Gene: ENSG00000173334 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000173334
Transcript Identifier
ENST00000311922
Gene Type
Coding gene
Location
8 : 125430903-125436471 : positive

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM014057
(4 genes in 2 species)
specific family

Descriptions

gene_descr
tribbles pseudokinase 1

Identifiers

Type Value
pidENSP00000312150
HGNC16891
UniprotQ96RU8
RefSeq_mRNANM_025195.3
EMBLAC091114
EMBLAF205437
EMBLAF250310
EMBLAJ000480
EMBLAK297539
EMBLAL832388
EMBLBC063292
EMBLCH471060
EMBLFJ515869

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
TAS
Genome Projectprotein phosphorylation
GO:0006468
TAS
Gene Ontologyprotein phosphorylation1
GO:0048662
IMP
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0048662
IMP
Gene Ontologynegative regulation of smooth muscle cell proliferation2
GO:0045659
IEA
Genome Projectnegative regulation of neutrophil differentiation
GO:0045651
IEA
Genome Projectpositive regulation of macrophage differentiation
GO:0045645
IEA
Genome Projectpositive regulation of eosinophil differentiation
GO:0043433
IMP
ISS
Genome Projectnegative regulation of DNA-binding transcription factor activity
GO:0043433
IMP
ISS
Gene Ontologynegative regulation of DNA-binding transcription factor activity3 4
GO:0043405
IDA
Genome Projectregulation of MAP kinase activity
GO:0043405
IDA
Gene Ontologyregulation of MAP kinase activity3
GO:0032496
IMP
ISS
Genome Projectresponse to lipopolysaccharide
GO:0032496
IMP
ISS
Gene Ontologyresponse to lipopolysaccharide2 4
GO:0032436
ISS, IBA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
ISS
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process1
GO:0031665
IMP
Genome Projectnegative regulation of lipopolysaccharide-mediated signaling pathway
GO:0031665
IMP
Gene Ontologynegative regulation of lipopolysaccharide-mediated signaling pathway2
GO:0014912
IMP
Genome Projectnegative regulation of smooth muscle cell migration
GO:0014912
IMP
Gene Ontologynegative regulation of smooth muscle cell migration2
GO:0007254
IMP
Genome ProjectJNK cascade
GO:0007254
IMP
Gene OntologyJNK cascade2
GO:0006469
IMP
Genome Projectnegative regulation of protein kinase activity
GO:0006469
IMP
Gene Ontologynegative regulation of protein kinase activity3
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process FBgn0028978
GO:0032613
IEA
PLAZA Integrative Orthologyinterleukin-10 production ENSG00000071575
GO:0045081
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-10 biosynthetic process ENSG00000071575
GO:0048598
IEA
PLAZA Integrative Orthologyembryonic morphogenesis FBgn0028978
GO:0051235
IEA
PLAZA Integrative Orthologymaintenance of location FBgn0028978
GO:0042091
IEA
PLAZA Integrative Orthologyinterleukin-10 biosynthetic process ENSG00000071575
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle FBgn0028978
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization FBgn0028978
GO:1901698
IEA
PLAZA Integrative Orthologyresponse to nitrogen compound FBgn0028978
GO:0007167
IEA
PLAZA Integrative Orthologyenzyme linked receptor protein signaling pathway FBgn0028978
GO:1901699
IEA
PLAZA Integrative Orthologycellular response to nitrogen compound FBgn0028978
GO:0007169
IEA
PLAZA Integrative Orthologytransmembrane receptor protein tyrosine kinase signaling pathway FBgn0028978
GO:0042089
IEA
PLAZA Integrative Orthologycytokine biosynthetic process ENSG00000071575
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization FBgn0028978
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process ENSG00000071575
GO:0032868
IEA
PLAZA Integrative Orthologyresponse to insulin FBgn0028978
GO:0032869
IEA
PLAZA Integrative Orthologycellular response to insulin stimulus FBgn0028978
GO:0045074
IEA
PLAZA Integrative Orthologyregulation of interleukin-10 biosynthetic process ENSG00000071575
GO:1901566
IEA
PLAZA Integrative Orthologyorganonitrogen compound biosynthetic process ENSG00000071575
GO:1902532
IEA
PLAZA Integrative Orthologynegative regulation of intracellular signal transduction FBgn0028978
GO:1900077
IEA
PLAZA Integrative Orthologynegative regulation of cellular response to insulin stimulus FBgn0028978
GO:0008361
IEA
PLAZA Integrative Orthologyregulation of cell size FBgn0028978
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization FBgn0028978
GO:1900076
IEA
PLAZA Integrative Orthologyregulation of cellular response to insulin stimulus FBgn0028978
GO:0032870
IEA
PLAZA Integrative Orthologycellular response to hormone stimulus FBgn0028978
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis FBgn0028978
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization FBgn0028978
GO:0042593
IEA
PLAZA Integrative Orthologyglucose homeostasis FBgn0028978
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process FBgn0028978
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle FBgn0028978
GO:0043434
IEA
PLAZA Integrative Orthologyresponse to peptide hormone FBgn0028978
GO:0042107
IEA
