Gene: ENSG00000176170 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000176170
Transcript Identifier
ENST00000323374
Gene Type
Coding gene
Location
17 : 76385106-76387586 : positive

Family Information

Homologous gene family
HOM02SEM001656
(36 genes in 24 species)
specific family

Descriptions

gene_descr
sphingosine kinase 1

Identifiers

Type Value
pidENSP00000313681
HGNC11240
UniprotQ9NYA1
RefSeq_mRNANM_182965.2
EMBLCHEMBL4394
EMBLAC090699
EMBLAF200328
EMBLAF238083
EMBLAF266756
EMBLAJ245504
EMBLAK022402
EMBLAK023393
EMBLAK292294
EMBLBC009419
EMBLBC014439
EMBLBC030553
EMBLCH471099

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051092
IMP
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IMP
Gene Ontologypositive regulation of NF-kappaB transcription factor activity1
GO:0048146
IDA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048146
IDA
Gene Ontologypositive regulation of fibroblast proliferation2
GO:0046834
IEA
Genome Projectlipid phosphorylation
GO:0046521
NAS
Genome Projectsphingoid catabolic process
GO:0046521
NAS
Gene Ontologysphingoid catabolic process3
GO:0046512
IMP, IGI
Genome Projectsphingosine biosynthetic process
GO:0046512
IMP, IGI
Gene Ontologysphingosine biosynthetic process4
GO:0045987
IDA
Genome Projectpositive regulation of smooth muscle contraction
GO:0045987
IDA
Gene Ontologypositive regulation of smooth muscle contraction5
GO:0045931
IDA
Genome Projectpositive regulation of mitotic cell cycle
GO:0045931
IDA
Gene Ontologypositive regulation of mitotic cell cycle6
GO:0045766
IDA
Genome Projectpositive regulation of angiogenesis
GO:0045766
IDA
Gene Ontologypositive regulation of angiogenesis6
GO:0043066
IDA
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043066
IDA
TAS
Gene Ontologynegative regulation of apoptotic process2 7
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0035556
TAS
Gene Ontologyintracellular signal transduction7
GO:0032651
IEA
Genome Projectregulation of interleukin-1 beta production
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0031398
IDA
Gene Ontologypositive regulation of protein ubiquitination1
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0030335
IDA
Gene Ontologypositive regulation of cell migration6
GO:0030307
IDA
Genome Projectpositive regulation of cell growth
GO:0030307
IDA
Gene Ontologypositive regulation of cell growth6
GO:0030148
TAS
Genome Projectsphingolipid biosynthetic process
GO:0030148
TAS
Gene Ontologysphingolipid biosynthetic process
GO:0019722
IDA
Genome Projectcalcium-mediated signaling
GO:0019722
IDA
Gene Ontologycalcium-mediated signaling7
GO:0010803
IDA
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0010803
IDA
Gene Ontologyregulation of tumor necrosis factor-mediated signaling pathway1
GO:0010800
IMP
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0010800
IMP
Gene Ontologypositive regulation of peptidyl-threonine phosphorylation4
GO:0007420
IEA
Genome Projectbrain development
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction8
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006670
IDA
Genome Projectsphingosine metabolic process
GO:0006670
IDA
Gene Ontologysphingosine metabolic process1
GO:0006457
TAS
Genome Projectprotein folding
GO:0006457
TAS
Gene Ontologyprotein folding
GO:0003376
IEA
Genome Projectsphingosine-1-phosphate receptor signaling pathway
GO:0001568
IEA
Genome Projectblood vessel development
GO:1901224
IMP
Gene Ontologypositive regulation of NIK/NF-kappaB signaling1
GO:0071229
IEA
PLAZA Integrative Orthologycellular response to acid chemical AT4G21540
GO:0042493
IEA
PLAZA Integrative Orthologyresponse to drug WBGene00007918
GO:0019098
IEA
PLAZA Integrative Orthologyreproductive behavior FBgn0052484
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization WBGene00007918
GO:0009737
IEA
PLAZA Integrative Orthologyresponse to abscisic acid AT4G21534
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0052484
GO:0001101
IEA
PLAZA Integrative Orthologyresponse to acid chemical AT4G21534
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0052484
GO:2001025
IEA
PLAZA Integrative Orthologypositive regulation of response to drug WBGene00007918
GO:0098916
IEA
PLAZA Integrative Orthologyanterograde trans-synaptic signaling WBGene00007918
GO:2001023
IEA
PLAZA Integrative Orthologyregulation of response to drug WBGene00007918
GO:0032222
IEA
PLAZA Integrative Orthologyregulation of synaptic transmission, cholinergic WBGene00007918
GO:0032224
IEA
PLAZA Integrative Orthologypositive regulation of synaptic transmission, cholinergic WBGene00007918
GO:0097305
IEA
PLAZA Integrative Orthologyresponse to alcohol AT4G21534
GO:0097306
IEA
PLAZA Integrative Orthologycellular response to alcohol AT4G21540
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0052484
GO:0051588
IEA
PLAZA Integrative Orthologyregulation of neurotransmitter transport WBGene00007918
GO:0099177
IEA
PLAZA Integrative Orthologyregulation of trans-synaptic signaling WBGene00007918
GO:0090351
IEA
PLAZA Integrative Orthologyseedling development AT4G21540
GO:0051590
IEA
PLAZA Integrative Orthologypositive regulation of neurotransmitter transport WBGene00007918
GO:0015695
IEA
PLAZA Integrative Orthologyorganic cation transport WBGene00007918
GO:0015696
IEA
PLAZA Integrative Orthologyammonium transport WBGene00007918
GO:0060341
IEA
PLAZA Integrative Orthologyregulation of cellular localization WBGene00007918
GO:0007271
IEA
PLAZA Integrative Orthologysynaptic transmission, cholinergic WBGene00007918
