Gene: ENSG00000176697 (Homo sapiens)

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Gene Identifier
ENSG00000176697
Transcript Identifier
ENST00000438929
Gene Type
Coding gene
Location
11 : 27657821-27674284 : negative

Family Information

Homologous gene family
HOM02SEM019507
(4 genes in 1 species)
specific family

Descriptions

gene_descr
brain-derived neurotrophic factor

Identifiers

Type Value
pidENSP00000414303
HGNC1033
UniprotP23560
RefSeq_mRNANM_001143810.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000008
TAS
Genome Projectregulation of protein localization to cell surface
GO:2000008
TAS
Gene Ontologyregulation of protein localization to cell surface1
GO:1900122
IDA
Genome Projectpositive regulation of receptor binding
GO:1900122
IDA
Gene Ontologypositive regulation of receptor binding1
GO:0051965
IDA
Genome Projectpositive regulation of synapse assembly
GO:0051965
IDA
Gene Ontologypositive regulation of synapse assembly2
GO:0048672
IDA
Genome Projectpositive regulation of collateral sprouting
GO:0048672
IDA
Gene Ontologypositive regulation of collateral sprouting2
GO:0048668
IDA
Genome Projectcollateral sprouting
GO:0048668
IDA
Gene Ontologycollateral sprouting2
GO:0043524
IBA
Genome Projectnegative regulation of neuron apoptotic process
GO:0031550
TAS
Genome Projectpositive regulation of brain-derived neurotrophic factor receptor signaling pathway
GO:0031550
TAS
Gene Ontologypositive regulation of brain-derived neurotrophic factor receptor signaling pathway2
GO:0031547
TAS
Genome Projectbrain-derived neurotrophic factor receptor signaling pathway
GO:0031547
TAS
Gene Ontologybrain-derived neurotrophic factor receptor signaling pathway2
GO:0010832
ISS
Genome Projectnegative regulation of myotube differentiation
GO:0010832
ISS
Gene Ontologynegative regulation of myotube differentiation
GO:0007416
IDA
Genome Projectsynapse assembly
GO:0007416
IDA
Gene Ontologysynapse assembly2
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007411
TAS
Gene Ontologyaxon guidance2
GO:0007399
TAS
Genome Projectnervous system development
GO:0007399
TAS
Gene Ontologynervous system development3
GO:0007267
IBA
Genome Projectcell-cell signaling
GO:0071900
IEA
PLAZA Integrative Orthologyregulation of protein serine/threonine kinase activity ENSG00000185652
GO:0031400
IEA
PLAZA Integrative Orthologynegative regulation of protein modification process ENSG00000185652
GO:0030036
IEA
PLAZA Integrative Orthologyactin cytoskeleton organization ENSG00000185652
GO:0071902
IEA
PLAZA Integrative Orthologypositive regulation of protein serine/threonine kinase activity ENSG00000185652
GO:0010563
IEA
PLAZA Integrative Orthologynegative regulation of phosphorus metabolic process ENSG00000185652
GO:0032970
IEA
PLAZA Integrative Orthologyregulation of actin filament-based process ENSG00000185652
GO:0032455
IEA
PLAZA Integrative Orthologynerve growth factor processing ENSG00000134259
GO:0043065
IEA
PLAZA Integrative Orthologypositive regulation of apoptotic process ENSG00000134259
GO:0006508
IEA
PLAZA Integrative Orthologyproteolysis ENSG00000134259
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process ENSG00000185652
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000185652
GO:0048870
IEA
PLAZA Integrative Orthologycell motility ENSG00000185652
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000185652
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization ENSG00000185652
GO:0030162
IEA
PLAZA Integrative Orthologyregulation of proteolysis ENSG00000134259
GO:0050930
IEA
PLAZA Integrative Orthologyinduction of positive chemotaxis ENSG00000185652
GO:0010950
IEA
PLAZA Integrative Orthologypositive regulation of endopeptidase activity ENSG00000134259
GO:0031532
IEA
PLAZA Integrative Orthologyactin cytoskeleton reorganization ENSG00000185652
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process ENSG00000134259
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus ENSG00000185652
GO:0010951
IEA
PLAZA Integrative Orthologynegative regulation of endopeptidase activity ENSG00000134259
GO:0032103
IEA
PLAZA Integrative Orthologypositive regulation of response to external stimulus ENSG00000185652
GO:0010952
IEA
PLAZA Integrative Orthologypositive regulation of peptidase activity ENSG00000134259
GO:0051346
IEA