PLAZA Integrative Orthologycytokine metabolic process ENSG00000071575
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle FBgn0028978
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission FBgn0028978
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process FBgn0028978
GO:0010883
IEA
PLAZA Integrative Orthologyregulation of lipid storage FBgn0028978
GO:0010004
IEA
PLAZA Integrative Orthologygastrulation involving germ band extension FBgn0028978
GO:0010243
IEA
PLAZA Integrative Orthologyresponse to organonitrogen compound FBgn0028978
GO:0032535
IEA
PLAZA Integrative Orthologyregulation of cellular component size FBgn0028978
GO:0001818
IEA
PLAZA Integrative Orthologynegative regulation of cytokine production ENSG00000071575
GO:0001817
IEA
PLAZA Integrative Orthologyregulation of cytokine production ENSG00000071575
GO:0010888
IEA
PLAZA Integrative Orthologynegative regulation of lipid storage FBgn0028978
GO:0001816
IEA
PLAZA Integrative Orthologycytokine production ENSG00000071575
GO:0032653
IEA
PLAZA Integrative Orthologyregulation of interleukin-10 production ENSG00000071575
GO:0033500
IEA
PLAZA Integrative Orthologycarbohydrate homeostasis FBgn0028978
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process ENSG00000071575
GO:1901652
IEA
PLAZA Integrative Orthologyresponse to peptide FBgn0028978
GO:1901653
IEA
PLAZA Integrative Orthologycellular response to peptide FBgn0028978
GO:0007088
IEA
PLAZA Integrative Orthologyregulation of mitotic nuclear division FBgn0028978
GO:0045839
IEA
PLAZA Integrative Orthologynegative regulation of mitotic nuclear division FBgn0028978
GO:0010876
IEA
PLAZA Integrative Orthologylipid localization FBgn0028978
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division FBgn0028978
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division FBgn0028978
GO:0010639
IEA
PLAZA Integrative Orthologynegative regulation of organelle organization FBgn0028978
GO:0045793
IEA
PLAZA Integrative Orthologypositive regulation of cell size FBgn0028978
GO:0051784
IEA
PLAZA Integrative Orthologynegative regulation of nuclear division FBgn0028978
GO:0043491
IEA
PLAZA Integrative Orthologyprotein kinase B signaling FBgn0028978
GO:0051783
IEA
PLAZA Integrative Orthologyregulation of nuclear division FBgn0028978
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle FBgn0028978
GO:0042036
IEA
PLAZA Integrative Orthologynegative regulation of cytokine biosynthetic process ENSG00000071575
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0028978
GO:0042035
IEA
PLAZA Integrative Orthologyregulation of cytokine biosynthetic process ENSG00000071575
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle FBgn0028978
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process ENSG00000071575
GO:0008286
IEA
PLAZA Integrative Orthologyinsulin receptor signaling pathway FBgn0028978
GO:0051898
IEA
PLAZA Integrative Orthologynegative regulation of protein kinase B signaling FBgn0028978
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus FBgn0028978
GO:0010948
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle process FBgn0028978
GO:0051896
IEA
PLAZA Integrative Orthologyregulation of protein kinase B signaling FBgn0028978
GO:0046627
IEA
PLAZA Integrative Orthologynegative regulation of insulin receptor signaling pathway FBgn0028978
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone FBgn0028978
GO:0046626
IEA
PLAZA Integrative Orthologyregulation of insulin receptor signaling pathway FBgn0028978
GO:1905953
IEA
PLAZA Integrative Orthologynegative regulation of lipid localization FBgn0028978
GO:0090066
IEA
PLAZA Integrative Orthologyregulation of anatomical structure size FBgn0028978
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis FBgn0028978
GO:0045930
IEA
PLAZA Integrative Orthologynegative regulation of mitotic cell cycle FBgn0028978
GO:1905952
IEA
PLAZA Integrative Orthologyregulation of lipid localization FBgn0028978
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality FBgn0028978
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0028978
GO:0071417
IEA
PLAZA Integrative Orthologycellular response to organonitrogen compound FBgn0028978
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization FBgn0028978
GO:0071375
IEA
PLAZA Integrative Orthologycellular response to peptide hormone stimulus FBgn0028978
GO:0001703
IEA
PLAZA Integrative Orthologygastrulation with mouth forming first FBgn0028978
GO:0071495
IEA
PLAZA Integrative Orthologycellular response to endogenous stimulus FBgn0028978
GO:0048878
IEA
PLAZA Integrative Orthologychemical homeostasis FBgn0028978
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process FBgn0028978
GO:0032693
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-10 production ENSG00000071575
GO:0019915
IEA
PLAZA Integrative Orthologylipid storage FBgn0028978
GO:0007370
IEA
PLAZA Integrative Orthologyventral furrow formation FBgn0028978
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development FBgn0028978