GO:0032870
IEA
PLAZA Integrative Orthologycellular response to hormone stimulus AT4G21540
GO:0050804
IEA
PLAZA Integrative Orthologymodulation of chemical synaptic transmission WBGene00007918
GO:0009914
IEA
PLAZA Integrative Orthologyhormone transport WBGene00007918
GO:0006810
IEA
PLAZA Integrative Orthologytransport WBGene00007918
GO:0061526
IEA
PLAZA Integrative Orthologyacetylcholine secretion WBGene00007918
GO:0050806
IEA
PLAZA Integrative Orthologypositive regulation of synaptic transmission WBGene00007918
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0052484
GO:0018991
IEA
PLAZA Integrative Orthologyoviposition FBgn0052484
GO:0071215
IEA
PLAZA Integrative Orthologycellular response to abscisic acid stimulus AT4G21540
GO:0001505
IEA
PLAZA Integrative Orthologyregulation of neurotransmitter levels WBGene00007918
GO:0043270
IEA
PLAZA Integrative Orthologypositive regulation of ion transport WBGene00007918
GO:0051047
IEA
PLAZA Integrative Orthologypositive regulation of secretion WBGene00007918
GO:0051046
IEA
PLAZA Integrative Orthologyregulation of secretion WBGene00007918
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus YLR260W
GO:0007610
IEA
PLAZA Integrative Orthologybehavior FBgn0052484
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport WBGene00007918
GO:0043269
IEA
PLAZA Integrative Orthologyregulation of ion transport WBGene00007918
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound AT4G21534
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport WBGene00007918
GO:1901701
IEA
PLAZA Integrative Orthologycellular response to oxygen-containing compound AT4G21540
GO:0015870
IEA
PLAZA Integrative Orthologyacetylcholine transport WBGene00007918
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport WBGene00007918
GO:0051954
IEA
PLAZA Integrative Orthologypositive regulation of amine transport WBGene00007918
GO:0051952
IEA
PLAZA Integrative Orthologyregulation of amine transport WBGene00007918
GO:0099537
IEA
PLAZA Integrative Orthologytrans-synaptic signaling WBGene00007918
GO:0099536
IEA
PLAZA Integrative Orthologysynaptic signaling WBGene00007918
GO:1901374
IEA
PLAZA Integrative Orthologyacetate ester transport WBGene00007918
GO:0046887
IEA
PLAZA Integrative Orthologypositive regulation of hormone secretion WBGene00007918
GO:0014055
IEA
PLAZA Integrative Orthologyacetylcholine secretion, neurotransmission WBGene00007918
GO:0009266
IEA
PLAZA Integrative Orthologyresponse to temperature stimulus YLR260W
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport WBGene00007918
GO:0014056
IEA
PLAZA Integrative Orthologyregulation of acetylcholine secretion, neurotransmission WBGene00007918
GO:0014057
IEA
PLAZA Integrative Orthologypositive regulation of acetylcholine secretion, neurotransmission WBGene00007918
GO:0046928
IEA
PLAZA Integrative Orthologyregulation of neurotransmitter secretion WBGene00007918
GO:0032940
IEA
PLAZA Integrative Orthologysecretion by cell WBGene00007918
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid AT4G21534
GO:0007629
IEA
PLAZA Integrative Orthologyflight behavior FBgn0052484
GO:0046883
IEA
PLAZA Integrative Orthologyregulation of hormone secretion WBGene00007918
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid AT4G21540
GO:0007626
IEA
PLAZA Integrative Orthologylocomotory behavior FBgn0052484
GO:0006812
IEA
PLAZA Integrative Orthologycation transport WBGene00007918
GO:0006811
IEA
PLAZA Integrative Orthologyion transport WBGene00007918
GO:0009408
IEA
PLAZA Integrative Orthologyresponse to heat YLR260W
GO:0099643
IEA
PLAZA Integrative Orthologysignal release from synapse WBGene00007918
GO:0046879
IEA
PLAZA Integrative Orthologyhormone secretion WBGene00007918
GO:0015893
IEA
PLAZA Integrative Orthologydrug transport WBGene00007918
GO:0015837
IEA
PLAZA Integrative Orthologyamine transport WBGene00007918
GO:0030534
IEA
PLAZA Integrative Orthologyadult behavior FBgn0052484
GO:0001956
IEA
PLAZA Integrative Orthologypositive regulation of neurotransmitter secretion WBGene00007918
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus AT4G21534
GO:0007269
IEA
PLAZA Integrative Orthologyneurotransmitter secretion WBGene00007918
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone AT4G21534
GO:0009845
IEA
PLAZA Integrative Orthologyseed germination AT4G21540
GO:0007268
IEA
PLAZA Integrative Orthologychemical synaptic transmission WBGene00007918
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling WBGene00007918
GO:1903530
IEA
PLAZA Integrative Orthologyregulation of secretion by cell WBGene00007918
GO:1903532
IEA
PLAZA Integrative Orthologypositive regulation of secretion by cell WBGene00007918
GO:0046903
IEA
PLAZA Integrative Orthologysecretion WBGene00007918
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality WBGene00007918
GO:0051649
IEA
PLAZA Integrative Orthologyestablishment of localization in cell WBGene00007918
GO:0071495
IEA
PLAZA Integrative Orthologycellular response to endogenous stimulus AT4G21540
GO:0023061
IEA
PLAZA Integrative Orthologysignal release WBGene00007918
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization WBGene00007918
GO:0006836
IEA
PLAZA Integrative Orthologyneurotransmitter transport WBGene00007918
GO:0010817
IEA
PLAZA Integrative Orthologyregulation of hormone levels WBGene00007918
GO:0008344
IEA
PLAZA Integrative Orthologyadult locomotory behavior FBgn0052484
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development AT4G21540

