Gene: ENSG00000176692 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000176692
Transcript Identifier
ENST00000320354
Gene Type
Coding gene
Location
16 : 86567336-86568841 : positive

Family Information

Homologous gene family
HOM02SEM000449
(82 genes in 6 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
forkhead box C2

Identifiers

Type Value
pidENSP00000326371
HGNC3801
UniprotQ99958
RefSeq_mRNANM_005251.2
EMBLBC113437
EMBLBC113439
EMBLGQ282998
EMBLY08223

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902257
IEA
Genome Projectnegative regulation of apoptotic process involved in outflow tract morphogenesis
GO:0090050
ISS
Genome Projectpositive regulation of cell migration involved in sprouting angiogenesis
GO:0090050
ISS
Gene Ontologypositive regulation of cell migration involved in sprouting angiogenesis
GO:0072144
IEA
Genome Projectglomerular mesangial cell development
GO:0072112
IEA
Genome Projectglomerular visceral epithelial cell differentiation
GO:0072011
IEA
Genome Projectglomerular endothelium development
GO:0060038
IEA
Genome Projectcardiac muscle cell proliferation
GO:0055010
IEA
Genome Projectventricular cardiac muscle tissue morphogenesis
GO:0050880
IEA
Genome Projectregulation of blood vessel size
GO:0048844
IEA
Genome Projectartery morphogenesis
GO:0048703
IEA
Genome Projectembryonic viscerocranium morphogenesis
GO:0048343
IEA
Genome Projectparaxial mesodermal cell fate commitment
GO:0048010
IEA
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0046620
IEA
Genome Projectregulation of organ growth
GO:0045944
ISS
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
ISS
Gene Ontologypositive regulation of transcription by RNA polymerase II1
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
IDA
Gene Ontologypositive regulation of transcription, DNA-templated2 3
GO:0043010
IEA
Genome Projectcamera-type eye development
GO:0035470
ISS
Genome Projectpositive regulation of vascular wound healing
GO:0035470
ISS
Gene Ontologypositive regulation of vascular wound healing
GO:0035050
IEA
Genome Projectembryonic heart tube development
GO:0033630
ISS
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0033630
ISS
Gene Ontologypositive regulation of cell adhesion mediated by integrin
GO:0030199
IEA
Genome Projectcollagen fibril organization
GO:0014032
IEA
Genome Projectneural crest cell development
GO:0010595
ISS
Genome Projectpositive regulation of endothelial cell migration
GO:0010595
ISS
Gene Ontologypositive regulation of endothelial cell migration
GO:0009725
IDA
Genome Projectresponse to hormone
GO:0009725
IDA
Gene Ontologyresponse to hormone4
GO:0008286
IDA
Genome Projectinsulin receptor signaling pathway
GO:0008286
IDA
Gene Ontologyinsulin receptor signaling pathway4
GO:0007507
IMP
Genome Projectheart development
GO:0007507
IMP
Gene Ontologyheart development5
GO:0007498
NAS
Genome Projectmesoderm development
GO:0007498
NAS
Gene Ontologymesoderm development6
GO:0007219
IEA
Genome ProjectNotch signaling pathway
GO:0006366
IEA
Genome Projecttranscription by RNA polymerase II
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0001946
IMP
Genome Projectlymphangiogenesis
GO:0001946
IMP
Gene Ontologylymphangiogenesis7
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001657
IEA
Genome Projectureteric bud development
GO:0001656
IEA
Genome Projectmetanephros development
GO:0001569
IEA
Genome Projectbranching involved in blood vessel morphogenesis
GO:0001503
IEA
Genome Projectossification
GO:0000122
ISS
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
ISS
Gene Ontologynegative regulation of transcription by RNA polymerase II
GO:0120163
IMP
Gene Ontologynegative regulation of cold-induced thermogenesis8
GO:0033146
IEA
PLAZA Integrative Orthologyregulation of intracellular estrogen receptor signaling pathway ENSG00000160973
GO:0071345
IEA
PLAZA Integrative Orthologycellular response to cytokine stimulus ENSG00000160973
GO:0033147
IEA
PLAZA Integrative Orthologynegative regulation of intracellular estrogen receptor signaling pathway ENSG00000160973
GO:1990874
IEA
PLAZA Integrative Orthologyvascular smooth muscle cell proliferation ENSG00000065970
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000065970
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle ENSG00000054598
GO:0045597
IEA
PLAZA Integrative Orthologypositive regulation of cell differentiation ENSG00000054598
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus ENSG00000160973
GO:0045596
IEA
PLAZA Integrative Orthologynegative regulation of cell differentiation ENSG00000065970
GO:0045595
IEA
PLAZA Integrative Orthologyregulation of cell differentiation ENSG00000054598
GO:1904707
IEA
PLAZA Integrative Orthologypositive regulation of vascular smooth muscle cell proliferation ENSG00000065970
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction ENSG00000160973
GO:0051101
IEA
PLAZA Integrative Orthologyregulation of DNA binding ENSG00000054598
GO:0010718
IEA
PLAZA Integrative Orthologypositive regulation of epithelial to mesenchymal transition ENSG00000054598
GO:0010717
IEA
PLAZA Integrative Orthologyregulation of epithelial to mesenchymal transition ENSG00000054598
GO:0042476
IEA
PLAZA Integrative Orthologyodontogenesis ENSG00000054598
GO:2000181
IEA
PLAZA Integrative Orthologynegative regulation of blood vessel morphogenesis ENSG00000065970
GO:0042475
IEA
PLAZA Integrative Orthologyodontogenesis of dentin-containing tooth ENSG00000054598
GO:0034097
IEA
PLAZA Integrative Orthologyresponse to cytokine ENSG00000160973
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function ENSG00000160973
GO:0010469
IEA
PLAZA Integrative Orthologyregulation of signaling receptor activity ENSG00000160973
GO:0030858
IEA
PLAZA Integrative Orthologypositive regulation of epithelial cell differentiation ENSG00000054598
GO:0060837
IEA
PLAZA Integrative Orthologyblood vessel endothelial cell differentiation ENSG00000065970
GO:0030856
IEA
PLAZA Integrative Orthologyregulation of epithelial cell differentiation ENSG00000054598
GO:0009913
IEA
PLAZA Integrative Orthologyepidermal cell differentiation ENSG00000054598
GO:0030857
IEA
PLAZA Integrative Orthologynegative regulation of epithelial cell differentiation ENSG00000065970
GO:0071560
IEA
PLAZA Integrative Orthologycellular response to transforming growth factor beta stimulus ENSG00000160973
GO:0030216
IEA
PLAZA Integrative Orthologykeratinocyte differentiation ENSG00000054598
GO:0044093
IEA
PLAZA Integrative Orthologypositive regulation of molecular function ENSG00000054598
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle ENSG00000054598
GO:1904705
IEA
PLAZA Integrative Orthologyregulation of vascular smooth muscle cell proliferation ENSG00000065970
