Orthologyregulation of transcription from RNA polymerase II promoter in response to stress ENSG00000172216
GO:0031214
IEA
PLAZA Integrative Orthologybiomineral tissue development ENSG00000172216
GO:0042107
IEA
PLAZA Homology (enrichment)cytokine metabolic process HOM02SEM019137
GO:0070169
IEA
PLAZA Integrative Orthologypositive regulation of biomineral tissue development ENSG00000172216
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction ENSG00000172216
GO:0006915
IEA
PLAZA Integrative Orthologyapoptotic process ENSG00000172216
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress ENSG00000172216
GO:0044341
IEA
PLAZA Integrative Orthologysodium-dependent phosphate transport ENSG00000172216
GO:0006817
IEA
PLAZA Integrative Orthologyphosphate ion transport ENSG00000172216
GO:0070167
IEA
PLAZA Integrative Orthologyregulation of biomineral tissue development ENSG00000172216
GO:0008219
IEA
PLAZA Integrative Orthologycell death ENSG00000172216
GO:0043270
IEA
PLAZA Integrative Orthologypositive regulation of ion transport ENSG00000172216
GO:2000118
IEA
PLAZA Integrative Orthologyregulation of sodium-dependent phosphate transport ENSG00000172216
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response ENSG00000172216
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport ENSG00000172216
GO:0006811
IEA
PLAZA Integrative Orthologyion transport ENSG00000172216
GO:0006820
IEA
PLAZA Integrative Orthologyanion transport ENSG00000172216
GO:0043269
IEA
PLAZA Integrative Orthologyregulation of ion transport ENSG00000172216
GO:0097193
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway ENSG00000172216
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport ENSG00000172216
GO:0097190
IEA
PLAZA Integrative Orthologyapoptotic signaling pathway ENSG00000172216
GO:0043620
IEA
PLAZA Integrative Orthologyregulation of DNA-templated transcription in response to stress ENSG00000172216
GO:0015698
IEA
PLAZA Integrative Orthologyinorganic anion transport ENSG00000172216
GO:2000120
IEA
PLAZA Integrative Orthologypositive regulation of sodium-dependent phosphate transport ENSG00000172216

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0044212
IDA
Gene Ontologytranscription regulatory region DNA binding1 10
GO:0042803
ISS
Genome Projectprotein homodimerization activity
GO:0042803
ISS
Gene Ontologyprotein homodimerization activity
GO:0019900
IPI
Genome Projectkinase binding
GO:0019900
IPI
Gene Ontologykinase binding11
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding6
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding11 12 13 14 15 16
GO:0003713
ISS
Genome Projecttranscription coactivator activity
GO:0003713
ISS
Gene Ontologytranscription coactivator activity
GO:0003700
IDA
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IDA
Gene OntologyDNA-binding transcription factor activity1 6 17
GO:0003677
TAS
Genome ProjectDNA binding
GO:0003677
TAS
Gene OntologyDNA binding8
GO:0001228
IMP
Genome ProjectDNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001228
IMP
Gene OntologyDNA-binding transcription activator activity, RNA polymerase II-specific3
GO:0000978
IEA
Genome ProjectRNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000981
ISA
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific
GO:0046982
IEA
PLAZA Homology (enrichment)protein heterodimerization activity HOM02SEM019137

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0090575
IMP
Genome ProjectRNA polymerase II transcription factor complex
GO:0090575
IMP
Gene OntologyRNA polymerase II transcription factor complex3
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle
GO:0005730
IEA
Genome Projectnucleolus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0005634
IDA
NAS
Genome Projectnucleus
GO:0005634
IDA
NAS
Gene Ontologynucleus9 17

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004827Basic-leucine zipper domain
IPR016468CCAAT/enhancer-binding protein, chordates

No MapMan annotations defined for this gene.
KeggID Description
K09055CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
No chloroplast target sequence found.