Gene: ENSG00000167034 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000167034
Transcript Identifier
ENST00000380871
Gene Type
Coding gene
Location
8 : 23681221-23682889 : negative

Family Information

Homologous gene family
HOM02SEM000138
(177 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
NK3 homeobox 1

Identifiers

Type Value
pidENSP00000370253
HGNC7838
UniprotQ99801
RefSeq_mRNANM_006167.3
EMBLAF247704
EMBLAF249669
EMBLAF249670
EMBLAF249671
EMBLAF249672
EMBLBC074863
EMBLBC074864
EMBLU80669
EMBLU91540

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001244
IDA
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:2001244
IDA
Gene Ontologypositive regulation of intrinsic apoptotic signaling pathway1
GO:2001235
IDA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:2001235
IDA
Gene Ontologypositive regulation of apoptotic signaling pathway2
GO:2001022
IDA
Genome Projectpositive regulation of response to DNA damage stimulus
GO:2001022
IDA
Gene Ontologypositive regulation of response to DNA damage stimulus3
GO:2000836
IDA
Genome Projectpositive regulation of androgen secretion
GO:2000836
IDA
Gene Ontologypositive regulation of androgen secretion4
GO:0071899
IDA
Genome Projectnegative regulation of estrogen receptor binding
GO:0071899
IDA
Gene Ontologynegative regulation of estrogen receptor binding5
GO:0071850
IDA
Genome Projectmitotic cell cycle arrest
GO:0071850
IDA
Gene Ontologymitotic cell cycle arrest6
GO:0071456
IDA
Genome Projectcellular response to hypoxia
GO:0071456
IDA
Gene Ontologycellular response to hypoxia7
GO:0071383
IDA
Genome Projectcellular response to steroid hormone stimulus
GO:0071383
IDA
Gene Ontologycellular response to steroid hormone stimulus4
GO:0071356
IEP
Genome Projectcellular response to tumor necrosis factor
GO:0071356
IEP
Gene Ontologycellular response to tumor necrosis factor8
GO:0071347
IEP
Genome Projectcellular response to interleukin-1
GO:0071347
IEP
Gene Ontologycellular response to interleukin-18
GO:0060770
ISS
Genome Projectnegative regulation of epithelial cell proliferation involved in prostate gland development
GO:0060770
ISS
Gene Ontologynegative regulation of epithelial cell proliferation involved in prostate gland development
GO:0060664
ISS
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0060664
ISS
Gene Ontologyepithelial cell proliferation involved in salivary gland morphogenesis
GO:0060442
ISS
Genome Projectbranching involved in prostate gland morphogenesis
GO:0060442
ISS
Gene Ontologybranching involved in prostate gland morphogenesis
GO:0060037
IEA
Genome Projectpharyngeal system development
GO:0051781
IMP
Genome Projectpositive regulation of cell division
GO:0051781
IMP
Gene Ontologypositive regulation of cell division9
GO:0050680
ISS
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050680
ISS
Gene Ontologynegative regulation of epithelial cell proliferation
GO:0048754
ISS
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048754
ISS
Gene Ontologybranching morphogenesis of an epithelial tube
GO:0045944
IDA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
Gene Ontologypositive regulation of transcription by RNA polymerase II9 10
GO:0045931
IMP
Genome Projectpositive regulation of mitotic cell cycle
GO:0045931
IMP
Gene Ontologypositive regulation of mitotic cell cycle9
GO:0045930
IDA
Genome Projectnegative regulation of mitotic cell cycle
GO:0045930
IDA
Gene Ontologynegative regulation of mitotic cell cycle6
GO:0045893
IMP
ISS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
IMP
ISS
Gene Ontologypositive regulation of transcription, DNA-templated11
GO:0045892
IDA, IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA, IMP
Gene Ontologynegative regulation of transcription, DNA-templated5 11 12 13
GO:0043569
ISS
Genome Projectnegative regulation of insulin-like growth factor receptor signaling pathway
GO:0043569
ISS
Gene Ontologynegative regulation of insulin-like growth factor receptor signaling pathway
GO:0043491
IMP
Genome Projectprotein kinase B signaling
GO:0043491
IMP
Gene Ontologyprotein kinase B signaling13
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process2
GO:0035907
IEA
Genome Projectdorsal aorta development
GO:0035690
IEP
Genome Projectcellular response to drug
GO:0035690
IEP
Gene Ontologycellular response to drug8
GO:0033574
ISS
Genome Projectresponse to testosterone
GO:0033574
ISS
Gene Ontologyresponse to testosterone
GO:0032147
IEA
Genome Projectactivation of protein kinase activity
GO:0030521
IDA
Genome Projectandrogen receptor signaling pathway
GO:0030521
IDA
Gene Ontologyandrogen receptor signaling pathway4
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014068
IDA
Gene Ontologypositive regulation of phosphatidylinositol 3-kinase signaling3
GO:0010942
IDA
Genome Projectpositive regulation of cell death
GO:0010942
IDA
Gene Ontologypositive regulation of cell death6
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010629
IDA
Gene Ontologynegative regulation of gene expression1
GO:0010628
IDA, IMP
Genome Projectpositive regulation of gene expression
GO:0010628
IDA, IMP
Gene Ontologypositive regulation of gene expression1 2 14
GO:0008584
IEA
Genome Projectmale gonad development
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0008285
IDA
Gene Ontologynegative regulation of cell proliferation1 6
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0008284
IMP
Gene Ontologypositive regulation of cell proliferation11
GO:0007507
IEA
Genome Projectheart development
GO:0007431
ISS
Genome Projectsalivary gland development
GO:0007431
ISS
Gene Ontologysalivary gland development
GO:0007275
TAS
Genome Projectmulticellular organism development
GO:0007275
TAS
Gene Ontologymulticellular organism development15
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process1 6
GO:0006355
NAS
Genome Projectregulation of transcription, DNA-templated
GO:0006355
NAS
Gene Ontologyregulation of transcription, DNA-templated16
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001934
IDA
Gene Ontologypositive regulation of protein phosphorylation3
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001656
IEA
Genome Projectmetanephros development
GO:0001708
IEA
PLAZA Integrative Orthologycell fate specification FBgn0004862
GO:0001707
IEA
PLAZA Integrative Orthologymesoderm formation FBgn0004862
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0004862
GO:0055123
IEA
PLAZA Integrative Orthologydigestive system development FBgn0004862
GO:0001704
IEA
PLAZA Integrative Orthologyformation of primary germ layer FBgn0004862
GO:0048332
IEA
PLAZA Integrative Orthologymesoderm morphogenesis FBgn0004862
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0004862
GO:0048333
IEA
PLAZA Integrative Orthologymesodermal cell differentiation FBgn0004862
GO:0048598
IEA
PLAZA Integrative Orthologyembryonic morphogenesis FBgn0004862
GO:0048565
IEA
PLAZA Integrative Orthologydigestive tract development FBgn0004862
GO:0001710
IEA
PLAZA Integrative Orthologymesodermal cell fate commitment FBgn0004862
GO:0001501
IEA
PLAZA Integrative Orthologyskeletal system development ENSG00000109705
GO:0007501
IEA
PLAZA Integrative Orthologymesodermal cell fate specification FBgn0004862
GO:0007369
IEA
PLAZA Integrative Orthologygastrulation FBgn0004862
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0004862
GO:0007498
IEA
PLAZA Integrative Orthologymesoderm development FBgn0004862
GO:0007494
IEA
PLAZA Integrative Orthologymidgut development FBgn0004862
GO:0060795
IEA
PLAZA Integrative Orthologycell fate commitment involved in formation of primary germ layer FBgn0004862

