Gene: ENSG00000197616 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000197616
Transcript Identifier
ENST00000356287
Gene Type
Coding gene
Location
14 : 23382040-23407223 : negative

Family Information

Homologous gene family
HOM02SEM000038
(396 genes in 24 species)
specific family
Orthologous gene family
ORTHO02SEM000037
(364 genes in 24 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
myosin, heavy chain 6, cardiac muscle, alpha

Identifiers

Type Value
pidENSP00000348634
HGNC7576
UniprotP13533

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0060420
IEA
Genome Projectregulation of heart growth
GO:0060070
IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060048
ISS
Genome Projectcardiac muscle contraction
GO:0060048
ISS
Gene Ontologycardiac muscle contraction1
GO:0055010
IMP
Genome Projectventricular cardiac muscle tissue morphogenesis
GO:0055010
IMP
Gene Ontologyventricular cardiac muscle tissue morphogenesis2 3
GO:0055009
IMP
Genome Projectatrial cardiac muscle tissue morphogenesis
GO:0055009
IMP
Gene Ontologyatrial cardiac muscle tissue morphogenesis4
GO:0048739
ISS
Genome Projectcardiac muscle fiber development
GO:0048739
ISS
Gene Ontologycardiac muscle fiber development
GO:0046034
IDA
Genome ProjectATP metabolic process
GO:0046034
IDA
Gene OntologyATP metabolic process5
GO:0045214
ISS
Genome Projectsarcomere organization
GO:0045214
ISS
Gene Ontologysarcomere organization
GO:0043462
ISS
Genome Projectregulation of ATPase activity
GO:0043462
ISS
Gene Ontologyregulation of ATPase activity
GO:0030509
IEA
Genome ProjectBMP signaling pathway
GO:0030239
ISS
Genome Projectmyofibril assembly
GO:0030239
ISS
Gene Ontologymyofibril assembly
GO:0030049
IMP
TAS
Genome Projectmuscle filament sliding
GO:0030049
IMP
TAS
Gene Ontologymuscle filament sliding6
GO:0014898
IEA
Genome Projectcardiac muscle hypertrophy in response to stress
GO:0008217
ISS
Genome Projectregulation of blood pressure
GO:0008217
ISS
Gene Ontologyregulation of blood pressure
GO:0008016
ISS
Genome Projectregulation of heart contraction
GO:0008016
ISS
Gene Ontologyregulation of heart contraction
GO:0007522
ISS
Genome Projectvisceral muscle development
GO:0007522
ISS
Gene Ontologyvisceral muscle development
GO:0007512
IMP
Genome Projectadult heart development
GO:0007512
IMP
Gene Ontologyadult heart development3 4
GO:0006941
IMP
ISS
Genome Projectstriated muscle contraction
GO:0006941
IMP
ISS
Gene Ontologystriated muscle contraction5
GO:0006936
IDA
Genome Projectmuscle contraction
GO:0006936
IDA
Gene Ontologymuscle contraction5
GO:0006470
IEA
Genome Projectprotein dephosphorylation
GO:0002027
IDA
Genome Projectregulation of heart rate
GO:0002027
IDA
Gene Ontologyregulation of heart rate5
GO:0002026
IDA
ISS
Genome Projectregulation of the force of heart contraction
GO:0002026
IDA
ISS
Gene Ontologyregulation of the force of heart contraction5
GO:0001701
ISS
Genome Projectin utero embryonic development
GO:0001701
ISS
Gene Ontologyin utero embryonic development
GO:0050821
IEA
PLAZA Integrative Orthologyprotein stabilization FBgn0264695
GO:0032970
IEA
PLAZA Integrative Orthologyregulation of actin filament-based process FBgn0264695
GO:0006909
IEA
PLAZA Integrative Orthologyphagocytosis ENSG00000125414
GO:0002429
IEA
PLAZA Integrative Orthologyimmune response-activating cell surface receptor signaling pathway ENSG00000125414
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0264695
GO:0048598
IEA
PLAZA Integrative Orthologyembryonic morphogenesis ENSG00000109063
GO:0019098
IEA
PLAZA Integrative Orthologyreproductive behavior WBGene00006789
GO:0031647
IEA
PLAZA Integrative Orthologyregulation of protein stability FBgn0264695
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000125414
GO:0048870
IEA
PLAZA Integrative Orthologycell motility FBgn0264695
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0264695
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00006789
GO:0002431
IEA
PLAZA Integrative OrthologyFc receptor mediated stimulatory signaling pathway ENSG00000125414
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00003515
GO:0010171
IEA
PLAZA Integrative Orthologybody morphogenesis ENSG00000109063
GO:0060173
IEA
PLAZA Integrative Orthologylimb development ENSG00000109063
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process WBGene00003515
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0264695
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response ENSG00000125414
GO:0050778
IEA
PLAZA Integrative Orthologypositive regulation of immune response ENSG00000125414
GO:0030728
IEA
PLAZA Integrative Orthologyovulation WBGene00003515
GO:0043050
IEA
PLAZA Integrative Orthologypharyngeal pumping WBGene00002348
GO:0007427
IEA
PLAZA Integrative Orthologyepithelial cell migration, open tracheal system FBgn0264695
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction WBGene00003515
GO:0030326
IEA
PLAZA Integrative Orthologyembryonic limb morphogenesis ENSG00000109063
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus ENSG00000125414
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus ENSG00000125414
GO:0042755
IEA
PLAZA Integrative Orthologyeating behavior WBGene00002348
GO:0048736
IEA
PLAZA Integrative Orthologyappendage development ENSG00000109063
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation WBGene00003515
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization FBgn0264695
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction WBGene00003515
GO:0071689
IEA
PLAZA Integrative Orthologymuscle thin filament assembly FBgn0264695
GO:0035108
IEA
PLAZA Integrative Orthologylimb morphogenesis ENSG00000109063
GO:0071688
IEA
PLAZA Integrative Orthologystriated muscle myosin thick filament assembly WBGene00006789
GO:0035107
IEA
PLAZA Integrative Orthologyappendage morphogenesis ENSG00000109063
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000125414
GO:0050881
IEA
PLAZA Integrative Orthologymusculoskeletal movement ENSG00000092054
GO:0030855
IEA
PLAZA Integrative Orthologyepithelial cell differentiation FBgn0264695
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000125414
GO:0060279
IEA
PLAZA Integrative Orthologypositive regulation of ovulation WBGene00003515
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis ENSG00000125414
GO:0060278
IEA
PLAZA Integrative Orthologyregulation of ovulation WBGene00003515
GO:0035113
IEA
PLAZA Integrative Orthologyembryonic appendage morphogenesis ENSG00000109063
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process WBGene00003515
GO:0031038
IEA
PLAZA Integrative Orthologymyosin II filament organization FBgn0264695
GO:0031034
IEA
PLAZA Integrative Orthologymyosin filament assembly WBGene00006789
GO:0050879
IEA
PLAZA Integrative Orthologymulticellular organismal movement ENSG00000092054
GO:0031033
IEA
PLAZA Integrative Orthologymyosin filament organization WBGene00006789
GO:0031036
IEA
