Gene: ENSG00000185345 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000185345
Transcript Identifier
ENST00000366898
Gene Type
Coding gene
Location
6 : 161350099-162727668 : negative

Family Information

Homologous gene family
HOM02SEM000183
(147 genes in 24 species)
specific family

Descriptions

gene_descr
parkin RBR E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000355865
HGNC8607
UniprotO60260
UniprotX5DR79
RefSeq_mRNANM_004562.2
EMBLKJ534912

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000378
IGI
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:2000378
IGI
Gene Ontologynegative regulation of reactive oxygen species metabolic process1
GO:2000377
IMP
Genome Projectregulation of reactive oxygen species metabolic process
GO:2000377
IMP
Gene Ontologyregulation of reactive oxygen species metabolic process1
GO:1905477
IMP
IC
Genome Projectpositive regulation of protein localization to membrane
GO:1905477
IMP
IC
Gene Ontologypositive regulation of protein localization to membrane2
GO:1905366
IMP
Genome Projectnegative regulation of intralumenal vesicle formation
GO:1905366
IMP
Gene Ontologynegative regulation of intralumenal vesicle formation2
GO:1905281
NAS
Genome Projectpositive regulation of retrograde transport, endosome to Golgi
GO:1905281
NAS
Gene Ontologypositive regulation of retrograde transport, endosome to Golgi2
GO:1904049
IMP
Genome Projectnegative regulation of spontaneous neurotransmitter secretion
GO:1904049
IMP
Gene Ontologynegative regulation of spontaneous neurotransmitter secretion3
GO:1903861
IEA
Genome Projectpositive regulation of dendrite extension
GO:1903599
IDA
ISS
Genome Projectpositive regulation of autophagy of mitochondrion
GO:1903599
IDA
Gene Ontologypositive regulation of autophagy of mitochondrion4
GO:1903542
IMP
Genome Projectnegative regulation of exosomal secretion
GO:1903542
IMP
Gene Ontologynegative regulation of exosomal secretion2
GO:1903382
IEA
Genome Projectnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378
IEA
Genome Projectpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903377
IDA
Genome Projectnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903377
IDA
Gene Ontologynegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway5
GO:1903351
TAS
Genome Projectcellular response to dopamine
GO:1903351
TAS
Gene Ontologycellular response to dopamine6
GO:1903265
IDA
Genome Projectpositive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903265
IDA
Gene Ontologypositive regulation of tumor necrosis factor-mediated signaling pathway7
GO:1903214
NAS
Genome Projectregulation of protein targeting to mitochondrion
GO:1903214
NAS
Gene Ontologyregulation of protein targeting to mitochondrion8
GO:1903202
TAS, NAS
Genome Projectnegative regulation of oxidative stress-induced cell death
GO:1903202
TAS, NAS
Gene Ontologynegative regulation of oxidative stress-induced cell death9 10
GO:1902803
NAS
Genome Projectregulation of synaptic vesicle transport
GO:1902803
NAS
Gene Ontologyregulation of synaptic vesicle transport11
GO:1902530
IGI
Genome Projectpositive regulation of protein linear polyubiquitination
GO:1902530
IGI
Gene Ontologypositive regulation of protein linear polyubiquitination7
GO:1902283
IMP
Genome Projectnegative regulation of primary amine oxidase activity
GO:1902283
IMP
Gene Ontologynegative regulation of primary amine oxidase activity3
GO:1902254
IMP
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902254
IMP
Gene Ontologynegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator12
GO:1902236
IDA, IMP
Genome Projectnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236
