Gene: ENSG00000158125 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000158125
Transcript Identifier
ENST00000379416
Gene Type
Coding gene
Location
2 : 31335958-31414666 : negative

Family Information

Homologous gene family
HOM02SEM000629
(65 genes in 22 species)
specific family
Orthologous gene family
ORTHO02SEM001113
(46 genes in 22 species)
specific family

Descriptions

gene_descr
xanthine dehydrogenase

Identifiers

Type Value
pidENSP00000368727
HGNC12805
UniprotP47989
RefSeq_mRNANM_000379.3
EMBLCHEMBL1929
EMBLD11456
EMBLDQ089481
EMBLU06117
EMBLU39487

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001213
IDA
Genome Projectnegative regulation of vasculogenesis
GO:2001213
IDA
Gene Ontologynegative regulation of vasculogenesis1
GO:2000379
IDA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2000379
IDA
Gene Ontologypositive regulation of reactive oxygen species metabolic process1
GO:1900747
IDA
Genome Projectnegative regulation of vascular endothelial growth factor signaling pathway
GO:1900747
IDA
Gene Ontologynegative regulation of vascular endothelial growth factor signaling pathway1
GO:1900745
IDA
Genome Projectpositive regulation of p38MAPK cascade
GO:1900745
IDA
Gene Ontologypositive regulation of p38MAPK cascade1
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0051898
IDA
Genome Projectnegative regulation of protein kinase B signaling
GO:0051898
IDA
Gene Ontologynegative regulation of protein kinase B signaling1
GO:0045602
IDA
Genome Projectnegative regulation of endothelial cell differentiation
GO:0045602
IDA
Gene Ontologynegative regulation of endothelial cell differentiation1
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010629
IDA
Gene Ontologynegative regulation of gene expression1
GO:0009115
IDA
Genome Projectxanthine catabolic process
GO:0009115
IDA
Gene Ontologyxanthine catabolic process2 3
GO:0007595
IEA
Genome Projectlactation
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:0006195
TAS
Genome Projectpurine nucleotide catabolic process
GO:0006195
TAS
Gene Ontologypurine nucleotide catabolic process
GO:0001937
IDA
Genome Projectnegative regulation of endothelial cell proliferation
GO:0001937
IDA
Gene Ontologynegative regulation of endothelial cell proliferation1
GO:0001933
IDA
Genome Projectnegative regulation of protein phosphorylation
GO:0001933
IDA
Gene Ontologynegative regulation of protein phosphorylation1
GO:0048072
IEA
PLAZA Integrative Orthologycompound eye pigmentation FBgn0003308
GO:0035967
IEA
PLAZA Integrative Orthologycellular response to topologically incorrect protein WBGene00015057
GO:0035966
IEA
PLAZA Integrative Orthologyresponse to topologically incorrect protein WBGene00015057
GO:0016143
IEA
PLAZA Integrative OrthologyS-glycoside metabolic process AT1G04580
GO:0006629
IEA
PLAZA Integrative Orthologylipid metabolic process AT2G27150
GO:0042493
IEA
PLAZA Integrative Orthologyresponse to drug FBgn0003308
GO:1901605
IEA
PLAZA Integrative Orthologyalpha-amino acid metabolic process FBgn0003308
GO:0001101
IEA
PLAZA Integrative Orthologyresponse to acid chemical AT4G34890
GO:1901615
IEA
PLAZA Integrative Orthologyorganic hydroxy compound metabolic process AT2G27150
GO:0006117
IEA
PLAZA Integrative Orthologyacetaldehyde metabolic process FBgn0038349
GO:0007568
IEA
PLAZA Integrative Orthologyaging FBgn0003308
GO:0009064
IEA
PLAZA Integrative Orthologyglutamine family amino acid metabolic process FBgn0003308
GO:0010035
IEA
PLAZA Integrative Orthologyresponse to inorganic substance AT4G34890
GO:0097305
IEA
PLAZA Integrative Orthologyresponse to alcohol FBgn0003308
GO:0051186
IEA
PLAZA Integrative Orthologycofactor metabolic process FBgn0267408
GO:0048069
IEA
PLAZA Integrative Orthologyeye pigmentation FBgn0003308
GO:0046165
IEA
PLAZA Integrative Orthologyalcohol biosynthetic process AT2G27150
GO:0030968
IEA
PLAZA Integrative Orthologyendoplasmic reticulum unfolded protein response WBGene00015057
GO:0048066
IEA
PLAZA Integrative Orthologydevelopmental pigmentation FBgn0003308
GO:0045471
IEA
PLAZA Integrative Orthologyresponse to ethanol FBgn0003308
GO:0006979
IEA
PLAZA Integrative Orthologyresponse to oxidative stress AT4G34890
GO:0006986
IEA
PLAZA Integrative Orthologyresponse to unfolded protein WBGene00015057
GO:0043289
IEA
PLAZA Integrative Orthologyapocarotenoid biosynthetic process AT2G27150
GO:0009850
IEA
PLAZA Integrative Orthologyauxin metabolic process AT5G20960
GO:0006066
IEA
PLAZA Integrative Orthologyalcohol metabolic process AT2G27150
GO:0009851
IEA
PLAZA Integrative Orthologyauxin biosynthetic process AT5G20960
GO:0006586
IEA
PLAZA Integrative Orthologyindolalkylamine metabolic process FBgn0003308
GO:0044255
IEA
PLAZA Integrative Orthologycellular lipid metabolic process AT2G27150
GO:0046677
IEA
PLAZA Integrative Orthologyresponse to antibiotic FBgn0003308
GO:0043288
IEA
PLAZA Integrative Orthologyapocarotenoid metabolic process AT2G27150
GO:0006801
IEA
PLAZA Integrative Orthologysuperoxide metabolic process AT4G34890
GO:0006525
IEA
PLAZA Integrative Orthologyarginine metabolic process FBgn0003308
GO:0006767
IEA
PLAZA Integrative Orthologywater-soluble vitamin metabolic process ENSG00000138356
