Gene: ENSG00000168329 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000168329
Transcript Identifier
ENST00000358309
Gene Type
Coding gene
Location
3 : 39265442-39281695 : negative

Family Information

Homologous gene family
HOM02SEM000126
(196 genes in 3 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
chemokine (C-X3-C motif) receptor 1

Identifiers

Type Value
pidENSP00000351059
HGNC2558
UniprotP49238
RefSeq_mRNANM_001171174.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1900272
IEA
Genome Projectnegative regulation of long-term synaptic potentiation
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071222
ISS
Gene Ontologycellular response to lipopolysaccharide
GO:0070098
IEA
Genome Projectchemokine-mediated signaling pathway
GO:0048246
IEA
Genome Projectmacrophage chemotaxis
GO:0045766
IEA
Genome Projectpositive regulation of angiogenesis
GO:0030336
IEA
Genome Projectnegative regulation of cell migration
GO:0021795
IEA
Genome Projectcerebral cortex cell migration
GO:0016525
IEA
Genome Projectnegative regulation of angiogenesis
GO:0016032
IEA
Genome Projectviral process
GO:0009611
TAS
Genome Projectresponse to wounding
GO:0009611
TAS
Gene Ontologyresponse to wounding1
GO:0007613
IEA
Genome Projectmemory
GO:0007186
IEA
Genome ProjectG protein-coupled receptor signaling pathway
GO:0007186
TAS
Gene OntologyG protein-coupled receptor signaling pathway
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007155
ISS
Gene Ontologycell adhesion
GO:0006968
TAS
Genome Projectcellular defense response
GO:0006968
TAS
Gene Ontologycellular defense response1
GO:0006935
TAS
Genome Projectchemotaxis
GO:0006935
IGI
Gene Ontologychemotaxis2
GO:0002881
IEA
Genome Projectnegative regulation of chronic inflammatory response to non-antigenic stimulus
GO:0002282
IEA
Genome Projectmicroglial cell activation involved in immune response
GO:0002052
IEA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002052
ISS
Gene Ontologypositive regulation of neuroblast proliferation
GO:1904139
TAS
Gene Ontologyregulation of microglial cell migration3
GO:2001234
ISS
Gene Ontologynegative regulation of apoptotic signaling pathway
GO:0110091
ISS
Gene Ontologynegative regulation of hippocampal neuron apoptotic process
GO:1903721
ISS
Gene Ontologypositive regulation of I-kappaB phosphorylation
GO:0051897
ISS
Gene Ontologypositive regulation of protein kinase B signaling
GO:0051092
ISS
Gene Ontologypositive regulation of NF-kappaB transcription factor activity
GO:0050901
ISS
Gene Ontologyleukocyte tethering or rolling
GO:0050769
ISS
Gene Ontologypositive regulation of neurogenesis
GO:0050767
TAS
Gene Ontologyregulation of neurogenesis3
GO:0048167
TAS
Gene Ontologyregulation of synaptic plasticity3
GO:0045428
ISS
Gene Ontologyregulation of nitric oxide biosynthetic process
GO:0045087
IC
Gene Ontologyinnate immune response4
GO:0042534
ISS
Gene Ontologyregulation of tumor necrosis factor biosynthetic process
GO:0035425
ISS
Gene Ontologyautocrine signaling
GO:0032691
ISS
Gene Ontologynegative regulation of interleukin-1 beta production
GO:0007267
TAS
Gene Ontologycell-cell signaling3
GO:0007200
ISS
Gene Ontologyphospholipase C-activating G protein-coupled receptor signaling pathway
GO:0002931
ISS
Gene Ontologyresponse to ischemia

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0019960
IDA
Genome ProjectC-X3-C chemokine binding
GO:0019960
IDA
ISS
Gene OntologyC-X3-C chemokine binding5
GO:0016495
IEA
Genome ProjectC-X3-C chemokine receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding6
GO:0004950
TAS
Genome Projectchemokine receptor activity
GO:0004950
TAS
Gene Ontologychemokine receptor activity1
GO:0008528
TAS
Gene OntologyG protein-coupled peptide receptor activity3
GO:0004930
ISS
Gene OntologyG protein-coupled receptor activity
GO:0005044
IEA
PLAZA Integrative Orthologyscavenger receptor activity ENSG00000144648
GO:0038024
IEA
PLAZA Integrative Orthologycargo receptor activity ENSG00000144648
GO:0015026
IEA
PLAZA Integrative Orthologycoreceptor activity ENSG00000179934

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0048471
ISS
Gene Ontologyperinuclear region of cytoplasm
GO:0043005
IEA
Genome Projectneuron projection
GO:0043005
ISS
Gene Ontologyneuron projection
GO:0032809
IEA
Genome Projectneuronal cell body membrane
GO:0032809
ISS
Gene Ontologyneuronal cell body membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0005887
TAS
Gene Ontologyintegral component of plasma membrane7
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0097447
ISS
Gene Ontologydendritic tree
GO:0009986
ISS
TAS
Gene Ontologycell surface3 8
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0005634
IDA
Gene Ontologynucleus
GO:0031975
IEA
PLAZA Integrative Orthologyenvelope ENSG00000144648
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000144648
GO:0005829
IEA
PLAZA Integrative Orthologycytosol ENSG00000144648
GO:0015629
IEA
PLAZA Integrative Orthologyactin cytoskeleton ENSG00000144648
GO:0099513
IEA
PLAZA Integrative Orthologypolymeric cytoskeletal fiber ENSG00000144648
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part ENSG00000144648
GO:0099512
IEA
PLAZA Integrative Orthologysupramolecular fiber ENSG00000144648
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton ENSG00000144648
GO:0031965
IEA
PLAZA Integrative Orthologynuclear membrane ENSG00000144648
GO:0031967
IEA
PLAZA Integrative Orthologyorganelle envelope ENSG00000144648
GO:0005635
IEA
PLAZA Integrative Orthologynuclear envelope ENSG00000144648
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000144648
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000144648
GO:0005884
IEA
PLAZA Integrative Orthologyactin filament ENSG00000144648
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000144648
GO:0099081
IEA
PLAZA Integrative Orthologysupramolecular polymer ENSG00000144648
GO:0099080
IEA
PLAZA Integrative Orthologysupramolecular complex ENSG00000144648

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR005387CX3C chemokine receptor 1
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.
KeggID Description
K04192CX3CR1; CX3C chemokine receptor 1
No chloroplast target sequence found.