Gene: ENSG00000164741 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000164741
Transcript Identifier
ENST00000276297
Gene Type
Coding gene
Location
8 : 13085811-13500071 : negative

Family Information

Homologous gene family
HOM02SEM009289
(10 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM011943
(5 genes in 3 species)
specific family

Descriptions

gene_descr
DLC1 Rho GTPase activating protein

Identifiers

Type Value
pidENSP00000276297
HGNC2897
UniprotQ96QB1
RefSeq_mRNANM_182643.2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1900119
IDA
Genome Projectpositive regulation of execution phase of apoptosis
GO:1900119
IDA
Gene Ontologypositive regulation of execution phase of apoptosis1
GO:0051895
IDA
Genome Projectnegative regulation of focal adhesion assembly
GO:0051895
IDA
Gene Ontologynegative regulation of focal adhesion assembly2
GO:0051497
IDA
Genome Projectnegative regulation of stress fiber assembly
GO:0051497
IDA
Gene Ontologynegative regulation of stress fiber assembly3
GO:0051056
TAS
Genome Projectregulation of small GTPase mediated signal transduction
GO:0051056
TAS
Gene Ontologyregulation of small GTPase mediated signal transduction
GO:0048041
ISS
Genome Projectfocal adhesion assembly
GO:0048041
ISS
Gene Ontologyfocal adhesion assembly
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0035307
IDA
Genome Projectpositive regulation of protein dephosphorylation
GO:0035307
IDA
Gene Ontologypositive regulation of protein dephosphorylation4
GO:0035024
IMP
Genome Projectnegative regulation of Rho protein signal transduction
GO:0035024
IMP
Gene Ontologynegative regulation of Rho protein signal transduction5
GO:0032956
IMP
Genome Projectregulation of actin cytoskeleton organization
GO:0032956
IMP
Gene Ontologyregulation of actin cytoskeleton organization4
GO:0030900
ISS
Genome Projectforebrain development
GO:0030900
ISS
Gene Ontologyforebrain development
GO:0030336
IDA, IMP
Genome Projectnegative regulation of cell migration
GO:0030336
IDA, IMP
Gene Ontologynegative regulation of cell migration1 2 3 4
GO:0030036
ISS
Genome Projectactin cytoskeleton organization
GO:0030036
ISS
Gene Ontologyactin cytoskeleton organization
GO:0021575
ISS
Genome Projecthindbrain morphogenesis
GO:0021575
ISS
Gene Ontologyhindbrain morphogenesis
GO:0008360
IMP
Genome Projectregulation of cell shape
GO:0008360
IMP
Gene Ontologyregulation of cell shape4
GO:0008285
IDA, IMP
Genome Projectnegative regulation of cell proliferation
GO:0008285
IDA, IMP
Gene Ontologynegative regulation of cell proliferation3 4 6
GO:0007165
IEA
Genome Projectsignal transduction
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:0006915
IDA
Genome Projectapoptotic process
GO:0006915
IDA
Gene Ontologyapoptotic process4
GO:0003007
ISS
Genome Projectheart morphogenesis
GO:0003007
ISS
Gene Ontologyheart morphogenesis
GO:0001843
ISS
Genome Projectneural tube closure
GO:0001843
ISS
Gene Ontologyneural tube closure
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process FBgn0086901
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process ENSG00000133121
GO:0010965
IEA
PLAZA Integrative Orthologyregulation of mitotic sister chromatid separation FBgn0086901
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0086901
GO:0048871
IEA
PLAZA Integrative Orthologymulticellular organismal homeostasis FBgn0086901
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization FBgn0086901
GO:0000132
IEA
PLAZA Integrative Orthologyestablishment of mitotic spindle orientation FBgn0086901
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle FBgn0086901
GO:0007442
IEA
PLAZA Integrative Orthologyhindgut morphogenesis FBgn0086901
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0086901
GO:0007167
IEA
PLAZA Integrative Orthologyenzyme linked receptor protein signaling pathway FBgn0086901
GO:0007166
IEA
PLAZA Integrative Orthologycell surface receptor signaling pathway FBgn0086901
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0086901
GO:0007169
IEA
PLAZA Integrative Orthologytransmembrane receptor protein tyrosine kinase signaling pathway FBgn0086901
GO:0007443
IEA
PLAZA Integrative OrthologyMalpighian tubule morphogenesis FBgn0086901
GO:0008258
IEA
PLAZA Integrative Orthologyhead involution FBgn0086901
GO:0044784
IEA
PLAZA Integrative Orthologymetaphase/anaphase transition of cell cycle FBgn0086901
GO:0007163
IEA
PLAZA Integrative Orthologyestablishment or maintenance of cell polarity FBgn0086901
