Gene: ENSG00000184254 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000184254
Transcript Identifier
ENST00000329841
Gene Type
Coding gene
Location
15 : 100879908-100914773 : positive

Family Information

Homologous gene family
HOM02SEM000059
(314 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000134
(162 genes in 26 species)
specific family

Descriptions

gene_descr
aldehyde dehydrogenase 1 family, member A3

Identifiers

Type Value
pidENSP00000332256
HGNC409
UniprotP47895
UniprotA0A024RC95
RefSeq_mRNANM_000693.3
EMBLCHEMBL3579
EMBLBC069274
EMBLCH471101
EMBLU07919

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070384
IEA
Genome ProjectHarderian gland development
GO:0060324
IEA
Genome Projectface development
GO:0060166
IEA
Genome Projectolfactory pit development
GO:0060013
IEA
Genome Projectrighting reflex
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0051289
IDA
Genome Projectprotein homotetramerization
GO:0051289
IDA
Gene Ontologyprotein homotetramerization1
GO:0050885
IEA
Genome Projectneuromuscular process controlling balance
GO:0048048
ISS
Genome Projectembryonic eye morphogenesis
GO:0048048
ISS
Gene Ontologyembryonic eye morphogenesis
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0042574
IDA
Genome Projectretinal metabolic process
GO:0042574
IDA
Gene Ontologyretinal metabolic process2
GO:0042573
IDA
Genome Projectretinoic acid metabolic process
GO:0042573
IDA
Gene Ontologyretinoic acid metabolic process2
GO:0042572
IEA
Genome Projectretinol metabolic process
GO:0042472
IEA
Genome Projectinner ear morphogenesis
GO:0031076
ISS
Genome Projectembryonic camera-type eye development
GO:0031076
ISS
Gene Ontologyembryonic camera-type eye development
GO:0021768
IEA
Genome Projectnucleus accumbens development
GO:0007626
IEA
Genome Projectlocomotory behavior
GO:0002138
IDA
Genome Projectretinoic acid biosynthetic process
GO:0002138
IDA
Gene Ontologyretinoic acid biosynthetic process1
GO:0002072
IEA
Genome Projectoptic cup morphogenesis involved in camera-type eye development
GO:0019413
IEA
PLAZA Integrative Orthologyacetate biosynthetic process YOR374W
GO:0044550
IEA
PLAZA Integrative Orthologysecondary metabolite biosynthetic process AT3G24503
GO:0006753
IEA
PLAZA Integrative Orthologynucleoside phosphate metabolic process YOR374W
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000128918
GO:0042402
IEA
PLAZA Integrative Orthologycellular biogenic amine catabolic process YMR169C
GO:0006598
IEA
PLAZA Integrative Orthologypolyamine catabolic process YMR169C
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle SPCC550.10
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction SPCC550.10
GO:0006595
IEA
PLAZA Integrative Orthologypolyamine metabolic process YMR169C
GO:1901698
IEA
PLAZA Integrative Orthologyresponse to nitrogen compound SPCC550.10
GO:0008652
IEA
PLAZA Integrative Orthologycellular amino acid biosynthetic process YMR169C
GO:0046686
IEA
PLAZA Integrative Orthologyresponse to cadmium ion AT3G48000
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process YMR169C
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process SPCC550.10
GO:0035295
IEA
PLAZA Integrative Orthologytube development ENSG00000128918
GO:0010035
IEA
PLAZA Integrative Orthologyresponse to inorganic substance AT3G48000
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process YMR169C
GO:1990748
IEA
PLAZA Integrative Orthologycellular detoxification SPCC550.10
GO:0010038
IEA
PLAZA Integrative Orthologyresponse to metal ion AT3G48000
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress SPCC550.10
GO:0017000
IEA
PLAZA Integrative Orthologyantibiotic biosynthetic process YOR374W
GO:0051186
IEA
PLAZA Integrative Orthologycofactor metabolic process YOR374W
GO:0006739
IEA
PLAZA Integrative OrthologyNADP metabolic process YOR374W
GO:0098754
IEA
PLAZA Integrative Orthologydetoxification SPCC550.10
GO:0006067
IEA
PLAZA Integrative Orthologyethanol metabolic process YOR374W
GO:1901566
IEA
PLAZA Integrative Orthologyorganonitrogen compound biosynthetic process YMR169C
GO:0006069
IEA
PLAZA Integrative Orthologyethanol oxidation ENSG00000165092
GO:0006740
IEA
PLAZA Integrative OrthologyNADPH regeneration YOR374W
GO:1901564
IEA
PLAZA Integrative Orthologyorganonitrogen compound metabolic process YMR169C
GO:0009698
IEA
PLAZA Integrative Orthologyphenylpropanoid metabolic process AT3G24503
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process YMR169C
GO:0009699
IEA
PLAZA Integrative Orthologyphenylpropanoid biosynthetic process AT3G24503
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process YMR169C
GO:0034097
IEA
PLAZA Integrative Orthologyresponse to cytokine ENSG00000128918
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process AT3G24503
GO:0006090
IEA
PLAZA Integrative Orthologypyruvate metabolic process YOR374W
GO:0006807
IEA
PLAZA Integrative Orthologynitrogen compound metabolic process YMR169C
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process YOR374W
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical SPCC550.10
