Gene: ENSG00000174371 (Homo sapiens)

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Gene Identifier
ENSG00000174371
Transcript Identifier
ENST00000348581
Gene Type
Coding gene
Location
1 : 241850426-241889600 : positive

Family Information

Homologous gene family
HOM02SEM001637
(36 genes in 19 species)
specific family

Descriptions

gene_descr
exonuclease 1

Identifiers

Type Value
pidENSP00000311873
HGNC3511
UniprotQ9UQ84
RefSeq_mRNANM_006027.4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1901796
TAS
Genome Projectregulation of signal transduction by p53 class mediator
GO:0090656
TAS
Genome Projectt-circle formation
GO:0090656
TAS
Gene Ontologyt-circle formation1
GO:0090502
IEA
Genome ProjectRNA phosphodiester bond hydrolysis, endonucleolytic
GO:0051321
IEA
Genome Projectmeiotic cell cycle
GO:0045190
IEA
Genome Projectisotype switching
GO:0016446
IEA
Genome Projectsomatic hypermutation of immunoglobulin genes
GO:0006310
IGI
Genome ProjectDNA recombination
GO:0006310
IGI
Gene OntologyDNA recombination2
GO:0006298
IDA, IPI, IMP
ISS
TAS
Genome Projectmismatch repair
GO:0006298
IDA, IPI, IMP
ISS
TAS
Gene Ontologymismatch repair3 4 5 6
GO:0006281
TAS
Genome ProjectDNA repair
GO:0006281
TAS
Gene OntologyDNA repair2
GO:0006260
TAS
Genome ProjectDNA replication
GO:0006260
TAS
Gene OntologyDNA replication
GO:0002455
IEA
Genome Projecthumoral immune response mediated by circulating immunoglobulin
GO:0000732
TAS
Genome Projectstrand displacement
GO:0000731
TAS
Genome ProjectDNA synthesis involved in DNA repair
GO:0033260
IEA
PLAZA Integrative Orthologynuclear DNA replication SPBC29A10.05
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process SPBC29A10.05
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process SPBC29A10.05
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process SPBC29A10.05
GO:0045005
IEA
PLAZA Integrative OrthologyDNA-dependent DNA replication maintenance of fidelity SPBC29A10.05
GO:0007531
IEA
PLAZA Integrative Orthologymating type determination YOR033C
GO:0007530
IEA
PLAZA Integrative Orthologysex determination YOR033C
GO:0007533
IEA
PLAZA Integrative Orthologymating type switching YOR033C
GO:0007534
IEA
PLAZA Integrative Orthologygene conversion at mating-type locus YOR033C
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction YOR033C
GO:0110025
IEA
PLAZA Integrative OrthologyDNA strand resection involved in replication fork processing SPBC29A10.05
GO:0000706
IEA
PLAZA Integrative Orthologymeiotic DNA double-strand break processing SPBC29A10.05
GO:1903211
IEA
PLAZA Integrative Orthologymitotic recombination involved in replication fork processing SPBC29A10.05
GO:0035822
IEA
PLAZA Integrative Orthologygene conversion YOR033C
GO:0031860
IEA
PLAZA Integrative Orthologytelomeric 3' overhang formation YOR033C
GO:0006261
IEA
PLAZA Integrative OrthologyDNA-dependent DNA replication SPBC29A10.05
GO:1902298
IEA
PLAZA Integrative Orthologycell cycle DNA replication maintenance of fidelity SPBC29A10.05
GO:0000710
IEA
PLAZA Integrative Orthologymeiotic mismatch repair SPBC29A10.05
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle SPBC29A10.05
GO:0006302
IEA
PLAZA Integrative Orthologydouble-strand break repair SPBC29A10.05
GO:1902969
IEA
PLAZA Integrative Orthologymitotic DNA replication SPBC29A10.05
GO:0032505
IEA
PLAZA Integrative Orthologyreproduction of a single-celled organism YOR033C
GO:0043570
IEA
PLAZA Integrative Orthologymaintenance of DNA repeat elements SPBC29A10.05
GO:1990426
IEA
PLAZA Integrative Orthologymitotic recombination-dependent replication fork processing SPBC29A10.05
GO:1990505
IEA
PLAZA Integrative Orthologymitotic DNA replication maintenance of fidelity SPBC29A10.05
GO:0031297
IEA
PLAZA Integrative Orthologyreplication fork processing SPBC29A10.05
GO:0016233
IEA
PLAZA Integrative Orthologytelomere capping YOR033C
GO:0031292
IEA
PLAZA Integrative Orthologygene conversion at mating-type locus, DNA double-strand break processing YOR033C
GO:0061982
IEA
PLAZA Integrative Orthologymeiosis I cell cycle process SPBC29A10.05
GO:0000729
IEA
PLAZA Integrative OrthologyDNA double-strand break processing SPBC29A10.05
GO:0022616
IEA
PLAZA Integrative OrthologyDNA strand elongation YOR033C
GO:0022413
IEA
PLAZA Integrative Orthologyreproductive process in single-celled organism YOR033C
GO:0044786
IEA
PLAZA Integrative Orthologycell cycle DNA replication SPBC29A10.05
GO:0006312
IEA
PLAZA Integrative Orthologymitotic recombination SPBC29A10.05
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process YOR033C
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment YOR033C
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation YOR033C