GO:0007560
IEA
PLAZA Integrative Orthologyimaginal disc morphogenesis FBgn0086901
GO:0098916
IEA
PLAZA Integrative Orthologyanterograde trans-synaptic signaling FBgn0086901
GO:0045595
IEA
PLAZA Integrative Orthologyregulation of cell differentiation FBgn0086901
GO:0001568
IEA
PLAZA Integrative Orthologyblood vessel development ENSG00000133121
GO:0007427
IEA
PLAZA Integrative Orthologyepithelial cell migration, open tracheal system FBgn0086901
GO:0032506
IEA
PLAZA Integrative Orthologycytokinetic process FBgn0086901
GO:0051983
IEA
PLAZA Integrative Orthologyregulation of chromosome segregation FBgn0086901
GO:0050773
IEA
PLAZA Integrative Orthologyregulation of dendrite development FBgn0086901
GO:0048736
IEA
PLAZA Integrative Orthologyappendage development FBgn0086901
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0086901
GO:0048737
IEA
PLAZA Integrative Orthologyimaginal disc-derived appendage development FBgn0086901
GO:0007552
IEA
PLAZA Integrative Orthologymetamorphosis FBgn0086901
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0086901
GO:0000910
IEA
PLAZA Integrative Orthologycytokinesis FBgn0086901
GO:0044772
IEA
PLAZA Integrative Orthologymitotic cell cycle phase transition FBgn0086901
GO:0000912
IEA
PLAZA Integrative Orthologyassembly of actomyosin apparatus involved in cytokinesis FBgn0086901
GO:0061154
IEA
PLAZA Integrative Orthologyendothelial tube morphogenesis ENSG00000133121
GO:0033044
IEA
PLAZA Integrative Orthologyregulation of chromosome organization FBgn0086901
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0086901
GO:0033045
IEA
PLAZA Integrative Orthologyregulation of sister chromatid segregation FBgn0086901
GO:0007274
IEA
PLAZA Integrative Orthologyneuromuscular synaptic transmission FBgn0086901
GO:0048619
IEA
PLAZA Integrative Orthologyembryonic hindgut morphogenesis FBgn0086901
GO:2000181
IEA
PLAZA Integrative Orthologynegative regulation of blood vessel morphogenesis ENSG00000133121
GO:0035220
IEA
PLAZA Integrative Orthologywing disc development FBgn0086901
GO:0007391
IEA
PLAZA Integrative Orthologydorsal closure FBgn0086901
GO:0050767
IEA
PLAZA Integrative Orthologyregulation of neurogenesis FBgn0086901
GO:0033047
IEA
PLAZA Integrative Orthologyregulation of mitotic sister chromatid segregation FBgn0086901
GO:0035107
IEA
PLAZA Integrative Orthologyappendage morphogenesis FBgn0086901
GO:0044770
IEA
PLAZA Integrative Orthologycell cycle phase transition FBgn0086901
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process FBgn0086901
GO:0061525
IEA
PLAZA Integrative Orthologyhindgut development FBgn0086901
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle FBgn0086901
GO:0048569
IEA
PLAZA Integrative Orthologypost-embryonic animal organ development FBgn0086901
GO:0009886
IEA
PLAZA Integrative Orthologypost-embryonic animal morphogenesis FBgn0086901
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation FBgn0086901
GO:0010594
IEA
PLAZA Integrative Orthologyregulation of endothelial cell migration ENSG00000133121
GO:0061640
IEA
PLAZA Integrative Orthologycytoskeleton-dependent cytokinesis FBgn0086901
GO:0035114
IEA
PLAZA Integrative Orthologyimaginal disc-derived appendage morphogenesis FBgn0086901
GO:0010975
IEA
PLAZA Integrative Orthologyregulation of neuron projection development FBgn0086901
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation FBgn0086901
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle FBgn0086901
GO:0055123
IEA
PLAZA Integrative Orthologydigestive system development FBgn0086901
GO:0048563
IEA
PLAZA Integrative Orthologypost-embryonic animal organ morphogenesis FBgn0086901
GO:0048565
IEA
PLAZA Integrative Orthologydigestive tract development FBgn0086901
GO:0051960
IEA
PLAZA Integrative Orthologyregulation of nervous system development FBgn0086901
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission FBgn0086901
GO:0030865
IEA
PLAZA Integrative Orthologycortical cytoskeleton organization FBgn0086901
GO:0030866
IEA
PLAZA Integrative Orthologycortical actin cytoskeleton organization FBgn0086901
GO:0002165
IEA
PLAZA Integrative Orthologyinstar larval or pupal development FBgn0086901
GO:0090130
IEA
PLAZA Integrative Orthologytissue migration ENSG00000133121
GO:0043542
IEA
PLAZA Integrative Orthologyendothelial cell migration ENSG00000133121
GO:0002042
IEA
PLAZA Integrative Orthologycell migration involved in sprouting angiogenesis ENSG00000133121
