Gene: ENSG00000186790 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000186790
Transcript Identifier
ENST00000335071
Gene Type
Coding gene
Location
1 : 47416316-47417275 : positive

Family Information

Homologous gene family
HOM02SEM000449
(82 genes in 6 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
forkhead box E3

Identifiers

Type Value
pidENSP00000334472
HGNC3808
UniprotQ13461
UniprotA0A0A1EII5
RefSeq_mRNANM_012186.2
EMBLAF275722
EMBLAL607122
EMBLKM433708
EMBLU42990

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001111
IMP
ISS
Genome Projectpositive regulation of lens epithelial cell proliferation
GO:2001111
IMP
ISS
Gene Ontologypositive regulation of lens epithelial cell proliferation1 2
GO:1902747
ISS
Genome Projectnegative regulation of lens fiber cell differentiation
GO:1902747
ISS
Gene Ontologynegative regulation of lens fiber cell differentiation1
GO:0071157
IMP
Genome Projectnegative regulation of cell cycle arrest
GO:0071157
IMP
Gene Ontologynegative regulation of cell cycle arrest2
GO:0061303
ISS
Genome Projectcornea development in camera-type eye
GO:0061303
ISS
Gene Ontologycornea development in camera-type eye3
GO:0061073
ISS
Genome Projectciliary body morphogenesis
GO:0061073
ISS
Gene Ontologyciliary body morphogenesis3
GO:0061072
ISS
Genome Projectiris morphogenesis
GO:0061072
ISS
Gene Ontologyiris morphogenesis3
GO:0048468
IEA
Genome Projectcell development
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043066
IMP
Gene Ontologynegative regulation of apoptotic process2
GO:0042789
IDA
Genome ProjectmRNA transcription by RNA polymerase II
GO:0042789
IDA
Gene OntologymRNA transcription by RNA polymerase II4
GO:0006366
IDA
Genome Projecttranscription by RNA polymerase II
GO:0006366
IDA
Gene Ontologytranscription by RNA polymerase II5
GO:0006357
IEA
Genome Projectregulation of transcription by RNA polymerase II
GO:0002930
ISS
Genome Projecttrabecular meshwork development
GO:0002930
ISS
Gene Ontologytrabecular meshwork development3
GO:0002088
IMP
ISS
Genome Projectlens development in camera-type eye
GO:0002088
IMP
ISS
Gene Ontologylens development in camera-type eye3 4
GO:0001654
IMP
Genome Projecteye development
GO:0001654
IMP
Gene Ontologyeye development4
GO:0033146
IEA
PLAZA Integrative Orthologyregulation of intracellular estrogen receptor signaling pathway ENSG00000160973
GO:0071345
IEA
PLAZA Integrative Orthologycellular response to cytokine stimulus ENSG00000160973
GO:0033147
IEA
PLAZA Integrative Orthologynegative regulation of intracellular estrogen receptor signaling pathway ENSG00000160973
GO:0034599
IEA
PLAZA Integrative Orthologycellular response to oxidative stress YCR065W
GO:0072310
IEA
PLAZA Integrative Orthologyglomerular epithelial cell development ENSG00000129654
GO:0072311
IEA
PLAZA Integrative Orthologyglomerular epithelial cell differentiation ENSG00000129654
GO:0010604
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule metabolic process YCR065W
GO:1903508
IEA
PLAZA Integrative Orthologypositive regulation of nucleic acid-templated transcription YCR065W
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization YCR065W
GO:0007167
IEA
PLAZA Integrative Orthologyenzyme linked receptor protein signaling pathway ENSG00000160973
GO:0007166
IEA
PLAZA Integrative Orthologycell surface receptor signaling pathway ENSG00000160973
GO:0045597
IEA
PLAZA Integrative Orthologypositive regulation of cell differentiation ENSG00000129654
GO:0035295
IEA
PLAZA Integrative Orthologytube development ENSG00000129654
GO:0007165
IEA
PLAZA Integrative Orthologysignal transduction ENSG00000160973
GO:0061141
IEA
PLAZA Integrative Orthologylung ciliated cell differentiation ENSG00000129654
GO:0035850
IEA
PLAZA Integrative Orthologyepithelial cell differentiation involved in kidney development ENSG00000129654
GO:0030324
IEA
PLAZA Integrative Orthologylung development ENSG00000129654
GO:0050896
IEA
PLAZA Integrative Orthologyresponse to stimulus YCR065W
GO:0030323
IEA
PLAZA Integrative Orthologyrespiratory tube development ENSG00000129654
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process YCR065W
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress YCR065W
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus ENSG00000160973
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction ENSG00000160973
GO:0072163
IEA
PLAZA Integrative Orthologymesonephric epithelium development ENSG00000129654
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus ENSG00000160973
GO:0072164
IEA
PLAZA Integrative Orthologymesonephric tubule development ENSG00000129654
GO:0006979
IEA
PLAZA Integrative Orthologyresponse to oxidative stress YCR065W
GO:0062009
IEA
PLAZA Integrative Orthologysecondary palate development ENSG00000178919
