Gene: ENSG00000185950 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000185950
Transcript Identifier
ENST00000375856
Gene Type
Coding gene
Location
13 : 109756304-109786053 : negative

Family Information

Homologous gene family
HOM02SEM021195
(4 genes in 2 species)
specific family
Orthologous gene family
ORTHO02SEM014056
(4 genes in 2 species)
specific family

Descriptions

gene_descr
insulin receptor substrate 2

Identifiers

Type Value
pidENSP00000365016
HGNC6126
UniprotQ9Y4H2
RefSeq_mRNANM_003749.2
EMBLAB000732
EMBLAF073310
EMBLAF288517
EMBLAF322114
EMBLAF322115
EMBLAL162497

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071333
IEA
Genome Projectcellular response to glucose stimulus
GO:0055088
TAS
Genome Projectlipid homeostasis
GO:0055088
TAS
Gene Ontologylipid homeostasis1
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0048015
TAS
Gene Ontologyphosphatidylinositol-mediated signaling
GO:0046854
IEA
Genome Projectphosphatidylinositol phosphorylation
GO:0046326
IMP
Genome Projectpositive regulation of glucose import
GO:0046326
IMP
Gene Ontologypositive regulation of glucose import1
GO:0045725
IMP
NAS
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0045725
IMP
NAS
Gene Ontologypositive regulation of glycogen biosynthetic process1 2
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0036092
IEA
Genome Projectphosphatidylinositol-3-phosphate biosynthetic process
GO:0033673
ISS
Genome Projectnegative regulation of kinase activity
GO:0033673
ISS
Gene Ontologynegative regulation of kinase activity
GO:0032869
IMP
Genome Projectcellular response to insulin stimulus
GO:0032869
IMP
Gene Ontologycellular response to insulin stimulus1
GO:0032024
ISS
Genome Projectpositive regulation of insulin secretion
GO:0032024
ISS
Gene Ontologypositive regulation of insulin secretion
GO:0032000
IMP
Genome Projectpositive regulation of fatty acid beta-oxidation
GO:0032000
IMP
Gene Ontologypositive regulation of fatty acid beta-oxidation1
GO:0030890
ISS
Genome Projectpositive regulation of B cell proliferation
GO:0030890
ISS
Gene Ontologypositive regulation of B cell proliferation
GO:0030879
IEA
Genome Projectmammary gland development
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0019216
TAS
Genome Projectregulation of lipid metabolic process
GO:0019216
TAS
Gene Ontologyregulation of lipid metabolic process1
GO:0014066
TAS
Genome Projectregulation of phosphatidylinositol 3-kinase signaling
GO:0010907
IMP
Genome Projectpositive regulation of glucose metabolic process
GO:0010907
IMP
Gene Ontologypositive regulation of glucose metabolic process1
GO:0010748
IMP
Genome Projectnegative regulation of plasma membrane long-chain fatty acid transport
GO:0010748
IMP
Gene Ontologynegative regulation of plasma membrane long-chain fatty acid transport1
GO:0009749
ISS
Genome Projectresponse to glucose
GO:0009749
ISS
Gene Ontologyresponse to glucose
GO:0008286
ISS, IBA
Genome Projectinsulin receptor signaling pathway
GO:0008286
ISS
Gene Ontologyinsulin receptor signaling pathway
GO:0008284
NAS
Genome Projectpositive regulation of cell proliferation
GO:0008284
NAS
Gene Ontologypositive regulation of cell proliferation2
GO:0008283
IEA
Genome Projectcell proliferation
GO:0007420
IEA
Genome Projectbrain development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007411
TAS
Gene Ontologyaxon guidance
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction3
GO:0006006
TAS
Genome Projectglucose metabolic process
GO:0006006
TAS
Gene Ontologyglucose metabolic process4
GO:0002903
ISS
Genome Projectnegative regulation of B cell apoptotic process
GO:0002903
ISS
Gene Ontologynegative regulation of B cell apoptotic process
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0000165
TAS
Genome ProjectMAPK cascade
GO:0000165
TAS
Gene OntologyMAPK cascade
GO:0051897
TAS
Gene Ontologypositive regulation of protein kinase B signaling
GO:0038111
TAS
Gene Ontologyinterleukin-7-mediated signaling pathway
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process FBgn0024248
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0024248
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation FBgn0024248
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0024248
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0024248
GO:0007568
IEA
PLAZA Integrative Orthologyaging FBgn0024248
GO:0002792
IEA
PLAZA Integrative Orthologynegative regulation of peptide secretion ENSG00000169047
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth FBgn0024248
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0024248
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis FBgn0024248
GO:0050709
IEA
PLAZA Integrative Orthologynegative regulation of protein secretion ENSG00000169047
GO:0007285
IEA
PLAZA Integrative Orthologyprimary spermatocyte growth FBgn0024248
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0024248
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0024248
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response FBgn0024248
GO:0098916