GO:0046394
IEA
PLAZA Integrative Orthologycarboxylic acid biosynthetic process AT2G27150
GO:0043436
IEA
PLAZA Integrative Orthologyoxoacid metabolic process AT2G27150
GO:0000302
IEA
PLAZA Integrative Orthologyresponse to reactive oxygen species AT4G34890
GO:0006650
IEA
PLAZA Integrative Orthologyglycerophospholipid metabolic process FBgn0003308
GO:1902645
IEA
PLAZA Integrative Orthologytertiary alcohol biosynthetic process AT2G27150
GO:1902644
IEA
PLAZA Integrative Orthologytertiary alcohol metabolic process AT2G27150
GO:0017144
IEA
PLAZA Integrative Orthologydrug metabolic process ENSG00000138356
GO:0016053
IEA
PLAZA Integrative Orthologyorganic acid biosynthetic process AT2G27150
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus AT4G34890
GO:0009636
IEA
PLAZA Integrative Orthologyresponse to toxic substance FBgn0003308
GO:0006766
IEA
PLAZA Integrative Orthologyvitamin metabolic process ENSG00000138356
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound AT4G34890
GO:0006644
IEA
PLAZA Integrative Orthologyphospholipid metabolic process FBgn0003308
GO:0006520
IEA
PLAZA Integrative Orthologycellular amino acid metabolic process FBgn0003308
GO:0009072
IEA
PLAZA Integrative Orthologyaromatic amino acid family metabolic process FBgn0003308
GO:0006081
IEA
PLAZA Integrative Orthologycellular aldehyde metabolic process FBgn0267408
GO:0006082
IEA
PLAZA Integrative Orthologyorganic acid metabolic process AT2G27150
GO:0042446
IEA
PLAZA Integrative Orthologyhormone biosynthetic process AT5G20960
GO:0042445
IEA
PLAZA Integrative Orthologyhormone metabolic process AT5G20960
GO:0044106
IEA
PLAZA Integrative Orthologycellular amine metabolic process FBgn0003308
GO:0006952
IEA
PLAZA Integrative Orthologydefense response ENSG00000138356
GO:1901657
IEA
PLAZA Integrative Orthologyglycosyl compound metabolic process AT1G04580
GO:0008299
IEA
PLAZA Integrative Orthologyisoprenoid biosynthetic process AT2G27150
GO:1901135
IEA
PLAZA Integrative Orthologycarbohydrate derivative metabolic process AT1G04580
GO:0008610
IEA
PLAZA Integrative Orthologylipid biosynthetic process AT2G27150
GO:0006790
IEA
PLAZA Integrative Orthologysulfur compound metabolic process AT1G04580
GO:0032787
IEA
PLAZA Integrative Orthologymonocarboxylic acid metabolic process AT2G27150
GO:0072527
IEA
PLAZA Integrative Orthologypyrimidine-containing compound metabolic process FBgn0003308
GO:0016114
IEA
PLAZA Integrative Orthologyterpenoid biosynthetic process AT2G27150
GO:0072524
IEA
PLAZA Integrative Orthologypyridine-containing compound metabolic process ENSG00000138356
GO:0046486
IEA
PLAZA Integrative Orthologyglycerolipid metabolic process FBgn0003308
GO:0009414
IEA
PLAZA Integrative Orthologyresponse to water deprivation AT4G34890
GO:0009415
IEA
PLAZA Integrative Orthologyresponse to water AT4G34890
GO:0042554
IEA
PLAZA Integrative Orthologysuperoxide anion generation AT4G34890
GO:0042430
IEA
PLAZA Integrative Orthologyindole-containing compound metabolic process FBgn0003308
GO:0016106
IEA
PLAZA Integrative Orthologysesquiterpenoid biosynthetic process AT2G27150
GO:0034976
IEA
PLAZA Integrative Orthologyresponse to endoplasmic reticulum stress WBGene00015057
GO:0019757
IEA
PLAZA Integrative Orthologyglycosinolate metabolic process AT1G04580
GO:0019752
IEA
PLAZA Integrative Orthologycarboxylic acid metabolic process AT2G27150
GO:0006206
IEA
PLAZA Integrative Orthologypyrimidine nucleobase metabolic process FBgn0003308
GO:0072330
IEA
PLAZA Integrative Orthologymonocarboxylic acid biosynthetic process AT2G27150
GO:0006576
IEA
PLAZA Integrative Orthologycellular biogenic amine metabolic process FBgn0003308
GO:0009687
IEA
PLAZA Integrative Orthologyabscisic acid metabolic process AT2G27150
GO:0009688
IEA
PLAZA Integrative Orthologyabscisic acid biosynthetic process AT2G27150
GO:0019748
IEA
PLAZA Integrative Orthologysecondary metabolic process AT1G04580
GO:0034620
IEA
PLAZA Integrative Orthologycellular response to unfolded protein WBGene00015057
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging FBgn0003308
GO:0043473
IEA
PLAZA Integrative Orthologypigmentation FBgn0003308
GO:0019760
IEA
PLAZA Integrative Orthologyglucosinolate metabolic process AT1G04580
GO:0009308
IEA
PLAZA Integrative Orthologyamine metabolic process FBgn0003308
GO:0006954
IEA
PLAZA Integrative Orthologyinflammatory response ENSG00000138356
GO:1901617
IEA
PLAZA Integrative Orthologyorganic hydroxy compound biosynthetic process AT2G27150
GO:0006714
IEA
PLAZA Integrative Orthologysesquiterpenoid metabolic process AT2G27150
GO:0010817
IEA
PLAZA Integrative Orthologyregulation of hormone levels AT5G20960
GO:0006720
IEA
PLAZA Integrative Orthologyisoprenoid metabolic process AT2G27150
GO:0006568
IEA
PLAZA Integrative Orthologytryptophan metabolic process FBgn0003308
GO:0006721
IEA
PLAZA Integrative Orthologyterpenoid metabolic process AT2G27150
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan FBgn0003308
GO:0042817
IEA
PLAZA Integrative Orthologypyridoxal metabolic process FBgn0267408
GO:0042816
IEA
PLAZA Integrative Orthologyvitamin B6 metabolic process ENSG00000138356

