Gene: ENSG00000164327 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000164327
Transcript Identifier
ENST00000296782
Gene Type
Coding gene
Location
5 : 38942304-39074377 : negative

Family Information

Homologous gene family
HOM02SEM010786
(8 genes in 8 species)
specific family
Orthologous gene family
ORTHO02SEM009296
(8 genes in 8 species)
specific family

Descriptions

gene_descr
RPTOR independent companion of MTOR, complex 2

Identifiers

Type Value
pidENSP00000296782
HGNC28611
UniprotQ6R327
RefSeq_mRNANM_001285439.1
EMBLCHEMBL1795179
EMBLAB082530
EMBLAC008964
EMBLAC109467
EMBLAL834497
EMBLAY515854
EMBLBC051729
EMBLBC137163
EMBLBC137164
EMBLBC144509
EMBLCH471119
EMBLCR749280

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000114
IEA
Genome Projectregulation of establishment of cell polarity
GO:0051897
IBA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051896
IDA
Genome Projectregulation of protein kinase B signaling
GO:0051896
IDA
Gene Ontologyregulation of protein kinase B signaling1
GO:0050731
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050727
IEA
Genome Projectregulation of inflammatory response
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0043087
IEA
Genome Projectregulation of GTPase activity
GO:0043085
IEA
Genome Projectpositive regulation of catalytic activity
GO:0042325
IBA
Genome Projectregulation of phosphorylation
GO:0033135
IEA
Genome Projectregulation of peptidyl-serine phosphorylation
GO:0032956
IMP
Genome Projectregulation of actin cytoskeleton organization
GO:0032956
IMP
Gene Ontologyregulation of actin cytoskeleton organization2
GO:0032008
IMP
Genome Projectpositive regulation of TOR signaling
GO:0032008
IMP
Gene Ontologypositive regulation of TOR signaling2
GO:0031929
IEA
Genome ProjectTOR signaling
GO:0031532
IMP
Genome Projectactin cytoskeleton reorganization
GO:0031532
IMP
Gene Ontologyactin cytoskeleton reorganization3
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0030950
IBA
Genome Projectestablishment or maintenance of actin cytoskeleton polarity
GO:0030838
IEA
Genome Projectpositive regulation of actin filament polymerization
GO:0030010
IBA
Genome Projectestablishment of cell polarity
GO:0018105
IGI
Genome Projectpeptidyl-serine phosphorylation
GO:0018105
IGI
Gene Ontologypeptidyl-serine phosphorylation4
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0009790
ISS
Genome Projectembryo development
GO:0001938
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0032148
TAS
Gene Ontologyactivation of protein kinase B activity
GO:0009792
ISS
Gene Ontologyembryo development ending in birth or egg hatching
GO:0071900
IEA
PLAZA Integrative Orthologyregulation of protein serine/threonine kinase activity FBgn0031006
GO:0071902
IEA
PLAZA Integrative Orthologypositive regulation of protein serine/threonine kinase activity FBgn0031006
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process FBgn0031006
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0031006
GO:0006629
IEA
PLAZA Integrative Orthologylipid metabolic process YER093C
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process FBgn0031006
GO:1903508
IEA
PLAZA Integrative Orthologypositive regulation of nucleic acid-templated transcription FBgn0031006
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0031006
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0031006
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth FBgn0031006
GO:1901698
IEA
PLAZA Integrative Orthologyresponse to nitrogen compound FBgn0031006
GO:0007167
IEA
PLAZA Integrative Orthologyenzyme linked receptor protein signaling pathway FBgn0031006
GO:1901699
IEA
PLAZA Integrative Orthologycellular response to nitrogen compound FBgn0031006
GO:0007166
IEA
PLAZA Integrative Orthologycell surface receptor signaling pathway FBgn0031006
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated FBgn0031006
GO:0007169
IEA
PLAZA Integrative Orthologytransmembrane receptor protein tyrosine kinase signaling pathway FBgn0031006
GO:1901576
IEA
PLAZA Integrative Orthologyorganic substance biosynthetic process YER093C
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated FBgn0031006
GO:0038203
IEA
PLAZA Integrative OrthologyTORC2 signaling SPBC12C2.02c
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process FBgn0031006
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process FBgn0031006
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process FBgn0031006
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization FBgn0031006
