Gene: ENSG00000174405 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000174405
Transcript Identifier
ENST00000356922
Gene Type
Coding gene
Location
13 : 108208533-108211268 : negative

Family Information

Homologous gene family
HOM02SEM000528
(73 genes in 26 species)
specific family

Descriptions

gene_descr
ligase IV, DNA, ATP-dependent

Identifiers

Type Value
pidENSP00000349393
HGNC6601
UniprotP49917
UniprotA0A024RE06
RefSeq_mRNANM_002312.3
EMBLAF479264
EMBLAL157762
EMBLBC037491
EMBLCH471085
EMBLX83441

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006273
IBA
Genome Projectlagging strand elongation
GO:2001252
IMP
Genome Projectpositive regulation of chromosome organization
GO:2001252
IMP
Gene Ontologypositive regulation of chromosome organization1
GO:0097680
IMP
Genome Projectdouble-strand break repair via classical nonhomologous end joining
GO:0097680
IMP
Gene Ontologydouble-strand break repair via classical nonhomologous end joining2
GO:0075713
TAS
Genome Projectestablishment of integrated proviral latency
GO:0075713
TAS
Gene Ontologyestablishment of integrated proviral latency
GO:0071897
IEA
Genome ProjectDNA biosynthetic process
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0051402
ISS
Genome Projectneuron apoptotic process
GO:0051402
ISS
Gene Ontologyneuron apoptotic process
GO:0051301
IEA
Genome Projectcell division
GO:0051276
ISS
Genome Projectchromosome organization
GO:0051276
ISS
Gene Ontologychromosome organization
GO:0051103
IDA
ISS
Genome ProjectDNA ligation involved in DNA repair
GO:0051103
IDA
ISS
Gene OntologyDNA ligation involved in DNA repair3
GO:0051102
ISS
Genome ProjectDNA ligation involved in DNA recombination
GO:0051102
ISS
Gene OntologyDNA ligation involved in DNA recombination
GO:0050769
ISS
Genome Projectpositive regulation of neurogenesis
GO:0050769
ISS
Gene Ontologypositive regulation of neurogenesis
GO:0048146
ISS
Genome Projectpositive regulation of fibroblast proliferation
GO:0048146
ISS
Gene Ontologypositive regulation of fibroblast proliferation
GO:0045190
ISS
Genome Projectisotype switching
GO:0045190
ISS
Gene Ontologyisotype switching
GO:0043524
ISS
Genome Projectnegative regulation of neuron apoptotic process
GO:0043524
ISS
Gene Ontologynegative regulation of neuron apoptotic process
GO:0035019
ISS
Genome Projectsomatic stem cell population maintenance
GO:0035019
ISS
Gene Ontologysomatic stem cell population maintenance
GO:0033153
ISS
Genome ProjectT cell receptor V(D)J recombination
GO:0033153
ISS
Gene OntologyT cell receptor V(D)J recombination
GO:0033152
IBA
Genome Projectimmunoglobulin V(D)J recombination
GO:0033151
IDA
Genome ProjectV(D)J recombination
GO:0033151
IDA
Gene OntologyV(D)J recombination4
GO:0033077
ISS
Genome ProjectT cell differentiation in thymus
GO:0033077
ISS
Gene OntologyT cell differentiation in thymus
GO:0010332
ISS
Genome Projectresponse to gamma radiation
GO:0010332
ISS
Gene Ontologyresponse to gamma radiation
GO:0010165
IMP
Genome Projectresponse to X-ray
GO:0010165
IMP
Gene Ontologyresponse to X-ray4
GO:0008283
ISS
Genome Projectcell proliferation
GO:0008283
ISS
Gene Ontologycell proliferation
GO:0007417
ISS
Genome Projectcentral nervous system development
GO:0007417
ISS
Gene Ontologycentral nervous system development
GO:0007049
IEA
Genome Projectcell cycle
GO:0006303
IDA, IMP, IGI
ISS
TAS
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0006303
IDA, IMP, IGI
ISS
TAS
Gene Ontologydouble-strand break repair via nonhomologous end joining1 3 4
GO:0006302
IDA
ISS
Genome Projectdouble-strand break repair
GO:0006302
IDA
ISS
Gene Ontologydouble-strand break repair5 6
GO:0006297
IDA
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
IDA
Gene Ontologynucleotide-excision repair, DNA gap filling3
GO:0006266
IDA
Genome ProjectDNA ligation
GO:0006266
IDA
Gene OntologyDNA ligation3
GO:0002328
ISS
Genome Projectpro-B cell differentiation
GO:0002328
ISS
Gene Ontologypro-B cell differentiation
GO:0001701
ISS
Genome Projectin utero embryonic development
GO:0001701
ISS
Gene Ontologyin utero embryonic development
GO:0000012
IDA
Genome Projectsingle strand break repair
GO:0000012
IDA
Gene Ontologysingle strand break repair7
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality AT5G57160
GO:0015074
IEA
PLAZA Integrative OrthologyDNA integration AT5G57160
GO:0000723
IEA
PLAZA Integrative Orthologytelomere maintenance AT5G57160
GO:0007568
IEA
PLAZA Integrative Orthologyaging YOR005C
GO:0001302
IEA
PLAZA Integrative Orthologyreplicative cell aging YOR005C
GO:0007569
IEA
PLAZA Integrative Orthologycell aging YOR005C
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis AT5G57160
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process AT5G57160
GO:0032200
IEA
PLAZA Integrative Orthologytelomere organization AT5G57160

