Gene: ENSG00000183087 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000183087
Transcript Identifier
ENST00000327773
Gene Type
Coding gene
Location
13 : 113820864-113863920 : negative

Family Information

Homologous gene family
HOM02SEM008630
(10 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
growth arrest-specific 6

Identifiers

Type Value
pidENSP00000331831
HGNC4168
UniprotQ14393
RefSeq_mRNANM_000820.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000669
IDA
Genome Projectnegative regulation of dendritic cell apoptotic process
GO:2000669
IDA
Gene Ontologynegative regulation of dendritic cell apoptotic process1
GO:2000533
ISS
Genome Projectnegative regulation of renal albumin absorption
GO:2000533
ISS
Gene Ontologynegative regulation of renal albumin absorption
GO:2000510
IDA
Genome Projectpositive regulation of dendritic cell chemotaxis
GO:2000510
IDA
Gene Ontologypositive regulation of dendritic cell chemotaxis1
GO:2000352
IDA
Genome Projectnegative regulation of endothelial cell apoptotic process
GO:2000352
IDA
Gene Ontologynegative regulation of endothelial cell apoptotic process2 3 4
GO:2000273
IEA
Genome Projectpositive regulation of signaling receptor activity
GO:2000270
IDA
Genome Projectnegative regulation of fibroblast apoptotic process
GO:2000270
IDA
Gene Ontologynegative regulation of fibroblast apoptotic process2
GO:1900165
IDA
Genome Projectnegative regulation of interleukin-6 secretion
GO:1900165
IDA
Gene Ontologynegative regulation of interleukin-6 secretion5
GO:1900142
IDA
Genome Projectnegative regulation of oligodendrocyte apoptotic process
GO:1900142
IDA
Gene Ontologynegative regulation of oligodendrocyte apoptotic process6
GO:0097241
IDA
Genome Projecthematopoietic stem cell migration to bone marrow
GO:0097241
IDA
Gene Ontologyhematopoietic stem cell migration to bone marrow7
GO:0097028
IEP
Genome Projectdendritic cell differentiation
GO:0097028
IEP
Gene Ontologydendritic cell differentiation1
GO:0085029
ISS
Genome Projectextracellular matrix assembly
GO:0085029
ISS
Gene Ontologyextracellular matrix assembly
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071333
ISS
Genome Projectcellular response to glucose stimulus
GO:0071333
ISS
Gene Ontologycellular response to glucose stimulus
GO:0071307
IDA
Genome Projectcellular response to vitamin K
GO:0071307
IDA
Gene Ontologycellular response to vitamin K2
GO:0070588
IDA
Genome Projectcalcium ion transmembrane transport
GO:0070588
IDA
Gene Ontologycalcium ion transmembrane transport8
GO:0070527
TAS
Genome Projectplatelet aggregation
GO:0070527
TAS
Gene Ontologyplatelet aggregation9
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070374
IDA
Gene Ontologypositive regulation of ERK1 and ERK2 cascade10
GO:0070168
IDA
Genome Projectnegative regulation of biomineral tissue development
GO:0070168
IDA
Gene Ontologynegative regulation of biomineral tissue development11
GO:0061098
IDA
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0061098
IDA
Gene Ontologypositive regulation of protein tyrosine kinase activity5
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051897
IDA
Gene Ontologypositive regulation of protein kinase B signaling2 3 6
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050900
TAS
Gene Ontologyleukocyte migration
GO:0050766
IDA
Genome Projectpositive regulation of phagocytosis
GO:0050766
IDA
Gene Ontologypositive regulation of phagocytosis8
GO:0050711
IDA
Genome Projectnegative regulation of interleukin-1 secretion
GO:0050711
IDA
Gene Ontologynegative regulation of interleukin-1 secretion5
GO:0048146
IDA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048146
IDA
Gene Ontologypositive regulation of fibroblast proliferation10 12
GO:0046827
IDA
Genome Projectpositive regulation of protein export from nucleus
GO:0046827
IDA
Gene Ontologypositive regulation of protein export from nucleus3
GO:0046813
IDA
Genome Projectreceptor-mediated virion attachment to host cell
GO:0046813
IDA
Gene Ontologyreceptor-mediated virion attachment to host cell13
GO:0046718
IDA
Genome Projectviral entry into host cell
GO:0046718
IDA
Gene Ontologyviral entry into host cell13
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA
Gene Ontologynegative regulation of transcription, DNA-templated3
GO:0045860
IDA
Genome Projectpositive regulation of protein kinase activity
GO:0045860
IDA
Gene Ontologypositive regulation of protein kinase activity12
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0044267
TAS
Gene Ontologycellular protein metabolic process
GO:0043687
TAS
Genome Projectpost-translational protein modification
GO:0043687
TAS
Gene Ontologypost-translational protein modification
GO:0043491
IDA
Genome Projectprotein kinase B signaling
GO:0043491
IDA
Gene Ontologyprotein kinase B signaling5 6
GO:0043433
IDA
Genome Projectnegative regulation of DNA-binding transcription factor activity
GO:0043433
IDA
Gene Ontologynegative regulation of DNA-binding transcription factor activity3
GO:0043277
IDA
Genome Projectapoptotic cell clearance
GO:0043277
IDA
Gene Ontologyapoptotic cell clearance13
GO:0043154
IDA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043154
IDA
Gene Ontologynegative regulation of cysteine-type endopeptidase activity involved in apoptotic process6
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043066
IDA
Gene Ontologynegative regulation of apoptotic process7
GO:0040008
IEA
Genome Projectregulation of growth