GO:0051294
IEA
PLAZA Integrative Orthologyestablishment of spindle orientation FBgn0086901
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation FBgn0086901
GO:0090132
IEA
PLAZA Integrative Orthologyepithelium migration ENSG00000133121
GO:0051293
IEA
PLAZA Integrative Orthologyestablishment of spindle localization FBgn0086901
GO:0002040
IEA
PLAZA Integrative Orthologysprouting angiogenesis ENSG00000133121
GO:0035120
IEA
PLAZA Integrative Orthologypost-embryonic appendage morphogenesis FBgn0086901
GO:0060284
IEA
PLAZA Integrative Orthologyregulation of cell development FBgn0086901
GO:0007173
IEA
PLAZA Integrative Orthologyepidermal growth factor receptor signaling pathway FBgn0086901
GO:0007052
IEA
PLAZA Integrative Orthologymitotic spindle organization FBgn0086901
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0086901
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process FBgn0086901
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0086901
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation FBgn0086901
GO:0120035
IEA
PLAZA Integrative Orthologyregulation of plasma membrane bounded cell projection organization FBgn0086901
GO:0007051
IEA
PLAZA Integrative Orthologyspindle organization FBgn0086901
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development ENSG00000133121
GO:0072358
IEA
PLAZA Integrative Orthologycardiovascular system development ENSG00000133121
GO:0051276
IEA
PLAZA Integrative Orthologychromosome organization FBgn0086901
GO:0099537
IEA
PLAZA Integrative Orthologytrans-synaptic signaling FBgn0086901
GO:0099536
IEA
PLAZA Integrative Orthologysynaptic signaling FBgn0086901
GO:0010769
IEA
PLAZA Integrative Orthologyregulation of cell morphogenesis involved in differentiation FBgn0086901
GO:0001655
IEA
PLAZA Integrative Orthologyurogenital system development FBgn0086901
GO:0001894
IEA
PLAZA Integrative Orthologytissue homeostasis FBgn0086901
GO:0003159
IEA
PLAZA Integrative Orthologymorphogenesis of an endothelium ENSG00000133121
GO:0043535
IEA
PLAZA Integrative Orthologyregulation of blood vessel endothelial cell migration ENSG00000133121
GO:0043534
IEA
PLAZA Integrative Orthologyblood vessel endothelial cell migration ENSG00000133121
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development FBgn0086901
GO:0048546
IEA
PLAZA Integrative Orthologydigestive tract morphogenesis FBgn0086901
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation FBgn0086901
GO:0007088
IEA
PLAZA Integrative Orthologyregulation of mitotic nuclear division FBgn0086901
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0086901
GO:0048707
IEA
PLAZA Integrative Orthologyinstar larval or pupal morphogenesis FBgn0086901
GO:0038127
IEA
PLAZA Integrative OrthologyERBB signaling pathway FBgn0086901
GO:0090049
IEA
PLAZA Integrative Orthologyregulation of cell migration involved in sprouting angiogenesis ENSG00000133121
GO:1903671
IEA
PLAZA Integrative Orthologynegative regulation of sprouting angiogenesis ENSG00000133121
GO:0043537
IEA
PLAZA Integrative Orthologynegative regulation of blood vessel endothelial cell migration ENSG00000133121
GO:1903670
IEA
PLAZA Integrative Orthologyregulation of sprouting angiogenesis ENSG00000133121
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0086901
GO:0051304
IEA
PLAZA Integrative Orthologychromosome separation FBgn0086901
GO:0010631
IEA
PLAZA Integrative Orthologyepithelial cell migration ENSG00000133121
GO:0051306
IEA
PLAZA Integrative Orthologymitotic sister chromatid separation FBgn0086901
GO:0010596
IEA
PLAZA Integrative Orthologynegative regulation of endothelial cell migration ENSG00000133121
GO:0010632
IEA
PLAZA Integrative Orthologyregulation of epithelial cell migration ENSG00000133121
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division FBgn0086901
GO:0010633
IEA
PLAZA Integrative Orthologynegative regulation of epithelial cell migration ENSG00000133121
GO:0072001
IEA
PLAZA Integrative Orthologyrenal system development FBgn0086901
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division FBgn0086901
GO:0072002
IEA
PLAZA Integrative OrthologyMalpighian tubule development FBgn0086901
GO:0001525
IEA
PLAZA Integrative Orthologyangiogenesis ENSG00000133121
GO:0051783
IEA
PLAZA Integrative Orthologyregulation of nuclear division FBgn0086901
GO:0051301
IEA
PLAZA Integrative Orthologycell division FBgn0086901
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0086901