PLAZA Integrative Orthologymyosin II filament assembly FBgn0264695
GO:0018991
IEA
PLAZA Integrative Orthologyoviposition WBGene00006789
GO:0098657
IEA
PLAZA Integrative Orthologyimport into cell ENSG00000125414
GO:0044087
IEA
PLAZA Integrative Orthologyregulation of cellular component biogenesis FBgn0264695
GO:0014819
IEA
PLAZA Integrative Orthologyregulation of skeletal muscle contraction ENSG00000092054
GO:0003009
IEA
PLAZA Integrative Orthologyskeletal muscle contraction ENSG00000092054
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0264695
GO:0002433
IEA
PLAZA Integrative Orthologyimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis ENSG00000125414
GO:0007610
IEA
PLAZA Integrative Orthologybehavior WBGene00003515
GO:0060325
IEA
PLAZA Integrative Orthologyface morphogenesis ENSG00000109063
GO:0002684
IEA
PLAZA Integrative Orthologypositive regulation of immune system process ENSG00000125414
GO:0060324
IEA
PLAZA Integrative Orthologyface development ENSG00000109063
GO:0060323
IEA
PLAZA Integrative Orthologyhead morphogenesis ENSG00000109063
GO:0002682
IEA
PLAZA Integrative Orthologyregulation of immune system process ENSG00000125414
GO:0090130
IEA
PLAZA Integrative Orthologytissue migration FBgn0264695
GO:0007298
IEA
PLAZA Integrative Orthologyborder follicle cell migration FBgn0264695
GO:0003010
IEA
PLAZA Integrative Orthologyvoluntary skeletal muscle contraction ENSG00000092054
GO:0090132
IEA
PLAZA Integrative Orthologyepithelium migration FBgn0264695
GO:0007297
IEA
PLAZA Integrative Orthologyovarian follicle cell migration FBgn0264695
GO:0090257
IEA
PLAZA Integrative Orthologyregulation of muscle system process ENSG00000092054
GO:0060322
IEA
PLAZA Integrative Orthologyhead development ENSG00000109063
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation WBGene00003515
GO:0031444
IEA
PLAZA Integrative Orthologyslow-twitch skeletal muscle fiber contraction ENSG00000092054
GO:0014721
IEA
PLAZA Integrative Orthologytwitch skeletal muscle contraction ENSG00000092054
GO:0014724
IEA
PLAZA Integrative Orthologyregulation of twitch skeletal muscle contraction ENSG00000092054
GO:0014728
IEA
PLAZA Integrative Orthologyregulation of the force of skeletal muscle contraction ENSG00000092054
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell FBgn0264695
GO:0031449
IEA
PLAZA Integrative Orthologyregulation of slow-twitch skeletal muscle fiber contraction ENSG00000092054
GO:0007525
IEA
PLAZA Integrative Orthologysomatic muscle development FBgn0264695
GO:0043254
IEA
PLAZA Integrative Orthologyregulation of protein complex assembly FBgn0264695
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization WBGene00006789
GO:0010631
IEA
PLAZA Integrative Orthologyepithelial cell migration FBgn0264695
GO:0016477
IEA
PLAZA Integrative Orthologycell migration FBgn0264695
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process WBGene00003515
GO:0030241
IEA
PLAZA Integrative Orthologyskeletal muscle myosin thick filament assembly WBGene00006789
GO:0006937
IEA
PLAZA Integrative Orthologyregulation of muscle contraction ENSG00000092054
GO:0007626
IEA
PLAZA Integrative Orthologylocomotory behavior WBGene00003515
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport ENSG00000125414
GO:0038093
IEA
PLAZA Integrative OrthologyFc receptor signaling pathway ENSG00000125414
GO:0006942
IEA
PLAZA Integrative Orthologyregulation of striated muscle contraction ENSG00000092054
GO:0002066
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell development FBgn0264695
GO:0043520
IEA
PLAZA Integrative Orthologyregulation of myosin II filament assembly FBgn0264695
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development FBgn0264695
GO:0002065
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell differentiation FBgn0264695
GO:0048017
IEA
PLAZA Integrative Orthologyinositol lipid-mediated signaling WBGene00002348
GO:0038096
IEA
PLAZA Integrative OrthologyFc-gamma receptor signaling pathway involved in phagocytosis ENSG00000125414
GO:0002064
IEA
PLAZA Integrative Orthologyepithelial cell development FBgn0264695
GO:0007631
IEA
PLAZA Integrative Orthologyfeeding behavior WBGene00002348
GO:0038094
IEA
PLAZA Integrative OrthologyFc-gamma receptor signaling pathway ENSG00000125414
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion WBGene00006789
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development FBgn0264695
GO:0014866
IEA
PLAZA Integrative Orthologyskeletal myofibril assembly WBGene00006789
GO:2000243
IEA
PLAZA Integrative Orthologypositive regulation of reproductive process WBGene00003515
GO:0051493
IEA
PLAZA Integrative Orthologyregulation of cytoskeleton organization FBgn0264695
GO:0002768
IEA
PLAZA Integrative Orthologyimmune response-regulating cell surface receptor signaling pathway ENSG00000125414
GO:0032956
IEA
PLAZA Integrative Orthologyregulation of actin cytoskeleton organization FBgn0264695
GO:0002764
IEA
PLAZA Integrative Orthologyimmune response-regulating signaling pathway ENSG00000125414
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0264695
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process ENSG00000125414
GO:0002253
IEA
PLAZA Integrative Orthologyactivation of immune response ENSG00000125414
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process ENSG00000125414
GO:0043519
IEA
PLAZA Integrative Orthologyregulation of myosin II filament organization FBgn0264695
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly WBGene00006789
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0264695
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction WBGene00002348
GO:0034622
IEA
PLAZA Integrative Orthologycellular protein-containing complex assembly WBGene00006789
GO:0030707
IEA
PLAZA Integrative Orthologyovarian follicle cell development FBgn0264695
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process WBGene00003515
GO:0002757
IEA
PLAZA Integrative Orthologyimmune response-activating signal transduction ENSG00000125414
GO:0001667
IEA
PLAZA Integrative Orthologyameboidal-type cell migration FBgn0264695
GO:0007527
IEA
PLAZA Integrative Orthologyadult somatic muscle development FBgn0264695
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response ENSG00000125414
GO:0048518
IEA
PLAZA Integrative Orthologypositive regulation of biological process ENSG00000125414
GO:0007015
IEA
PLAZA Integrative Orthologyactin filament organization FBgn0264695
GO:0060361
IEA
PLAZA Integrative Orthologyflight FBgn0264695
GO:2000241
IEA
PLAZA Integrative Orthologyregulation of reproductive process WBGene00003515
GO:0043902
IEA
PLAZA Integrative Orthologypositive regulation of multi-organism process WBGene00003515
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process WBGene00003515
GO:0014862
IEA
PLAZA Integrative Orthologyregulation of skeletal muscle contraction by chemo-mechanical energy conversion ENSG00000092054