GO:0006091
IEA
PLAZA Integrative Orthologygeneration of precursor metabolites and energy ENSG00000165092
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus SPCC550.10
GO:0017144
IEA
PLAZA Integrative Orthologydrug metabolic process YOR374W
GO:0019682
IEA
PLAZA Integrative Orthologyglyceraldehyde-3-phosphate metabolic process ENSG00000165092
GO:0001505
IEA
PLAZA Integrative Orthologyregulation of neurotransmitter levels YMR169C
GO:0019320
IEA
PLAZA Integrative Orthologyhexose catabolic process ENSG00000165092
GO:0016052
IEA
PLAZA Integrative Orthologycarbohydrate catabolic process ENSG00000165092
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus YPL061W
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle SPCC550.10
GO:0009117
IEA
PLAZA Integrative Orthologynucleotide metabolic process YOR374W
GO:0009636
IEA
PLAZA Integrative Orthologyresponse to toxic substance SPCC550.10
GO:0006001
IEA
PLAZA Integrative Orthologyfructose catabolic process ENSG00000165092
GO:0006000
IEA
PLAZA Integrative Orthologyfructose metabolic process ENSG00000165092
GO:0006520
IEA
PLAZA Integrative Orthologycellular amino acid metabolic process YMR169C
GO:0019318
IEA
PLAZA Integrative Orthologyhexose metabolic process ENSG00000165092
GO:0006083
IEA
PLAZA Integrative Orthologyacetate metabolic process YOR374W
GO:0021915
IEA
PLAZA Integrative Orthologyneural tube development ENSG00000128918
GO:0070458
IEA
PLAZA Integrative Orthologycellular detoxification of nitrogen compound SPCC550.10
GO:0051716
IEA
PLAZA Integrative Orthologycellular response to stimulus SPCC550.10
GO:0046496
IEA
PLAZA Integrative Orthologynicotinamide nucleotide metabolic process YOR374W
GO:0097237
IEA
PLAZA Integrative Orthologycellular response to toxic substance SPCC550.10
GO:0005975
IEA
PLAZA Integrative Orthologycarbohydrate metabolic process ENSG00000165092
GO:0061624
IEA
PLAZA Integrative Orthologyfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate ENSG00000165092
GO:0006796
IEA
PLAZA Integrative Orthologyphosphate-containing compound metabolic process YOR374W
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress SPCC550.10
GO:0044106
IEA
PLAZA Integrative Orthologycellular amine metabolic process YMR169C
GO:0006793
IEA
PLAZA Integrative Orthologyphosphorus metabolic process YOR374W
GO:1901135
IEA
PLAZA Integrative Orthologycarbohydrate derivative metabolic process ENSG00000165092
GO:0055086
IEA
PLAZA Integrative Orthologynucleobase-containing small molecule metabolic process YOR374W
GO:0072524
IEA
PLAZA Integrative Orthologypyridine-containing compound metabolic process YOR374W
GO:0046365
IEA
PLAZA Integrative Orthologymonosaccharide catabolic process ENSG00000165092
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process YOR374W
GO:0008285
IEA
PLAZA Integrative Orthologynegative regulation of cell proliferation ENSG00000128918
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process AT3G24503
GO:0009651
IEA
PLAZA Integrative Orthologyresponse to salt stress YPL061W
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process AT3G24503
GO:0043009
IEA
PLAZA Integrative Orthologychordate embryonic development ENSG00000128918
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation ENSG00000128918
GO:0051410
IEA
PLAZA Integrative Orthologydetoxification of nitrogen compound SPCC550.10
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process AT3G24503
GO:0006576
IEA
PLAZA Integrative Orthologycellular biogenic amine metabolic process YMR169C
GO:0006733
IEA
PLAZA Integrative Orthologyoxidoreduction coenzyme metabolic process YOR374W
GO:0006732
IEA
PLAZA Integrative Orthologycoenzyme metabolic process YOR374W
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process ENSG00000128918
GO:0006970
IEA
PLAZA Integrative Orthologyresponse to osmotic stress YPL061W
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance ENSG00000128918
GO:0016999
IEA
PLAZA Integrative Orthologyantibiotic metabolic process YOR374W
GO:0019748
IEA
PLAZA Integrative Orthologysecondary metabolic process AT3G24503
GO:0019482
IEA
PLAZA Integrative Orthologybeta-alanine metabolic process YMR169C
GO:0019362
IEA
PLAZA Integrative Orthologypyridine nucleotide metabolic process YOR374W
GO:0019483
IEA
PLAZA Integrative Orthologybeta-alanine biosynthetic process YMR169C
GO:0044282
IEA
PLAZA Integrative Orthologysmall molecule catabolic process ENSG00000165092
GO:0009308
IEA
PLAZA Integrative Orthologyamine metabolic process YMR169C
GO:0005996
IEA
PLAZA Integrative Orthologymonosaccharide metabolic process ENSG00000165092
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process ENSG00000128918
GO:0042136
IEA
PLAZA Integrative Orthologyneurotransmitter biosynthetic process YMR169C
GO:0042133
IEA
PLAZA Integrative Orthologyneurotransmitter metabolic process YMR169C
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching ENSG00000128918
GO:0009310
IEA
PLAZA Integrative Orthologyamine catabolic process YMR169C
GO:0019637
IEA
PLAZA Integrative Orthologyorganophosphate metabolic process YOR374W