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051721
IPI
Genome Projectprotein phosphatase 2A binding
GO:0051721
IPI
Gene Ontologyprotein phosphatase 2A binding9
GO:0038036
IMP
Genome Projectsphingosine-1-phosphate receptor activity
GO:0038036
IMP
Gene Ontologysphingosine-1-phosphate receptor activity4
GO:0017050
IDA
TAS
Genome ProjectD-erythro-sphingosine kinase activity
GO:0017050
IDA
TAS
Gene OntologyD-erythro-sphingosine kinase activity1 3
GO:0008481
IDA
TAS
Genome Projectsphinganine kinase activity
GO:0008481
IDA
TAS
Gene Ontologysphinganine kinase activity2 10
GO:0005524
IDA
Genome ProjectATP binding
GO:0005524
IDA
Gene OntologyATP binding10
GO:0005516
IDA
Genome Projectcalmodulin binding
GO:0005516
IDA
Gene Ontologycalmodulin binding7 10
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding11 12 13 14 15 16
GO:0003951
IEA
Genome ProjectNAD+ kinase activity
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding10
GO:0000287
IDA
ISS
Genome Projectmagnesium ion binding
GO:0000287
IDA
ISS
Gene Ontologymagnesium ion binding7
GO:0005543
IEA
PLAZA Integrative Orthologyphospholipid binding AT4G21534
GO:0070300
IEA
PLAZA Integrative Orthologyphosphatidic acid binding AT4G21534
GO:0008289
IEA
PLAZA Integrative Orthologylipid binding AT4G21534

