Gene: ENSG00000164362 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000164362
Transcript Identifier
ENST00000310581
Gene Type
Coding gene
Location
5 : 1253728-1294989 : negative

Family Information

Homologous gene family
HOM02SEM003530
(22 genes in 19 species)
specific family

Descriptions

gene_descr
telomerase reverse transcriptase

Identifiers

Type Value
pidENSP00000309572
HGNC11730
UniprotO14746
RefSeq_mRNANM_198253.2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001240
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240
IMP
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway in absence of ligand1
GO:2000773
IDA, IMP
Genome Projectnegative regulation of cellular senescence
GO:2000773
IDA, IMP
Gene Ontologynegative regulation of cellular senescence2 3
GO:2000648
ISS
Genome Projectpositive regulation of stem cell proliferation
GO:2000648
ISS
Gene Ontologypositive regulation of stem cell proliferation
GO:2000352
IEA
Genome Projectnegative regulation of endothelial cell apoptotic process
GO:1904837
TAS
Genome Projectbeta-catenin-TCF complex assembly
GO:1904837
TAS
Gene Ontologybeta-catenin-TCF complex assembly
GO:1904754
IEA
Genome Projectpositive regulation of vascular associated smooth muscle cell migration
GO:1904751
IDA
Genome Projectpositive regulation of protein localization to nucleolus
GO:1904751
IDA
Gene Ontologypositive regulation of protein localization to nucleolus4
GO:1904707
IEA
Genome Projectpositive regulation of vascular smooth muscle cell proliferation
GO:1903704
IDA
Genome Projectnegative regulation of production of siRNA involved in RNA interference
GO:1903704
IDA
Gene Ontologynegative regulation of production of siRNA involved in RNA interference5
GO:1903620
IEA
Genome Projectpositive regulation of transdifferentiation
GO:1902895
IMP
Genome Projectpositive regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895
IMP
Gene Ontologypositive regulation of pri-miRNA transcription by RNA polymerase II6
GO:1900087
IEA
Genome Projectpositive regulation of G1/S transition of mitotic cell cycle
GO:0090399
IMP
Genome Projectreplicative senescence
GO:0090399
IMP
Gene Ontologyreplicative senescence7
GO:0071897
IDA
Genome ProjectDNA biosynthetic process
GO:0071897
IDA
Gene OntologyDNA biosynthetic process5 8
GO:0071456
IMP
Genome Projectcellular response to hypoxia
GO:0071456
IMP
Gene Ontologycellular response to hypoxia2
GO:0070200
IDA
Genome Projectestablishment of protein localization to telomere
GO:0070200
IDA
Gene Ontologyestablishment of protein localization to telomere9
GO:0060253
IEA
Genome Projectnegative regulation of glial cell proliferation
GO:0051000
IDA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051000
IDA
Gene Ontologypositive regulation of nitric-oxide synthase activity3
GO:0046686
IEA
Genome Projectresponse to cadmium ion
GO:0046326
IEA
Genome Projectpositive regulation of glucose import
GO:0045766
IEA
Genome Projectpositive regulation of angiogenesis
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0042635
ISS
Genome Projectpositive regulation of hair cycle
GO:0042635
ISS
Gene Ontologypositive regulation of hair cycle
GO:0032774
IDA
Genome ProjectRNA biosynthetic process
GO:0032774
IDA
Gene OntologyRNA biosynthetic process5
GO:0032092
IDA
Genome Projectpositive regulation of protein binding
GO:0032092
IDA
Gene Ontologypositive regulation of protein binding4
GO:0031647
IDA, IMP
Genome Projectregulation of protein stability
GO:0031647
IDA, IMP
Gene Ontologyregulation of protein stability4 10
GO:0030422
IDA
Genome Projectproduction of siRNA involved in RNA interference
GO:0030422
IDA
Gene Ontologyproduction of siRNA involved in RNA interference5
GO:0030177
IGI
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030177
IGI
Gene Ontologypositive regulation of Wnt signaling pathway11
GO:0022616
IDA
Genome ProjectDNA strand elongation
GO:0022616
IDA
Gene OntologyDNA strand elongation12
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010629
IDA
Gene Ontologynegative regulation of gene expression3
GO:0007005
IDA
Genome Projectmitochondrion organization
GO:0007005
IDA
Gene Ontologymitochondrion organization13
GO:0007004
IDA, IMP
TAS, NAS
Genome Projecttelomere maintenance via telomerase