IDA, IMP
Gene Ontologynegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway7 13 14 15 16
GO:1901800
IGI
Genome Projectpositive regulation of proteasomal protein catabolic process
GO:1901800
IGI
Gene Ontologypositive regulation of proteasomal protein catabolic process17
GO:1901215
IGI
Genome Projectnegative regulation of neuron death
GO:1901215
IGI
Gene Ontologynegative regulation of neuron death18
GO:1900407
IDA, IMP
ISS
Genome Projectregulation of cellular response to oxidative stress
GO:1900407
IDA, IMP
ISS
Gene Ontologyregulation of cellular response to oxidative stress3 19
GO:0099074
IDA
Genome Projectmitochondrion to lysosome transport
GO:0099074
IDA
Gene Ontologymitochondrion to lysosome transport19
GO:0098779
IDA, IMP
Genome Projectpositive regulation of mitophagy in response to mitochondrial depolarization
GO:0098779
IDA, IMP
Gene Ontologypositive regulation of mitophagy in response to mitochondrial depolarization20 21 22
GO:0097237
IMP
Genome Projectcellular response to toxic substance
GO:0097237
IMP
Gene Ontologycellular response to toxic substance23
GO:0090201
IDA
Genome Projectnegative regulation of release of cytochrome c from mitochondria
GO:0090201
IDA
Gene Ontologynegative regulation of release of cytochrome c from mitochondria7 24
GO:0090141
ISS
Genome Projectpositive regulation of mitochondrial fission
GO:0090141
ISS
Gene Ontologypositive regulation of mitochondrial fission
GO:0090090
IDA
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090090
IDA
TAS
Gene Ontologynegative regulation of canonical Wnt signaling pathway25 26
GO:0085020
IDA
TAS
Genome Projectprotein K6-linked ubiquitination
GO:0085020
IDA
TAS
Gene Ontologyprotein K6-linked ubiquitination6 27
GO:0071287
TAS
Genome Projectcellular response to manganese ion
GO:0071287
TAS
Gene Ontologycellular response to manganese ion28
GO:0070979
IDA
Genome Projectprotein K11-linked ubiquitination
GO:0070979
IDA
Gene Ontologyprotein K11-linked ubiquitination27
GO:0070936
IDA
Genome Projectprotein K48-linked ubiquitination
GO:0070936
IDA
Gene Ontologyprotein K48-linked ubiquitination17 18
GO:0070842
IMP
Genome Projectaggresome assembly
GO:0070842
IMP
Gene Ontologyaggresome assembly29
GO:0070585
IEA
Genome Projectprotein localization to mitochondrion
GO:0070534
IDA
TAS, NAS
Genome Projectprotein K63-linked ubiquitination
GO:0070534
IDA
TAS, NAS
Gene Ontologyprotein K63-linked ubiquitination5 8 24 27 30 31
GO:0070050
ISS
Genome Projectneuron cellular homeostasis
GO:0070050
ISS
Gene Ontologyneuron cellular homeostasis
GO:0061734
IDA
Genome Projectparkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0061734
IDA
Gene Ontologyparkin-mediated stimulation of mitophagy in response to mitochondrial depolarization32
GO:0060828
TAS
Genome Projectregulation of canonical Wnt signaling pathway
GO:0060828
TAS
Gene Ontologyregulation of canonical Wnt signaling pathway33
GO:0060548
IDA
Genome Projectnegative regulation of cell death
GO:0060548
IDA
Gene Ontologynegative regulation of cell death34
GO:0055069
ISS
Genome Projectzinc ion homeostasis
GO:0055069
ISS
Gene Ontologyzinc ion homeostasis
GO:0051881
IEA
Genome Projectregulation of mitochondrial membrane potential
GO:0051865
IDA
Genome Projectprotein autoubiquitination
GO:0051865
IDA
Gene Ontologyprotein autoubiquitination23 30 35 36
GO:0051583
IEA
Genome Projectdopamine uptake involved in synaptic transmission
GO:0051582
IMP
Genome Projectpositive regulation of neurotransmitter uptake
GO:0051582
IMP
Gene Ontologypositive regulation of neurotransmitter uptake3
GO:0050821
IMP
Genome Projectprotein stabilization
