Gene: ENSG00000185104 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000185104
Transcript Identifier
ENST00000396153
Gene Type
Coding gene
Location
1 : 50441440-50959811 : negative

Family Information

Homologous gene family
HOM02SEM016541
(5 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM013334
(4 genes in 3 species)
specific family

Descriptions

gene_descr
Fas (TNFRSF6) associated factor 1

Identifiers

Type Value
pidENSP00000379457
HGNC3578
UniprotQ9UNN5
RefSeq_mRNANM_007051.2
EMBLAC091610
EMBLAC118557
EMBLAF094700
EMBLAF106798
EMBLAF132938
EMBLAF136173
EMBLAJ271408
EMBLAL049637
EMBLAL133631
EMBLAL359977
EMBLAL603746
EMBLBC004970
EMBLBC067100
EMBLCH471059

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045859
IEA
Genome Projectregulation of protein kinase activity
GO:0043161
NAS
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043161
NAS
Gene Ontologyproteasome-mediated ubiquitin-dependent protein catabolic process1
GO:0043065
NAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
NAS
Gene Ontologypositive regulation of apoptotic process2
GO:0042176
IMP
Genome Projectregulation of protein catabolic process
GO:0042176
IMP
Gene Ontologyregulation of protein catabolic process1
GO:0031334
IMP
Genome Projectpositive regulation of protein complex assembly
GO:0031334
IMP
Gene Ontologypositive regulation of protein complex assembly3
GO:0030155
IEA
Genome Projectregulation of cell adhesion
GO:0010942
IDA
Genome Projectpositive regulation of cell death
GO:0010942
IDA
Gene Ontologypositive regulation of cell death4
GO:0008219
IMP
Genome Projectcell death
GO:0008219
IMP
Gene Ontologycell death1
GO:0007253
IMP
Genome Projectcytoplasmic sequestering of NF-kappaB
GO:0007253
IMP
Gene Ontologycytoplasmic sequestering of NF-kappaB5
GO:0006915
IEA
Genome Projectapoptotic process
GO:1903364
IMP
Gene Ontologypositive regulation of cellular protein catabolic process6
GO:0045740
IMP
Gene Ontologypositive regulation of DNA replication6
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process WBGene00018586
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process FBgn0034068
GO:0002701
IEA
PLAZA Integrative Orthologynegative regulation of production of molecular mediator of immune response FBgn0034068
GO:0002700
IEA
PLAZA Integrative Orthologyregulation of production of molecular mediator of immune response FBgn0034068
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium FBgn0034068
GO:0002787
IEA
PLAZA Integrative Orthologynegative regulation of antibacterial peptide production FBgn0034068
GO:0002786
IEA
PLAZA Integrative Orthologyregulation of antibacterial peptide production FBgn0034068
GO:0002785
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial peptide production FBgn0034068
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation WBGene00018586
GO:0042006
IEA
PLAZA Integrative Orthologymasculinization of hermaphroditic germ-line WBGene00018586
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle WBGene00018586
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00018586
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00018586
GO:0045995
IEA
PLAZA Integrative Orthologyregulation of embryonic development WBGene00018586
GO:0030162
IEA
PLAZA Integrative Orthologyregulation of proteolysis FBgn0034068
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis WBGene00018586
GO:0050829
IEA
PLAZA Integrative Orthologydefense response to Gram-negative bacterium FBgn0034068
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process WBGene00018586
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response FBgn0034068
GO:0034249
IEA
PLAZA Integrative Orthologynegative regulation of cellular amide metabolic process FBgn0034068
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00018586
GO:0050777
IEA
PLAZA Integrative Orthologynegative regulation of immune response FBgn0034068
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process WBGene00018586
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus FBgn0034068
GO:0034248
IEA
PLAZA Integrative Orthologyregulation of cellular amide metabolic process FBgn0034068
GO:0032102
IEA
PLAZA Integrative Orthologynegative regulation of response to external stimulus FBgn0034068
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus FBgn0034068
GO:0002814
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria FBgn0034068
GO:0002813
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria FBgn0034068
GO:0002812
IEA
PLAZA Integrative Orthologybiosynthetic process of antibacterial peptides active against Gram-negative bacteria FBgn0034068
GO:0002778
IEA
PLAZA Integrative Orthologyantibacterial peptide production FBgn0034068
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction FBgn0034068
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0034068
GO:0002777
IEA
PLAZA Integrative Orthologyantimicrobial peptide biosynthetic process FBgn0034068
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction WBGene00018586
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus FBgn0034068
GO:0002775
IEA
PLAZA Integrative Orthologyantimicrobial peptide production FBgn0034068
GO:0002784
IEA
PLAZA Integrative Orthologyregulation of antimicrobial peptide production FBgn0034068
GO:1901566
IEA
PLAZA Integrative Orthologyorganonitrogen compound biosynthetic process FBgn0034068
GO:0002780
IEA
PLAZA Integrative Orthologyantibacterial peptide biosynthetic process FBgn0034068
GO:0045861
IEA
PLAZA Integrative Orthologynegative regulation of proteolysis FBgn0034068
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation WBGene00018586
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development WBGene00018586
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development WBGene00018586
GO:0043603
IEA
PLAZA Integrative Orthologycellular amide metabolic process FBgn0034068
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus FBgn0034068
GO:0043604
IEA
PLAZA Integrative Orthologyamide biosynthetic process FBgn0034068
GO:0060341
IEA
PLAZA Integrative Orthologyregulation of cellular localization WBGene00018586
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction WBGene00018586
GO:0043043
IEA
PLAZA Integrative Orthologypeptide biosynthetic process FBgn0034068
GO:0071168
IEA
PLAZA Integrative Orthologyprotein localization to chromatin WBGene00018586
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization WBGene00018586
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism FBgn0034068
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle WBGene00018586