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030898
IMP
Genome Projectactin-dependent ATPase activity
GO:0030898
IMP
Gene Ontologyactin-dependent ATPase activity6
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding7 8
GO:0017018
TAS
Genome Projectmyosin phosphatase activity
GO:0017018
TAS
Gene Ontologymyosin phosphatase activity
GO:0016887
IDA
Genome ProjectATPase activity
GO:0016887
IDA
Gene OntologyATPase activity5
GO:0005524
IEA
Genome ProjectATP binding
GO:0005516
IEA
Genome Projectcalmodulin binding
GO:0003779
IEA
Genome Projectactin binding
GO:0000146
IDA
ISS
Genome Projectmicrofilament motor activity
GO:0000146
IDA
ISS
Gene Ontologymicrofilament motor activity5
GO:0042803
IEA
PLAZA Integrative Orthologyprotein homodimerization activity FBgn0264695
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding FBgn0264695
GO:0008307
IEA
PLAZA Integrative Orthologystructural constituent of muscle WBGene00002348
GO:0017022
IEA
PLAZA Integrative Orthologymyosin binding ENSG00000133020
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding ENSG00000109063
GO:0003676
IEA
PLAZA Integrative Orthologynucleic acid binding ENSG00000264424
GO:0032027
IEA
PLAZA Integrative Orthologymyosin light chain binding ENSG00000133020
GO:0051015
IEA
PLAZA Integrative Orthologyactin filament binding ENSG00000109063
GO:0046983
IEA
PLAZA Integrative Orthologyprotein dimerization activity FBgn0264695
GO:0003725
IEA
PLAZA Integrative Orthologydouble-stranded RNA binding ENSG00000264424
GO:0003723
IEA
PLAZA Integrative OrthologyRNA binding ENSG00000264424
GO:0005198
IEA
PLAZA Integrative Orthologystructural molecule activity WBGene00002348