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051908
IDA
Genome Projectdouble-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0051908
IDA
Gene Ontologydouble-stranded DNA 5'-3' exodeoxyribonuclease activity7 8
GO:0048256
IDA
Genome Projectflap endonuclease activity
GO:0048256
IDA
Gene Ontologyflap endonuclease activity7 8
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0045145
IDA
Genome Projectsingle-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0045145
IDA
Gene Ontologysingle-stranded DNA 5'-3' exodeoxyribonuclease activity7
GO:0035312
IDA
Genome Project5'-3' exodeoxyribonuclease activity
GO:0035312
IDA
Gene Ontology5'-3' exodeoxyribonuclease activity7
GO:0008409
ISS
TAS
Genome Project5'-3' exonuclease activity
GO:0008409
ISS
TAS
Gene Ontology5'-3' exonuclease activity3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 9 10 11 12 13 14 15 16 17 18
GO:0004527
TAS
Genome Projectexonuclease activity
GO:0004527
TAS
Gene Ontologyexonuclease activity4
GO:0004523
TAS
Genome ProjectRNA-DNA hybrid ribonuclease activity
GO:0004523
TAS
Gene OntologyRNA-DNA hybrid ribonuclease activity2
GO:0003682
IEA
Genome Projectchromatin binding
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding8
GO:0016888
IEA
PLAZA Integrative Orthologyendodeoxyribonuclease activity, producing 5'-phosphomonoesters YOR033C
GO:0003690
IEA
PLAZA Integrative Orthologydouble-stranded DNA binding SPBC29A10.05
GO:0017108
IEA
PLAZA Integrative Orthology5'-flap endonuclease activity YOR033C

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus12 14
GO:0005886
IDA
Gene Ontologyplasma membrane
GO:0090734
IEA
PLAZA Integrative Orthologysite of DNA damage SPBC29A10.05
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton SPBC29A10.05
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle SPBC29A10.05
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle SPBC29A10.05
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part YDR263C
GO:0035861
IEA
PLAZA Integrative Orthologysite of double-strand break SPBC29A10.05
GO:0005694
IEA
PLAZA Integrative Orthologychromosome SPBC29A10.05
GO:0072686
IEA
PLAZA Integrative Orthologymitotic spindle SPBC29A10.05
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part SPBC29A10.05
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton SPBC29A10.05
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm YDR263C
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part SPBC29A10.05
GO:0005739
IEA
PLAZA Integrative Orthologymitochondrion YDR263C
GO:0005819
IEA
PLAZA Integrative Orthologyspindle SPBC29A10.05

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006084XPG/Rad2 endonuclease
IPR006085XPG N-terminal
IPR006086XPG-I domain
IPR008918Helix-hairpin-helix motif, class 2
IPR019974XPG conserved site
IPR020045DNA polymerase I-like, H3TH domain
IPR029060PIN-like domain superfamily
IPR032641Exonuclease 1

No MapMan annotations defined for this gene.
KeggID Description
K10746EXO1; exonuclease 1 [EC:3.1.-.-]
No chloroplast target sequence found.