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008656
IDA
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
IDA
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process6
GO:0097162
IEA
Genome ProjectMADS box domain binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0044212
IDA
Gene Ontologytranscription regulatory region DNA binding17
GO:0043621
IDA
Genome Projectprotein self-association
GO:0043621
IDA
Gene Ontologyprotein self-association18
GO:0043565
IDA
Genome Projectsequence-specific DNA binding
GO:0043565
IDA
Gene Ontologysequence-specific DNA binding18
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0042826
IPI
Gene Ontologyhistone deacetylase binding12
GO:0030331
IDA
Genome Projectestrogen receptor binding
GO:0030331
IDA
Gene Ontologyestrogen receptor binding5
GO:0030295
IDA
Genome Projectprotein kinase activator activity
GO:0030295
IDA
Gene Ontologyprotein kinase activator activity3
GO:0030284
IDA
Genome Projectestrogen receptor activity
GO:0030284
IDA
Gene Ontologyestrogen receptor activity5
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding14
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding10 19 20 21
GO:0004882
IDA
Genome Projectandrogen receptor activity
GO:0004882
IDA
Gene Ontologyandrogen receptor activity4
GO:0003700
IDA
NAS
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IDA
NAS
Gene OntologyDNA-binding transcription factor activity9 16
GO:0001047
IDA
Genome Projectcore promoter binding
GO:0000976
IDA
Genome Projecttranscription regulatory region sequence-specific DNA binding
GO:0000976
IDA
Gene Ontologytranscription regulatory region sequence-specific DNA binding9
GO:0000981
ISA, ISM
NAS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific22
GO:0000978
IDA
Gene OntologyRNA polymerase II proximal promoter sequence-specific DNA binding12
GO:0001228
IEA
PLAZA Integrative OrthologyDNA-binding transcription activator activity, RNA polymerase II-specific ENSG00000151650

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
NAS, IC
Genome Projectnucleus
GO:0005634
IDA
NAS, IC
Gene Ontologynucleus8 9 16 17
GO:0005622
IDA
Genome Projectintracellular
GO:0005622
IDA
Gene Ontologyintracellular13

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001356Homeobox domain
IPR009057Homeobox-like domain superfamily
IPR017970Homeobox, conserved site
IPR020479Homeobox domain, metazoa

No MapMan annotations defined for this gene.
KeggID Description
K09348NKX3-1; homeobox protein Nkx-3.1
No chloroplast target sequence found.