Gene: ENSG00000188906 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000188906
Transcript Identifier
ENST00000298910
Gene Type
Coding gene
Location
12 : 40225132-40367765 : positive

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family

Descriptions

gene_descr
leucine-rich repeat kinase 2

Identifiers

Type Value
pidENSP00000298910
HGNC18618
UniprotQ5S007
RefSeq_mRNANM_198578.3
EMBLCHEMBL1075104
EMBLAC079630
EMBLAC084290
EMBLAC107023
EMBLAL834529
EMBLAY792511

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000300
IMP
Genome Projectregulation of synaptic vesicle exocytosis
GO:2000300
IMP
Gene Ontologyregulation of synaptic vesicle exocytosis1
GO:2000172
IMP
Genome Projectregulation of branching morphogenesis of a nerve
GO:2000172
IMP
Gene Ontologyregulation of branching morphogenesis of a nerve2
GO:1905289
IMP
Genome Projectregulation of CAMKK-AMPK signaling cascade
GO:1905289
IMP
Gene Ontologyregulation of CAMKK-AMPK signaling cascade3
GO:1905279
IGI
Genome Projectregulation of retrograde transport, endosome to Golgi
GO:1905279
IGI
Gene Ontologyregulation of retrograde transport, endosome to Golgi4
GO:1904887
IPI
TAS
Genome ProjectWnt signalosome assembly
GO:1904887
IPI
TAS
Gene OntologyWnt signalosome assembly5 6
GO:1903351
IMP
Genome Projectcellular response to dopamine
GO:1903351
IMP
Gene Ontologycellular response to dopamine7
GO:1903217
IC
Genome Projectnegative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903217
IC
Gene Ontologynegative regulation of protein processing involved in protein targeting to mitochondrion8
GO:1903215
IDA
Genome Projectnegative regulation of protein targeting to mitochondrion
GO:1903215
IDA
Gene Ontologynegative regulation of protein targeting to mitochondrion8
GO:1903206
IMP
Genome Projectnegative regulation of hydrogen peroxide-induced cell death
GO:1903206
IMP
Gene Ontologynegative regulation of hydrogen peroxide-induced cell death9
GO:1903125
IDA
Genome Projectnegative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903125
IDA
Gene Ontologynegative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation10
GO:1902902
IMP
Genome Projectnegative regulation of autophagosome assembly
GO:1902902
IMP
Gene Ontologynegative regulation of autophagosome assembly11
GO:1902823
TAS
Genome Projectnegative regulation of late endosome to lysosome transport
GO:1902823
TAS
Gene Ontologynegative regulation of late endosome to lysosome transport1
GO:1902803
ISS
TAS
Genome Projectregulation of synaptic vesicle transport
GO:1902803
ISS
TAS
Gene Ontologyregulation of synaptic vesicle transport12
GO:1902692
IMP
Genome Projectregulation of neuroblast proliferation
GO:1902692
IMP
Gene Ontologyregulation of neuroblast proliferation2
GO:1902499
IDA
Genome Projectpositive regulation of protein autoubiquitination
GO:1902499
IDA
Gene Ontologypositive regulation of protein autoubiquitination13
GO:1902236
IMP
Genome Projectnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236
IMP
Gene Ontologynegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway14
GO:1901215
IGI
Genome Projectnegative regulation of neuron death
GO:1901215
IGI
Gene Ontologynegative regulation of neuron death14
GO:1901214
IMP
Genome Projectregulation of neuron death
GO:1901214
IMP
Gene Ontologyregulation of neuron death15
GO:0090394
ISS
Genome Projectnegative regulation of excitatory postsynaptic potential
GO:0090394
ISS
Gene Ontologynegative regulation of excitatory postsynaptic potential
GO:0090263
IGI
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:0090263
IGI
Gene Ontologypositive regulation of canonical Wnt signaling pathway5
GO:0090140
TAS
Genome Projectregulation of mitochondrial fission
GO:0090140
TAS
Gene Ontologyregulation of mitochondrial fission16
GO:0072593
IMP