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress SPBC12C2.02c
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process FBgn0031006
GO:0045595
IEA
PLAZA Integrative Orthologyregulation of cell differentiation FBgn0031006
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0031006
GO:0032868
IEA
PLAZA Integrative Orthologyresponse to insulin FBgn0031006
GO:0032869
IEA
PLAZA Integrative Orthologycellular response to insulin stimulus FBgn0031006
GO:0050773
IEA
PLAZA Integrative Orthologyregulation of dendrite development FBgn0031006
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0031006
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription FBgn0031006
GO:0045229
IEA
PLAZA Integrative Orthologyexternal encapsulating structure organization YER093C
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0031006
GO:1901566
IEA
PLAZA Integrative Orthologyorganonitrogen compound biosynthetic process YER093C
GO:0009058
IEA
PLAZA Integrative Orthologybiosynthetic process YER093C
GO:0009059
IEA
PLAZA Integrative Orthologymacromolecule biosynthetic process FBgn0031006
GO:0044255
IEA
PLAZA Integrative Orthologycellular lipid metabolic process YER093C
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0031006
GO:0042594
IEA
PLAZA Integrative Orthologyresponse to starvation SPBC12C2.02c
GO:1904398
IEA
PLAZA Integrative Orthologypositive regulation of neuromuscular junction development FBgn0031006
GO:0008361
IEA
PLAZA Integrative Orthologyregulation of cell size FBgn0031006
GO:1900078
IEA
PLAZA Integrative Orthologypositive regulation of cellular response to insulin stimulus FBgn0031006
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0031006
GO:1900076
IEA
PLAZA Integrative Orthologyregulation of cellular response to insulin stimulus FBgn0031006
GO:1904396
IEA
PLAZA Integrative Orthologyregulation of neuromuscular junction development FBgn0031006
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process FBgn0031006
GO:0016049
IEA
PLAZA Integrative Orthologycell growth YER093C
GO:0050767
IEA
PLAZA Integrative Orthologyregulation of neurogenesis FBgn0031006
GO:0031667
IEA
PLAZA Integrative Orthologyresponse to nutrient levels SPBC12C2.02c
GO:0032870
IEA
PLAZA Integrative Orthologycellular response to hormone stimulus FBgn0031006
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process FBgn0031006
GO:0050803
IEA
PLAZA Integrative Orthologyregulation of synapse structure or activity FBgn0031006
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression FBgn0031006
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0031006
GO:0051179
IEA
PLAZA Integrative Orthologylocalization FBgn0031006
GO:0031669
IEA
PLAZA Integrative Orthologycellular response to nutrient levels SPBC12C2.02c
GO:0031668
IEA
PLAZA Integrative Orthologycellular response to extracellular stimulus SPBC12C2.02c
GO:0009888
IEA
PLAZA Integrative Orthologytissue development WBGene00009245
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process FBgn0031006
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process FBgn0031006
GO:0043434
IEA
PLAZA Integrative Orthologyresponse to peptide hormone FBgn0031006
GO:0044249
IEA
PLAZA Integrative Orthologycellular biosynthetic process YER093C
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical FBgn0031006
GO:0050808
IEA
PLAZA Integrative Orthologysynapse organization FBgn0031006
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation FBgn0031006
GO:0050807
IEA
PLAZA Integrative Orthologyregulation of synapse organization FBgn0031006
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process FBgn0031006
GO:0090304
IEA
PLAZA Integrative Orthologynucleic acid metabolic process FBgn0031006
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus FBgn0031006
GO:0051963
IEA
PLAZA Integrative Orthologyregulation of synapse assembly FBgn0031006
GO:0051965
IEA
PLAZA Integrative Orthologypositive regulation of synapse assembly FBgn0031006
GO:0010975
IEA
PLAZA Integrative Orthologyregulation of neuron projection development FBgn0031006
GO:0071852
IEA
PLAZA Integrative Orthologyfungal-type cell wall organization or biogenesis YER093C
GO:0051960
IEA
PLAZA Integrative Orthologyregulation of nervous system development FBgn0031006
GO:0051962
IEA
PLAZA Integrative Orthologypositive regulation of nervous system development FBgn0031006
GO:0006643
IEA
PLAZA Integrative Orthologymembrane lipid metabolic process YER093C
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound FBgn0031006