GO:0043433
IEA
PLAZA Integrative Orthologynegative regulation of DNA-binding transcription factor activity ENSG00000160973
GO:0009880
IEA
PLAZA Integrative Orthologyembryonic pattern specification FBgn0014143
GO:0045616
IEA
PLAZA Integrative Orthologyregulation of keratinocyte differentiation ENSG00000054598
GO:0045618
IEA
PLAZA Integrative Orthologypositive regulation of keratinocyte differentiation ENSG00000054598
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle ENSG00000054598
GO:0009755
IEA
PLAZA Integrative Orthologyhormone-mediated signaling pathway ENSG00000160973
GO:0045602
IEA
PLAZA Integrative Orthologynegative regulation of endothelial cell differentiation ENSG00000065970
GO:0045601
IEA
PLAZA Integrative Orthologyregulation of endothelial cell differentiation ENSG00000065970
GO:0002164
IEA
PLAZA Integrative Orthologylarval development WBGene00003976
GO:0045604
IEA
PLAZA Integrative Orthologyregulation of epidermal cell differentiation ENSG00000054598
GO:0007178
IEA
PLAZA Integrative Orthologytransmembrane receptor protein serine/threonine kinase signaling pathway ENSG00000160973
GO:0043388
IEA
PLAZA Integrative Orthologypositive regulation of DNA binding ENSG00000054598
GO:0045446
IEA
PLAZA Integrative Orthologyendothelial cell differentiation ENSG00000065970
GO:0008544
IEA
PLAZA Integrative Orthologyepidermis development ENSG00000054598
GO:0007179
IEA
PLAZA Integrative Orthologytransforming growth factor beta receptor signaling pathway ENSG00000160973
GO:0060322
IEA
PLAZA Integrative Orthologyhead development FBgn0014143
GO:0045606
IEA
PLAZA Integrative Orthologypositive regulation of epidermal cell differentiation ENSG00000054598
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000160973
GO:0045682
IEA
PLAZA Integrative Orthologyregulation of epidermis development ENSG00000054598
GO:2000824
IEA
PLAZA Integrative Orthologynegative regulation of androgen receptor activity ENSG00000160973
GO:0045684
IEA
PLAZA Integrative Orthologypositive regulation of epidermis development ENSG00000054598
GO:2000823
IEA
PLAZA Integrative Orthologyregulation of androgen receptor activity ENSG00000160973
GO:0030518
IEA
PLAZA Integrative Orthologyintracellular steroid hormone receptor signaling pathway ENSG00000160973
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000160973
GO:0110057
IEA
PLAZA Integrative Orthologyregulation of blood vessel endothelial cell differentiation ENSG00000065970
GO:0071383
IEA
PLAZA Integrative Orthologycellular response to steroid hormone stimulus ENSG00000160973
GO:0110059
IEA
PLAZA Integrative Orthologynegative regulation of blood vessel endothelial cell differentiation ENSG00000065970
GO:0048545
IEA
PLAZA Integrative Orthologyresponse to steroid hormone ENSG00000160973
GO:2000272
IEA
PLAZA Integrative Orthologynegative regulation of signaling receptor activity ENSG00000160973
GO:0071559
IEA
PLAZA Integrative Orthologyresponse to transforming growth factor beta ENSG00000160973
GO:0030522
IEA
PLAZA Integrative Orthologyintracellular receptor signaling pathway ENSG00000160973
GO:0030520
IEA
PLAZA Integrative Orthologyintracellular estrogen receptor signaling pathway ENSG00000160973
GO:0030521
IEA
PLAZA Integrative Orthologyandrogen receptor signaling pathway ENSG00000160973
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid ENSG00000160973
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid ENSG00000160973
GO:0048660
IEA
PLAZA Integrative Orthologyregulation of smooth muscle cell proliferation ENSG00000065970
GO:0048661
IEA
PLAZA Integrative Orthologypositive regulation of smooth muscle cell proliferation ENSG00000065970
GO:0048659
IEA
PLAZA Integrative Orthologysmooth muscle cell proliferation ENSG00000065970
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle ENSG00000054598
GO:0043401
IEA
PLAZA Integrative Orthologysteroid hormone mediated signaling pathway ENSG00000160973
GO:0007350
IEA
PLAZA Integrative Orthologyblastoderm segmentation FBgn0014143
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle ENSG00000054598
GO:0008284
IEA
PLAZA Integrative Orthologypositive regulation of cell proliferation ENSG00000065970
GO:0071407
IEA
PLAZA Integrative Orthologycellular response to organic cyclic compound ENSG00000160973
GO:0001837
IEA
PLAZA Integrative Orthologyepithelial to mesenchymal transition ENSG00000054598
GO:0051098
IEA
PLAZA Integrative Orthologyregulation of binding ENSG00000054598
GO:0071364
IEA
PLAZA Integrative Orthologycellular response to epidermal growth factor stimulus ENSG00000054598
GO:0071363
IEA
PLAZA Integrative Orthologycellular response to growth factor stimulus ENSG00000054598
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000160973
GO:0051099
IEA
PLAZA Integrative Orthologypositive regulation of binding ENSG00000054598
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000160973
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function ENSG00000054598
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000160973
GO:0014070
IEA
PLAZA Integrative Orthologyresponse to organic cyclic compound ENSG00000160973
GO:0045930
IEA
PLAZA Integrative Orthologynegative regulation of mitotic cell cycle ENSG00000054598
GO:0007380
IEA
PLAZA Integrative Orthologyspecification of segmental identity, head FBgn0014143
GO:0002119
IEA
PLAZA Integrative Orthologynematode larval development WBGene00003976
GO:0060766
IEA
PLAZA Integrative Orthologynegative regulation of androgen receptor signaling pathway ENSG00000160973
GO:0051090
IEA
PLAZA Integrative Orthologyregulation of DNA-binding transcription factor activity ENSG00000160973
GO:0007379
IEA
PLAZA Integrative Orthologysegment specification FBgn0014143
GO:0060765
IEA
PLAZA Integrative Orthologyregulation of androgen receptor signaling pathway ENSG00000160973
GO:0043588
IEA
PLAZA Integrative Orthologyskin development ENSG00000054598
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development WBGene00003976
GO:1901343
IEA
PLAZA Integrative Orthologynegative regulation of vasculature development ENSG00000065970
GO:0033143
IEA
PLAZA Integrative Orthologyregulation of intracellular steroid hormone receptor signaling pathway ENSG00000160973
GO:0033144
IEA
PLAZA Integrative Orthologynegative regulation of intracellular steroid hormone receptor signaling pathway ENSG00000160973
GO:0070848
IEA
PLAZA Integrative Orthologyresponse to growth factor ENSG00000054598
GO:0035287
IEA
PLAZA Integrative Orthologyhead segmentation FBgn0014143
GO:0070849
IEA
PLAZA Integrative Orthologyresponse to epidermal growth factor ENSG00000054598
GO:0016525
IEA
PLAZA Integrative Orthologynegative regulation of angiogenesis ENSG00000065970