GO:0007004
IDA, IMP
TAS, NAS
Gene Ontologytelomere maintenance via telomerase5 7 12 14 15 16 17 18
GO:0006278
IDA
Genome ProjectRNA-dependent DNA biosynthetic process
GO:0006278
IDA
Gene OntologyRNA-dependent DNA biosynthetic process8
GO:0001172
IDA
Genome Projecttranscription, RNA-templated
GO:0001172
IDA
Gene Ontologytranscription, RNA-templated5
GO:0000723
TAS
Genome Projecttelomere maintenance
GO:0000723
TAS
Gene Ontologytelomere maintenance19
GO:0098727
IEA
PLAZA Integrative Orthologymaintenance of cell number AT5G16850
GO:0050000
IEA
PLAZA Integrative Orthologychromosome localization AT5G16850
GO:0051053
IEA
PLAZA Integrative Orthologynegative regulation of DNA metabolic process SPBC29A3.14c
GO:0072695
IEA
PLAZA Integrative Orthologyregulation of DNA recombination at telomere SPBC29A3.14c
GO:0010449
IEA
PLAZA Integrative Orthologyroot meristem growth AT5G16850
GO:0045910
IEA
PLAZA Integrative Orthologynegative regulation of DNA recombination SPBC29A3.14c
GO:1904868
IEA
PLAZA Integrative Orthologytelomerase catalytic core complex assembly SPBC29A3.14c
GO:0040007
IEA
PLAZA Integrative Orthologygrowth AT5G16850
GO:0009888
IEA
PLAZA Integrative Orthologytissue development AT5G16850
GO:0006312
IEA
PLAZA Integrative Orthologymitotic recombination SPBC29A3.14c
GO:0048507
IEA
PLAZA Integrative Orthologymeristem development AT5G16850
GO:0006997
IEA
PLAZA Integrative Orthologynucleus organization AT5G16850
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth AT5G16850
GO:0045950
IEA
PLAZA Integrative Orthologynegative regulation of mitotic recombination SPBC29A3.14c
GO:0000722
IEA
PLAZA Integrative Orthologytelomere maintenance via recombination SPBC29A3.14c
GO:0022613
IEA
PLAZA Integrative Orthologyribonucleoprotein complex biogenesis SPBC29A3.14c
GO:0006310
IEA
PLAZA Integrative OrthologyDNA recombination SPBC29A3.14c
GO:0022618
IEA
PLAZA Integrative Orthologyribonucleoprotein complex assembly SPBC29A3.14c
GO:0010073
IEA
PLAZA Integrative Orthologymeristem maintenance AT5G16850
GO:0007000
IEA
PLAZA Integrative Orthologynucleolus organization AT5G16850
GO:0019827
IEA
PLAZA Integrative Orthologystem cell population maintenance AT5G16850
GO:0071826
IEA
PLAZA Integrative Orthologyribonucleoprotein complex subunit organization SPBC29A3.14c
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization SPBC29A3.14c
GO:0032204
IEA
PLAZA Integrative Orthologyregulation of telomere maintenance SPBC29A3.14c
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization SPBC29A3.14c
GO:0032205
IEA
PLAZA Integrative Orthologynegative regulation of telomere maintenance SPBC29A3.14c
GO:0034622
IEA
PLAZA Integrative Orthologycellular protein-containing complex assembly SPBC29A3.14c
GO:0099402
IEA
PLAZA Integrative Orthologyplant organ development AT5G16850
GO:0010639
IEA
PLAZA Integrative Orthologynegative regulation of organelle organization SPBC29A3.14c
GO:0032208
IEA
PLAZA Integrative Orthologynegative regulation of telomere maintenance via recombination SPBC29A3.14c
GO:0051640
IEA
PLAZA Integrative Orthologyorganelle localization AT5G16850
GO:0032207
IEA
PLAZA Integrative Orthologyregulation of telomere maintenance via recombination SPBC29A3.14c
GO:0048364
IEA
PLAZA Integrative Orthologyroot development AT5G16850
GO:0001302
IEA
PLAZA Integrative Orthologyreplicative cell aging YLR318W
GO:0000018
IEA
PLAZA Integrative Orthologyregulation of DNA recombination SPBC29A3.14c
GO:0051052
IEA
PLAZA Integrative Orthologyregulation of DNA metabolic process SPBC29A3.14c
GO:0000019
IEA
PLAZA Integrative Orthologyregulation of mitotic recombination SPBC29A3.14c
GO:0048239
IEA
PLAZA Integrative Orthologynegative regulation of DNA recombination at telomere SPBC29A3.14c
GO:0022622
IEA
PLAZA Integrative Orthologyroot system development AT5G16850
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization SPBC29A3.14c
GO:1905323
IEA
PLAZA Integrative Orthologytelomerase holoenzyme complex assembly SPBC29A3.14c
GO:0033044
IEA
PLAZA Integrative Orthologyregulation of chromosome organization SPBC29A3.14c
GO:0035266
IEA
PLAZA Integrative Orthologymeristem growth AT5G16850
GO:2001251
IEA
PLAZA Integrative Orthologynegative regulation of chromosome organization SPBC29A3.14c

