Gene: ENSG00000172071 (Homo sapiens)

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Gene Identifier
ENSG00000172071
Transcript Identifier
ENST00000303236
Gene Type
Coding gene
Location
2 : 88557736-88627274 : negative

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family

Descriptions

gene_descr
eukaryotic translation initiation factor 2-alpha kinase 3

Identifiers

Type Value
pidENSP00000307235
HGNC3255
UniprotQ9NZJ5
RefSeq_mRNANM_004836.5
EMBLCHEMBL6030
EMBLAC062029
EMBLAC104134
EMBLAF110146
EMBLAF193339
EMBLAF284604
EMBLAF284605
EMBLAF284606
EMBLAF284607
EMBLAF284608
EMBLAF284609
EMBLAF284610
EMBLAF284611
EMBLAF284612
EMBLAF284613
EMBLAF284614
EMBLAF284615
EMBLAK315287
EMBLBC126354
EMBLBC126356

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990737
IEA
Genome Projectresponse to manganese-induced endoplasmic reticulum stress
GO:1902235
IMP
Genome Projectregulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902235
IMP
Gene Ontologyregulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway1
GO:1900182
ISS
Genome Projectpositive regulation of protein localization to nucleus
GO:1900182
ISS
Gene Ontologypositive regulation of protein localization to nucleus
GO:0070417
IMP
Genome Projectcellular response to cold
GO:0070417
IMP
Gene Ontologycellular response to cold2
GO:0060734
ISS
Genome Projectregulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0060734
ISS
Gene Ontologyregulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0051260
IMP
Genome Projectprotein homooligomerization
GO:0051260
IMP
Gene Ontologyprotein homooligomerization3
GO:0048009
ISS
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0048009
ISS
Gene Ontologyinsulin-like growth factor receptor signaling pathway
GO:0046777
IDA, IMP
Genome Projectprotein autophosphorylation
GO:0046777
IDA, IMP
Gene Ontologyprotein autophosphorylation3 4 5
GO:0045943
IMP
Genome Projectpositive regulation of transcription by RNA polymerase I
GO:0045943
IMP
Gene Ontologypositive regulation of transcription by RNA polymerase I6
GO:0042149
IMP
Genome Projectcellular response to glucose starvation
GO:0042149
IMP
Gene Ontologycellular response to glucose starvation6
GO:0036499
TAS
Genome ProjectPERK-mediated unfolded protein response
GO:0036499
TAS
Gene OntologyPERK-mediated unfolded protein response7
GO:0036492
IMP
TAS
Genome ProjecteiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0036492
IMP
TAS
Gene OntologyeiF2alpha phosphorylation in response to endoplasmic reticulum stress2 7
GO:0034976
IMP
Genome Projectresponse to endoplasmic reticulum stress
GO:0034976
IMP
Gene Ontologyresponse to endoplasmic reticulum stress8
GO:0034198
IMP
Genome Projectcellular response to amino acid starvation
GO:0034198
IMP
Gene Ontologycellular response to amino acid starvation2
GO:0032057
TAS
Genome Projectnegative regulation of translational initiation in response to stress
GO:0032057
TAS
Gene Ontologynegative regulation of translational initiation in response to stress5 9 10
GO:0031642
ISS
Genome Projectnegative regulation of myelination
GO:0031642
ISS
Gene Ontologynegative regulation of myelination
GO:0031018
IMP
Genome Projectendocrine pancreas development
GO:0031018
IMP
Gene Ontologyendocrine pancreas development5
GO:0030968
IDA
TAS
Genome Projectendoplasmic reticulum unfolded protein response
GO:0030968
IDA
TAS
Gene Ontologyendoplasmic reticulum unfolded protein response3 9 10 11
GO:0030282
ISS
Genome Projectbone mineralization
GO:0030282
ISS
Gene Ontologybone mineralization
GO:0030073
ISS
Genome Projectinsulin secretion
GO:0019722
ISS
Genome Projectcalcium-mediated signaling
GO:0019722
ISS
Gene Ontologycalcium-mediated signaling
GO:0018105
ISS
Genome Projectpeptidyl-serine phosphorylation
GO:0018105
ISS
Gene Ontologypeptidyl-serine phosphorylation
GO:0017148
TAS
Genome Projectnegative regulation of translation
GO:0017148
TAS
Gene Ontologynegative regulation of translation5
GO:0010998
ISS
Genome Projectregulation of translational initiation by eIF2 alpha phosphorylation
GO:0010998
ISS
Gene Ontologyregulation of translational initiation by eIF2 alpha phosphorylation
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010628
IMP
Gene Ontologypositive regulation of gene expression6
GO:0010575
IMP
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010575
IMP
Gene Ontologypositive regulation of vascular endothelial growth factor production6
GO:0007029
ISS
Genome Projectendoplasmic reticulum organization
GO:0007029
ISS
Gene Ontologyendoplasmic reticulum organization
GO:0006983
IDA
Genome ProjectER overload response
GO:0006983
IDA
Gene OntologyER overload response3 9
GO:0006919
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
ISS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006468
ISS
Genome Projectprotein phosphorylation
GO:0006468
ISS
Gene Ontologyprotein phosphorylation
GO:0002063
ISS
Genome Projectchondrocyte development
GO:0002063
ISS
Gene Ontologychondrocyte development
GO:0001525
IMP
Genome Projectangiogenesis
GO:0001525
IMP
Gene Ontologyangiogenesis6
GO:0001503
IMP
Genome Projectossification
GO:0001503
IMP
Gene Ontologyossification5
GO:0001501
ISS
Genome Projectskeletal system development
GO:0001501
ISS
Gene Ontologyskeletal system development

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051879
IEA
Genome ProjectHsp90 protein binding
GO:0042803
TAS
Genome Projectprotein homodimerization activity
GO:0042803
TAS
Gene Ontologyprotein homodimerization activity7
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding3
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0019903
IPI
Gene Ontologyprotein phosphatase binding11
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding12
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 13 14 15
GO:0004694
IDA, IMP
Genome Projecteukaryotic translation initiation factor 2alpha kinase activity
GO:0004694
IDA, IMP
Gene Ontologyeukaryotic translation initiation factor 2alpha kinase activity2 3 4 5 9
GO:0004674
ISS
TAS
Genome Projectprotein serine/threonine kinase activity
GO:0004674
ISS
TAS
Gene Ontologyprotein serine/threonine kinase activity
GO:0004672
TAS
Genome Projectprotein kinase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0030176
NAS
Genome Projectintegral component of endoplasmic reticulum membrane
GO:0030176
NAS
Gene Ontologyintegral component of endoplasmic reticulum membrane7 16
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane17
GO:0005789
ISS
TAS, NAS
Genome Projectendoplasmic reticulum membrane
GO:0005789
ISS
TAS, NAS
Gene Ontologyendoplasmic reticulum membrane3
GO:0005783
ISS
TAS, IC
Genome Projectendoplasmic reticulum
GO:0005783
ISS
TAS, IC
Gene Ontologyendoplasmic reticulum3 5
GO:0005737
ISS
Genome Projectcytoplasm
GO:0005737
ISS
Gene Ontologycytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain superfamily
IPR011047Quinoprotein alcohol dehydrogenase-like superfamily
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.
KeggID Description
K08860EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
No chloroplast target sequence found.