Gene: ENSG00000168040 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000168040
Transcript Identifier
ENST00000301838
Gene Type
Coding gene
Location
11 : 70203460-70206473 : positive

Family Information

Homologous gene family
HOM02SEM099918
(orphan gene)
specific family

Descriptions

gene_descr
Fas (TNFRSF6)-associated via death domain

Identifiers

Type Value
pidENSP00000301838
HGNC3573
UniprotQ13158
RefSeq_mRNANM_003824.3
EMBLAK291005
EMBLAY423721
EMBLBC000334
EMBLBT006927
EMBLCH471076
EMBLCR456738
EMBLDQ449938
EMBLU24231
EMBLX84709

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001238
IMP
Gene Ontologypositive regulation of extrinsic apoptotic signaling pathway1
GO:2000454
ISS
Genome Projectpositive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2000454
ISS
Gene Ontologypositive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0097527
IMP
Genome Projectnecroptotic signaling pathway
GO:0097527
IMP
Gene Ontologynecroptotic signaling pathway2
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097202
IDA
Genome Projectactivation of cysteine-type endopeptidase activity
GO:0097202
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity3
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097191
IDA, IMP
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IDA, IMP
TAS
Gene Ontologyextrinsic apoptotic signaling pathway4 5 6
GO:0097190
IDA
TAS
Genome Projectapoptotic signaling pathway
GO:0097190
IDA
TAS
Gene Ontologyapoptotic signaling pathway2
GO:0097049
IEA
Genome Projectmotor neuron apoptotic process
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0071550
TAS
Gene Ontologydeath-inducing signaling complex assembly
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071260
IEP
Gene Ontologycellular response to mechanical stimulus7
GO:0070236
ISS
Genome Projectnegative regulation of activation-induced cell death of T cells
GO:0070236
ISS
Gene Ontologynegative regulation of activation-induced cell death of T cells
GO:0060546
IEA
Genome Projectnegative regulation of necroptotic process
GO:0060340
IMP
Genome Projectpositive regulation of type I interferon-mediated signaling pathway
GO:0060340
IMP
Gene Ontologypositive regulation of type I interferon-mediated signaling pathway8
GO:0051607
IMP
Genome Projectdefense response to virus
GO:0051607
IMP
Gene Ontologydefense response to virus8
GO:0048538
ISS
Genome Projectthymus development
GO:0048538
ISS
Gene Ontologythymus development
GO:0048536
ISS
Genome Projectspleen development
GO:0048536
ISS
Gene Ontologyspleen development
GO:0048535
ISS
Genome Projectlymph node development
GO:0048535
ISS
Gene Ontologylymph node development
GO:0048148
IEA
Genome Projectbehavioral response to cocaine
GO:0045944
IDA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
Gene Ontologypositive regulation of transcription by RNA polymerase II9
GO:0045862
IDA
Genome Projectpositive regulation of proteolysis
GO:0045862
IDA
Gene Ontologypositive regulation of proteolysis3
GO:0045651
IMP
Genome Projectpositive regulation of macrophage differentiation
GO:0045651
IMP
Gene Ontologypositive regulation of macrophage differentiation10
GO:0045087
IEA
Genome Projectinnate immune response
GO:0043278
IEA
Genome Projectresponse to morphine
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IEP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling11
GO:0043065
IMP
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA, IMP
Gene Ontologypositive regulation of apoptotic process12 13
GO:0043029
ISS
Genome ProjectT cell homeostasis
GO:0043029
ISS
Gene OntologyT cell homeostasis
GO:0042104
ISS
Genome Projectpositive regulation of activated T cell proliferation
GO:0042104
ISS
Gene Ontologypositive regulation of activated T cell proliferation
GO:0036462
IDA
Genome ProjectTRAIL-activated apoptotic signaling pathway
GO:0036462
IDA
Gene OntologyTRAIL-activated apoptotic signaling pathway6
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035666
TAS
Gene OntologyTRIF-dependent toll-like receptor signaling pathway
GO:0033077
ISS
Genome ProjectT cell differentiation in thymus
GO:0033077
ISS
Gene OntologyT cell differentiation in thymus
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032760
IDA
Gene Ontologypositive regulation of tumor necrosis factor production9
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032757
IDA
Gene Ontologypositive regulation of interleukin-8 production9
GO:0032729
ISS
Genome Projectpositive regulation of interferon-gamma production
GO:0032729
ISS
Gene Ontologypositive regulation of interferon-gamma production
GO:0008625
TAS
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008625
TAS
Gene Ontologyextrinsic apoptotic signaling pathway via death domain receptors14
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007166
TAS
Gene Ontologycell surface receptor signaling pathway
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IMP
Genome Projectapoptotic process
GO:0006915
IMP
Gene Ontologyapoptotic process15
GO:0002821
ISS
Genome Projectpositive regulation of adaptive immune response
GO:0002821
ISS
Gene Ontologypositive regulation of adaptive immune response
GO:0001916
ISS
Genome Projectpositive regulation of T cell mediated cytotoxicity
GO:0001916
ISS
Gene Ontologypositive regulation of T cell mediated cytotoxicity
GO:0034138
TAS
Gene Ontologytoll-like receptor 3 signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0089720
IPI
Genome Projectcaspase binding
GO:0089720
IPI
Gene Ontologycaspase binding16
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding17 18
GO:0035877
IPI
Genome Projectdeath effector domain binding
GO:0035877
IPI
Gene Ontologydeath effector domain binding19
GO:0033612
IEA
Genome Projectreceptor serine/threonine kinase binding
GO:0032813
IPI
Genome Projecttumor necrosis factor receptor superfamily binding
GO:0032813
IPI
Gene Ontologytumor necrosis factor receptor superfamily binding8
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 6 9 10 13 14 16 17 18 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005123
IEA
Genome Projectdeath receptor binding
GO:0002020
IPI
Genome Projectprotease binding
GO:0002020
IPI
Gene Ontologyprotease binding6 20

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097342
IDA
Genome Projectripoptosome
GO:0097342
IDA
Gene Ontologyripoptosome54
GO:0045121
IEA
Genome Projectmembrane raft
GO:0044297
IEA
Genome Projectcell body
GO:0043005
IEA
Genome Projectneuron projection
GO:0031265
IDA
Genome ProjectCD95 death-inducing signaling complex
GO:0031265
IDA
Gene OntologyCD95 death-inducing signaling complex13
GO:0031264
IDA
TAS
Genome Projectdeath-inducing signaling complex
GO:0031264
IDA
TAS
Gene Ontologydeath-inducing signaling complex2 5 43
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane47
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol6
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm47
GO:0005634
IEA
Genome Projectnucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000488Death domain
IPR001875Death effector domain
IPR011029Death-like domain superfamily
IPR016729FADD

No MapMan annotations defined for this gene.
KeggID Description
K02373FADD; FAS-associated death domain protein
No chloroplast target sequence found.