Gene: ENSG00000177595 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000177595
Transcript Identifier
ENST00000347755
Gene Type
Coding gene
Location
11 : 799307-804388 : negative

Family Information

Homologous gene family
HOM02SEM012011
(7 genes in 3 species)
specific family

Descriptions

gene_descr
p53-induced death domain protein 1

Identifiers

Type Value
pidENSP00000337797
HGNC16491
UniprotQ9HB75
RefSeq_mRNANM_145886.3
EMBLAB208832
EMBLAB208949
EMBLAB209529
EMBLAF229178
EMBLAF274972
EMBLAF465246
EMBLAK074893
EMBLAL833849
EMBLBC014904

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
TAS
Gene Ontologypositive regulation of NF-kappaB transcription factor activity1
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043066
IMP
Gene Ontologynegative regulation of apoptotic process2
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
TAS
Gene Ontologypositive regulation of apoptotic process1
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction3
GO:0006977
IMP
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006977
IMP
Gene OntologyDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0006974
IDA
Gene Ontologycellular response to DNA damage stimulus2
GO:0006919
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IEA
Genome Projectapoptotic process
GO:0032989
IEA
PLAZA Homology (enrichment)cellular component morphogenesis HOM02SEM012011
GO:0007010
IEA
PLAZA Homology (enrichment)cytoskeleton organization HOM02SEM012011

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 5 6 7 8
GO:0005123
TAS
Genome Projectdeath receptor binding
GO:0005123
TAS
Gene Ontologydeath receptor binding3
GO:0060090
IEA
PLAZA Homology (enrichment)molecular adaptor activity HOM02SEM012011
GO:0030674
IEA
PLAZA Homology (enrichment)protein binding, bridging HOM02SEM012011
GO:0008092
IEA
PLAZA Homology (enrichment)cytoskeletal protein binding HOM02SEM012011
GO:0030507
IEA
PLAZA Homology (enrichment)spectrin binding HOM02SEM012011

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005794
IDA
Gene OntologyGolgi apparatus
GO:0005737
IMP
Genome Projectcytoplasm
GO:0005737
IMP
Gene Ontologycytoplasm2
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IMP
Genome Projectnucleus
GO:0005634
IMP
Gene Ontologynucleus2
GO:0071944
IEA
PLAZA Homology (enrichment)cell periphery HOM02SEM012011
GO:0097458
IEA
PLAZA Homology (enrichment)neuron part HOM02SEM012011
GO:0044459
IEA
PLAZA Homology (enrichment)plasma membrane part HOM02SEM012011
GO:0005886
IEA
PLAZA Homology (enrichment)plasma membrane HOM02SEM012011
GO:0042995
IEA
PLAZA Homology (enrichment)cell projection HOM02SEM012011
GO:0043005
IEA
PLAZA Homology (enrichment)neuron projection HOM02SEM012011
GO:0097060
IEA
PLAZA Homology (enrichment)synaptic membrane HOM02SEM012011
GO:0045202
IEA
PLAZA Homology (enrichment)synapse HOM02SEM012011
GO:0044456
IEA
PLAZA Homology (enrichment)synapse part HOM02SEM012011
GO:0098590
IEA
PLAZA Homology (enrichment)plasma membrane region HOM02SEM012011
GO:0120025
IEA
PLAZA Homology (enrichment)plasma membrane bounded cell projection HOM02SEM012011

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR000906ZU5 domain
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR011029Death-like domain superfamily
IPR019502Peptidase S68, pidd
IPR032675Leucine-rich repeat domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K10130LRDD, PIDD; leucine-rich repeats and death domain-containing protein
No chloroplast target sequence found.