Gene: ENSG00000169855 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000169855
Transcript Identifier
ENST00000464233
Gene Type
Coding gene
Location
3 : 78598913-79589911 : negative

Family Information

Homologous gene family
HOM02SEM000453
(81 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
roundabout, axon guidance receptor, homolog 1 (Drosophila)

Identifiers

Type Value
pidENSP00000420321
HGNC10249
UniprotQ9Y6N7
RefSeq_mRNANM_002941.3
EMBLAC016946
EMBLAC055731
EMBLAC106718
EMBLAC106720
EMBLAC108719
EMBLAC117461
EMBLAC117479
EMBLAC119035
EMBLAC123565
EMBLAC125624
EMBLAC125766
EMBLAC125815
EMBLAC131008
EMBLAF040990
EMBLBC001969
EMBLBC115022
EMBLBC157861
EMBLBC171855
EMBLBX538319
EMBLCH471110
EMBLZ95705

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070100
IMP
Genome Projectnegative regulation of chemokine-mediated signaling pathway
GO:0070100
IMP
Gene Ontologynegative regulation of chemokine-mediated signaling pathway1
GO:0050925
IDA
Genome Projectnegative regulation of negative chemotaxis
GO:0050925
IDA
Gene Ontologynegative regulation of negative chemotaxis2
GO:0050772
IDA
Genome Projectpositive regulation of axonogenesis
GO:0050772
IDA
Gene Ontologypositive regulation of axonogenesis3
GO:0035385
IMP
Genome ProjectRoundabout signaling pathway
GO:0035385
IMP
Gene OntologyRoundabout signaling pathway1 4
GO:0035025
IMP
Genome Projectpositive regulation of Rho protein signal transduction
GO:0035025
IMP
Gene Ontologypositive regulation of Rho protein signal transduction4
GO:0033600
IMP
Genome Projectnegative regulation of mammary gland epithelial cell proliferation
GO:0033600
IMP
Gene Ontologynegative regulation of mammary gland epithelial cell proliferation1
GO:0030336
IMP
Genome Projectnegative regulation of cell migration
GO:0030336
IMP
Gene Ontologynegative regulation of cell migration4
GO:0021836
IDA
Genome Projectchemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021836
IDA
Gene Ontologychemorepulsion involved in postnatal olfactory bulb interneuron migration5
GO:0016199
ISS
Genome Projectaxon midline choice point recognition
GO:0016199
ISS
Gene Ontologyaxon midline choice point recognition
GO:0007507
IEA
Genome Projectheart development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007411
TAS
Gene Ontologyaxon guidance
GO:0007399
TAS
Genome Projectnervous system development
GO:0007399
TAS
Gene Ontologynervous system development6
GO:0007156
IDA
Genome Projecthomophilic cell adhesion via plasma membrane adhesion molecules
GO:0007156
IDA
Gene Ontologyhomophilic cell adhesion via plasma membrane adhesion molecules3
GO:0007155
TAS
Genome Projectcell adhesion
GO:0007155
TAS
Gene Ontologycell adhesion6
GO:0006919
IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IMP
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process7
GO:0002042
IMP
Genome Projectcell migration involved in sprouting angiogenesis
GO:0002042
IMP
Gene Ontologycell migration involved in sprouting angiogenesis8
GO:1900748
IMP
Gene Ontologypositive regulation of vascular endothelial growth factor signaling pathway9
GO:0060412
ISS
Gene Ontologyventricular septum morphogenesis
GO:0043406
IMP
Gene Ontologypositive regulation of MAP kinase activity9
GO:0035904
ISS
Gene Ontologyaorta development
GO:0035481
ISS
Gene Ontologypositive regulation of Notch signaling pathway involved in heart induction
GO:0010629
ISS
Gene Ontologynegative regulation of gene expression
GO:0010628
ISS
Gene Ontologypositive regulation of gene expression
GO:0003272
ISS
Gene Ontologyendocardial cushion formation
GO:0003184
ISS
Gene Ontologypulmonary valve morphogenesis
GO:0003180
ISS
Gene Ontologyaortic valve morphogenesis
GO:0003148
ISS
Gene Ontologyoutflow tract septum morphogenesis
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development FBgn0005631
GO:0022407
IEA
PLAZA Integrative Orthologyregulation of cell-cell adhesion FBgn0005631
GO:0022409
IEA
PLAZA Integrative Orthologypositive regulation of cell-cell adhesion FBgn0005631
GO:0061458
IEA
PLAZA Integrative Orthologyreproductive system development FBgn0041097
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis FBgn0005631
GO:0061061
IEA
PLAZA Integrative Orthologymuscle structure development ENSG00000064309
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality FBgn0005631
GO:0035272
IEA
PLAZA Integrative Orthologyexocrine system development FBgn0005631
GO:0045137
IEA
PLAZA Integrative Orthologydevelopment of primary sexual characteristics FBgn0041097
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0005631
GO:0097374
IEA