GO:0050821
IMP
Gene Ontologyprotein stabilization37
GO:0046676
IDA
Genome Projectnegative regulation of insulin secretion
GO:0046676
IDA
Gene Ontologynegative regulation of insulin secretion38
GO:0046329
ISS
Genome Projectnegative regulation of JNK cascade
GO:0046329
ISS
Gene Ontologynegative regulation of JNK cascade
GO:0045944
IDA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
Gene Ontologypositive regulation of transcription by RNA polymerase II7
GO:0045732
TAS
Genome Projectpositive regulation of protein catabolic process
GO:0045732
TAS
Gene Ontologypositive regulation of protein catabolic process26
GO:0044828
IDA
Genome Projectnegative regulation by host of viral genome replication
GO:0044828
IDA
Gene Ontologynegative regulation by host of viral genome replication39
GO:0044314
TAS
Genome Projectprotein K27-linked ubiquitination
GO:0044314
TAS
Gene Ontologyprotein K27-linked ubiquitination6 40
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0044267
TAS
Gene Ontologycellular protein metabolic process
GO:0044257
IMP
Genome Projectcellular protein catabolic process
GO:0044257
IMP
Gene Ontologycellular protein catabolic process18
GO:0043524
IDA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043524
IDA
Gene Ontologynegative regulation of neuron apoptotic process12 23 41
GO:0043388
IDA
Genome Projectpositive regulation of DNA binding
GO:0043388
IDA
Gene Ontologypositive regulation of DNA binding5
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043161
IDA
Gene Ontologyproteasome-mediated ubiquitin-dependent protein catabolic process14 18
GO:0043123
IDA, IMP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IDA, IMP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling5 7 24
GO:0042417
TAS
Genome Projectdopamine metabolic process
GO:0042417
TAS
Gene Ontologydopamine metabolic process6
GO:0042415
IEA
Genome Projectnorepinephrine metabolic process
GO:0042053
IMP
Genome Projectregulation of dopamine metabolic process
GO:0042053
IMP
Gene Ontologyregulation of dopamine metabolic process3
GO:0036503
NAS
Genome ProjectERAD pathway
GO:0036503
NAS
Gene OntologyERAD pathway13
GO:0035519
TAS
Genome Projectprotein K29-linked ubiquitination
GO:0035519
TAS
Gene Ontologyprotein K29-linked ubiquitination6
GO:0035249
IEA
Genome Projectsynaptic transmission, glutamatergic
GO:0034976
IMP
Genome Projectresponse to endoplasmic reticulum stress
GO:0034976
IMP
Gene Ontologyresponse to endoplasmic reticulum stress16
GO:0034620
TAS
Genome Projectcellular response to unfolded protein
GO:0034620
TAS
Gene Ontologycellular response to unfolded protein31
GO:0033132
IDA
Genome Projectnegative regulation of glucokinase activity
GO:0033132
IDA
Gene Ontologynegative regulation of glucokinase activity38
GO:0032436
TAS
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
TAS
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process33
GO:0032368
TAS
Genome Projectregulation of lipid transport
GO:0032368
TAS
Gene Ontologyregulation of lipid transport6
GO:0032232
IDA
Genome Projectnegative regulation of actin filament bundle assembly
GO:0032232
IDA
Gene Ontologynegative regulation of actin filament bundle assembly36
GO:0032092
IMP
Genome Projectpositive regulation of protein binding
GO:0032092
IMP
Gene Ontologypositive regulation of protein binding2
GO:0031648
IDA
Genome Projectprotein destabilization
GO:0031648
IDA
Gene Ontologyprotein destabilization25
GO:0031647
IMP
Genome Projectregulation of protein stability
GO:0031647
IMP
Gene Ontologyregulation of protein stability2
GO:0031396
IMP, IGI
Genome Projectregulation of protein ubiquitination