IEA
PLAZA Integrative Orthologyanterograde trans-synaptic signaling FBgn0024248
GO:0050778
IEA
PLAZA Integrative Orthologypositive regulation of immune response FBgn0024248
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress FBgn0024248
GO:0050890
IEA
PLAZA Integrative Orthologycognition FBgn0024248
GO:0048588
IEA
PLAZA Integrative Orthologydevelopmental cell growth FBgn0024248
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0024248
GO:0051224
IEA
PLAZA Integrative Orthologynegative regulation of protein transport ENSG00000169047
GO:0099177
IEA
PLAZA Integrative Orthologyregulation of trans-synaptic signaling FBgn0024248
GO:0046676
IEA
PLAZA Integrative Orthologynegative regulation of insulin secretion ENSG00000169047
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0024248
GO:0042078
IEA
PLAZA Integrative Orthologygerm-line stem cell division FBgn0024248
GO:0042594
IEA
PLAZA Integrative Orthologyresponse to starvation FBgn0024248
GO:0008361
IEA
PLAZA Integrative Orthologyregulation of cell size FBgn0024248
GO:1900078
IEA
PLAZA Integrative Orthologypositive regulation of cellular response to insulin stimulus ENSG00000169047
GO:1904950
IEA
PLAZA Integrative Orthologynegative regulation of establishment of protein localization ENSG00000169047
GO:1900076
IEA
PLAZA Integrative Orthologyregulation of cellular response to insulin stimulus ENSG00000169047
GO:0016049
IEA
PLAZA Integrative Orthologycell growth FBgn0024248
GO:0031667
IEA
PLAZA Integrative Orthologyresponse to nutrient levels FBgn0024248
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0024248
GO:0019433
IEA
PLAZA Integrative Orthologytriglyceride catabolic process FBgn0024248
GO:0050804
IEA
PLAZA Integrative Orthologymodulation of chemical synaptic transmission FBgn0024248
GO:0031669
IEA
PLAZA Integrative Orthologycellular response to nutrient levels FBgn0024248
GO:0031668
IEA
PLAZA Integrative Orthologycellular response to extracellular stimulus FBgn0024248
GO:0050806
IEA
PLAZA Integrative Orthologypositive regulation of synaptic transmission FBgn0024248
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0024248
GO:0050995
IEA
PLAZA Integrative Orthologynegative regulation of lipid catabolic process FBgn0024248
GO:0050877
IEA
PLAZA Integrative Orthologynervous system process FBgn0024248
GO:0017145
IEA
PLAZA Integrative Orthologystem cell division FBgn0024248
GO:0060291
IEA
PLAZA Integrative Orthologylong-term synaptic potentiation FBgn0024248
GO:0048167
IEA
PLAZA Integrative Orthologyregulation of synaptic plasticity FBgn0024248
GO:0006639
IEA
PLAZA Integrative Orthologyacylglycerol metabolic process FBgn0024248
GO:0003008
IEA
PLAZA Integrative Orthologysystem process FBgn0024248
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus FBgn0024248
GO:0070482
IEA
PLAZA Integrative Orthologyresponse to oxygen levels FBgn0024248
GO:0006638
IEA
PLAZA Integrative Orthologyneutral lipid metabolic process FBgn0024248
GO:0032925
IEA
PLAZA Integrative Orthologyregulation of activin receptor signaling pathway FBgn0024248
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0024248
GO:0032924
IEA
PLAZA Integrative Orthologyactivin receptor signaling pathway FBgn0024248
GO:0051048
IEA
PLAZA Integrative Orthologynegative regulation of secretion ENSG00000169047
GO:0007611
IEA
PLAZA Integrative Orthologylearning or memory FBgn0024248
GO:0007610
IEA
PLAZA Integrative Orthologybehavior FBgn0024248
GO:0090092
IEA
PLAZA Integrative Orthologyregulation of transmembrane receptor protein serine/threonine kinase signaling pathway FBgn0024248
GO:0008306
IEA
PLAZA Integrative Orthologyassociative learning FBgn0024248
GO:0007612
IEA
PLAZA Integrative Orthologylearning FBgn0024248
GO:0036293
IEA
PLAZA Integrative Orthologyresponse to decreased oxygen levels FBgn0024248
GO:0007178
IEA
PLAZA Integrative Orthologytransmembrane receptor protein serine/threonine kinase signaling pathway FBgn0024248
GO:0006641
IEA
PLAZA Integrative Orthologytriglyceride metabolic process FBgn0024248
GO:0007295
IEA
PLAZA Integrative Orthologygrowth of a germarium-derived egg chamber FBgn0024248
GO:0009991
IEA
PLAZA Integrative Orthologyresponse to extracellular stimulus FBgn0024248
GO:0007296
IEA
PLAZA Integrative Orthologyvitellogenesis FBgn0024248
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0024248
GO:0098728
IEA
PLAZA Integrative Orthologygermline stem cell asymmetric division FBgn0024248
GO:0090207
IEA
PLAZA Integrative Orthologyregulation of triglyceride metabolic process FBgn0024248
GO:0055116
IEA
PLAZA Integrative Orthologyentry into reproductive diapause FBgn0024248
GO:0090209
IEA
PLAZA Integrative Orthologynegative regulation of triglyceride metabolic process FBgn0024248
GO:0032535
IEA
PLAZA Integrative Orthologyregulation of cellular component size FBgn0024248
GO:0055115
IEA
PLAZA Integrative Orthologyentry into diapause FBgn0024248
GO:0099537
IEA
PLAZA Integrative Orthologytrans-synaptic signaling FBgn0024248
GO:0099536
IEA
PLAZA Integrative Orthologysynaptic signaling FBgn0024248