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990841
ISS
Genome Projectpromoter-specific chromatin binding
GO:1990841
ISS
Gene Ontologypromoter-specific chromatin binding
GO:0044212
ISS
Genome Projecttranscription regulatory region DNA binding
GO:0044212
ISS
Gene Ontologytranscription regulatory region DNA binding
GO:0043565
IDA
Genome Projectsequence-specific DNA binding
GO:0043565
IDA
Gene Ontologysequence-specific DNA binding3
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding9
GO:0031490
IDA
Genome Projectchromatin DNA binding
GO:0031490
IDA
Gene Ontologychromatin DNA binding4
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding10
GO:0003700
IDA
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IDA
Gene OntologyDNA-binding transcription factor activity2
GO:0000981
ISA, ISM
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific11
GO:0001228
IDA
Gene OntologyDNA-binding transcription activator activity, RNA polymerase II-specific1
GO:0000978
IDA
Gene OntologyRNA polymerase II proximal promoter sequence-specific DNA binding1
GO:0000977
IDA
Gene OntologyRNA polymerase II regulatory region sequence-specific DNA binding1
GO:0035326
IEA
PLAZA Integrative Orthologyenhancer binding ENSG00000160973
GO:0070410
IEA
PLAZA Integrative Orthologyco-SMAD binding ENSG00000160973
GO:0070412
IEA
PLAZA Integrative OrthologyR-SMAD binding ENSG00000160973
GO:0046332
IEA
PLAZA Integrative OrthologySMAD binding ENSG00000160973
GO:0008134
IEA
PLAZA Integrative Orthologytranscription factor binding ENSG00000054598
GO:0043425
IEA
PLAZA Integrative OrthologybHLH transcription factor binding ENSG00000160973
GO:0008301
IEA
PLAZA Integrative OrthologyDNA binding, bending ENSG00000054598
GO:0005102
IEA
PLAZA Integrative Orthologysignaling receptor binding ENSG00000160973
GO:0051427
IEA
PLAZA Integrative Orthologyhormone receptor binding ENSG00000160973
GO:0035258
IEA
PLAZA Integrative Orthologysteroid hormone receptor binding ENSG00000160973
GO:0035257
IEA
PLAZA Integrative Orthologynuclear hormone receptor binding ENSG00000160973
GO:0050681
IEA
PLAZA Integrative Orthologyandrogen receptor binding ENSG00000160973
GO:0019904
IEA
PLAZA Integrative Orthologyprotein domain specific binding ENSG00000160973