Genome Projectreactive oxygen species metabolic process
GO:0072593
IMP
Gene Ontologyreactive oxygen species metabolic process9
GO:0071287
IMP
Genome Projectcellular response to manganese ion
GO:0071287
IMP
Gene Ontologycellular response to manganese ion7
GO:0070997
IMP
Genome Projectneuron death
GO:0070997
IMP
Gene Ontologyneuron death17
GO:0070585
TAS
Genome Projectprotein localization to mitochondrion
GO:0070585
TAS
Gene Ontologyprotein localization to mitochondrion16
GO:0061001
IMP
ISS
Genome Projectregulation of dendritic spine morphogenesis
GO:0061001
IMP
ISS
Gene Ontologyregulation of dendritic spine morphogenesis2
GO:0060828
TAS
Genome Projectregulation of canonical Wnt signaling pathway
GO:0060828
TAS
Gene Ontologyregulation of canonical Wnt signaling pathway18
GO:0060161
IMP
Genome Projectpositive regulation of dopamine receptor signaling pathway
GO:0060161
IMP
Gene Ontologypositive regulation of dopamine receptor signaling pathway19
GO:0060159
ISS
Genome Projectregulation of dopamine receptor signaling pathway
GO:0060159
ISS
Gene Ontologyregulation of dopamine receptor signaling pathway
GO:0060079
ISS
Genome Projectexcitatory postsynaptic potential
GO:0060079
ISS
Gene Ontologyexcitatory postsynaptic potential
GO:0060070
TAS
Genome Projectcanonical Wnt signaling pathway
GO:0060070
TAS
Gene Ontologycanonical Wnt signaling pathway6
GO:0051966
ISS
Genome Projectregulation of synaptic transmission, glutamatergic
GO:0051966
ISS
Gene Ontologyregulation of synaptic transmission, glutamatergic
GO:0051900
IMP
Genome Projectregulation of mitochondrial depolarization
GO:0051900
IMP
Gene Ontologyregulation of mitochondrial depolarization20
GO:0051646
IMP
Genome Projectmitochondrion localization
GO:0051646
IMP
Gene Ontologymitochondrion localization21
GO:0048812
IMP
Genome Projectneuron projection morphogenesis
GO:0048812
IMP
Gene Ontologyneuron projection morphogenesis22
GO:0048312
IMP
Genome Projectintracellular distribution of mitochondria
GO:0048312
IMP
Gene Ontologyintracellular distribution of mitochondria23
GO:0046777
IDA, IMP
Genome Projectprotein autophosphorylation
GO:0046777
IDA, IMP
Gene Ontologyprotein autophosphorylation24 25 26 27 28
GO:0046039
IDA
Genome ProjectGTP metabolic process
GO:0046039
IDA
Gene OntologyGTP metabolic process29
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0043406
IC
Genome Projectpositive regulation of MAP kinase activity
GO:0043406
IC
Gene Ontologypositive regulation of MAP kinase activity7
GO:0043068
IDA
Genome Projectpositive regulation of programmed cell death
GO:0043068
IDA
Gene Ontologypositive regulation of programmed cell death27
GO:0042391
IMP
Genome Projectregulation of membrane potential
GO:0042391
IMP
Gene Ontologyregulation of membrane potential23
GO:0040012
IMP
Genome Projectregulation of locomotion
GO:0040012
IMP
Gene Ontologyregulation of locomotion17
GO:0035751
IMP
Genome Projectregulation of lysosomal lumen pH
GO:0035751
IMP
Gene Ontologyregulation of lysosomal lumen pH3
GO:0035641
IEA
Genome Projectlocomotory exploration behavior
GO:0035640
IMP
Genome Projectexploration behavior
GO:0035640
IMP
Gene Ontologyexploration behavior19
GO:0035564
ISS
Genome Projectregulation of kidney size
GO:0035564
ISS
Gene Ontologyregulation of kidney size
GO:0035556
ISS
Genome Projectintracellular signal transduction
GO:0035556
ISS
Gene Ontologyintracellular signal transduction
GO:0034613
ISS
Genome Projectcellular protein localization
GO:0034613
ISS
Gene Ontologycellular protein localization
GO:0034599
IMP
Genome Projectcellular response to oxidative stress
GO:0034599
IMP
Gene Ontologycellular response to oxidative stress14 21 30
GO:0034260
IDA
Genome Projectnegative regulation of GTPase activity
GO:0034260
IDA
Gene Ontologynegative regulation of GTPase activity31
GO:0032436
ISS