GO:1901701
IEA
PLAZA Integrative Orthologycellular response to oxygen-containing compound FBgn0031006
GO:0060284
IEA
PLAZA Integrative Orthologyregulation of cell development FBgn0031006
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0031006
GO:0009991
IEA
PLAZA Integrative Orthologyresponse to extracellular stimulus SPBC12C2.02c
GO:0070925
IEA
PLAZA Integrative Orthologyorganelle assembly FBgn0031006
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0031006
GO:0120035
IEA
PLAZA Integrative Orthologyregulation of plasma membrane bounded cell projection organization FBgn0031006
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development FBgn0031006
GO:0010243
IEA
PLAZA Integrative Orthologyresponse to organonitrogen compound FBgn0031006
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process FBgn0031006
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process FBgn0031006
GO:0031328
IEA
PLAZA Integrative Orthologypositive regulation of cellular biosynthetic process FBgn0031006
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development FBgn0031006
GO:0009267
IEA
PLAZA Integrative Orthologycellular response to starvation SPBC12C2.02c
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation FBgn0031006
GO:0022613
IEA
PLAZA Integrative Orthologyribonucleoprotein complex biogenesis FBgn0031006
GO:1901652
IEA
PLAZA Integrative Orthologyresponse to peptide FBgn0031006
GO:1901653
IEA
PLAZA Integrative Orthologycellular response to peptide FBgn0031006
GO:0008610
IEA
PLAZA Integrative Orthologylipid biosynthetic process YER093C
GO:0022618
IEA
PLAZA Integrative Orthologyribonucleoprotein complex assembly FBgn0031006
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0031006
GO:0061586
IEA
PLAZA Integrative Orthologypositive regulation of transcription by transcription factor localization FBgn0031006
GO:0071826
IEA
PLAZA Integrative Orthologyribonucleoprotein complex subunit organization FBgn0031006
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0031006
GO:0048382
IEA
PLAZA Integrative Orthologymesendoderm development WBGene00009245
GO:0071555
IEA
PLAZA Integrative Orthologycell wall organization YER093C
GO:0071554
IEA
PLAZA Integrative Orthologycell wall organization or biogenesis YER093C
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance FBgn0031006
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process FBgn0031006
GO:0045793
IEA
PLAZA Integrative Orthologypositive regulation of cell size FBgn0031006
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process FBgn0031006
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process FBgn0031006
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0031006
GO:0006665
IEA
PLAZA Integrative Orthologysphingolipid metabolic process YER093C
GO:0045664
IEA
PLAZA Integrative Orthologyregulation of neuron differentiation FBgn0031006
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0031006
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0031006
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process FBgn0031006
GO:0008286
IEA
PLAZA Integrative Orthologyinsulin receptor signaling pathway FBgn0031006
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process FBgn0031006
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process FBgn0031006
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process FBgn0031006
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization FBgn0031006
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle FBgn0031006
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription FBgn0031006
GO:0031344
IEA
PLAZA Integrative Orthologyregulation of cell projection organization FBgn0031006
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process FBgn0031006
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus FBgn0031006
GO:0051254
IEA
PLAZA Integrative Orthologypositive regulation of RNA metabolic process FBgn0031006
GO:0001558
IEA
PLAZA Integrative Orthologyregulation of cell growth YER093C
GO:0007416
IEA
PLAZA Integrative Orthologysynapse assembly FBgn0031006
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process FBgn0031006
GO:0031505
IEA
PLAZA Integrative Orthologyfungal-type cell wall organization YER093C
GO:0040007
IEA
PLAZA Integrative Orthologygrowth YER093C
GO:0042149
IEA
PLAZA Integrative Orthologycellular response to glucose starvation SPBC12C2.02c
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth YER093C