GO:0042742
IEA
PLAZA Integrative Orthologydefense response to bacterium FBgn0034068
GO:0045977
IEA
PLAZA Integrative Orthologypositive regulation of mitotic cell cycle, embryonic WBGene00018586
GO:1905634
IEA
PLAZA Integrative Orthologyregulation of protein localization to chromatin WBGene00018586
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization WBGene00018586
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process WBGene00018586
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle WBGene00018586
GO:0018992
IEA
PLAZA Integrative Orthologygerm-line sex determination WBGene00018586
GO:0006518
IEA
PLAZA Integrative Orthologypeptide metabolic process FBgn0034068
GO:0002832
IEA
PLAZA Integrative Orthologynegative regulation of response to biotic stimulus FBgn0034068
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus FBgn0034068
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction WBGene00018586
GO:0045448
IEA
PLAZA Integrative Orthologymitotic cell cycle, embryonic WBGene00018586
GO:0002683
IEA
PLAZA Integrative Orthologynegative regulation of immune system process FBgn0034068
GO:0002682
IEA
PLAZA Integrative Orthologyregulation of immune system process FBgn0034068
GO:0002440
IEA
PLAZA Integrative Orthologyproduction of molecular mediator of immune response FBgn0034068
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process FBgn0034068
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process FBgn0034068
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development WBGene00018586
GO:0019730
IEA
PLAZA Integrative Orthologyantimicrobial humoral response FBgn0034068
GO:0019731
IEA
PLAZA Integrative Orthologyantibacterial humoral response FBgn0034068
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication FBgn0034068
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process FBgn0034068
GO:1903827
IEA
PLAZA Integrative Orthologyregulation of cellular protein localization WBGene00018586
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress FBgn0034068
GO:0006952
IEA
PLAZA Integrative Orthologydefense response FBgn0034068
GO:0040021
IEA
PLAZA Integrative Orthologyhermaphrodite germ-line sex determination WBGene00018586
GO:0032269
IEA
PLAZA Integrative Orthologynegative regulation of cellular protein metabolic process FBgn0034068
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process WBGene00018586
GO:0002698
IEA
PLAZA Integrative Orthologynegative regulation of immune effector process FBgn0034068
GO:0002697
IEA
PLAZA Integrative Orthologyregulation of immune effector process FBgn0034068
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle WBGene00018586
GO:0040019
IEA
PLAZA Integrative Orthologypositive regulation of embryonic development WBGene00018586
GO:0045787
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle WBGene00018586
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process FBgn0034068
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism FBgn0034068
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process FBgn0034068
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization WBGene00018586
GO:0031348
IEA
PLAZA Integrative Orthologynegative regulation of defense response FBgn0034068
GO:0002809
IEA
PLAZA Integrative Orthologynegative regulation of antibacterial peptide biosynthetic process FBgn0034068
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response FBgn0034068
GO:0002808
IEA
PLAZA Integrative Orthologyregulation of antibacterial peptide biosynthetic process FBgn0034068
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle WBGene00018586
GO:0002806
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial peptide biosynthetic process FBgn0034068
GO:0002805
IEA
PLAZA Integrative Orthologyregulation of antimicrobial peptide biosynthetic process FBgn0034068
GO:0002921
IEA
PLAZA Integrative Orthologynegative regulation of humoral immune response FBgn0034068
GO:0002920
IEA
PLAZA Integrative Orthologyregulation of humoral immune response FBgn0034068
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling FBgn0034068
GO:0061844
IEA
PLAZA Integrative Orthologyantimicrobial humoral immune response mediated by antimicrobial peptide FBgn0034068
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process FBgn0034068
GO:0045931
IEA
PLAZA Integrative Orthologypositive regulation of mitotic cell cycle WBGene00018586
GO:1900424
IEA
PLAZA Integrative Orthologyregulation of defense response to bacterium FBgn0034068
GO:1900425
IEA
PLAZA Integrative Orthologynegative regulation of defense response to bacterium FBgn0034068
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process FBgn0034068
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process FBgn0034068
GO:0034502
IEA
PLAZA Integrative Orthologyprotein localization to chromosome WBGene00018586
GO:0051248
IEA
PLAZA Integrative Orthologynegative regulation of protein metabolic process FBgn0034068
GO:0061060
IEA
PLAZA Integrative Orthologynegative regulation of peptidoglycan recognition protein signaling pathway FBgn0034068
GO:0006959
IEA
PLAZA Integrative Orthologyhumoral immune response FBgn0034068
GO:0002759
IEA
PLAZA Integrative Orthologyregulation of antimicrobial humoral response FBgn0034068
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process WBGene00018586
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response FBgn0034068
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization WBGene00018586
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process WBGene00018586
GO:0008348
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial humoral response FBgn0034068
GO:0007530
IEA
PLAZA Integrative Orthologysex determination WBGene00018586
GO:0051094
IEA
PLAZA Integrative Orthologypositive regulation of developmental process WBGene00018586
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress FBgn0034068
GO:0009794
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle, embryonic WBGene00018586
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization WBGene00018586
GO:0061058
IEA
PLAZA Integrative Orthologyregulation of peptidoglycan recognition protein signaling pathway FBgn0034068
GO:0061057
IEA
PLAZA Integrative Orthologypeptidoglycan recognition protein signaling pathway FBgn0034068
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process FBgn0034068
GO:0043901
IEA
PLAZA Integrative Orthologynegative regulation of multi-organism process FBgn0034068
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00018586