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032982
IEA
Genome Projectmyosin filament
GO:0030018
IEA
Genome ProjectZ disc
GO:0030017
TAS
Genome Projectsarcomere
GO:0030017
TAS
Gene Ontologysarcomere9
GO:0030016
ISS
Genome Projectmyofibril
GO:0030016
ISS
Gene Ontologymyofibril
GO:0016459
TAS
Genome Projectmyosin complex
GO:0016459
TAS
Gene Ontologymyosin complex9
GO:0005859
TAS
Genome Projectmuscle myosin complex
GO:0005859
TAS
Gene Ontologymuscle myosin complex10
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0001725
IEA
Genome Projectstress fiber
GO:0036379
IEA
PLAZA Integrative Orthologymyofilament WBGene00003515
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part FBgn0264695
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000006788
GO:1990904
IEA
PLAZA Integrative Orthologyribonucleoprotein complex ENSG00000109061
GO:0031672
IEA
PLAZA Integrative OrthologyA band WBGene00003515
GO:0005703
IEA
PLAZA Integrative Orthologypolytene chromosome puff FBgn0264695
GO:0005700
IEA
PLAZA Integrative Orthologypolytene chromosome FBgn0264695
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000006788
GO:0098687
IEA
PLAZA Integrative Orthologychromosomal region FBgn0264695
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000006788
GO:0005863
IEA
PLAZA Integrative Orthologystriated muscle myosin thick filament WBGene00003515
GO:0036464
IEA
PLAZA Integrative Orthologycytoplasmic ribonucleoprotein granule ENSG00000109061
GO:0035770
IEA
PLAZA Integrative Orthologyribonucleoprotein granule ENSG00000109061
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000006788
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000006788
GO:0005694
IEA
PLAZA Integrative Orthologychromosome FBgn0264695
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000006788
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000006788
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000006788

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000048IQ motif, EF-hand binding site
IPR001609Myosin head, motor domain
IPR002928Myosin tail
IPR004009Myosin, N-terminal, SH3-like
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K17751MYH6_7; myosin heavy chain 6/7
No chloroplast target sequence found.