PLAZA Integrative Orthologynegative regulation of hydrolase activity ENSG00000134259
GO:0045862
IEA
PLAZA Integrative Orthologypositive regulation of proteolysis ENSG00000134259
GO:0060627
IEA
PLAZA Integrative Orthologyregulation of vesicle-mediated transport ENSG00000185652
GO:1902533
IEA
PLAZA Integrative Orthologypositive regulation of intracellular signal transduction ENSG00000185652
GO:0045861
IEA
PLAZA Integrative Orthologynegative regulation of proteolysis ENSG00000134259
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization ENSG00000185652
GO:1902531
IEA
PLAZA Integrative Orthologyregulation of intracellular signal transduction ENSG00000185652
GO:0090630
IEA
PLAZA Integrative Orthologyactivation of GTPase activity ENSG00000185652
GO:0018209
IEA
PLAZA Integrative Orthologypeptidyl-serine modification ENSG00000185652
GO:0043603
IEA
PLAZA Integrative Orthologycellular amide metabolic process ENSG00000134259
GO:0052547
IEA
PLAZA Integrative Orthologyregulation of peptidase activity ENSG00000134259
GO:0030335
IEA
PLAZA Integrative Orthologypositive regulation of cell migration ENSG00000185652
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function ENSG00000134259
GO:0010466
IEA
PLAZA Integrative Orthologynegative regulation of peptidase activity ENSG00000134259
GO:0050921
IEA
PLAZA Integrative Orthologypositive regulation of chemotaxis ENSG00000185652
GO:0052548
IEA
PLAZA Integrative Orthologyregulation of endopeptidase activity ENSG00000134259
GO:0030334
IEA
PLAZA Integrative Orthologyregulation of cell migration ENSG00000185652
GO:0018105
IEA
PLAZA Integrative Orthologypeptidyl-serine phosphorylation ENSG00000185652
GO:0050920
IEA
PLAZA Integrative Orthologyregulation of chemotaxis ENSG00000185652
GO:0010467
IEA
PLAZA Integrative Orthologygene expression ENSG00000134259
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression ENSG00000134259
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression ENSG00000134259
GO:0043281
IEA
PLAZA Integrative Orthologyregulation of cysteine-type endopeptidase activity involved in apoptotic process ENSG00000134259
GO:0043280
IEA
PLAZA Integrative Orthologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process ENSG00000134259
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000185652
GO:0006898
IEA
PLAZA Integrative Orthologyreceptor-mediated endocytosis ENSG00000185652
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis ENSG00000185652
GO:0050927
IEA
PLAZA Integrative Orthologypositive regulation of positive chemotaxis ENSG00000185652
GO:0050926
IEA
PLAZA Integrative Orthologyregulation of positive chemotaxis ENSG00000185652
GO:0006919
IEA
PLAZA Integrative Orthologyactivation of cysteine-type endopeptidase activity involved in apoptotic process ENSG00000134259
GO:0030100
IEA
PLAZA Integrative Orthologyregulation of endocytosis ENSG00000185652
GO:0051604
IEA
PLAZA Integrative Orthologyprotein maturation ENSG00000134259
GO:0043154
IEA
PLAZA Integrative Orthologynegative regulation of cysteine-type endopeptidase activity involved in apoptotic process ENSG00000134259
GO:0006518
IEA
PLAZA Integrative Orthologypeptide metabolic process ENSG00000134259
GO:0098657
IEA
PLAZA Integrative Orthologyimport into cell ENSG00000185652
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport ENSG00000185652
GO:0043547
IEA
PLAZA Integrative Orthologypositive regulation of GTPase activity ENSG00000185652
GO:0023014
IEA
PLAZA Integrative Orthologysignal transduction by protein phosphorylation ENSG00000185652
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport ENSG00000185652
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process ENSG00000185652
GO:0050918
IEA
PLAZA Integrative Orthologypositive chemotaxis ENSG00000185652
GO:2000147
IEA
PLAZA Integrative Orthologypositive regulation of cell motility ENSG00000185652
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process ENSG00000185652
GO:2000145
IEA
PLAZA Integrative Orthologyregulation of cell motility ENSG00000185652
GO:0001933
IEA
PLAZA Integrative Orthologynegative regulation of protein phosphorylation ENSG00000185652
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell ENSG00000185652
GO:0042326
IEA
PLAZA Integrative Orthologynegative regulation of phosphorylation ENSG00000185652
GO:0042445
