Gene: ENSG00000176720 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000176720
Transcript Identifier
ENST00000318407
Gene Type
Coding gene
Location
2 : 241559484-241572422 : positive

Family Information

Homologous gene family
HOM02SEM027926
(3 genes in 2 species)
specific family
Orthologous gene family
ORTHO02SEM016725
(3 genes in 2 species)
specific family

Descriptions

gene_descr
BCL2-related ovarian killer

Identifiers

Type Value
pidENSP00000314132
HGNC1087
UniprotQ9UMX3
UniprotA0A024R4A8
RefSeq_mRNANM_032515.4
EMBLAF174487
EMBLBC006203
EMBLBT007272
EMBLCH471063

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001244
ISS
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:2001244
ISS
Gene Ontologypositive regulation of intrinsic apoptotic signaling pathway
GO:1904708
IMP
Genome Projectregulation of granulosa cell apoptotic process
GO:1904708
IMP
Gene Ontologyregulation of granulosa cell apoptotic process1
GO:1903899
ISS
Genome Projectpositive regulation of PERK-mediated unfolded protein response
GO:1903899
ISS
Gene Ontologypositive regulation of PERK-mediated unfolded protein response
GO:1902237
ISS
Genome Projectpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902237
ISS
Gene Ontologypositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1901382
IDA
Genome Projectregulation of chorionic trophoblast cell proliferation
GO:1901382
IDA
Gene Ontologyregulation of chorionic trophoblast cell proliferation2
GO:1901030
ISS
Genome Projectpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030
ISS
Gene Ontologypositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901029
IEA
Genome Projectnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1900119
IMP
Genome Projectpositive regulation of execution phase of apoptosis
GO:1900119
IMP
Gene Ontologypositive regulation of execution phase of apoptosis1
GO:0072332
IMP
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0072332
IMP
Gene Ontologyintrinsic apoptotic signaling pathway by p53 class mediator3
GO:0060546
IEA
Genome Projectnegative regulation of necroptotic process
GO:0051902
IEA
Genome Projectnegative regulation of mitochondrial depolarization
GO:0051480
IEA
Genome Projectregulation of cytosolic calcium ion concentration
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0051259
ISS
Genome Projectprotein complex oligomerization
GO:0051259
ISS
Gene Ontologyprotein complex oligomerization
GO:0048709
IEA
Genome Projectoligodendrocyte differentiation
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA
Gene Ontologypositive regulation of apoptotic process4 5
GO:0010506
IMP
Genome Projectregulation of autophagy
GO:0010506
IMP
Gene Ontologyregulation of autophagy6
GO:0008635
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008635
ISS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008584
IEA
Genome Projectmale gonad development
GO:0008283
IEP
Genome Projectcell proliferation
GO:0008283
IEP
Gene Ontologycell proliferation7
GO:0007420
IEA
Genome Projectbrain development
GO:0006921
ISS
Genome Projectcellular component disassembly involved in execution phase of apoptosis
GO:0006921
ISS
Gene Ontologycellular component disassembly involved in execution phase of apoptosis
GO:0006919
IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IMP
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:0006915
IDA
Genome Projectapoptotic process
GO:0006915
IDA
Gene Ontologyapoptotic process3
GO:0001836
IDA
Genome Projectrelease of cytochrome c from mitochondria
GO:0001836
IDA
Gene Ontologyrelease of cytochrome c from mitochondria5
GO:0031667
IEA
PLAZA Integrative Orthologyresponse to nutrient levels FBgn0029131
GO:0010623
IEA
PLAZA Integrative Orthologyprogrammed cell death involved in cell development FBgn0029131
GO:0010940
IEA
PLAZA Integrative Orthologypositive regulation of necrotic cell death FBgn0029131
GO:0016241
IEA
PLAZA Integrative Orthologyregulation of macroautophagy FBgn0029131
GO:0031669
IEA
PLAZA Integrative Orthologycellular response to nutrient levels FBgn0029131
GO:0031668
IEA
PLAZA Integrative Orthologycellular response to extracellular stimulus FBgn0029131
GO:0070050
IEA
PLAZA Integrative Orthologyneuron cellular homeostasis FBgn0029131
GO:0006974
IEA
PLAZA Integrative Orthologycellular response to DNA damage stimulus FBgn0029131
GO:0010508
IEA
PLAZA Integrative Orthologypositive regulation of autophagy FBgn0029131
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0029131
GO:0009267
IEA
PLAZA Integrative Orthologycellular response to starvation FBgn0029131
GO:1902742
IEA
PLAZA Integrative Orthologyapoptotic process involved in development FBgn0029131
GO:0008630
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway in response to DNA damage FBgn0029131
GO:0035234
IEA
PLAZA Integrative Orthologyectopic germ cell programmed cell death FBgn0029131
GO:0016239
IEA
PLAZA Integrative Orthologypositive regulation of macroautophagy FBgn0029131
GO:0016236
IEA
PLAZA Integrative Orthologymacroautophagy FBgn0029131
GO:0010212
IEA
PLAZA Integrative Orthologyresponse to ionizing radiation FBgn0029131
GO:0031331
IEA
PLAZA Integrative Orthologypositive regulation of cellular catabolic process FBgn0029131
GO:0071496
IEA
PLAZA Integrative Orthologycellular response to external stimulus FBgn0029131
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0029131
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus FBgn0029131
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis FBgn0029131
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0029131
GO:0009896
IEA
PLAZA Integrative Orthologypositive regulation of catabolic process FBgn0029131
GO:0042594
IEA
PLAZA Integrative Orthologyresponse to starvation FBgn0029131
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation FBgn0029131
GO:0009991
IEA
PLAZA Integrative Orthologyresponse to extracellular stimulus FBgn0029131
GO:0060561
IEA
PLAZA Integrative Orthologyapoptotic process involved in morphogenesis FBgn0029131