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051059
IPI
Genome ProjectNF-kappaB binding
GO:0051059
IPI
Gene OntologyNF-kappaB binding5
GO:0043130
IDA
Genome Projectubiquitin binding
GO:0043130
IDA
Gene Ontologyubiquitin binding7
GO:0031625
IDA
Genome Projectubiquitin protein ligase binding
GO:0031625
IDA
Gene Ontologyubiquitin protein ligase binding7
GO:0031072
IDA
Genome Projectheat shock protein binding
GO:0031072
IDA
Gene Ontologyheat shock protein binding4
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0019901
IDA
Genome Projectprotein kinase binding
GO:0019901
IDA
Gene Ontologyprotein kinase binding8
GO:0019887
NAS
Genome Projectprotein kinase regulator activity
GO:0019887
NAS
Gene Ontologyprotein kinase regulator activity8
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3 6
GO:0036435
IEA
PLAZA Integrative OrthologyK48-linked polyubiquitin modification-dependent protein binding WBGene00018586
GO:0140030
IEA
PLAZA Integrative Orthologymodification-dependent protein binding WBGene00018586
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding WBGene00018586
GO:0031593
IEA
PLAZA Integrative Orthologypolyubiquitin modification-dependent protein binding WBGene00018586

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0048471
IDA
Gene Ontologyperinuclear region of cytoplasm8
GO:0034098
IDA
Genome ProjectVCP-NPL4-UFD1 AAA ATPase complex
GO:0034098
IDA
Gene OntologyVCP-NPL4-UFD1 AAA ATPase complex7
GO:0031265
NAS
Genome ProjectCD95 death-inducing signaling complex
GO:0031265
NAS
Gene OntologyCD95 death-inducing signaling complex9
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol4
GO:0005635
IEA
Genome Projectnuclear envelope
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4 6
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part WBGene00018586
GO:0000785
IEA
PLAZA Integrative Orthologychromatin WBGene00018586
GO:0005694
IEA
PLAZA Integrative Orthologychromosome WBGene00018586
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle WBGene00018586
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle WBGene00018586

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001012UBX domain
IPR006577UAS
IPR012336Thioredoxin-like fold
IPR029071Ubiquitin-like domain superfamily
IPR033043FAS-associated factor 1, UBX domain

No MapMan annotations defined for this gene.
No Kegg annotations defined for this gene.
No chloroplast target sequence found.