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus3 12
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part ENSG00000054598
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000160973
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin ENSG00000054598
GO:0000792
IEA
PLAZA Integrative Orthologyheterochromatin ENSG00000054598
GO:0005720
IEA
PLAZA Integrative Orthologynuclear heterochromatin ENSG00000054598
GO:0000785
IEA
PLAZA Integrative Orthologychromatin ENSG00000054598
GO:0005829
IEA
PLAZA Integrative Orthologycytosol ENSG00000054598
GO:0005667
IEA
PLAZA Integrative Orthologytranscription factor complex ENSG00000160973
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm ENSG00000054598
GO:0001650
IEA
PLAZA Integrative Orthologyfibrillar center ENSG00000065970
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus ENSG00000065970
GO:0005694
IEA
PLAZA Integrative Orthologychromosome ENSG00000054598
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part ENSG00000054598
GO:0044452
IEA
PLAZA Integrative Orthologynucleolar part ENSG00000065970
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part ENSG00000054598
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome ENSG00000054598
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000054598
GO:0032444
IEA
PLAZA Integrative Orthologyactivin responsive factor complex ENSG00000160973
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000054598
GO:0044798
IEA
PLAZA Integrative Orthologynuclear transcription factor complex ENSG00000160973
GO:0090575
IEA
PLAZA Integrative OrthologyRNA polymerase II transcription factor complex ENSG00000160973

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001766Fork head domain
IPR011991ArsR-like helix-turn-helix domain
IPR018122Fork head domain conserved site1
IPR030456Fork head domain conserved site 2

No MapMan annotations defined for this gene.
KeggID Description
K09396FOXC; forkhead box protein C
No chloroplast target sequence found.