GO:0048732
IEA
PLAZA Integrative Orthologygland development ENSG00000178919
GO:0007154
IEA
PLAZA Integrative Orthologycell communication ENSG00000160973
GO:0060465
IEA
PLAZA Integrative Orthologypharynx development ENSG00000178919
GO:0034097
IEA
PLAZA Integrative Orthologyresponse to cytokine ENSG00000160973
GO:0035502
IEA
PLAZA Integrative Orthologymetanephric part of ureteric bud development ENSG00000129654
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function ENSG00000160973
GO:0010469
IEA
PLAZA Integrative Orthologyregulation of signaling receptor activity ENSG00000160973
GO:0072016
IEA
PLAZA Integrative Orthologyglomerular parietal epithelial cell development ENSG00000129654
GO:0031023
IEA
PLAZA Integrative Orthologymicrotubule organizing center organization YCR065W
GO:0032870
IEA
PLAZA Integrative Orthologycellular response to hormone stimulus ENSG00000160973
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis YCR065W
GO:0072139
IEA
PLAZA Integrative Orthologyglomerular parietal epithelial cell differentiation ENSG00000129654
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization YCR065W
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression YCR065W
GO:0030858
IEA
PLAZA Integrative Orthologypositive regulation of epithelial cell differentiation ENSG00000129654
GO:0071560
IEA
PLAZA Integrative Orthologycellular response to transforming growth factor beta stimulus ENSG00000160973
GO:0072010
IEA
PLAZA Integrative Orthologyglomerular epithelium development ENSG00000129654
GO:0061005
IEA
PLAZA Integrative Orthologycell differentiation involved in kidney development ENSG00000129654
GO:0043433
IEA
PLAZA Integrative Orthologynegative regulation of DNA-binding transcription factor activity ENSG00000160973
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical YCR065W
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus YCR065W
GO:0055123
IEA
PLAZA Integrative Orthologydigestive system development ENSG00000178919
GO:0048565
IEA
PLAZA Integrative Orthologydigestive tract development ENSG00000178919
GO:0009755
IEA
PLAZA Integrative Orthologyhormone-mediated signaling pathway ENSG00000160973
GO:0007178
IEA
PLAZA Integrative Orthologytransmembrane receptor protein serine/threonine kinase signaling pathway ENSG00000160973
GO:0051173
IEA
PLAZA Integrative Orthologypositive regulation of nitrogen compound metabolic process YCR065W
GO:0007179
IEA
PLAZA Integrative Orthologytransforming growth factor beta receptor signaling pathway ENSG00000160973
GO:0031325
IEA
PLAZA Integrative Orthologypositive regulation of cellular metabolic process YCR065W
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000160973
GO:0051716
IEA
PLAZA Integrative Orthologycellular response to stimulus YCR065W
GO:2000824
IEA
PLAZA Integrative Orthologynegative regulation of androgen receptor activity ENSG00000160973
GO:2000823
IEA
PLAZA Integrative Orthologyregulation of androgen receptor activity ENSG00000160973
GO:0001657
IEA
PLAZA Integrative Orthologyureteric bud development ENSG00000129654
GO:0030518
IEA
PLAZA Integrative Orthologyintracellular steroid hormone receptor signaling pathway ENSG00000160973
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000160973
GO:0001656
IEA
PLAZA Integrative Orthologymetanephros development ENSG00000129654
GO:0030878
IEA
PLAZA Integrative Orthologythyroid gland development ENSG00000178919
GO:0001655
IEA
PLAZA Integrative Orthologyurogenital system development ENSG00000129654
GO:0031328
IEA
PLAZA Integrative Orthologypositive regulation of cellular biosynthetic process YCR065W
GO:0071383
IEA
PLAZA Integrative Orthologycellular response to steroid hormone stimulus ENSG00000160973
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress YCR065W
GO:0007005
IEA
PLAZA Integrative Orthologymitochondrion organization YCR065W
GO:0048545
IEA
PLAZA Integrative Orthologyresponse to steroid hormone ENSG00000160973
GO:2000272
IEA
PLAZA Integrative Orthologynegative regulation of signaling receptor activity ENSG00000160973
GO:0030522
IEA
PLAZA Integrative Orthologyintracellular receptor signaling pathway ENSG00000160973
GO:0071559
IEA
PLAZA Integrative Orthologyresponse to transforming growth factor beta ENSG00000160973
GO:0072009
IEA
PLAZA Integrative Orthologynephron epithelium development ENSG00000129654
GO:0030520
IEA
PLAZA Integrative Orthologyintracellular estrogen receptor signaling pathway ENSG00000160973
GO:0030521
IEA
PLAZA Integrative Orthologyandrogen receptor signaling pathway ENSG00000160973
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid ENSG00000160973
GO:0072006
IEA
PLAZA Integrative Orthologynephron development ENSG00000129654
GO:0072001
IEA