GO:0031396
IMP, IGI
Gene Ontologyregulation of protein ubiquitination21 22
GO:0030433
IEA
Genome Projectubiquitin-dependent ERAD pathway
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016579
TAS
Gene Ontologyprotein deubiquitination
GO:0016567
IDA, IMP
Genome Projectprotein ubiquitination
GO:0016567
IDA, IMP
Gene Ontologyprotein ubiquitination2 5 13 14 23 42
GO:0016236
TAS
Genome Projectmacroautophagy
GO:0016236
TAS
Gene Ontologymacroautophagy
GO:0014059
TAS
Genome Projectregulation of dopamine secretion
GO:0014059
TAS
Gene Ontologyregulation of dopamine secretion11
GO:0010994
IMP
Genome Projectfree ubiquitin chain polymerization
GO:0010994
IMP
Gene Ontologyfree ubiquitin chain polymerization43
GO:0010906
TAS
Genome Projectregulation of glucose metabolic process
GO:0010906
TAS
Gene Ontologyregulation of glucose metabolic process6
GO:0010821
IDA, IGI
NAS
Genome Projectregulation of mitochondrion organization
GO:0010821
IDA, IGI
NAS
Gene Ontologyregulation of mitochondrion organization8 16 44
GO:0010637
ISS
Genome Projectnegative regulation of mitochondrial fusion
GO:0010637
ISS
Gene Ontologynegative regulation of mitochondrial fusion
GO:0010636
IMP
Genome Projectpositive regulation of mitochondrial fusion
GO:0010636
IMP
Gene Ontologypositive regulation of mitochondrial fusion7
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0010629
IMP
Gene Ontologynegative regulation of gene expression3 45
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010628
IMP
Gene Ontologypositive regulation of gene expression45
GO:0010506
IDA
Genome Projectregulation of autophagy
GO:0010506
IDA
Gene Ontologyregulation of autophagy46
GO:0010498
IMP
Genome Projectproteasomal protein catabolic process
GO:0010498
IMP
Gene Ontologyproteasomal protein catabolic process45
GO:0008344
ISS
Genome Projectadult locomotory behavior
GO:0008344
ISS
Gene Ontologyadult locomotory behavior
GO:0007612
IEA
Genome Projectlearning
GO:0007417
TAS
Genome Projectcentral nervous system development
GO:0007417
TAS
Gene Ontologycentral nervous system development47
GO:0007005
ISS
Genome Projectmitochondrion organization
GO:0007005
ISS
Gene Ontologymitochondrion organization
GO:0006979
ISS
Genome Projectresponse to oxidative stress
GO:0006979
ISS
Gene Ontologyresponse to oxidative stress
GO:0006513
IDA, IMP
Genome Projectprotein monoubiquitination
GO:0006513
IDA, IMP
Gene Ontologyprotein monoubiquitination43 46
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0001964
IEA
Genome Projectstartle response
GO:0001933
IDA
Genome Projectnegative regulation of protein phosphorylation
GO:0001933
IDA
Gene Ontologynegative regulation of protein phosphorylation36
GO:0000423
IEA
Genome Projectmitophagy
GO:0000422
IDA, IMP
Genome Projectautophagy of mitochondrion
GO:0000422
IDA, IMP
Gene Ontologyautophagy of mitochondrion27 32 42 48
GO:0000266
ISS
Genome Projectmitochondrial fission
GO:0000266
ISS
Gene Ontologymitochondrial fission
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0000209
IDA
Gene Ontologyprotein polyubiquitination1 15 24 49
GO:0000122
IMP
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
IMP
Gene Ontologynegative regulation of transcription by RNA polymerase II12
GO:0006511
IDA
TAS, NAS, IC
Gene Ontologyubiquitin-dependent protein catabolic process18 23 50 51 52
GO:0048072
IEA
PLAZA Integrative Orthologycompound eye pigmentation FBgn0041100
GO:0048073
IEA
PLAZA Integrative Orthologyregulation of eye pigmentation FBgn0041100
GO:2000425
IEA
PLAZA Integrative Orthologyregulation of apoptotic cell clearance WBGene00003967
GO:0010324
IEA
PLAZA Integrative Orthologymembrane invagination WBGene00003967