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
ISS
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092
IDA
Genome Projectpositive regulation of protein binding
GO:0032092
IDA
Gene Ontologypositive regulation of protein binding8
GO:0032091
IMP
Genome Projectnegative regulation of protein binding
GO:0032091
IMP
Gene Ontologynegative regulation of protein binding1
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0031398
IDA
Gene Ontologypositive regulation of protein ubiquitination13 32
GO:0022028
IMP
Genome Projecttangential migration from the subventricular zone to the olfactory bulb
GO:0022028
IMP
Gene Ontologytangential migration from the subventricular zone to the olfactory bulb2
GO:0021772
IMP
Genome Projectolfactory bulb development
GO:0021772
IMP
Gene Ontologyolfactory bulb development2
GO:0019722
IMP
Genome Projectcalcium-mediated signaling
GO:0019722
IMP
Gene Ontologycalcium-mediated signaling33
GO:0018107
IDA, IMP
Genome Projectpeptidyl-threonine phosphorylation
GO:0018107
IDA, IMP
Gene Ontologypeptidyl-threonine phosphorylation1 29
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018105
IDA
Gene Ontologypeptidyl-serine phosphorylation34
GO:0016310
IMP
Genome Projectphosphorylation
GO:0016310
IMP
Gene Ontologyphosphorylation11
GO:0016242
IMP
Genome Projectnegative regulation of macroautophagy
GO:0016242
IMP
Gene Ontologynegative regulation of macroautophagy35
GO:0014041
IMP
Genome Projectregulation of neuron maturation
GO:0014041
IMP
Gene Ontologyregulation of neuron maturation2
GO:0010955
IDA
Genome Projectnegative regulation of protein processing
GO:0010955
IDA
Gene Ontologynegative regulation of protein processing8
GO:0010738
ISS
Genome Projectregulation of protein kinase A signaling
GO:0010738
ISS
Gene Ontologyregulation of protein kinase A signaling
GO:0010508
IMP
ISS
Genome Projectpositive regulation of autophagy
GO:0010508
IMP
ISS
Gene Ontologypositive regulation of autophagy3
GO:0010506
IMP
Genome Projectregulation of autophagy
GO:0010506
IMP
Gene Ontologyregulation of autophagy36
GO:0009267
IMP
Genome Projectcellular response to starvation
GO:0009267
IMP
Gene Ontologycellular response to starvation36
GO:0008340
IMP
Genome Projectdetermination of adult lifespan
GO:0008340
IMP
Gene Ontologydetermination of adult lifespan17
GO:0007528
IMP
Genome Projectneuromuscular junction development
GO:0007528
IMP
Gene Ontologyneuromuscular junction development23
GO:0007264
IEA
Genome Projectsmall GTPase mediated signal transduction
GO:0007040
IMP
Genome Projectlysosome organization
GO:0007040
IMP
Gene Ontologylysosome organization33
GO:0007030
IMP
Genome ProjectGolgi organization
GO:0007030
IMP
Gene OntologyGolgi organization37
GO:0007005
IMP
Genome Projectmitochondrion organization
GO:0007005
IMP
Gene Ontologymitochondrion organization21
GO:0006979
IMP
Genome Projectresponse to oxidative stress
GO:0006979
IMP
Gene Ontologyresponse to oxidative stress17
GO:0006914
IEA
Genome Projectautophagy
GO:0006897
IMP, IGI
Genome Projectendocytosis
GO:0006897
IMP, IGI
Gene Ontologyendocytosis9
GO:0006468
IDA, IMP
Genome Projectprotein phosphorylation
GO:0006468
IDA, IMP
Gene Ontologyprotein phosphorylation7 38
GO:0001934
IDA, IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0001934
IDA, IMP
Gene Ontologypositive regulation of protein phosphorylation3 19
GO:0001933
ISS
Genome Projectnegative regulation of protein phosphorylation
GO:0001933
ISS
Gene Ontologynegative regulation of protein phosphorylation
GO:0000187
IMP
Genome Projectactivation of MAPK activity
GO:0000187
IMP
Gene Ontologyactivation of MAPK activity14
GO:0000186
IDA
Genome Projectactivation of MAPKK activity
GO:0000186
IDA
Gene Ontologyactivation of MAPKK activity39
GO:0000165
IDA
Genome ProjectMAPK cascade
GO:0000165
IDA
Gene OntologyMAPK cascade27

