Gene: ENSG00000164093 (Homo sapiens)

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Gene Identifier
ENSG00000164093
Transcript Identifier
ENST00000306732
Gene Type
Coding gene
Location
4 : 110618125-110622460 : negative

Family Information

Homologous gene family
HOM02SEM000303
(105 genes in 4 species)
specific family

Descriptions

gene_descr
paired-like homeodomain 2

Identifiers

Type Value
pidENSP00000304169
HGNC9005
UniprotQ99697
RefSeq_mRNANM_000325.5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000288
IEA
Genome Projectpositive regulation of myoblast proliferation
GO:0070986
ISS
Genome Projectleft/right axis specification
GO:0070986
ISS
Gene Ontologyleft/right axis specification
GO:0061325
ISS
Genome Projectcell proliferation involved in outflow tract morphogenesis
GO:0061325
ISS
Gene Ontologycell proliferation involved in outflow tract morphogenesis
GO:0061072
IMP
Genome Projectiris morphogenesis
GO:0061072
IMP
Gene Ontologyiris morphogenesis1
GO:0061031
IEA
Genome Projectendodermal digestive tract morphogenesis
GO:0060578
IEA
Genome Projectsuperior vena cava morphogenesis
GO:0060577
IEA
Genome Projectpulmonary vein morphogenesis
GO:0060460
IEA
Genome Projectleft lung morphogenesis
GO:0060412
IEA
Genome Projectventricular septum morphogenesis
GO:0060127
TAS
Genome Projectprolactin secreting cell differentiation
GO:0060127
TAS
Gene Ontologyprolactin secreting cell differentiation2
GO:0060126
TAS
Genome Projectsomatotropin secreting cell differentiation
GO:0060126
TAS
Gene Ontologysomatotropin secreting cell differentiation2
GO:0055015
IEA
Genome Projectventricular cardiac muscle cell development
GO:0055009
IEA
Genome Projectatrial cardiac muscle tissue morphogenesis
GO:0048557
IEA
Genome Projectembryonic digestive tract morphogenesis
GO:0048536
ISS
Genome Projectspleen development
GO:0048536
ISS
Gene Ontologyspleen development
GO:0045944
IDA
TAS
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
TAS
Gene Ontologypositive regulation of transcription by RNA polymerase II3 4
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0043010
IMP
Genome Projectcamera-type eye development
GO:0043010
IMP
Gene Ontologycamera-type eye development5
GO:0042476
IMP
Genome Projectodontogenesis
GO:0042476
IMP
Gene Ontologyodontogenesis6
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0035993
IMP
Genome Projectdeltoid tuberosity development
GO:0035993
IMP
Gene Ontologydeltoid tuberosity development7
GO:0035886
IEA
Genome Projectvascular smooth muscle cell differentiation
GO:0035315
IC
Genome Projecthair cell differentiation
GO:0035315
IC
Gene Ontologyhair cell differentiation4
GO:0035116
IEA
Genome Projectembryonic hindlimb morphogenesis
GO:0033189
IEA
Genome Projectresponse to vitamin A
GO:0031076
IEA
Genome Projectembryonic camera-type eye development
GO:0030334
IEA
Genome Projectregulation of cell migration
GO:0021855
IEA
Genome Projecthypothalamus cell migration
GO:0021763
IEA
Genome Projectsubthalamic nucleus development
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0009725
IEA
Genome Projectresponse to hormone
GO:0008585
IEA
Genome Projectfemale gonad development
GO:0008584
IEA
Genome Projectmale gonad development
GO:0007520
IEA
Genome Projectmyoblast fusion
GO:0007368
ISS
Genome Projectdetermination of left/right symmetry
GO:0007368
ISS
Gene Ontologydetermination of left/right symmetry
GO:0006366
IEA
Genome Projecttranscription by RNA polymerase II
GO:0006357
IDA
Genome Projectregulation of transcription by RNA polymerase II
GO:0006357
IDA
Gene Ontologyregulation of transcription by RNA polymerase II8
GO:0006355
IDA
Genome Projectregulation of transcription, DNA-templated
GO:0006355
IDA
Gene Ontologyregulation of transcription, DNA-templated9
GO:0003350
IEA
Genome Projectpulmonary myocardium development
GO:0003253
ISS
Genome Projectcardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003253
ISS
Gene Ontologycardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003171
IEA
Genome Projectatrioventricular valve development
GO:0002074
IEA
Genome Projectextraocular skeletal muscle development
GO:0001764
IEA
Genome Projectneuron migration
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001570
IEA
Genome Projectvasculogenesis
GO:0001569
IEA
Genome Projectbranching involved in blood vessel morphogenesis
GO:0033563
IEA
PLAZA Integrative Orthologydorsal/ventral axon guidance WBGene00006766
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis WBGene00006766
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization WBGene00006766
GO:0071542
IEA
PLAZA Integrative Orthologydopaminergic neuron differentiation ENSG00000107859
GO:0097154
IEA
PLAZA Integrative OrthologyGABAergic neuron differentiation WBGene00006766
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development WBGene00006766
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation WBGene00006766
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis WBGene00006766
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development WBGene00006766
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation WBGene00006766
GO:0061564
IEA
PLAZA Integrative Orthologyaxon development WBGene00006766
GO:0007409
IEA
PLAZA Integrative Orthologyaxonogenesis WBGene00006766
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis WBGene00006766
GO:0006935
IEA
PLAZA Integrative Orthologychemotaxis WBGene00006766
GO:0097485
IEA
PLAZA Integrative Orthologyneuron projection guidance WBGene00006766
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis WBGene00006766
GO:0007411
IEA
PLAZA Integrative Orthologyaxon guidance WBGene00006766
GO:0042330
IEA
PLAZA Integrative Orthologytaxis WBGene00006766
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis WBGene00006766
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization WBGene00006766
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis WBGene00006766
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis WBGene00006766
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization WBGene00006766

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031490
IEA
Genome Projectchromatin DNA binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding9
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding10 11 12 13
GO:0003700
IDA
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IDA
Gene OntologyDNA-binding transcription factor activity9
GO:0001102
IPI
Genome ProjectRNA polymerase II activating transcription factor binding
GO:0001102
IPI
Gene OntologyRNA polymerase II activating transcription factor binding3
GO:0000978
IEA
Genome ProjectRNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000976
IDA
Genome Projecttranscription regulatory region sequence-specific DNA binding
GO:0000976
IDA
Gene Ontologytranscription regulatory region sequence-specific DNA binding3
GO:0003713
IDA
Gene Ontologytranscription coactivator activity3
GO:0000981
ISA, ISM
NAS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific14

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005667
IDA
Gene Ontologytranscription factor complex9
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000069011
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000069011
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus ENSG00000069011

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001356Homeobox domain
IPR003654OAR domain
IPR009057Homeobox-like domain superfamily
IPR016233Homeobox protein Pitx/unc30
IPR017970Homeobox, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K04686PITX2; paired-like homeodomain transcription factor 2
No chloroplast target sequence found.