GO:2000145
IEA
PLAZA Integrative Orthologyregulation of cell motility WBGene00003967
GO:0048070
IEA
PLAZA Integrative Orthologyregulation of developmental pigmentation FBgn0041100
GO:0006909
IEA
PLAZA Integrative Orthologyphagocytosis WBGene00003967
GO:2000146
IEA
PLAZA Integrative Orthologynegative regulation of cell motility WBGene00003967
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0041100
GO:0048075
IEA
PLAZA Integrative Orthologypositive regulation of eye pigmentation FBgn0041100
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell WBGene00003967
GO:2000426
IEA
PLAZA Integrative Orthologynegative regulation of apoptotic cell clearance WBGene00003967
GO:0048076
IEA
PLAZA Integrative Orthologyregulation of compound eye pigmentation FBgn0041100
GO:0048078
IEA
PLAZA Integrative Orthologypositive regulation of compound eye pigmentation FBgn0041100
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation FBgn0041100
GO:0048870
IEA
PLAZA Integrative Orthologycell motility WBGene00003967
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0041100
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0041100
GO:0007568
IEA
PLAZA Integrative Orthologyaging WBGene00003967
GO:0043652
IEA
PLAZA Integrative Orthologyengulfment of apoptotic cell WBGene00003967
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0041100
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis FBgn0041100
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0041100
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0041100
GO:0060099
IEA
PLAZA Integrative Orthologyregulation of phagocytosis, engulfment WBGene00003967
GO:0016477
IEA
PLAZA Integrative Orthologycell migration WBGene00003967
GO:0048069
IEA
PLAZA Integrative Orthologyeye pigmentation FBgn0041100
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0041100
GO:0048066
IEA
PLAZA Integrative Orthologydevelopmental pigmentation FBgn0041100
GO:0051270
IEA
PLAZA Integrative Orthologyregulation of cellular component movement WBGene00003967
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0041100
GO:0051271
IEA
PLAZA Integrative Orthologynegative regulation of cellular component movement WBGene00003967
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion WBGene00003967
GO:0040012
IEA
PLAZA Integrative Orthologyregulation of locomotion WBGene00003967
GO:0040013
IEA
PLAZA Integrative Orthologynegative regulation of locomotion WBGene00003967
GO:0060101
IEA
PLAZA Integrative Orthologynegative regulation of phagocytosis, engulfment WBGene00003967
GO:0050765
IEA
PLAZA Integrative Orthologynegative regulation of phagocytosis WBGene00003967
GO:0030336
IEA
PLAZA Integrative Orthologynegative regulation of cell migration WBGene00003967
GO:0050764
IEA
PLAZA Integrative Orthologyregulation of phagocytosis WBGene00003967
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0041100
GO:0030334
IEA
PLAZA Integrative Orthologyregulation of cell migration WBGene00003967
GO:0006928
IEA
PLAZA Integrative Orthologymovement of cell or subcellular component WBGene00003967
GO:0030537
IEA
PLAZA Integrative Orthologylarval behavior FBgn0041100
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis WBGene00003967
GO:0043277
IEA
PLAZA Integrative Orthologyapoptotic cell clearance WBGene00003967
GO:0030382
IEA
PLAZA Integrative Orthologysperm mitochondrion organization FBgn0041100
GO:1905153
IEA
PLAZA Integrative Orthologyregulation of membrane invagination WBGene00003967
GO:1901074
IEA
PLAZA Integrative Orthologyregulation of engulfment of apoptotic cell WBGene00003967
