Gene: ENSG00000177628 (Homo sapiens)

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Gene Identifier
ENSG00000177628
Transcript Identifier
ENST00000327247
Gene Type
Coding gene
Location
1 : 155234995-155241112 : negative

Family Information

Homologous gene family
HOM02SEM002546
(28 genes in 16 species)
specific family
Orthologous gene family
ORTHO02SEM002796
(27 genes in 16 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
glucosidase, beta, acid

Identifiers

Type Value
pidENSP00000314508
HGNC4177
UniprotP04062
UniprotA0A068F658
RefSeq_mRNANM_001005741.2
RefSeq_mRNANM_001005742.2
EMBLCHEMBL2179
EMBLAF023268
EMBLAK291911
EMBLAK298900
EMBLAK300829
EMBLAL713999
EMBLBC003356
EMBLD13286
EMBLD13287
EMBLJ03059
EMBLK02920
EMBLKJ690771
EMBLM16328
EMBLM18916
EMBLM18917
EMBLM19285
EMBLM20248
EMBLM20282

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0036473
IMP
Genome Projectcell death in response to oxidative stress
GO:0036473
IMP
Gene Ontologycell death in response to oxidative stress1
GO:0031175
IMP
Genome Projectneuron projection development
GO:0031175
IMP
Gene Ontologyneuron projection development1
GO:0007005
IMP
Genome Projectmitochondrion organization
GO:0007005
IMP
Gene Ontologymitochondrion organization1
GO:1905165
TAS
Genome Projectregulation of lysosomal protein catabolic process
GO:1905165
TAS
Gene Ontologyregulation of lysosomal protein catabolic process1
GO:1905037
IEA
Genome Projectautophagosome organization
GO:1904925
IEA
Genome Projectpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO:1904457
IMP
Genome Projectpositive regulation of neuronal action potential
GO:1904457
IMP
Gene Ontologypositive regulation of neuronal action potential1
GO:1903061
IGI
Genome Projectpositive regulation of protein lipidation
GO:1903061
IGI
Gene Ontologypositive regulation of protein lipidation2
GO:1903052
IMP
Genome Projectpositive regulation of proteolysis involved in cellular protein catabolic process
GO:1903052
IMP
Gene Ontologypositive regulation of proteolysis involved in cellular protein catabolic process3
GO:1901805
IEA
Genome Projectbeta-glucoside catabolic process
GO:1901215
IGI
Genome Projectnegative regulation of neuron death
GO:1901215
IGI
Gene Ontologynegative regulation of neuron death2
GO:0097066
IEA
Genome Projectresponse to thyroid hormone
GO:0071356
IMP
Genome Projectcellular response to tumor necrosis factor
GO:0071356
IMP
Gene Ontologycellular response to tumor necrosis factor4
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051247
IGI
Genome Projectpositive regulation of protein metabolic process
GO:0051247
IGI
Gene Ontologypositive regulation of protein metabolic process2
GO:0050728
IC
Genome Projectnegative regulation of inflammatory response
GO:0050728
IC
Gene Ontologynegative regulation of inflammatory response4
GO:0046513
IMP
Genome Projectceramide biosynthetic process
GO:0046513
IMP
Gene Ontologyceramide biosynthetic process5
GO:0046512
IMP
Genome Projectsphingosine biosynthetic process
GO:0046512
IMP
Gene Ontologysphingosine biosynthetic process5
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0043589
IEA
Genome Projectskin morphogenesis
GO:0043407
IMP
Genome Projectnegative regulation of MAP kinase activity
GO:0043407
IMP
Gene Ontologynegative regulation of MAP kinase activity4
GO:0043243
IDA
Genome Projectpositive regulation of protein complex disassembly
GO:0043243
IDA
Gene Ontologypositive regulation of protein complex disassembly2
GO:0035307
IMP
Genome Projectpositive regulation of protein dephosphorylation
GO:0035307
IMP
Gene Ontologypositive regulation of protein dephosphorylation4
GO:0033574
IEA
Genome Projectresponse to testosterone
GO:0033561
IEA
Genome Projectregulation of water loss via skin
GO:0032715
IDA
Genome Projectnegative regulation of interleukin-6 production
GO:0032715
IDA
Gene Ontologynegative regulation of interleukin-6 production4
GO:0032463
IDA
Genome Projectnegative regulation of protein homooligomerization
GO:0032463
IDA
Gene Ontologynegative regulation of protein homooligomerization2
GO:0032436
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032268
IMP
Genome Projectregulation of cellular protein metabolic process
GO:0032268
IMP
Gene Ontologyregulation of cellular protein metabolic process1
GO:0023021
IMP
Genome Projecttermination of signal transduction
GO:0023021
IMP
Gene Ontologytermination of signal transduction4
GO:0016241
TAS
Genome Projectregulation of macroautophagy
GO:0016241
TAS
Gene Ontologyregulation of macroautophagy6
GO:0009268
IEA
Genome Projectresponse to pH
GO:0009267
IEA
Genome Projectcellular response to starvation
GO:0006687
TAS
Genome Projectglycosphingolipid metabolic process
GO:0006680
IMP
Genome Projectglucosylceramide catabolic process
GO:0006680
IMP
Gene Ontologyglucosylceramide catabolic process3 5
GO:0030534
IEA
PLAZA Integrative Orthologyadult behavior FBgn0051414
GO:0035967
IEA
PLAZA Integrative Orthologycellular response to topologically incorrect protein FBgn0051414
GO:0034620
IEA
PLAZA Integrative Orthologycellular response to unfolded protein FBgn0051414
GO:0035966
IEA
PLAZA Integrative Orthologyresponse to topologically incorrect protein FBgn0051414
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging FBgn0051414
GO:0050890
IEA
PLAZA Integrative Orthologycognition FBgn0051414
GO:0007626
IEA
PLAZA Integrative Orthologylocomotory behavior FBgn0051414
GO:0070050
IEA
PLAZA Integrative Orthologyneuron cellular homeostasis FBgn0051414
GO:0007611
IEA
PLAZA Integrative Orthologylearning or memory FBgn0051414
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis FBgn0051414
GO:0007610
IEA
PLAZA Integrative Orthologybehavior FBgn0051414
GO:0006986
IEA
PLAZA Integrative Orthologyresponse to unfolded protein FBgn0051414
GO:0007613
IEA
PLAZA Integrative Orthologymemory FBgn0051414
GO:0007568
IEA
PLAZA Integrative Orthologyaging FBgn0051414
GO:0008344
IEA
PLAZA Integrative Orthologyadult locomotory behavior FBgn0051414
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan FBgn0051414
GO:0019725
IEA
PLAZA Integrative Orthologycellular homeostasis FBgn0051414

