Gene: ENSG00000182446 (Homo sapiens)

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Gene Identifier
ENSG00000182446
Transcript Identifier
ENST00000374747
Gene Type
Coding gene
Location
17 : 81565320-81636930 : negative

Family Information

Homologous gene family
HOM02SEM014204
(6 genes in 5 species)
specific family

Descriptions

gene_descr
nuclear protein localization 4 homolog (S. cerevisiae)

Identifiers

Type Value
pidENSP00000363879
HGNC18261
UniprotQ8TAT6

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0039536
IMP
Genome Projectnegative regulation of RIG-I signaling pathway
GO:0039536
IMP
Gene Ontologynegative regulation of RIG-I signaling pathway1
GO:0032480
IMP
Genome Projectnegative regulation of type I interferon production
GO:0032480
IMP
Gene Ontologynegative regulation of type I interferon production1
GO:0030970
IMP
Genome Projectretrograde protein transport, ER to cytosol
GO:0030970
IMP
Gene Ontologyretrograde protein transport, ER to cytosol2
GO:0030433
ISS
Genome Projectubiquitin-dependent ERAD pathway
GO:0030433
ISS
Gene Ontologyubiquitin-dependent ERAD pathway3
GO:0007030
ISS
Genome ProjectGolgi organization
GO:0007030
ISS
Gene OntologyGolgi organization3
GO:0006511
IMP
IBA
Genome Projectubiquitin-dependent protein catabolic process
GO:0006511
IMP
Gene Ontologyubiquitin-dependent protein catabolic process1
GO:0035967
IEA
PLAZA Integrative Orthologycellular response to topologically incorrect protein YBR170C
GO:0035966
IEA
PLAZA Integrative Orthologyresponse to topologically incorrect protein YBR170C
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0039348
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process YBR170C
GO:0051230
IEA
PLAZA Integrative Orthologyspindle disassembly YBR170C
GO:0070651
IEA
PLAZA Integrative Orthologynonfunctional rRNA decay YBR170C
GO:1990116
IEA
PLAZA Integrative Orthologyribosome-associated ubiquitin-dependent protein catabolic process YBR170C
GO:0044270
IEA
PLAZA Integrative Orthologycellular nitrogen compound catabolic process YBR170C
GO:0072671
IEA
PLAZA Integrative Orthologymitochondria-associated ubiquitin-dependent protein catabolic process YBR170C
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0039348
GO:0022411
IEA
PLAZA Integrative Orthologycellular component disassembly YBR170C
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle YBR170C
GO:0071629
IEA
PLAZA Integrative Orthologycytoplasm protein quality control by the ubiquitin-proteasome system YBR170C
GO:0051348
IEA
PLAZA Integrative Orthologynegative regulation of transferase activity YBR170C
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process WBGene00019121
GO:0051228
IEA
PLAZA Integrative Orthologymitotic spindle disassembly YBR170C
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process YBR170C
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process YBR170C
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0039348
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development WBGene00019121
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development WBGene00019121
GO:0060341
IEA
PLAZA Integrative Orthologyregulation of cellular localization YBR170C
GO:1900180
IEA
PLAZA Integrative Orthologyregulation of protein localization to nucleus YBR170C
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function YBR170C
GO:0051974
IEA
PLAZA Integrative Orthologynegative regulation of telomerase activity YBR170C
GO:0051338
IEA
PLAZA Integrative Orthologyregulation of transferase activity YBR170C
GO:0034655
IEA
PLAZA Integrative Orthologynucleobase-containing compound catabolic process YBR170C
GO:0051053
IEA
PLAZA Integrative Orthologynegative regulation of DNA metabolic process YBR170C
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0039348
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization YBR170C
GO:0051972
IEA
PLAZA Integrative Orthologyregulation of telomerase activity YBR170C
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process YBR170C
GO:0046700
IEA
PLAZA Integrative Orthologyheterocycle catabolic process YBR170C
GO:0034660
IEA
PLAZA Integrative OrthologyncRNA metabolic process YBR170C
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization YBR170C
GO:0034661
IEA
PLAZA Integrative OrthologyncRNA catabolic process YBR170C
GO:1900182
IEA
PLAZA Integrative Orthologypositive regulation of protein localization to nucleus YBR170C
GO:2000279
IEA
PLAZA Integrative Orthologynegative regulation of DNA biosynthetic process YBR170C
GO:0071218
IEA
PLAZA Integrative Orthologycellular response to misfolded protein YBR170C
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus YBR170C
GO:0072665
IEA
PLAZA Integrative Orthologyprotein localization to vacuole YBR170C
GO:2000278
IEA
PLAZA Integrative Orthologyregulation of DNA biosynthetic process YBR170C
GO:0006515
IEA
PLAZA Integrative Orthologyprotein quality control for misfolded or incompletely synthesized proteins YBR170C
GO:0006401
IEA
PLAZA Integrative OrthologyRNA catabolic process YBR170C
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process YBR170C
GO:0051052
IEA
PLAZA Integrative Orthologyregulation of DNA metabolic process YBR170C
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process YBR170C
GO:0007052
IEA
PLAZA Integrative Orthologymitotic spindle organization YBR170C
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process YBR170C
GO:0019439
IEA
PLAZA Integrative Orthologyaromatic compound catabolic process YBR170C
GO:0007051
IEA
PLAZA Integrative Orthologyspindle organization YBR170C
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process YBR170C
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process YBR170C
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process YBR170C
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process YBR170C
GO:1903827
IEA
PLAZA Integrative Orthologyregulation of cellular protein localization YBR170C
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process YBR170C
GO:1903829
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein localization YBR170C
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process YBR170C
GO:0051788
IEA
PLAZA Integrative Orthologyresponse to misfolded protein YBR170C
GO:0071712
IEA
PLAZA Integrative OrthologyER-associated misfolded protein catabolic process YBR170C
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process YBR170C
GO:0016075
IEA
PLAZA Integrative OrthologyrRNA catabolic process YBR170C
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance YBR170C
GO:0016072
IEA
PLAZA Integrative OrthologyrRNA metabolic process YBR170C
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process YBR170C
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle YBR170C
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process YBR170C
GO:1902850
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization involved in mitosis YBR170C
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process YBR170C
GO:1901361
IEA
PLAZA Integrative Orthologyorganic cyclic compound catabolic process YBR170C
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process YBR170C
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle YBR170C
GO:0043086
IEA
PLAZA Integrative Orthologynegative regulation of catalytic activity YBR170C
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function YBR170C
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process YBR170C
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization YBR170C
GO:0034504
IEA
PLAZA Integrative Orthologyprotein localization to nucleus YBR170C
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process YBR170C
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process YBR170C
GO:0050790
IEA
PLAZA Integrative Orthologyregulation of catalytic activity YBR170C
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process YBR170C
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0039348
GO:1903008
IEA
PLAZA Integrative Orthologyorganelle disassembly YBR170C
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process YBR170C
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00019121
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization YBR170C
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00019121