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051400
IEA
Genome ProjectBH domain binding
GO:0046982
ISS
Genome Projectprotein heterodimerization activity
GO:0046982
ISS
Gene Ontologyprotein heterodimerization activity
GO:0042803
ISS
Genome Projectprotein homodimerization activity
GO:0042803
ISS
Gene Ontologyprotein homodimerization activity
GO:0031625
IEA
Genome Projectubiquitin protein ligase binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding8 9
GO:0005102
IEA
Genome Projectsignaling receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0055038
ISS
Genome Projectrecycling endosome membrane
GO:0055038
ISS
Gene Ontologyrecycling endosome membrane
GO:0033106
ISS
Genome Projectcis-Golgi network membrane
GO:0033106
ISS
Gene Ontologycis-Golgi network membrane
GO:0032588
ISS
Genome Projecttrans-Golgi network membrane
GO:0032588
ISS
Gene Ontologytrans-Golgi network membrane
GO:0031966
IDA
Genome Projectmitochondrial membrane
GO:0031966
IDA
Gene Ontologymitochondrial membrane5 8
GO:0031901
ISS
Genome Projectearly endosome membrane
GO:0031901
ISS
Gene Ontologyearly endosome membrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005794
IDA
Gene OntologyGolgi apparatus5
GO:0005789
IDA
Genome Projectendoplasmic reticulum membrane
GO:0005789
IDA
Gene Ontologyendoplasmic reticulum membrane5
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum4
GO:0005743
IDA
Genome Projectmitochondrial inner membrane
GO:0005743
IDA
Gene Ontologymitochondrial inner membrane6
GO:0005741
IEA
Genome Projectmitochondrial outer membrane
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion2 3 7
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm1 2 4 8
GO:0005640
IEA
Genome Projectnuclear outer membrane
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus1 4 7

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002475Bcl2-like
IPR026298Blc2 family
IPR026309Bcl-2-related ovarian killer protein

No MapMan annotations defined for this gene.
KeggID Description
K02561BOK; Bcl-2-related ovarian killer protein
No chloroplast target sequence found.