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0041100
GO:1905154
IEA
PLAZA Integrative Orthologynegative regulation of membrane invagination WBGene00003967
GO:1901075
IEA
PLAZA Integrative Orthologynegative regulation of engulfment of apoptotic cell WBGene00003967
GO:0030100
IEA
PLAZA Integrative Orthologyregulation of endocytosis WBGene00003967
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging WBGene00003967
GO:0043473
IEA
PLAZA Integrative Orthologypigmentation FBgn0041100
GO:0006911
IEA
PLAZA Integrative Orthologyphagocytosis, engulfment WBGene00003967
GO:0048087
IEA
PLAZA Integrative Orthologypositive regulation of developmental pigmentation FBgn0041100
GO:0099024
IEA
PLAZA Integrative Orthologyplasma membrane invagination WBGene00003967
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0041100
GO:0008345
IEA
PLAZA Integrative Orthologylarval locomotory behavior FBgn0041100
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan WBGene00003967
GO:0045806
IEA
PLAZA Integrative Orthologynegative regulation of endocytosis WBGene00003967
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0041100

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990444
IPI
Genome ProjectF-box domain binding
GO:1990444
IPI
Gene OntologyF-box domain binding23
GO:1990381
IPI
Genome Projectubiquitin-specific protease binding
GO:1990381
IPI
Gene Ontologyubiquitin-specific protease binding53
GO:0097602
IDA
Genome Projectcullin family protein binding
GO:0097602
IDA
Gene Ontologycullin family protein binding23
GO:0061630
IDA
TAS, NAS
Genome Projectubiquitin protein ligase activity
GO:0061630
IDA
TAS, NAS
Gene Ontologyubiquitin protein ligase activity13 14 15 17 18 23 24 27 31 37 49 51 54
GO:0051087
IPI
Genome Projectchaperone binding
GO:0051087
IPI
Gene Ontologychaperone binding34 45 55
GO:0043274
IPI
Genome Projectphospholipase binding
GO:0043274
IPI
Gene Ontologyphospholipase binding45
GO:0043130
IDA
Genome Projectubiquitin binding
GO:0043130
IDA
Gene Ontologyubiquitin binding56
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0042826
IPI
Gene Ontologyhistone deacetylase binding55
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding57
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding7 15 58
GO:0031624
IDA, IPI
Genome Projectubiquitin conjugating enzyme binding
GO:0031624
IDA, IPI
Gene Ontologyubiquitin conjugating enzyme binding13 14 23
GO:0031072
IPI
Genome Projectheat shock protein binding
GO:0031072
IPI
Gene Ontologyheat shock protein binding15
GO:0030544
IPI
Genome ProjectHsp70 protein binding
GO:0030544
IPI
Gene OntologyHsp70 protein binding15 55
GO:0030165
IPI
Genome ProjectPDZ domain binding
GO:0030165
IPI
Gene OntologyPDZ domain binding36
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding59
GO:0019900
IPI
Genome Projectkinase binding
GO:0019900
IPI
Gene Ontologykinase binding24 36 37 38
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding45
GO:0017124
TAS
Genome ProjectSH3 domain binding
GO:0017124
TAS
Gene OntologySH3 domain binding6
GO:0015631
IPI
Genome Projecttubulin binding
GO:0015631
IPI
Gene Ontologytubulin binding55
GO:0008270
TAS
Genome Projectzinc ion binding
GO:0008270
TAS
Gene Ontologyzinc ion binding6
GO:0008013
IDA
Genome Projectbeta-catenin binding
GO:0008013
IDA
Gene Ontologybeta-catenin binding25
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 14 17 18 23 30 34 35 37 39 42 43 45 46 50 51 52 53 55 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76
GO:0004842
IDA
TAS
Genome Projectubiquitin-protein transferase activity
GO:0004842
IDA
TAS
Gene Ontologyubiquitin-protein transferase activity1 18 30 46 48 52 56 60