PLAZA Integrative Orthologysensory neuron axon guidance WBGene00004729
GO:0007419
IEA
PLAZA Integrative Orthologyventral cord development FBgn0041097
GO:0031987
IEA
PLAZA Integrative Orthologylocomotion involved in locomotory behavior FBgn0005631
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development FBgn0005631
GO:0008045
IEA
PLAZA Integrative Orthologymotor neuron axon guidance FBgn0005631
GO:0051272
IEA
PLAZA Integrative Orthologypositive regulation of cellular component movement FBgn0005631
GO:0045785
IEA
PLAZA Integrative Orthologypositive regulation of cell adhesion FBgn0005631
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0005631
GO:0040017
IEA
PLAZA Integrative Orthologypositive regulation of locomotion FBgn0005631
GO:0051147
IEA
PLAZA Integrative Orthologyregulation of muscle cell differentiation ENSG00000064309
GO:0001764
IEA
PLAZA Integrative Orthologyneuron migration WBGene00004729
GO:0009649
IEA
PLAZA Integrative Orthologyentrainment of circadian clock FBgn0005631
GO:0007626
IEA
PLAZA Integrative Orthologylocomotory behavior FBgn0005631
GO:0010632
IEA
PLAZA Integrative Orthologyregulation of epithelial cell migration FBgn0005631
GO:0070983
IEA
PLAZA Integrative Orthologydendrite guidance FBgn0005631
GO:0051149
IEA
PLAZA Integrative Orthologypositive regulation of muscle cell differentiation ENSG00000064309
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0005631
GO:0019725
IEA
PLAZA Integrative Orthologycellular homeostasis FBgn0005631
GO:2000274
IEA
PLAZA Integrative Orthologyregulation of epithelial cell migration, open tracheal system FBgn0005631
GO:0050905
IEA
PLAZA Integrative Orthologyneuromuscular process FBgn0005631
GO:0048036
IEA
PLAZA Integrative Orthologycentral complex development FBgn0041097
GO:0042692
IEA
PLAZA Integrative Orthologymuscle cell differentiation ENSG00000064309
GO:2000147
IEA
PLAZA Integrative Orthologypositive regulation of cell motility FBgn0005631
GO:0007610
IEA
PLAZA Integrative Orthologybehavior FBgn0005631
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0041097
GO:0003008
IEA
PLAZA Integrative Orthologysystem process FBgn0005631
GO:0050877
IEA
PLAZA Integrative Orthologynervous system process FBgn0005631
GO:0048608
IEA
PLAZA Integrative Orthologyreproductive structure development FBgn0041097
GO:0016319
IEA
PLAZA Integrative Orthologymushroom body development FBgn0041097
GO:0048568
IEA
PLAZA Integrative Orthologyembryonic organ development FBgn0005631
GO:0007623
IEA
PLAZA Integrative Orthologycircadian rhythm FBgn0005631
GO:0008039
IEA
PLAZA Integrative Orthologysynaptic target recognition FBgn0041097
GO:0072499
IEA
PLAZA Integrative Orthologyphotoreceptor cell axon guidance FBgn0005631
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process FBgn0005631
GO:0033563
IEA
PLAZA Integrative Orthologydorsal/ventral axon guidance WBGene00004729
GO:0016201
IEA
PLAZA Integrative Orthologysynaptic target inhibition FBgn0041097
GO:0030335
IEA
PLAZA Integrative Orthologypositive regulation of cell migration FBgn0005631
GO:0046716
IEA
PLAZA Integrative Orthologymuscle cell cellular homeostasis FBgn0005631
GO:1905489
IEA
PLAZA Integrative Orthologyregulation of sensory neuron axon guidance WBGene00004729
GO:0010160
IEA
PLAZA Integrative Orthologyformation of animal organ boundary FBgn0005631
GO:0007432
IEA
PLAZA Integrative Orthologysalivary gland boundary specification FBgn0005631
GO:0048854
IEA
PLAZA Integrative Orthologybrain morphogenesis FBgn0005631
GO:0007431
IEA
PLAZA Integrative Orthologysalivary gland development FBgn0005631
GO:0042752
IEA
PLAZA Integrative Orthologyregulation of circadian rhythm FBgn0005631
GO:0048859
IEA
PLAZA Integrative Orthologyformation of anatomical boundary FBgn0005631
GO:0050773
IEA
PLAZA Integrative Orthologyregulation of dendrite development FBgn0005631
GO:0007548
IEA
PLAZA Integrative Orthologysex differentiation FBgn0041097
GO:0007427
IEA
PLAZA Integrative Orthologyepithelial cell migration, open tracheal system FBgn0005631
GO:0001964
IEA
PLAZA Integrative Orthologystartle response FBgn0005631
GO:1902667
IEA
PLAZA Integrative Orthologyregulation of axon guidance WBGene00004729
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0041097
GO:0035050
IEA
PLAZA Integrative Orthologyembryonic heart tube development FBgn0005631
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0041097
GO:0008406
IEA
PLAZA Integrative Orthologygonad development FBgn0041097
GO:0048511
IEA
PLAZA Integrative Orthologyrhythmic process FBgn0005631
GO:0030155
IEA
PLAZA Integrative Orthologyregulation of cell adhesion FBgn0005631