PLAZA Integrative Orthologyrenal system development ENSG00000129654
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid ENSG00000160973
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance ENSG00000160973
GO:0051300
IEA
PLAZA Integrative Orthologyspindle pole body organization YCR065W
GO:0048538
IEA
PLAZA Integrative Orthologythymus development ENSG00000178919
GO:0043401
IEA
PLAZA Integrative Orthologysteroid hormone mediated signaling pathway ENSG00000160973
GO:0045944
IEA
PLAZA Integrative Orthologypositive regulation of transcription by RNA polymerase II YCR065W
GO:0048534
IEA
PLAZA Integrative Orthologyhematopoietic or lymphoid organ development ENSG00000178919
GO:0002064
IEA
PLAZA Integrative Orthologyepithelial cell development ENSG00000129654
GO:0060428
IEA
PLAZA Integrative Orthologylung epithelium development ENSG00000129654
GO:1901248
IEA
PLAZA Integrative Orthologypositive regulation of lung ciliated cell differentiation ENSG00000129654
GO:1901246
IEA
PLAZA Integrative Orthologyregulation of lung ciliated cell differentiation ENSG00000129654
GO:0060021
IEA
PLAZA Integrative Orthologyroof of mouth development ENSG00000178919
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process YCR065W
GO:0009893
IEA
PLAZA Integrative Orthologypositive regulation of metabolic process YCR065W
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development ENSG00000129654
GO:0060023
IEA
PLAZA Integrative Orthologysoft palate development ENSG00000178919
GO:0060022
IEA
PLAZA Integrative Orthologyhard palate development ENSG00000178919
GO:0071407
IEA
PLAZA Integrative Orthologycellular response to organic cyclic compound ENSG00000160973
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus ENSG00000160973
GO:0023052
IEA
PLAZA Integrative Orthologysignaling ENSG00000160973
GO:0071363
IEA
PLAZA Integrative Orthologycellular response to growth factor stimulus ENSG00000160973
GO:0051254
IEA
PLAZA Integrative Orthologypositive regulation of RNA metabolic process YCR065W
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000160973
GO:0032835
IEA
PLAZA Integrative Orthologyglomerulus development ENSG00000129654
GO:0003338
IEA
PLAZA Integrative Orthologymetanephros morphogenesis ENSG00000129654
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000160973
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function ENSG00000160973
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process ENSG00000178919
GO:0060479
IEA
PLAZA Integrative Orthologylung cell differentiation ENSG00000129654
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000160973
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone ENSG00000160973
GO:0014070
IEA
PLAZA Integrative Orthologyresponse to organic cyclic compound ENSG00000160973
GO:0035270
IEA
PLAZA Integrative Orthologyendocrine system development ENSG00000178919
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization YCR065W
GO:0060993
IEA
PLAZA Integrative Orthologykidney morphogenesis ENSG00000129654
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance ENSG00000160973
GO:0045935
IEA
PLAZA Integrative Orthologypositive regulation of nucleobase-containing compound metabolic process YCR065W
GO:1902680
IEA
PLAZA Integrative Orthologypositive regulation of RNA biosynthetic process YCR065W
GO:0071495
IEA
PLAZA Integrative Orthologycellular response to endogenous stimulus ENSG00000160973
GO:0001823
IEA
PLAZA Integrative Orthologymesonephros development ENSG00000129654
GO:0001822
IEA
PLAZA Integrative Orthologykidney development ENSG00000129654
GO:0045893
IEA
PLAZA Integrative Orthologypositive regulation of transcription, DNA-templated YCR065W
GO:0060766
IEA
PLAZA Integrative Orthologynegative regulation of androgen receptor signaling pathway ENSG00000160973
GO:0051090
IEA
PLAZA Integrative Orthologyregulation of DNA-binding transcription factor activity ENSG00000160973
GO:0002520
IEA
PLAZA Integrative Orthologyimmune system development ENSG00000178919
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process YCR065W
GO:0060765
IEA
PLAZA Integrative Orthologyregulation of androgen receptor signaling pathway ENSG00000160973
GO:0072073
IEA
PLAZA Integrative Orthologykidney epithelium development ENSG00000129654
GO:0033143
IEA
PLAZA Integrative Orthologyregulation of intracellular steroid hormone receptor signaling pathway ENSG00000160973
GO:0033144
IEA
PLAZA Integrative Orthologynegative regulation of intracellular steroid hormone receptor signaling pathway ENSG00000160973
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization YCR065W
GO:0070848
IEA
PLAZA Integrative Orthologyresponse to growth factor ENSG00000160973
GO:0060487
IEA
PLAZA Integrative Orthologylung epithelial cell differentiation ENSG00000129654