IEA
PLAZA Integrative Orthologyhormone metabolic process ENSG00000134259
GO:0043410
IEA
PLAZA Integrative Orthologypositive regulation of MAPK cascade ENSG00000185652
GO:0050732
IEA
PLAZA Integrative Orthologynegative regulation of peptidyl-tyrosine phosphorylation ENSG00000185652
GO:0032269
IEA
PLAZA Integrative Orthologynegative regulation of cellular protein metabolic process ENSG00000185652
GO:0032148
IEA
PLAZA Integrative Orthologyactivation of protein kinase B activity ENSG00000185652
GO:0016477
IEA
PLAZA Integrative Orthologycell migration ENSG00000185652
GO:0048260
IEA
PLAZA Integrative Orthologypositive regulation of receptor-mediated endocytosis ENSG00000185652
GO:0010638
IEA
PLAZA Integrative Orthologypositive regulation of organelle organization ENSG00000185652
GO:0032147
IEA
PLAZA Integrative Orthologyactivation of protein kinase activity ENSG00000185652
GO:0000165
IEA
PLAZA Integrative OrthologyMAPK cascade ENSG00000185652
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport ENSG00000185652
GO:0040017
IEA
PLAZA Integrative Orthologypositive regulation of locomotion ENSG00000185652
GO:0051270
IEA
PLAZA Integrative Orthologyregulation of cellular component movement ENSG00000185652
GO:0048259
IEA
PLAZA Integrative Orthologyregulation of receptor-mediated endocytosis ENSG00000185652
GO:0048017
IEA
PLAZA Integrative Orthologyinositol lipid-mediated signaling ENSG00000185652
GO:0097190
IEA
PLAZA Integrative Orthologyapoptotic signaling pathway ENSG00000134259
GO:0051272
IEA
PLAZA Integrative Orthologypositive regulation of cellular component movement ENSG00000185652
GO:0097191
IEA
PLAZA Integrative Orthologyextrinsic apoptotic signaling pathway ENSG00000134259
GO:0008284
IEA
PLAZA Integrative Orthologypositive regulation of cell proliferation ENSG00000185652
GO:0008285
IEA
PLAZA Integrative Orthologynegative regulation of cell proliferation ENSG00000134259
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process ENSG00000185652
GO:0040012
IEA
PLAZA Integrative Orthologyregulation of locomotion ENSG00000185652
GO:0043408
IEA
PLAZA Integrative Orthologyregulation of MAPK cascade ENSG00000185652
GO:0043405
IEA
PLAZA Integrative Orthologyregulation of MAP kinase activity ENSG00000185652
GO:0043406
IEA
PLAZA Integrative Orthologypositive regulation of MAP kinase activity ENSG00000185652
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation ENSG00000185652
GO:0031623
IEA
PLAZA Integrative Orthologyreceptor internalization ENSG00000185652
GO:2001056
IEA
PLAZA Integrative Orthologypositive regulation of cysteine-type endopeptidase activity ENSG00000134259
GO:2000249
IEA
PLAZA Integrative Orthologyregulation of actin cytoskeleton reorganization ENSG00000185652
GO:0016486
IEA
PLAZA Integrative Orthologypeptide hormone processing ENSG00000134259
GO:0010942
IEA
PLAZA Integrative Orthologypositive regulation of cell death ENSG00000134259
GO:0016485
IEA
PLAZA Integrative Orthologyprotein processing ENSG00000134259
GO:0043087
IEA
PLAZA Integrative Orthologyregulation of GTPase activity ENSG00000185652
GO:0051493
IEA
PLAZA Integrative Orthologyregulation of cytoskeleton organization ENSG00000185652
GO:0048015
IEA
PLAZA Integrative Orthologyphosphatidylinositol-mediated signaling ENSG00000185652
GO:0043086
IEA
PLAZA Integrative Orthologynegative regulation of catalytic activity ENSG00000134259
GO:0051495
IEA
PLAZA Integrative Orthologypositive regulation of cytoskeleton organization ENSG00000185652
GO:0032956
IEA
PLAZA Integrative Orthologyregulation of actin cytoskeleton organization ENSG00000185652
GO:0043112
IEA
PLAZA Integrative Orthologyreceptor metabolic process ENSG00000185652
GO:0002092
IEA
PLAZA Integrative Orthologypositive regulation of receptor internalization ENSG00000185652
GO:2000251
IEA
PLAZA Integrative Orthologypositive regulation of actin cytoskeleton reorganization ENSG00000185652
GO:0002090
IEA
PLAZA Integrative Orthologyregulation of receptor internalization ENSG00000185652
GO:0045936
IEA
PLAZA Integrative Orthologynegative regulation of phosphate metabolic process ENSG00000185652
GO:0033138
IEA
PLAZA Integrative Orthologypositive regulation of peptidyl-serine phosphorylation ENSG00000185652
GO:0051248
IEA
PLAZA Integrative Orthologynegative regulation of protein metabolic process ENSG00000185652