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904713
NAS
Genome Projectbeta-catenin destruction complex binding
GO:1904713
NAS
Gene Ontologybeta-catenin destruction complex binding6
GO:0051018
IPI
Genome Projectprotein kinase A binding
GO:0051018
IPI
Gene Ontologyprotein kinase A binding40
GO:0044325
IPI
Genome Projection channel binding
GO:0044325
IPI
Gene Ontologyion channel binding3 8
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0042803
IPI
Gene Ontologyprotein homodimerization activity25
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding25 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56
GO:0039706
TAS
Genome Projectco-receptor binding
GO:0039706
TAS
Gene Ontologyco-receptor binding6
GO:0036479
IDA
Genome Projectperoxidase inhibitor activity
GO:0036479
IDA
Gene Ontologyperoxidase inhibitor activity10
GO:0034211
IDA, IMP
Genome ProjectGTP-dependent protein kinase activity
GO:0034211
IDA, IMP
Gene OntologyGTP-dependent protein kinase activity27 57
GO:0030276
IPI
Genome Projectclathrin binding
GO:0030276
IPI
Gene Ontologyclathrin binding58
GO:0030159
IC
Genome Projectreceptor signaling complex scaffold activity
GO:0030159
IC
Gene Ontologyreceptor signaling complex scaffold activity5
GO:0017075
IPI
Genome Projectsyntaxin-1 binding
GO:0017075
IPI
Gene Ontologysyntaxin-1 binding58
GO:0017048
IPI
Genome ProjectRho GTPase binding
GO:0017048
IPI
Gene OntologyRho GTPase binding29
GO:0016301
IDA, IMP
Genome Projectkinase activity
GO:0016301
IDA, IMP
Gene Ontologykinase activity11 22
GO:0015631
IDA
Genome Projecttubulin binding
GO:0015631
IDA
Gene Ontologytubulin binding23
GO:0008017
TAS
Genome Projectmicrotubule binding
GO:0008017
TAS
Gene Ontologymicrotubule binding6
GO:0005525
IDA
TAS
Genome ProjectGTP binding
GO:0005525
IDA
TAS
Gene OntologyGTP binding5 26 28 57
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 4 5 8 10 13 23 25 29 32 37 38 40 43 47 48 50 51 53 54 55 56 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
GO:0005096
IDA
Genome ProjectGTPase activator activity
GO:0005096
IDA
Gene OntologyGTPase activator activity28
GO:0004708
IDA
Genome ProjectMAP kinase kinase activity
GO:0004708
IDA
Gene OntologyMAP kinase kinase activity39
GO:0004674
IDA
TAS
Genome Projectprotein serine/threonine kinase activity
GO:0004674
IDA
TAS
Gene Ontologyprotein serine/threonine kinase activity1 5 10 27 29 31 34
GO:0004672
IDA
Genome Projectprotein kinase activity
GO:0004672
IDA
Gene Ontologyprotein kinase activity10 24 25 28 38
GO:0003924
IDA
Genome ProjectGTPase activity
GO:0003924
IDA
Gene OntologyGTPase activity29
GO:0003779
IPI
Genome Projectactin binding
GO:0003779
IPI
Gene Ontologyactin binding58
GO:0000149
IPI
Genome ProjectSNARE binding
GO:0000149
IPI
Gene OntologySNARE binding58