GO:0035754
IDA
Genome ProjectB cell chemotaxis
GO:0035754
IDA
Gene OntologyB cell chemotaxis7
GO:0035690
IDA
Genome Projectcellular response to drug
GO:0035690
IDA
Gene Ontologycellular response to drug2
GO:0035457
IDA
Genome Projectcellular response to interferon-alpha
GO:0035457
IDA
Gene Ontologycellular response to interferon-alpha1
GO:0034765
IEA
Genome Projectregulation of ion transmembrane transport
GO:0033159
IDA
Genome Projectnegative regulation of protein import into nucleus, translocation
GO:0033159
IDA
Gene Ontologynegative regulation of protein import into nucleus, translocation5
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033138
IDA
Gene Ontologypositive regulation of peptidyl-serine phosphorylation6
GO:0032825
IDA
Genome Projectpositive regulation of natural killer cell differentiation
GO:0032825
IDA
Gene Ontologypositive regulation of natural killer cell differentiation14
GO:0032720
IDA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032720
IDA
Gene Ontologynegative regulation of tumor necrosis factor production1 5
GO:0032715
IDA
Genome Projectnegative regulation of interleukin-6 production
GO:0032715
IDA
Gene Ontologynegative regulation of interleukin-6 production1
GO:0032689
IDA
Genome Projectnegative regulation of interferon-gamma production
GO:0032689
IDA
Gene Ontologynegative regulation of interferon-gamma production14
GO:0032148
ISS
Genome Projectactivation of protein kinase B activity
GO:0032148
ISS
Gene Ontologyactivation of protein kinase B activity
GO:0032008
ISS
Genome Projectpositive regulation of TOR signaling
GO:0032008
ISS
Gene Ontologypositive regulation of TOR signaling
GO:0031589
IEA
Genome Projectcell-substrate adhesion
GO:0031100
IEA
Genome Projectanimal organ regeneration
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030168
TAS
Gene Ontologyplatelet activation9
GO:0019079
IDA
Genome Projectviral genome replication
GO:0019079
IDA
Gene Ontologyviral genome replication13
GO:0019064
IDA
Genome Projectfusion of virus membrane with host plasma membrane
GO:0019064
IDA
Gene Ontologyfusion of virus membrane with host plasma membrane13
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018105
IDA
Gene Ontologypeptidyl-serine phosphorylation3 5
GO:0016477
TAS
Genome Projectcell migration
GO:0016477
TAS
Gene Ontologycell migration9
GO:0010934
IEA
Genome Projectmacrophage cytokine production
GO:0010804
IDA
Genome Projectnegative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010804
IDA
Gene Ontologynegative regulation of tumor necrosis factor-mediated signaling pathway1
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0010628
IDA
Gene Ontologypositive regulation of gene expression1
GO:0009267
IEA
Genome Projectcellular response to starvation
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008283
TAS
Gene Ontologycell proliferation9
GO:0007167
IEA
Genome Projectenzyme linked receptor protein signaling pathway
GO:0007165
IDA
TAS
Genome Projectsignal transduction
GO:0007165
IDA
TAS
Gene Ontologysignal transduction3 9 12
GO:0007155
TAS
Genome Projectcell adhesion
GO:0007155
TAS
Gene Ontologycell adhesion9
GO:0007050
TAS
Genome Projectcell cycle arrest
GO:0007050
TAS
Gene Ontologycell cycle arrest9
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006909
IDA
Genome Projectphagocytosis
GO:0006909
IDA
Gene Ontologyphagocytosis13
GO:0006888
TAS
Genome ProjectER to Golgi vesicle-mediated transport
GO:0006888
TAS
Gene OntologyER to Golgi vesicle-mediated transport
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0006468
IDA
Gene Ontologyprotein phosphorylation2
GO:0006465
TAS
Genome Projectsignal peptide processing
GO:0003104
ISS
Genome Projectpositive regulation of glomerular filtration
GO:0003104
ISS
Gene Ontologypositive regulation of glomerular filtration
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0002576
TAS
Gene Ontologyplatelet degranulation
GO:0001961
IMP
Genome Projectpositive regulation of cytokine-mediated signaling pathway
GO:0001961
IMP
Gene Ontologypositive regulation of cytokine-mediated signaling pathway14
GO:0001934
IDA
ISS
Genome Projectpositive regulation of protein phosphorylation
GO:0001934
IDA
ISS
Gene Ontologypositive regulation of protein phosphorylation5 6 12
GO:0001764
IEA
Genome Projectneuron migration
GO:0072659
IDA
Gene Ontologyprotein localization to plasma membrane2
GO:0018200
IEA
PLAZA Integrative Orthologypeptidyl-glutamic acid modification ENSG00000126231
GO:0002920
IEA
PLAZA Integrative Orthologyregulation of humoral immune response ENSG00000184500
GO:0002253
IEA
PLAZA Integrative Orthologyactivation of immune response ENSG00000184500
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process ENSG00000184500
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response ENSG00000184500
GO:0050778
IEA
PLAZA Integrative Orthologypositive regulation of immune response ENSG00000184500
GO:0018214
IEA
PLAZA Integrative Orthologyprotein carboxylation ENSG00000126231
GO:0017187
IEA
PLAZA Integrative Orthologypeptidyl-glutamic acid carboxylation ENSG00000126231
GO:0006959
IEA
PLAZA Integrative Orthologyhumoral immune response ENSG00000184500
GO:0030449
IEA
PLAZA Integrative Orthologyregulation of complement activation ENSG00000184500
GO:0002697
IEA
PLAZA Integrative Orthologyregulation of immune effector process ENSG00000184500
GO:0006956
IEA
PLAZA Integrative Orthologycomplement activation ENSG00000184500