GO:0098722
IEA
PLAZA Integrative Orthologyasymmetric stem cell division FBgn0024248
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000169047
GO:0045833
IEA
PLAZA Integrative Orthologynegative regulation of lipid metabolic process FBgn0024248
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress FBgn0024248
GO:0046888
IEA
PLAZA Integrative Orthologynegative regulation of hormone secretion ENSG00000169047
GO:0042048
IEA
PLAZA Integrative Orthologyolfactory behavior FBgn0024248
GO:0009267
IEA
PLAZA Integrative Orthologycellular response to starvation FBgn0024248
GO:0022611
IEA
PLAZA Integrative Orthologydormancy process FBgn0024248
GO:0060250
IEA
PLAZA Integrative Orthologygerm-line stem-cell niche homeostasis FBgn0024248
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0024248
GO:0031330
IEA
PLAZA Integrative Orthologynegative regulation of cellular catabolic process FBgn0024248
GO:0045793
IEA
PLAZA Integrative Orthologypositive regulation of cell size FBgn0024248
GO:0051301
IEA
PLAZA Integrative Orthologycell division FBgn0024248
GO:0040018
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organism growth FBgn0024248
GO:0007635
IEA
PLAZA Integrative Orthologychemosensory behavior FBgn0024248
GO:0009895
IEA
PLAZA Integrative Orthologynegative regulation of catabolic process FBgn0024248
GO:0090278
IEA
PLAZA Integrative Orthologynegative regulation of peptide hormone secretion ENSG00000169047
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development FBgn0024248
GO:0040014
IEA
PLAZA Integrative Orthologyregulation of multicellular organism growth FBgn0024248
GO:0035265
IEA
PLAZA Integrative Orthologyorgan growth FBgn0024248
GO:0035264
IEA
PLAZA Integrative Orthologymulticellular organism growth FBgn0024248
GO:0034059
IEA
PLAZA Integrative Orthologyresponse to anoxia FBgn0024248
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000169047
GO:0048133
IEA
PLAZA Integrative Orthologymale germ-line stem cell asymmetric division FBgn0024248
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0024248
GO:0007028
IEA
PLAZA Integrative Orthologycytoplasm organization FBgn0024248
GO:0040007
IEA
PLAZA Integrative Orthologygrowth FBgn0024248
GO:0046503
IEA
PLAZA Integrative Orthologyglycerolipid catabolic process FBgn0024248
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth FBgn0024248
GO:0046626
IEA
PLAZA Integrative Orthologyregulation of insulin receptor signaling pathway ENSG00000169047
GO:0008355
IEA
PLAZA Integrative Orthologyolfactory learning FBgn0024248
GO:0046620
IEA
PLAZA Integrative Orthologyregulation of organ growth FBgn0024248
GO:0090066
IEA
PLAZA Integrative Orthologyregulation of anatomical structure size FBgn0024248
GO:0008356
IEA
PLAZA Integrative Orthologyasymmetric cell division FBgn0024248
GO:0007268
IEA
PLAZA Integrative Orthologychemical synaptic transmission FBgn0024248
GO:0046622
IEA
PLAZA Integrative Orthologypositive regulation of organ growth FBgn0024248
GO:0048009
IEA
PLAZA Integrative Orthologyinsulin-like growth factor receptor signaling pathway ENSG00000169047
GO:0035152
IEA
PLAZA Integrative Orthologyregulation of tube architecture, open tracheal system FBgn0024248
GO:0035151
IEA
PLAZA Integrative Orthologyregulation of tube size, open tracheal system FBgn0024248
GO:0035150
IEA
PLAZA Integrative Orthologyregulation of tube size FBgn0024248
GO:1903531
IEA
PLAZA Integrative Orthologynegative regulation of secretion by cell ENSG00000169047
GO:0046628
IEA
PLAZA Integrative Orthologypositive regulation of insulin receptor signaling pathway ENSG00000169047
GO:0035159
IEA
PLAZA Integrative Orthologyregulation of tube length, open tracheal system FBgn0024248
GO:0010896
IEA
PLAZA Integrative Orthologyregulation of triglyceride catabolic process FBgn0024248
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging FBgn0024248
GO:0010897
IEA
PLAZA Integrative Orthologynegative regulation of triglyceride catabolic process FBgn0024248
GO:0071496
IEA
PLAZA Integrative Orthologycellular response to external stimulus FBgn0024248
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process FBgn0024248
GO:0046464
IEA
PLAZA Integrative Orthologyacylglycerol catabolic process FBgn0024248
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response FBgn0024248
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process FBgn0024248
GO:0046461
IEA
PLAZA Integrative Orthologyneutral lipid catabolic process FBgn0024248
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis FBgn0024248
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth FBgn0024248
GO:0048639
IEA
PLAZA Integrative Orthologypositive regulation of developmental growth FBgn0024248
GO:0051094
IEA
PLAZA Integrative Orthologypositive regulation of developmental process FBgn0024248
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan FBgn0024248
GO:0014068
IEA
PLAZA Integrative Orthologypositive regulation of phosphatidylinositol 3-kinase signaling FBgn0024248
GO:0045927
IEA
PLAZA Integrative Orthologypositive regulation of growth FBgn0024248