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042802
IDA
Genome Projectidentical protein binding
GO:0042802
IDA
Gene Ontologyidentical protein binding3
GO:0030275
IPI
Genome ProjectLRR domain binding
GO:0030275
IPI
Gene OntologyLRR domain binding10
GO:0008046
TAS
Genome Projectaxon guidance receptor activity
GO:0008046
TAS
Gene Ontologyaxon guidance receptor activity11
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 5 10 12
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding FBgn0005631
GO:0008201
IEA
PLAZA Integrative Orthologyheparin binding FBgn0005631
GO:1901681
IEA
PLAZA Integrative Orthologysulfur compound binding FBgn0005631
GO:0043167
IEA
PLAZA Integrative Orthologyion binding FBgn0005631
GO:0043168
IEA
PLAZA Integrative Orthologyanion binding FBgn0005631
GO:0005539
IEA
PLAZA Integrative Orthologyglycosaminoglycan binding FBgn0005631

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030424
IEA
Genome Projectaxon
GO:0009986
IDA
Genome Projectcell surface
GO:0009986
IDA
Gene Ontologycell surface3
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0005887
TAS
Gene Ontologyintegral component of plasma membrane6
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005886
IDA
TAS
Gene Ontologyplasma membrane
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm7
GO:0062023
IEA
PLAZA Integrative Orthologycollagen-containing extracellular matrix ENSG00000064309
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle ENSG00000154133
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000154133
GO:0030426
IEA
PLAZA Integrative Orthologygrowth cone FBgn0005631
GO:0030425
IEA
PLAZA Integrative Orthologydendrite FBgn0005631
GO:0030427
IEA
PLAZA Integrative Orthologysite of polarized growth FBgn0005631
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000154133
GO:0044295
IEA
PLAZA Integrative Orthologyaxonal growth cone FBgn0005631
GO:0044297
IEA
PLAZA Integrative Orthologycell body FBgn0005631
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000154133
GO:0036477
IEA
PLAZA Integrative Orthologysomatodendritic compartment FBgn0005631
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000154133
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000154133
GO:0044463
IEA
PLAZA Integrative Orthologycell projection part FBgn0005631
GO:0150034
IEA
PLAZA Integrative Orthologydistal axon FBgn0005631
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000154133
GO:0071666
IEA
PLAZA Integrative OrthologySlit-Robo signaling complex FBgn0005631
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000154133
GO:0120038
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection part FBgn0005631
GO:0043025
IEA
PLAZA Integrative Orthologyneuronal cell body FBgn0005631
GO:0097447
IEA
PLAZA Integrative Orthologydendritic tree FBgn0005631
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex FBgn0005631
GO:0032992
IEA
PLAZA Integrative Orthologyprotein-carbohydrate complex FBgn0005631
GO:0031012
IEA
PLAZA Integrative Orthologyextracellular matrix ENSG00000064309
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000154133
GO:0033267
IEA
PLAZA Integrative Orthologyaxon part FBgn0005631

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR013098Immunoglobulin I-set
IPR013106Immunoglobulin V-set domain
IPR013783Immunoglobulin-like fold
IPR032986Roundabout homologue 1

No MapMan annotations defined for this gene.
KeggID Description
K06753ROBO1; roundabout, axon guidance receptor 1
No chloroplast target sequence found.