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043565
ISS
Genome Projectsequence-specific DNA binding
GO:0043565
ISS
Gene Ontologysequence-specific DNA binding6
GO:0003700
IDA
TAS
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IDA
TAS
Gene OntologyDNA-binding transcription factor activity5 7 8
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding8
GO:0000981
IBA
Genome ProjectDNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000981
ISA, ISM
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific9
GO:0035326
IEA
PLAZA Integrative Orthologyenhancer binding ENSG00000160973
GO:0070410
IEA
PLAZA Integrative Orthologyco-SMAD binding ENSG00000160973
GO:0070412
IEA
PLAZA Integrative OrthologyR-SMAD binding ENSG00000160973
GO:0046332
IEA
PLAZA Integrative OrthologySMAD binding ENSG00000160973
GO:0001067
IEA
PLAZA Integrative Orthologyregulatory region nucleic acid binding ENSG00000129654
GO:0008134
IEA
PLAZA Integrative Orthologytranscription factor binding ENSG00000160973
GO:0043425
IEA
PLAZA Integrative OrthologybHLH transcription factor binding ENSG00000160973
GO:1990837
IEA
PLAZA Integrative Orthologysequence-specific double-stranded DNA binding ENSG00000129654
GO:0005102
IEA
PLAZA Integrative Orthologysignaling receptor binding ENSG00000160973
GO:0051427
IEA
PLAZA Integrative Orthologyhormone receptor binding ENSG00000160973
GO:0035258
IEA
PLAZA Integrative Orthologysteroid hormone receptor binding ENSG00000160973
GO:0035257
IEA
PLAZA Integrative Orthologynuclear hormone receptor binding ENSG00000160973
GO:0044212
IEA
PLAZA Integrative Orthologytranscription regulatory region DNA binding ENSG00000129654
GO:0050681
IEA
PLAZA Integrative Orthologyandrogen receptor binding ENSG00000160973
GO:0005515
IEA
PLAZA Integrative Orthologyprotein binding ENSG00000129654
GO:0019904
IEA
PLAZA Integrative Orthologyprotein domain specific binding ENSG00000160973
GO:0000976
IEA
PLAZA Integrative Orthologytranscription regulatory region sequence-specific DNA binding ENSG00000129654
GO:0003690
IEA
PLAZA Integrative Orthologydouble-stranded DNA binding ENSG00000129654

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005667
IDA
Gene Ontologytranscription factor complex5
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus8
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen YCR065W
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part YCR065W
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part YCR065W
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part YCR065W
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000160973
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin YCR065W
GO:0000785
IEA
PLAZA Integrative Orthologychromatin YCR065W
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm YCR065W
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen YCR065W
GO:0005694
IEA
PLAZA Integrative Orthologychromosome YCR065W
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part YCR065W
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen YCR065W
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part YCR065W
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle YCR065W
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome YCR065W
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen YCR065W
GO:0032444
IEA
PLAZA Integrative Orthologyactivin responsive factor complex ENSG00000160973
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle YCR065W
GO:0044798
IEA
PLAZA Integrative Orthologynuclear transcription factor complex ENSG00000160973
GO:0090575
IEA
PLAZA Integrative OrthologyRNA polymerase II transcription factor complex ENSG00000160973

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001766Fork head domain
IPR011991ArsR-like helix-turn-helix domain
IPR018122Fork head domain conserved site1
IPR030456Fork head domain conserved site 2

No MapMan annotations defined for this gene.
KeggID Description
K09398FOXE; forkhead box protein E
No chloroplast target sequence found.