Gene: ENSG00000163918 (Homo sapiens)

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Gene Identifier
ENSG00000163918
Transcript Identifier
ENST00000296273
Gene Type
Coding gene
Location
3 : 186789969-186804713 : negative

Family Information

Homologous gene family
HOM02SEM000388
(90 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000793
(57 genes in 26 species)
specific family

Descriptions

gene_descr
replication factor C (activator 1) 4, 37kDa

Identifiers

Type Value
pidENSP00000296273
HGNC9972
UniprotP35249
RefSeq_mRNANM_002916.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1901796
TAS
Genome Projectregulation of signal transduction by p53 class mediator
GO:1900264
IDA
Genome Projectpositive regulation of DNA-directed DNA polymerase activity
GO:1900264
IDA
Gene Ontologypositive regulation of DNA-directed DNA polymerase activity1
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0042276
TAS
Genome Projecterror-prone translesion synthesis
GO:0042276
TAS
Gene Ontologyerror-prone translesion synthesis
GO:0033683
TAS
Genome Projectnucleotide-excision repair, DNA incision
GO:0033683
TAS
Gene Ontologynucleotide-excision repair, DNA incision
GO:0019985
TAS
Genome Projecttranslesion synthesis
GO:0019985
TAS
Gene Ontologytranslesion synthesis
GO:0006297
TAS
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
TAS
Gene Ontologynucleotide-excision repair, DNA gap filling
GO:0006296
TAS
Genome Projectnucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006296
TAS
Gene Ontologynucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006283
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006283
TAS
Gene Ontologytranscription-coupled nucleotide-excision repair
GO:0006271
TAS
Genome ProjectDNA strand elongation involved in DNA replication
GO:0006271
TAS
Gene OntologyDNA strand elongation involved in DNA replication2
GO:0006260
TAS
Genome ProjectDNA replication
GO:0006260
TAS
Gene OntologyDNA replication
GO:0000722
TAS
Genome Projecttelomere maintenance via recombination
GO:0032201
TAS
Gene Ontologytelomere maintenance via semi-conservative replication
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process SPAC23D3.02
GO:0031122
IEA
PLAZA Integrative Orthologycytoplasmic microtubule organization FBgn0030871
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0030871
GO:0097435
IEA
PLAZA Integrative Orthologysupramolecular fiber organization FBgn0030871
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0030871
GO:0046331
IEA
PLAZA Integrative Orthologylateral inhibition FBgn0030871
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0030871
GO:0006272
IEA
PLAZA Integrative Orthologyleading strand elongation YJR068W
GO:0031570
IEA
PLAZA Integrative OrthologyDNA integrity checkpoint SPAC23D3.02
GO:0033314
IEA
PLAZA Integrative Orthologymitotic DNA replication checkpoint SPAC23D3.02
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0030871
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation SPAC23D3.02
GO:0034644
IEA
PLAZA Integrative Orthologycellular response to UV SPAC23D3.02
GO:0000086
IEA
PLAZA Integrative OrthologyG2/M transition of mitotic cell cycle SPAC23D3.02
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process YJR068W
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle SPAC23D3.02
GO:0009416
IEA
PLAZA Integrative Orthologyresponse to light stimulus SPAC23D3.02
GO:0044774
IEA
PLAZA Integrative Orthologymitotic DNA integrity checkpoint SPAC23D3.02
GO:0009411
IEA
PLAZA Integrative Orthologyresponse to UV SPAC23D3.02
GO:0044772
IEA
PLAZA Integrative Orthologymitotic cell cycle phase transition SPAC23D3.02
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle SPAC23D3.02
GO:0044818
IEA
PLAZA Integrative Orthologymitotic G2/M transition checkpoint SPAC23D3.02
GO:0010389
IEA
PLAZA Integrative Orthologyregulation of G2/M transition of mitotic cell cycle SPAC23D3.02
GO:0104004
IEA
PLAZA Integrative Orthologycellular response to environmental stimulus SPAC23D3.02
GO:0044770
IEA
PLAZA Integrative Orthologycell cycle phase transition SPAC23D3.02
GO:0000075
IEA
PLAZA Integrative Orthologycell cycle checkpoint SPAC23D3.02
GO:0000076
IEA
PLAZA Integrative OrthologyDNA replication checkpoint SPAC23D3.02
GO:0010948
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle process SPAC23D3.02
GO:0071482
IEA
PLAZA Integrative Orthologycellular response to light stimulus SPAC23D3.02
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle SPAC23D3.02
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization FBgn0030871
GO:0006298
IEA
PLAZA Integrative Orthologymismatch repair YJR068W
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process SPAC23D3.02
GO:0045930
IEA
PLAZA Integrative Orthologynegative regulation of mitotic cell cycle SPAC23D3.02
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0030871
GO:1901991
IEA
PLAZA Integrative Orthologynegative regulation of mitotic cell cycle phase transition SPAC23D3.02
GO:1901990
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle phase transition SPAC23D3.02
GO:0070914
IEA
PLAZA Integrative OrthologyUV-damage excision repair SPAC23D3.02
GO:0007062
IEA
PLAZA Integrative Orthologysister chromatid cohesion YJR068W
GO:0010972
IEA
PLAZA Integrative Orthologynegative regulation of G2/M transition of mitotic cell cycle SPAC23D3.02
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation YJR068W
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle SPAC23D3.02
GO:0071214
IEA
PLAZA Integrative Orthologycellular response to abiotic stimulus SPAC23D3.02
GO:1902749
IEA
PLAZA Integrative Orthologyregulation of cell cycle G2/M phase transition SPAC23D3.02
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus SPAC23D3.02
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process FBgn0030871
GO:1901988
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle phase transition SPAC23D3.02
GO:1901987
IEA
PLAZA Integrative Orthologyregulation of cell cycle phase transition SPAC23D3.02
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process SPAC23D3.02
GO:0045168
IEA
PLAZA Integrative Orthologycell-cell signaling involved in cell fate commitment FBgn0030871
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation YJR068W
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation SPAC23D3.02
GO:0044839
IEA
PLAZA Integrative Orthologycell cycle G2/M phase transition SPAC23D3.02
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization FBgn0030871
GO:1902750
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle G2/M phase transition SPAC23D3.02
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process SPAC23D3.02
GO:0007093
IEA
PLAZA Integrative Orthologymitotic cell cycle checkpoint SPAC23D3.02
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation YJR068W