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071889
IEA
Genome Project14-3-3 protein binding
GO:0046934
TAS
Genome Projectphosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046934
TAS
Gene Ontologyphosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0043548
IBA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0016303
TAS
Genome Project1-phosphatidylinositol-3-kinase activity
GO:0016303
TAS
Gene Ontology1-phosphatidylinositol-3-kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5 6 7 8 9
GO:0005158
IBA
Genome Projectinsulin receptor binding
GO:0005088
TAS
Genome ProjectRas guanyl-nucleotide exchange factor activity
GO:0005088
TAS
Gene OntologyRas guanyl-nucleotide exchange factor activity
GO:0030674
IEA
PLAZA Integrative Orthologyprotein binding, bridging ENSG00000169047
GO:0051219
IEA
PLAZA Integrative Orthologyphosphoprotein binding ENSG00000169047
GO:0035591
IEA
PLAZA Integrative Orthologysignaling adaptor activity ENSG00000169047
GO:0005159
IEA
PLAZA Integrative Orthologyinsulin-like growth factor receptor binding ENSG00000169047
GO:0042169
IEA
PLAZA Homology (enrichment)SH2 domain binding HOM02SEM021195
GO:0045309
IEA
PLAZA Integrative Orthologyprotein phosphorylated amino acid binding ENSG00000169047
GO:0060090
IEA
PLAZA Integrative Orthologymolecular adaptor activity ENSG00000169047
GO:0001784
IEA
PLAZA Integrative Orthologyphosphotyrosine residue binding ENSG00000169047
GO:0005070
IEA
PLAZA Integrative OrthologySH3/SH2 adaptor activity ENSG00000169047

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IBA
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0005829
IBA
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane ENSG00000169047
GO:0045121
IEA
PLAZA Integrative Orthologymembrane raft ENSG00000169047
GO:0005938
IEA
PLAZA Integrative Orthologycell cortex FBgn0024248
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000169047
GO:0099568
IEA
PLAZA Integrative Orthologycytoplasmic region FBgn0024248
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part ENSG00000169047
GO:0044853
IEA
PLAZA Integrative Orthologyplasma membrane raft ENSG00000169047
GO:0098589
IEA
PLAZA Integrative Orthologymembrane region ENSG00000169047
GO:0005634
IEA
PLAZA Integrative Orthologynucleus ENSG00000169047
GO:0098590
IEA
PLAZA Integrative Orthologyplasma membrane region ENSG00000169047
GO:0098857
IEA
PLAZA Integrative Orthologymembrane microdomain ENSG00000169047
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle ENSG00000169047
GO:0005901
IEA
PLAZA Integrative Orthologycaveola ENSG00000169047
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000169047
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle ENSG00000169047
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle ENSG00000169047

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001849Pleckstrin homology domain
IPR002404IRS-type PTB domain
IPR011993PH-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K07187IRS2; insulin receptor substrate 2
No chloroplast target sequence found.