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051537
IDA
Genome Project2 iron, 2 sulfur cluster binding
GO:0051537
IDA
Gene Ontology2 iron, 2 sulfur cluster binding3
GO:0050660
IDA
Genome Projectflavin adenine dinucleotide binding
GO:0050660
IDA
Gene Ontologyflavin adenine dinucleotide binding3
GO:0043546
IDA
Genome Projectmolybdopterin cofactor binding
GO:0043546
IDA
Gene Ontologymolybdopterin cofactor binding3
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0042803
IPI
Gene Ontologyprotein homodimerization activity3
GO:0016903
IBA
Genome Projectoxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0016614
IEA
Genome Projectoxidoreductase activity, acting on CH-OH group of donors
GO:0009055
IEA
Genome Projectelectron transfer activity
GO:0005506
IEA
Genome Projectiron ion binding
GO:0004855
EXP, IDA
Genome Projectxanthine oxidase activity
GO:0004855
EXP, IDA
Gene Ontologyxanthine oxidase activity2 3
GO:0004854
IDA
Genome Projectxanthine dehydrogenase activity
GO:0004854
IDA
Gene Ontologyxanthine dehydrogenase activity2
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding AT2G27150
GO:0050302
IEA
PLAZA Integrative Orthologyindole-3-acetaldehyde oxidase activity AT5G20960
GO:0044389
IEA
PLAZA Integrative Orthologyubiquitin-like protein ligase binding AT2G27150
GO:0010293
IEA
PLAZA Integrative Orthologyabscisic aldehyde oxidase activity AT2G27150
GO:0018479
IEA
PLAZA Integrative Orthologybenzaldehyde dehydrogenase (NAD+) activity AT1G04580
GO:0004732
IEA
PLAZA Integrative Orthologypyridoxal oxidase activity FBgn0267408
GO:0016620
IEA
PLAZA Integrative Orthologyoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor AT1G04580
GO:0018488
IEA
PLAZA Integrative Orthologyaryl-aldehyde oxidase activity AT5G20960
GO:0016623
IEA
PLAZA Integrative Orthologyoxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor AT5G20960
GO:0031625
IEA
PLAZA Integrative Orthologyubiquitin protein ligase binding AT2G27150
GO:0004029
IEA
PLAZA Integrative Orthologyaldehyde dehydrogenase (NAD) activity AT1G04580
GO:0004031
IEA
PLAZA Integrative Orthologyaldehyde oxidase activity AT5G20960