GO:0003158
IEA
PLAZA Integrative Orthologyendothelium development ENSG00000133121
GO:0048814
IEA
PLAZA Integrative Orthologyregulation of dendrite morphogenesis FBgn0086901
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle FBgn0086901
GO:0045664
IEA
PLAZA Integrative Orthologyregulation of neuron differentiation FBgn0086901
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0086901
GO:0007476
IEA
PLAZA Integrative Orthologyimaginal disc-derived wing morphogenesis FBgn0086901
GO:1902850
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization involved in mitosis FBgn0086901
GO:0007472
IEA
PLAZA Integrative Orthologywing disc morphogenesis FBgn0086901
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development FBgn0086901
GO:0051656
IEA
PLAZA Integrative Orthologyestablishment of organelle localization FBgn0086901
GO:0030010
IEA
PLAZA Integrative Orthologyestablishment of cell polarity FBgn0086901
GO:0031344
IEA
PLAZA Integrative Orthologyregulation of cell projection organization FBgn0086901
GO:0000070
IEA
PLAZA Integrative Orthologymitotic sister chromatid segregation FBgn0086901
GO:0010669
IEA
PLAZA Integrative Orthologyepithelial structure maintenance FBgn0086901
GO:0097498
IEA
PLAZA Integrative Orthologyendothelial tube lumen extension ENSG00000133121
GO:0051653
IEA
PLAZA Integrative Orthologyspindle localization FBgn0086901
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0086901
GO:0061326
IEA
PLAZA Integrative Orthologyrenal tubule development FBgn0086901
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization FBgn0086901
GO:0007268
IEA
PLAZA Integrative Orthologychemical synaptic transmission FBgn0086901
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0086901
GO:0035152
IEA
PLAZA Integrative Orthologyregulation of tube architecture, open tracheal system FBgn0086901
GO:0040001
IEA
PLAZA Integrative Orthologyestablishment of mitotic spindle localization FBgn0086901
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0086901
GO:0035277
IEA
PLAZA Integrative Orthologyspiracle morphogenesis, open tracheal system FBgn0086901
GO:0007091
IEA
PLAZA Integrative Orthologymetaphase/anaphase transition of mitotic cell cycle FBgn0086901
GO:0051649
IEA
PLAZA Integrative Orthologyestablishment of localization in cell FBgn0086901
GO:0051241
IEA
PLAZA Integrative Orthologynegative regulation of multicellular organismal process ENSG00000133121
GO:0001944
IEA
PLAZA Integrative Orthologyvasculature development ENSG00000133121
GO:0001700
IEA
PLAZA Integrative Orthologyembryonic development via the syncytial blastoderm FBgn0086901
GO:0001667
IEA
PLAZA Integrative Orthologyameboidal-type cell migration ENSG00000133121
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization FBgn0086901
GO:1905818
IEA
PLAZA Integrative Orthologyregulation of chromosome separation FBgn0086901
GO:0051640
IEA
PLAZA Integrative Orthologyorganelle localization FBgn0086901
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis FBgn0086901
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process FBgn0086901
GO:0090051
IEA
PLAZA Integrative Orthologynegative regulation of cell migration involved in sprouting angiogenesis ENSG00000133121
GO:0035160
IEA
PLAZA Integrative Orthologymaintenance of epithelial integrity, open tracheal system FBgn0086901
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0086901
GO:0008586
IEA
PLAZA Integrative Orthologyimaginal disc-derived wing vein morphogenesis FBgn0086901
GO:0051093
IEA
PLAZA Integrative Orthologynegative regulation of developmental process ENSG00000133121
GO:0048514
IEA
PLAZA Integrative Orthologyblood vessel morphogenesis ENSG00000133121
GO:0045765
IEA
PLAZA Integrative Orthologyregulation of angiogenesis ENSG00000133121
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process FBgn0086901
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0086901
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development FBgn0086901
GO:1901342
IEA
PLAZA Integrative Orthologyregulation of vasculature development ENSG00000133121
GO:1901343
IEA
PLAZA Integrative Orthologynegative regulation of vasculature development ENSG00000133121
GO:0007494
IEA
PLAZA Integrative Orthologymidgut development FBgn0086901
GO:0061333
IEA
PLAZA Integrative Orthologyrenal tubule morphogenesis FBgn0086901
GO:0016525
IEA
PLAZA Integrative Orthologynegative regulation of angiogenesis ENSG00000133121