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070403
IEA
Genome ProjectNAD+ binding
GO:0070324
IEA
Genome Projectthyroid hormone binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042803
IDA
Gene Ontologyprotein homodimerization activity2
GO:0004030
IDA
Genome Projectaldehyde dehydrogenase [NAD(P)+] activity
GO:0004030
IDA
Gene Ontologyaldehyde dehydrogenase [NAD(P)+] activity2
GO:0004029
IBA
Genome Projectaldehyde dehydrogenase (NAD) activity
GO:0001758
IDA
TAS
Genome Projectretinal dehydrogenase activity
GO:0001758
IDA
TAS
Gene Ontologyretinal dehydrogenase activity1
GO:0050269
IEA
PLAZA Integrative Orthologyconiferyl-aldehyde dehydrogenase activity AT3G24503
GO:0030554
IEA
PLAZA Integrative Orthologyadenyl nucleotide binding AT3G48000
GO:0017076
IEA
PLAZA Integrative Orthologypurine nucleotide binding AT3G48000
GO:0005524
IEA
PLAZA Integrative OrthologyATP binding AT3G48000
GO:0008886
IEA
PLAZA Integrative Orthologyglyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity AT2G24270
GO:0060589
IEA
PLAZA Integrative Orthologynucleoside-triphosphatase regulator activity ENSG00000165092
GO:0005497
IEA
PLAZA Integrative Orthologyandrogen binding ENSG00000165092
GO:0005096
IEA
PLAZA Integrative OrthologyGTPase activator activity ENSG00000165092
GO:0030695
IEA
PLAZA Integrative OrthologyGTPase regulator activity ENSG00000165092
GO:0035639
IEA
PLAZA Integrative Orthologypurine ribonucleoside triphosphate binding AT3G48000
GO:0098772
IEA
PLAZA Integrative Orthologymolecular function regulator ENSG00000165092
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding AT3G48000
GO:0030234
IEA
PLAZA Integrative Orthologyenzyme regulator activity ENSG00000165092
GO:0008047
IEA
PLAZA Integrative Orthologyenzyme activator activity ENSG00000165092
GO:0032555
IEA
PLAZA Integrative Orthologypurine ribonucleotide binding AT3G48000
GO:0032553
IEA
PLAZA Integrative Orthologyribonucleotide binding AT3G48000
GO:0032559
IEA
PLAZA Integrative Orthologyadenyl ribonucleotide binding AT3G48000
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding AT3G48000

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome3
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm2
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system SPAC9E9.09c
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen YOR374W
GO:0042645
IEA
PLAZA Integrative Orthologymitochondrial nucleoid YOR374W
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part YOR374W
GO:0044429
IEA
PLAZA Integrative Orthologymitochondrial part YOR374W
GO:0009295
IEA
PLAZA Integrative Orthologynucleoid YOR374W
GO:0009507
IEA
PLAZA Integrative Orthologychloroplast AT3G48000
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus SPAC9E9.09c
GO:0005739
IEA
PLAZA Integrative Orthologymitochondrion AT3G48000
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen YOR374W
GO:0009536
IEA
PLAZA Integrative Orthologyplastid AT3G48000
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part YOR374W
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle YOR374W
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen YOR374W
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle YOR374W

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR015590Aldehyde dehydrogenase domain
IPR016160Aldehyde dehydrogenase, cysteine active site
IPR016161Aldehyde/histidinol dehydrogenase
IPR016162Aldehyde dehydrogenase, N-terminal
IPR029510Aldehyde dehydrogenase, glutamic acid active site

No MapMan annotations defined for this gene.
KeggID Description
K00129E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
No chloroplast target sequence found.