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0016874
IDA
Genome Projectligase activity
GO:0016874
IDA
Gene Ontologyligase activity5
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0008022
IPI
Gene Ontologyprotein C-terminus binding8
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 5 9 10 11 12 13 14 15 16 17 18 19 20
GO:0003910
IDA
Genome ProjectDNA ligase (ATP) activity
GO:0003910
IDA
Gene OntologyDNA ligase (ATP) activity7 21
GO:0003909
IDA
TAS
Genome ProjectDNA ligase activity
GO:0003909
IDA
TAS
Gene OntologyDNA ligase activity3
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding7

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070419
IDA
Genome Projectnonhomologous end joining complex
GO:0070419
IDA
Gene Ontologynonhomologous end joining complex22 23
GO:0032807
IMP
Genome ProjectDNA ligase IV complex
GO:0032807
IMP
Gene OntologyDNA ligase IV complex4
GO:0005958
IDA
ISS
Genome ProjectDNA-dependent protein kinase-DNA ligase 4 complex
GO:0005958
IDA
ISS
Gene OntologyDNA-dependent protein kinase-DNA ligase 4 complex24
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005829
IDA
Genome Projectcytosol
GO:0005737
IBA
Genome Projectcytoplasm
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus7 8
GO:0000793
IDA
Genome Projectcondensed chromosome
GO:0000793
IDA
Gene Ontologycondensed chromosome8
GO:0000784
IC
Genome Projectnuclear chromosome, telomeric region
GO:0000784
IC
Gene Ontologynuclear chromosome, telomeric region1
GO:0036464
IDA
Gene Ontologycytoplasmic ribonucleoprotein granule
GO:0055044
IEA
PLAZA Integrative Orthologysymplast AT5G57160
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus SPCC1183.05c
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region AT5G57160
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPCC1183.05c
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPCC1183.05c
GO:0009506
IEA
PLAZA Integrative Orthologyplasmodesma AT5G57160
GO:0005911
IEA
PLAZA Integrative Orthologycell-cell junction AT5G57160
GO:0048046
IEA
PLAZA Integrative Orthologyapoplast AT5G57160

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000977DNA ligase, ATP-dependent
IPR001357BRCT domain
IPR012308DNA ligase, ATP-dependent, N-terminal
IPR012309DNA ligase, ATP-dependent, C-terminal
IPR012310DNA ligase, ATP-dependent, central
IPR012340Nucleic acid-binding, OB-fold
IPR016059DNA ligase, ATP-dependent, conserved site
IPR021536DNA ligase IV domain
IPR029710DNA ligase 4

No MapMan annotations defined for this gene.
KeggID Description
K10777LIG4, DNL4; DNA ligase 4
No chloroplast target sequence found.