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 8
GO:0005102
ISS
Genome Projectsignaling receptor binding
GO:0005102
ISS
Gene Ontologysignaling receptor binding9
GO:0004348
IDA, IMP
Genome Projectglucosylceramidase activity
GO:0004348
IDA, IMP
Gene Ontologyglucosylceramidase activity3 5 10
GO:0005124
IPI
Gene Ontologyscavenger receptor binding11

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome12
GO:0043202
ISS
Genome Projectlysosomal lumen
GO:0043202
ISS
Gene Ontologylysosomal lumen9
GO:0005765
IDA
ISS
TAS
Genome Projectlysosomal membrane
GO:0005765
ISS
TAS
Gene Ontologylysosomal membrane9 13
GO:0005615
IEA
Genome Projectextracellular space
GO:0019898
NAS
Gene Ontologyextrinsic component of membrane11
GO:0005764
IMP
Gene Ontologylysosome11

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001139Glycoside hydrolase family 30
IPR017853Glycoside hydrolase superfamily
IPR033452Glycosyl hydrolase family 30, beta sandwich domain
IPR033453Glycosyl hydrolase family 30, TIM-barrel domain

No MapMan annotations defined for this gene.
KeggID Description
K01201GBA, srfJ; glucosylceramidase [EC:3.2.1.45]
No chloroplast target sequence found.