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990909
IDA
NAS
Genome ProjectWnt signalosome
GO:1990909
IDA
NAS
Gene OntologyWnt signalosome5 6
GO:0099400
IDA
Genome Projectcaveola neck
GO:0099400
IDA
Gene Ontologycaveola neck35
GO:0098794
IEA
Genome Projectpostsynapse
GO:0097487
IDA
Genome Projectmultivesicular body, internal vesicle
GO:0097487
IDA
Gene Ontologymultivesicular body, internal vesicle35
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome101
GO:0044754
IDA
Genome Projectautolysosome
GO:0044754
IDA
Gene Ontologyautolysosome35
GO:0044753
IDA
Genome Projectamphisome
GO:0044753
IDA
Gene Ontologyamphisome35
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle
GO:0043204
IDA
ISS
Genome Projectperikaryon
GO:0043204
IDA
ISS
Gene Ontologyperikaryon102
GO:0043195
TAS
Genome Projectterminal bouton
GO:0043195
TAS
Gene Ontologyterminal bouton12
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043025
IDA
Gene Ontologyneuronal cell body29 103
GO:0043005
IDA
Genome Projectneuron projection
GO:0043005
IDA
Gene Ontologyneuron projection29 63
GO:0032839
IDA
Genome Projectdendrite cytoplasm
GO:0032839
IDA
Gene Ontologydendrite cytoplasm103
GO:0032473
IDA
Genome Projectcytoplasmic side of mitochondrial outer membrane
GO:0032473
IDA
Gene Ontologycytoplasmic side of mitochondrial outer membrane24
GO:0031966
IDA
Genome Projectmitochondrial membrane
GO:0031966
IDA
Gene Ontologymitochondrial membrane20
GO:0031410
ISS
Genome Projectcytoplasmic vesicle
GO:0031410
ISS
Gene Ontologycytoplasmic vesicle
GO:0030672
IEA
Genome Projectsynaptic vesicle membrane
GO:0030426
IDA
Genome Projectgrowth cone
GO:0030426
IDA
Gene Ontologygrowth cone63
GO:0030425
IDA
ISS
Genome Projectdendrite
GO:0030425
IDA
ISS
Gene Ontologydendrite102
GO:0030424
IDA
ISS
Genome Projectaxon
GO:0030424
IDA
ISS
Gene Ontologyaxon102
GO:0030054
IEA
Genome Projectcell junction
GO:0016234
IMP
Genome Projectinclusion body
GO:0016234
IMP
Gene Ontologyinclusion body15
GO:0005902
IDA
Genome Projectmicrovillus
GO:0005902
IDA
Gene Ontologymicrovillus35
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane5
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol5 10 15 20
GO:0005802
IEA
Genome Projecttrans-Golgi network
GO:0005798
IDA
Genome ProjectGolgi-associated vesicle
GO:0005798
IDA
Gene OntologyGolgi-associated vesicle37
GO:0005794
IDA
ISS
Genome ProjectGolgi apparatus
GO:0005794
IDA
ISS
Gene OntologyGolgi apparatus4
GO:0005783
IDA
ISS
Genome Projectendoplasmic reticulum
GO:0005783
IDA
ISS
Gene Ontologyendoplasmic reticulum35
GO:0005768
ISS
Genome Projectendosome
GO:0005768
ISS
Gene Ontologyendosome
GO:0005764
ISS
Genome Projectlysosome
GO:0005764
ISS
Gene Ontologylysosome
GO:0005759
ISS
Genome Projectmitochondrial matrix
GO:0005759
ISS
Gene Ontologymitochondrial matrix
GO:0005743
ISS
Genome Projectmitochondrial inner membrane
GO:0005743
ISS
Gene Ontologymitochondrial inner membrane
GO:0005741
ISS
Genome Projectmitochondrial outer membrane
GO:0005741
ISS
Gene Ontologymitochondrial outer membrane
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion10
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm13 25 63
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus
GO:0005622
IMP
Genome Projectintracellular
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
Gene Ontologyextracellular space104

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR005225Small GTP-binding protein domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain superfamily
IPR011989Armadillo-like helical
IPR015943WD40/YVTN repeat-like-containing domain superfamily
IPR016024Armadillo-type fold
IPR017441Protein kinase, ATP binding site
IPR017986WD40-repeat-containing domain
IPR020683Ankyrin repeat-containing domain
IPR020859Roc domain
IPR025875Leucine rich repeat 4
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR032171C-terminal of Roc (COR) domain
IPR032675Leucine-rich repeat domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K08844LRRK2; leucine-rich repeat kinase 2
No chloroplast target sequence found.