GO:0003779
IPI
Genome Projectactin binding
GO:0003779
IPI
Gene Ontologyactin binding55
GO:0003700
IC
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IC
Gene OntologyDNA-binding transcription factor activity12
GO:0001664
IPI
Genome ProjectG protein-coupled receptor binding
GO:0001664
IPI
Gene OntologyG protein-coupled receptor binding15
GO:0000976
IDA
Genome Projecttranscription regulatory region sequence-specific DNA binding
GO:0000976
IDA
Gene Ontologytranscription regulatory region sequence-specific DNA binding12

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0099073
IDA
Genome Projectmitochondrion-derived vesicle
GO:0099073
IDA
Gene Ontologymitochondrion-derived vesicle19
GO:0071797
IPI
Genome ProjectLUBAC complex
GO:0071797
IPI
Gene OntologyLUBAC complex7
GO:0005739
IDA, IMP
Genome Projectmitochondrion
GO:0005739
IDA, IMP
Gene Ontologymitochondrion32 37 39 42 46 77
GO:0019005
IDA
Genome ProjectSCF ubiquitin ligase complex
GO:0019005
IDA
Gene OntologySCF ubiquitin ligase complex23
GO:1990452
IPI
Genome ProjectParkin-FBXW7-Cul1 ubiquitin ligase complex
GO:1990452
IPI
Gene OntologyParkin-FBXW7-Cul1 ubiquitin ligase complex23
GO:0098793
IEA
Genome Projectpresynapse
GO:0097413
TAS
Genome ProjectLewy body
GO:0097413
TAS
Gene OntologyLewy body10
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0048471
IDA
Gene Ontologyperinuclear region of cytoplasm52
GO:0043005
IDA
Genome Projectneuron projection
GO:0043005
IDA
Gene Ontologyneuron projection51
GO:0016235
IDA
Genome Projectaggresome
GO:0016235
IDA
Gene Ontologyaggresome29
GO:0005829
IDA, IMP
TAS
Genome Projectcytosol
GO:0005829
IDA, IMP
TAS
Gene Ontologycytosol24 32 37 42 46 55 77
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005794
IDA
Gene OntologyGolgi apparatus52
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum15
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm12 17 18 25 36 39
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus12
GO:0000151
IDA
Genome Projectubiquitin ligase complex
GO:0000151
IDA
Gene Ontologyubiquitin ligase complex5 15 42
GO:0016607
IDA
Gene Ontologynuclear speck
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane WBGene00003967
GO:0016020
IEA
PLAZA Integrative Orthologymembrane WBGene00003967
GO:0031966
IEA
PLAZA Integrative Orthologymitochondrial membrane WBGene00003967
GO:0031968
IEA
PLAZA Integrative Orthologyorganelle outer membrane WBGene00003967
GO:0031967
IEA
PLAZA Integrative Orthologyorganelle envelope WBGene00003967
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane WBGene00003967
GO:0005740
IEA
PLAZA Integrative Orthologymitochondrial envelope WBGene00003967
GO:0005741
IEA
PLAZA Integrative Orthologymitochondrial outer membrane WBGene00003967
GO:0044429
IEA
PLAZA Integrative Orthologymitochondrial part WBGene00003967
GO:0019867
IEA
PLAZA Integrative Orthologyouter membrane WBGene00003967
GO:0031975
IEA
PLAZA Integrative Orthologyenvelope WBGene00003967
GO:0036477
IEA
PLAZA Integrative Orthologysomatodendritic compartment WBGene00003967
GO:0044297
IEA
PLAZA Integrative Orthologycell body WBGene00003967
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle WBGene00003967
GO:0043025
IEA
PLAZA Integrative Orthologyneuronal cell body WBGene00003967

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000626Ubiquitin domain
IPR002867IBR domain
IPR003977E3 ubiquitin-protein ligase parkin
IPR029071Ubiquitin-like domain superfamily
IPR031127E3 ubiquitin ligase RBR family

No MapMan annotations defined for this gene.
KeggID Description
K04556PARK2; parkin
No chloroplast target sequence found.