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0043130
IBA
Genome Projectubiquitin binding
GO:0031625
IBA
Genome Projectubiquitin protein ligase binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 5 6
GO:0008270
IEA
PLAZA Homology (enrichment)zinc ion binding HOM02SEM014204
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding WBGene00019120
GO:0046914
IEA
PLAZA Homology (enrichment)transition metal ion binding HOM02SEM014204

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042175
ISS
Genome Projectnuclear outer membrane-endoplasmic reticulum membrane network
GO:0042175
ISS
Gene Ontologynuclear outer membrane-endoplasmic reticulum membrane network3
GO:0036501
IPI
Genome ProjectUFD1-NPL4 complex
GO:0036501
IPI
Gene OntologyUFD1-NPL4 complex3
GO:0034098
IDA
ISS
Genome ProjectVCP-NPL4-UFD1 AAA ATPase complex
GO:0034098
IDA
ISS
Gene OntologyVCP-NPL4-UFD1 AAA ATPase complex1
GO:0005829
IEA
Genome Projectcytosol
GO:0005783
ISS
Genome Projectendoplasmic reticulum
GO:0005783
ISS
Gene Ontologyendoplasmic reticulum3
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
Gene Ontologynucleus7
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane YBR170C
GO:1990234
IEA
PLAZA Integrative Orthologytransferase complex YBR170C
GO:1990112
IEA
PLAZA Integrative OrthologyRQC complex YBR170C
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane YBR170C
GO:0036266
IEA
PLAZA Integrative OrthologyCdc48p-Npl4p-Vms1p AAA ATPase complex YBR170C
GO:0044429
IEA
PLAZA Integrative Orthologymitochondrial part YBR170C
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex YBR170C
GO:0000151
IEA
PLAZA Integrative Orthologyubiquitin ligase complex YBR170C
GO:0000153
IEA
PLAZA Integrative Orthologycytoplasmic ubiquitin ligase complex YBR170C
GO:0005739
IEA
PLAZA Integrative Orthologymitochondrion YBR170C
GO:0031966
IEA
PLAZA Integrative Orthologymitochondrial membrane YBR170C
GO:0031968
IEA
PLAZA Integrative Orthologyorganelle outer membrane YBR170C
GO:0031967
IEA
PLAZA Integrative Orthologyorganelle envelope YBR170C
GO:0005740
IEA
PLAZA Integrative Orthologymitochondrial envelope YBR170C
GO:0005741
IEA
PLAZA Integrative Orthologymitochondrial outer membrane YBR170C
GO:0019867
IEA
PLAZA Integrative Orthologyouter membrane YBR170C
GO:0031975
IEA
PLAZA Integrative Orthologyenvelope YBR170C
GO:0098798
IEA
PLAZA Integrative Orthologymitochondrial protein complex YBR170C
GO:0098799
IEA
PLAZA Integrative Orthologyouter mitochondrial membrane protein complex YBR170C
GO:0044455
IEA
PLAZA Integrative Orthologymitochondrial membrane part YBR170C
GO:0000835
IEA
PLAZA Integrative OrthologyER ubiquitin ligase complex YBR170C
GO:0000836
IEA
PLAZA Integrative OrthologyHrd1p ubiquitin ligase complex YBR170C
GO:0000837
IEA
PLAZA Integrative OrthologyDoa10p ubiquitin ligase complex YBR170C
GO:0000839
IEA
PLAZA Integrative OrthologyHrd1p ubiquitin ligase ERAD-L complex YBR170C
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle YBR170C

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001876Zinc finger, RanBP2-type
IPR007716NPL4, zinc-binding putative
IPR007717Nuclear pore localisation protein NPL4, C-terminal
IPR016563Nuclear protein localization protein 4
IPR024682Nuclear pore localisation protein Npl4, ubiquitin-like domain
IPR029071Ubiquitin-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K14015NPLOC4, NPL4; nuclear protein localization protein 4 homolog
No chloroplast target sequence found.