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane9 15
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol3
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm2 9 15
GO:0005634
IEA
Genome Projectnucleus
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane AT4G21540
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system YLR260W
GO:0005938
IEA
PLAZA Integrative Orthologycell cortex YOR171C
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane AT4G21540
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part WBGene00007918
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part AT4G21540
GO:0005783
IEA
PLAZA Integrative Orthologyendoplasmic reticulum YOR171C
GO:0099568
IEA
PLAZA Integrative Orthologycytoplasmic region YOR171C
GO:0042995
IEA
PLAZA Integrative Orthologycell projection WBGene00007918
GO:0005773
IEA
PLAZA Integrative Orthologyvacuole AT4G21540
GO:0005774
IEA
PLAZA Integrative Orthologyvacuolar membrane AT4G21540
GO:0098827
IEA
PLAZA Integrative Orthologyendoplasmic reticulum subcompartment YOR171C
GO:0097458
IEA
PLAZA Integrative Orthologyneuron part WBGene00007918
GO:0097060
IEA
PLAZA Integrative Orthologysynaptic membrane WBGene00007918
GO:0120025
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection WBGene00007918
GO:0043025
IEA
PLAZA Integrative Orthologyneuronal cell body WBGene00007918
GO:0045202
IEA
PLAZA Integrative Orthologysynapse WBGene00007918
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus YLR260W
GO:0042734
IEA
PLAZA Integrative Orthologypresynaptic membrane WBGene00007918
GO:0071782
IEA
PLAZA Integrative Orthologyendoplasmic reticulum tubular network YOR171C
GO:0000323
IEA
PLAZA Integrative Orthologylytic vacuole FBgn0052484
GO:0036062
IEA
PLAZA Integrative Orthologypresynaptic periactive zone WBGene00007918
GO:0000325
IEA
PLAZA Integrative Orthologyplant-type vacuole AT4G21540
GO:0032541
IEA
PLAZA Integrative Orthologycortical endoplasmic reticulum YOR171C
GO:0098793
IEA
PLAZA Integrative Orthologypresynapse WBGene00007918
GO:0043005
IEA
PLAZA Integrative Orthologyneuron projection WBGene00007918
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part WBGene00007918
GO:0044456
IEA
PLAZA Integrative Orthologysynapse part WBGene00007918
GO:0036477
IEA
PLAZA Integrative Orthologysomatodendritic compartment WBGene00007918
GO:0031984
IEA
PLAZA Integrative Orthologyorganelle subcompartment YOR171C
GO:0044297
IEA
PLAZA Integrative Orthologycell body WBGene00007918
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle AT4G21540
GO:0005764
IEA
PLAZA Integrative Orthologylysosome FBgn0052484
GO:0044448
IEA
PLAZA Integrative Orthologycell cortex part YOR171C
GO:0005765
IEA
PLAZA Integrative Orthologylysosomal membrane FBgn0052484
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part AT4G21540
GO:0098590
IEA
PLAZA Integrative Orthologyplasma membrane region WBGene00007918
GO:0030424
IEA
PLAZA Integrative Orthologyaxon WBGene00007918
GO:0098852
IEA
PLAZA Integrative Orthologylytic vacuole membrane FBgn0052484
GO:0009705
IEA
PLAZA Integrative Orthologyplant-type vacuole membrane AT4G21540
GO:0044437
IEA
PLAZA Integrative Orthologyvacuolar part AT4G21540
GO:0044432
IEA
PLAZA Integrative Orthologyendoplasmic reticulum part YOR171C

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001206Diacylglycerol kinase, catalytic domain
IPR016064NAD kinase/diacylglycerol kinase-like domain superfamily
IPR017438Inorganic polyphosphate/ATP-NAD kinase, N-terminal

No MapMan annotations defined for this gene.
KeggID Description
K04718SPHK; sphingosine kinase [EC:2.7.1.91]
No chloroplast target sequence found.