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016529
IEA
Genome Projectsarcoplasmic reticulum
GO:0005829
IBA
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005777
IEA
Genome Projectperoxisome
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
Gene Ontologyextracellular space4
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part FBgn0003308
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000138356
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000138356
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000138356
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000138356
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex FBgn0003308
GO:0016604
IEA
PLAZA Integrative Orthologynuclear body ENSG00000138356
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton FBgn0003308
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000138356
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton FBgn0003308
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000138356
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000138356
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000138356
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000138356
GO:0044451
IEA
PLAZA Integrative Orthologynucleoplasm part ENSG00000138356
GO:0005634
IEA
PLAZA Integrative Orthologynucleus ENSG00000138356
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000138356
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle FBgn0003308
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000138356
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000138356
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle FBgn0003308
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0003308

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000674Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR0010412Fe-2S ferredoxin-type iron-sulfur binding domain
IPR002346Molybdopterin dehydrogenase, FAD-binding
IPR002888[2Fe-2S]-binding
IPR005107CO dehydrogenase flavoprotein, C-terminal
IPR0060582Fe-2S ferredoxin, iron-sulphur binding site
IPR008274Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
IPR012675Beta-grasp domain superfamily
IPR014307Xanthine dehydrogenase, small subunit
IPR016166FAD-binding domain, PCMH-type
IPR016167FAD-binding, type PCMH, subdomain 1
IPR016169FAD-binding, type PCMH, subdomain 2
IPR016208Aldehyde oxidase/xanthine dehydrogenase
IPR022407Oxidoreductase, molybdopterin binding site

No MapMan annotations defined for this gene.
KeggID Description
K00106XDH; xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]
No chloroplast target sequence found.