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
TAS
Genome ProjectATP binding
GO:0005524
TAS
Gene OntologyATP binding1
GO:0004672
TAS
Genome Projectprotein kinase activity
GO:0004672
TAS
Gene Ontologyprotein kinase activity1
GO:0055106
ISS
Genome Projectubiquitin-protein transferase regulator activity
GO:0055106
ISS
Gene Ontologyubiquitin-protein transferase regulator activity1
GO:0031625
ISS
Genome Projectubiquitin protein ligase binding
GO:0031625
ISS
Gene Ontologyubiquitin protein ligase binding1
GO:0031434
IDA
Genome Projectmitogen-activated protein kinase kinase binding
GO:0031434
IDA
Gene Ontologymitogen-activated protein kinase kinase binding2 3
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding4
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5
GO:0004860
IMP
Genome Projectprotein kinase inhibitor activity
GO:0004860
IMP
Gene Ontologyprotein kinase inhibitor activity3
GO:0042803
IEA
PLAZA Integrative Orthologyprotein homodimerization activity FBgn0028978
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding FBgn0028978
GO:0004674
IEA
PLAZA Integrative Orthologyprotein serine/threonine kinase activity FBgn0028978
GO:0046983
IEA
PLAZA Integrative Orthologyprotein dimerization activity FBgn0028978
GO:0046982
IEA
PLAZA Integrative Orthologyprotein heterodimerization activity FBgn0028978

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm2
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus2
GO:0005829
IEA
PLAZA Integrative Orthologycytosol FBgn0028978
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part FBgn0028978

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR011009Protein kinase-like domain superfamily
IPR024104Pseudokinase tribbles family/serine-threonine-protein kinase 40
IPR024105Tribbles homologue 1

No MapMan annotations defined for this gene.
KeggID Description
K08814TRIB1_2; tribbles homolog 1/2
No chloroplast target sequence found.