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone FBgn0031006
GO:0006974
IEA
PLAZA Integrative Orthologycellular response to DNA damage stimulus FBgn0031006
GO:0046626
IEA
PLAZA Integrative Orthologyregulation of insulin receptor signaling pathway FBgn0031006
GO:0046467
IEA
PLAZA Integrative Orthologymembrane lipid biosynthetic process YER093C
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0031006
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0031006
GO:0045935
IEA
PLAZA Integrative Orthologypositive regulation of nucleobase-containing compound metabolic process FBgn0031006
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance FBgn0031006
GO:0046628
IEA
PLAZA Integrative Orthologypositive regulation of insulin receptor signaling pathway FBgn0031006
GO:0034063
IEA
PLAZA Integrative Orthologystress granule assembly FBgn0031006
GO:1902680
IEA
PLAZA Integrative Orthologypositive regulation of RNA biosynthetic process FBgn0031006
GO:0030148
IEA
PLAZA Integrative Orthologysphingolipid biosynthetic process YER093C
GO:0034504
IEA
PLAZA Integrative Orthologyprotein localization to nucleus FBgn0031006
GO:0071417
IEA
PLAZA Integrative Orthologycellular response to organonitrogen compound FBgn0031006
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process FBgn0031006
GO:0071375
IEA
PLAZA Integrative Orthologycellular response to peptide hormone stimulus FBgn0031006
GO:0071496
IEA
PLAZA Integrative Orthologycellular response to external stimulus SPBC12C2.02c
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process FBgn0031006
GO:0071495
IEA
PLAZA Integrative Orthologycellular response to endogenous stimulus FBgn0031006
GO:0045893
IEA
PLAZA Integrative Orthologypositive regulation of transcription, DNA-templated FBgn0031006
GO:0051124
IEA
PLAZA Integrative Orthologysynaptic growth at neuromuscular junction FBgn0031006
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization FBgn0031006
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process FBgn0031006
GO:0007528
IEA
PLAZA Integrative Orthologyneuromuscular junction development FBgn0031006
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth FBgn0031006
GO:0045887
IEA
PLAZA Integrative Orthologypositive regulation of synaptic growth at neuromuscular junction FBgn0031006
GO:0048639
IEA
PLAZA Integrative Orthologypositive regulation of developmental growth FBgn0031006
GO:0051094
IEA
PLAZA Integrative Orthologypositive regulation of developmental process FBgn0031006
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0031006
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization FBgn0031006
GO:0007498
IEA
PLAZA Integrative Orthologymesoderm development WBGene00009245
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0031006
GO:0008582
IEA
PLAZA Integrative Orthologyregulation of synaptic growth at neuromuscular junction FBgn0031006
GO:0007492
IEA
PLAZA Integrative Orthologyendoderm development WBGene00009245
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization FBgn0031006
GO:0045927
IEA
PLAZA Integrative Orthologypositive regulation of growth FBgn0031006

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043022
IEA
Genome Projectribosome binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding4 5
GO:0008047
IBA
Genome Projectenzyme activator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031932
IDA
Genome ProjectTORC2 complex
GO:0031932
IDA
Gene OntologyTORC2 complex2 3 19
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0032153
IEA
PLAZA Integrative Orthologycell division site SPBC12C2.02c
GO:0005634
IEA
PLAZA Integrative Orthologynucleus SPBC12C2.02c
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle SPBC12C2.02c
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle SPBC12C2.02c
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle SPBC12C2.02c
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle SPBC12C2.02c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR011989Armadillo-like helical
IPR016024Armadillo-type fold
IPR028267Rapamycin-insensitive companion of mTOR, N-terminal domain
IPR028268Pianissimo family
IPR029259Rapamycin-insensitive companion of mTOR, phosphorylation-site
IPR029451Rapamycin-insensitive companion of mTOR, middle domain
IPR029452Rapamycin-insensitive companion of mTOR, domain 5
IPR029453Rapamycin-insensitive companion of mTOR, domain 4

No MapMan annotations defined for this gene.
KeggID Description
K08267RICTOR; rapamycin-insensitive companion of mTOR
No chloroplast target sequence found.