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0098680
IDA
Genome Projecttemplate-free RNA nucleotidyltransferase
GO:0098680
IDA
Gene Ontologytemplate-free RNA nucleotidyltransferase5
GO:0016779
IDA
Genome Projectnucleotidyltransferase activity
GO:0016779
IDA
Gene Ontologynucleotidyltransferase activity5
GO:0003968
IDA
Genome ProjectRNA-directed 5'-3' RNA polymerase activity
GO:0003968
IDA
Gene OntologyRNA-directed 5'-3' RNA polymerase activity5
GO:0003721
IDA, IMP
TAS
Genome Projecttelomerase RNA reverse transcriptase activity
GO:0003721
IDA, IMP
TAS
Gene Ontologytelomerase RNA reverse transcriptase activity2 5 8 16 20 21
GO:0003720
IDA
TAS
Genome Projecttelomerase activity
GO:0003720
IDA
TAS
Gene Ontologytelomerase activity3 8 12 15 16 17 18 19 22 23 24 25
GO:0070034
IDA, IPI
Genome Projecttelomerase RNA binding
GO:0070034
IDA, IPI
Gene Ontologytelomerase RNA binding5 16 22 23 26 27
GO:0051087
IPI
Genome Projectchaperone binding
GO:0051087
IPI
Gene Ontologychaperone binding28 29
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0042803
IDA, IPI
Genome Projectprotein homodimerization activity
GO:0042803
IDA, IPI
Gene Ontologyprotein homodimerization activity24 26
GO:0042162
TAS
Genome Projecttelomeric DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding9 11 16 23 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46
GO:0003964
IDA
TAS
Genome ProjectRNA-directed DNA polymerase activity
GO:0003964
IDA
TAS
Gene OntologyRNA-directed DNA polymerase activity6 13
GO:0003723
IPI
Genome ProjectRNA binding
GO:0003723
IPI
Gene OntologyRNA binding5 16 22 23 27
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding13
GO:0001223
IPI
Genome Projecttranscription coactivator binding
GO:0001223
IPI
Gene Ontologytranscription coactivator binding11
GO:0000049
IDA
Genome ProjecttRNA binding
GO:0000049
IDA
Gene OntologytRNA binding13
GO:0047485
IPI
Gene Ontologyprotein N-terminus binding47
GO:0042802
IPI
Gene Ontologyidentical protein binding24
GO:0008022
IPI
Gene Ontologyprotein C-terminus binding47

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016605
IDA
Genome ProjectPML body
GO:0016605
IDA
Gene OntologyPML body38
GO:1990572
IDA
Genome ProjectTERT-RMRP complex
GO:1990572
IDA
Gene OntologyTERT-RMRP complex5
GO:0042645
IDA
Genome Projectmitochondrial nucleoid
GO:0042645
IDA
Gene Ontologymitochondrial nucleoid13
GO:0031379
IPI
Genome ProjectRNA-directed RNA polymerase complex
GO:0031379
IPI
Gene OntologyRNA-directed RNA polymerase complex5
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005730
IDA
NAS
Genome Projectnucleolus
GO:0005730
IDA
NAS
Gene Ontologynucleolus10 44
GO:0005697
IDA, IPI
TAS
Genome Projecttelomerase holoenzyme complex
GO:0005697
IDA, IPI
TAS
Gene Ontologytelomerase holoenzyme complex5 18 19 23 48 49
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm38
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4 41
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0000784
IDA
Gene Ontologynuclear chromosome, telomeric region9
GO:0000783
IC
Genome Projectnuclear telomere cap complex
GO:0000783
IC
Gene Ontologynuclear telomere cap complex21
GO:0000781
IC
Genome Projectchromosome, telomeric region
GO:0000781
IC
Gene Ontologychromosome, telomeric region19
GO:0000333
IDA, IPI, IMP
Genome Projecttelomerase catalytic core complex
GO:0000333
IDA, IPI, IMP
Gene Ontologytelomerase catalytic core complex2 5 8 15 16 22 23
GO:0016607
IDA
Gene Ontologynuclear speck
GO:0005829
IDA
Gene Ontologycytosol

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000477Reverse transcriptase domain
IPR003545Telomerase reverse transcriptase
IPR021891Telomerase ribonucleoprotein complex - RNA-binding domain

No MapMan annotations defined for this gene.
KeggID Description
K11126TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
No chloroplast target sequence found.