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005096
IDA, IMP
TAS
Genome ProjectGTPase activator activity
GO:0005096
IDA, IMP
TAS
Gene OntologyGTPase activator activity1 3
GO:0042169
IPI
Genome ProjectSH2 domain binding
GO:0042169
IPI
Gene OntologySH2 domain binding7
GO:0008289
IEA
Genome Projectlipid binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 5 8 9

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032587
IDA
Genome Projectruffle membrane
GO:0032587
IDA
Gene Ontologyruffle membrane2
GO:0030864
IDA
Genome Projectcortical actin cytoskeleton
GO:0030864
IDA
Gene Ontologycortical actin cytoskeleton2
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005925
IDA
Gene Ontologyfocal adhesion5 7
GO:0005901
IDA
Genome Projectcaveola
GO:0005901
IDA
Gene Ontologycaveola5
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol2
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm1 5
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus1
GO:0016323
IEA
PLAZA Integrative Orthologybasolateral plasma membrane FBgn0086901

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000198Rho GTPase-activating protein domain
IPR001660Sterile alpha motif domain
IPR002913START domain
IPR008936Rho GTPase activation protein
IPR013761Sterile alpha motif/pointed domain superfamily
IPR023393START-like domain superfamily
IPR028854Rho GTPase-activating protein 7

No MapMan annotations defined for this gene.
No Kegg annotations defined for this gene.
No chloroplast target sequence found.