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction ENSG00000185652
GO:2000116
IEA
PLAZA Integrative Orthologyregulation of cysteine-type endopeptidase activity ENSG00000134259
GO:2000117
IEA
PLAZA Integrative Orthologynegative regulation of cysteine-type endopeptidase activity ENSG00000134259
GO:0033135
IEA
PLAZA Integrative Orthologyregulation of peptidyl-serine phosphorylation ENSG00000185652
GO:0000186
IEA
PLAZA Integrative Orthologyactivation of MAPKK activity ENSG00000134259
GO:0000187
IEA
PLAZA Integrative Orthologyactivation of MAPK activity ENSG00000185652
GO:0030029
IEA
PLAZA Integrative Orthologyactin filament-based process ENSG00000185652
GO:0010817
IEA
PLAZA Integrative Orthologyregulation of hormone levels ENSG00000134259
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process ENSG00000134259
GO:0008625
IEA
PLAZA Integrative Orthologyextrinsic apoptotic signaling pathway via death domain receptors ENSG00000134259
GO:0007018
IEA
PLAZA Integrative Orthologymicrotubule-based movement ENSG00000134259
GO:0043068
IEA
PLAZA Integrative Orthologypositive regulation of programmed cell death ENSG00000134259
GO:0045807
IEA
PLAZA Integrative Orthologypositive regulation of endocytosis ENSG00000185652
GO:0014065
IEA
PLAZA Integrative Orthologyphosphatidylinositol 3-kinase signaling ENSG00000185652
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization ENSG00000185652
GO:0014066
IEA
PLAZA Integrative Orthologyregulation of phosphatidylinositol 3-kinase signaling ENSG00000185652
GO:0014068
IEA
PLAZA Integrative Orthologypositive regulation of phosphatidylinositol 3-kinase signaling ENSG00000185652
GO:1903997
TAS
Gene Ontologypositive regulation of non-membrane spanning protein tyrosine kinase activity
GO:0048011
TAS
Gene Ontologyneurotrophin TRK receptor signaling pathway
GO:0007202
TAS
Gene Ontologyactivation of phospholipase C activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008083
IBA
Genome Projectgrowth factor activity
GO:0005169
IBA
Genome Projectneurotrophin TRKB receptor binding
GO:0004866
IEA
PLAZA Integrative Orthologyendopeptidase inhibitor activity ENSG00000134259
GO:0005166
IEA
PLAZA Homology (enrichment)neurotrophin p75 receptor binding HOM02SEM019507
GO:0005163
IEA
PLAZA Integrative Orthologynerve growth factor receptor binding ENSG00000134259
GO:0004857
IEA
PLAZA Integrative Orthologyenzyme inhibitor activity ENSG00000134259
GO:0042056
IEA
PLAZA Integrative Orthologychemoattractant activity ENSG00000185652
GO:0061135
IEA
PLAZA Integrative Orthologyendopeptidase regulator activity ENSG00000134259
GO:0061134
IEA
PLAZA Integrative Orthologypeptidase regulator activity ENSG00000134259
GO:0030234
IEA
PLAZA Integrative Orthologyenzyme regulator activity ENSG00000134259
GO:0032813
IEA
PLAZA Integrative Orthologytumor necrosis factor receptor superfamily binding ENSG00000134259
GO:0008191
IEA
PLAZA Integrative Orthologymetalloendopeptidase inhibitor activity ENSG00000134259
GO:0030414
IEA
PLAZA Integrative Orthologypeptidase inhibitor activity ENSG00000134259
GO:0005123
IEA
PLAZA Integrative Orthologydeath receptor binding ENSG00000134259

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
ISS
Genome Projectperinuclear region of cytoplasm
GO:0048471
ISS
Gene Ontologyperinuclear region of cytoplasm
GO:0031410
IBA
Genome Projectcytoplasmic vesicle
GO:0016607
IDA
Genome Projectnuclear speck
GO:0016607
IDA
Gene Ontologynuclear speck
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion
GO:0005737
ISS
Genome Projectcytoplasm
GO:0005737
ISS
Gene Ontologycytoplasm
GO:0005576
IBA
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000134259
GO:0005768
IEA
PLAZA Integrative Orthologyendosome ENSG00000134259
GO:0005796
IEA
PLAZA Integrative OrthologyGolgi lumen ENSG00000134259
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000134259
GO:0044431
IEA
PLAZA Integrative OrthologyGolgi apparatus part ENSG00000134259

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002072Nerve growth factor-related
IPR019846Nerve growth factor conserved site
IPR020408Nerve growth factor-like
IPR020430Brain-derived neurotrophic factor
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.
KeggID Description
K04355BDNF; brain-derived neurotrophic factor
No chloroplast target sequence found.