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0060090
IDA
Genome Projectmolecular adaptor activity
GO:0060090
IDA
Gene Ontologymolecular adaptor activity13
GO:0048018
IDA
Genome Projectreceptor ligand activity
GO:0048018
IDA
Gene Ontologyreceptor ligand activity10
GO:0043027
IDA
Genome Projectcysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043027
IDA
Gene Ontologycysteine-type endopeptidase inhibitor activity involved in apoptotic process6
GO:0030971
IPI
Genome Projectreceptor tyrosine kinase binding
GO:0030971
IPI
Gene Ontologyreceptor tyrosine kinase binding15
GO:0030296
IDA
Genome Projectprotein tyrosine kinase activator activity
GO:0030296
IDA
Gene Ontologyprotein tyrosine kinase activator activity5
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 5 16 17
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005245
IDA
Genome Projectvoltage-gated calcium channel activity
GO:0005245
IDA
Gene Ontologyvoltage-gated calcium channel activity8
GO:0005102
IDA, IPI
Genome Projectsignaling receptor binding
GO:0005102
IDA, IPI
Gene Ontologysignaling receptor binding2 12
GO:0001786
IDA
Genome Projectphosphatidylserine binding
GO:0001786
IDA
Gene Ontologyphosphatidylserine binding13

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome18
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0031093
TAS
Gene Ontologyplatelet alpha granule lumen
GO:0005796
TAS
Genome ProjectGolgi lumen
GO:0005796
TAS
Gene OntologyGolgi lumen
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005788
TAS
Gene Ontologyendoplasmic reticulum lumen
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm8
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space7 8 17 19
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery ENSG00000184500
GO:0031984
IEA
PLAZA Integrative Orthologyorganelle subcompartment ENSG00000184500
GO:0098827
IEA
PLAZA Integrative Orthologyendoplasmic reticulum subcompartment ENSG00000184500
GO:0016020
IEA
PLAZA Integrative Orthologymembrane ENSG00000184500
GO:0042175
IEA
PLAZA Integrative Orthologynuclear outer membrane-endoplasmic reticulum membrane network ENSG00000184500
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle ENSG00000184500
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane ENSG00000184500
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000184500
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000184500
GO:0098791
IEA
PLAZA Integrative OrthologyGolgi subcompartment ENSG00000184500
GO:0072562
IEA
PLAZA Integrative Orthologyblood microparticle ENSG00000184500
GO:0005789
IEA
PLAZA Integrative Orthologyendoplasmic reticulum membrane ENSG00000184500
GO:0000139
IEA
PLAZA Integrative OrthologyGolgi membrane ENSG00000184500

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000152EGF-type aspartate/asparagine hydroxylation site
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742EGF-like domain
IPR001791Laminin G domain
IPR001881EGF-like calcium-binding domain
IPR009030Growth factor receptor cysteine-rich domain superfamily
IPR013032EGF-like, conserved site
IPR013320Concanavalin A-like lectin/glucanase domain superfamily
IPR017857Coagulation factor-like, Gla domain superfamily
IPR018097EGF-like calcium-binding, conserved site
IPR026823Complement Clr-like EGF domain

No MapMan annotations defined for this gene.
KeggID Description
K05464GAS6; growth arrest-specific 6
No chloroplast target sequence found.