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043142
IDA
Genome Projectsingle-stranded DNA-dependent ATPase activity
GO:0043142
IDA
Gene Ontologysingle-stranded DNA-dependent ATPase activity1
GO:0003689
IDA
Genome ProjectDNA clamp loader activity
GO:0003689
IDA
Gene OntologyDNA clamp loader activity1
GO:0019899
IEA
Genome Projectenzyme binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 5 6 7 8
GO:0003682
IEA
PLAZA Integrative Orthologychromatin binding SPAC23D3.02
GO:0061860
IEA
PLAZA Integrative OrthologyDNA clamp unloader activity SPAC23D3.02

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031390
IDA
Genome ProjectCtf18 RFC-like complex
GO:0031390
IDA
Gene OntologyCtf18 RFC-like complex1
GO:0005663
IDA
Genome ProjectDNA replication factor C complex
GO:0005663
IDA
Gene OntologyDNA replication factor C complex3
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0031391
IDA
Gene OntologyElg1 RFC-like complex7
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part FBgn0030871
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPAC23D3.02
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton FBgn0030871
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus AT1G21690
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part SPAC23D3.02
GO:0031389
IEA
PLAZA Integrative OrthologyRad17 RFC-like complex YJR068W
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPAC23D3.02
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPAC23D3.02
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPAC23D3.02
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome SPAC23D3.02
GO:0043596
IEA
PLAZA Integrative Orthologynuclear replication fork SPAC23D3.02
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPAC23D3.02
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0030871
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton FBgn0030871

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003593AAA+ ATPase domain
IPR003959ATPase, AAA-type, core
IPR008921DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR013748Replication factor C, C-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K10755RFC2_4; replication factor C subunit 2/4
No chloroplast target sequence found.