Gene: ENSG00000157933 (Homo sapiens)

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Gene Identifier
ENSG00000157933
Transcript Identifier
ENST00000378536
Gene Type
Coding gene
Location
1 : 2228767-2306765 : positive

Family Information

Homologous gene family
HOM02SEM014148
(6 genes in 2 species)
specific family
Orthologous gene family
ORTHO02SEM016697
(3 genes in 2 species)
specific family

Descriptions

gene_descr
SKI proto-oncogene

Identifiers

Type Value
pidENSP00000367797
HGNC10896
UniprotP12755
RefSeq_mRNANM_003036.3
EMBLAL590822
EMBLX15218

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070207
IDA
Genome Projectprotein homotrimerization
GO:0070207
IDA
Gene Ontologyprotein homotrimerization1
GO:0060395
IDA
Genome ProjectSMAD protein signal transduction
GO:0060395
IDA
Gene OntologySMAD protein signal transduction2
GO:0060349
ISS
Genome Projectbone morphogenesis
GO:0060349
ISS
Gene Ontologybone morphogenesis
GO:0060325
ISS
Genome Projectface morphogenesis
GO:0060325
ISS
Gene Ontologyface morphogenesis
GO:0060041
ISS
Genome Projectretina development in camera-type eye
GO:0060041
ISS
Gene Ontologyretina development in camera-type eye
GO:0060021
ISS
Genome Projectroof of mouth development
GO:0060021
ISS
Gene Ontologyroof of mouth development
GO:0048870
NAS
Genome Projectcell motility
GO:0048870
NAS
Gene Ontologycell motility3
GO:0048741
ISS
Genome Projectskeletal muscle fiber development
GO:0048741
ISS
Gene Ontologyskeletal muscle fiber development
GO:0048666
IBA
Genome Projectneuron development
GO:0048593
ISS
Genome Projectcamera-type eye morphogenesis
GO:0048593
ISS
Gene Ontologycamera-type eye morphogenesis
GO:0048147
ISS
Genome Projectnegative regulation of fibroblast proliferation
GO:0048147
ISS
Gene Ontologynegative regulation of fibroblast proliferation
GO:0045944
ISS
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
ISS
Gene Ontologypositive regulation of transcription by RNA polymerase II
GO:0045668
IDA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045668
IDA
Gene Ontologynegative regulation of osteoblast differentiation4
GO:0043585
ISS
Genome Projectnose morphogenesis
GO:0043585
ISS
Gene Ontologynose morphogenesis
GO:0043388
IDA
Genome Projectpositive regulation of DNA binding
GO:0043388
IDA
Gene Ontologypositive regulation of DNA binding5
GO:0043010
ISS
Genome Projectcamera-type eye development
GO:0043010
ISS
Gene Ontologycamera-type eye development
GO:0035019
ISS
Genome Projectsomatic stem cell population maintenance
GO:0035019
ISS
Gene Ontologysomatic stem cell population maintenance
GO:0032926
IDA
Genome Projectnegative regulation of activin receptor signaling pathway
GO:0032926
IDA
Gene Ontologynegative regulation of activin receptor signaling pathway4
GO:0031064
IEA
Genome Projectnegative regulation of histone deacetylation
GO:0030514
IDA, IMP
Genome Projectnegative regulation of BMP signaling pathway
GO:0030514
IDA, IMP
Gene Ontologynegative regulation of BMP signaling pathway4 6
GO:0030512
IDA, IMP, IGI
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0030512
IDA, IMP, IGI
Gene Ontologynegative regulation of transforming growth factor beta receptor signaling pathway6 7 8 9
GO:0030509
TAS
Genome ProjectBMP signaling pathway
GO:0030509
TAS
Gene OntologyBMP signaling pathway
GO:0030326
ISS
Genome Projectembryonic limb morphogenesis
GO:0030326
ISS
Gene Ontologyembryonic limb morphogenesis
GO:0030177
NAS
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030177
NAS
Gene Ontologypositive regulation of Wnt signaling pathway3
GO:0022011
ISS
Genome Projectmyelination in peripheral nervous system
GO:0022011
ISS
Gene Ontologymyelination in peripheral nervous system
GO:0021772
ISS
Genome Projectolfactory bulb development
GO:0021772
ISS
Gene Ontologyolfactory bulb development
GO:0014902
IDA
Genome Projectmyotube differentiation
GO:0014902
IDA
Gene Ontologymyotube differentiation10
GO:0010626
IGI
Genome Projectnegative regulation of Schwann cell proliferation
GO:0010626
IGI
Gene Ontologynegative regulation of Schwann cell proliferation7
GO:0009948
ISS
Genome Projectanterior/posterior axis specification
GO:0009948
ISS
Gene Ontologyanterior/posterior axis specification
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0008285
IDA
Gene Ontologynegative regulation of cell proliferation11
GO:0008283
NAS
Genome Projectcell proliferation
GO:0008283
NAS
Gene Ontologycell proliferation3
GO:0007179
NAS
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007179
NAS
Gene Ontologytransforming growth factor beta receptor signaling pathway3
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0002089
ISS
Genome Projectlens morphogenesis in camera-type eye
GO:0002089
ISS
Gene Ontologylens morphogenesis in camera-type eye
GO:0001843
ISS
Genome Projectneural tube closure
GO:0001843
ISS
Gene Ontologyneural tube closure
GO:0000122
IDA, IMP
TAS
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
IDA, IMP
TAS
Gene Ontologynegative regulation of transcription by RNA polymerase II8 12
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation FBgn0085450
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0085450
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0085450
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0085450
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0085450
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0085450
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0085450
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0085450
GO:0090097
IEA
PLAZA Integrative Orthologyregulation of decapentaplegic signaling pathway FBgn0085450
GO:0008101
IEA
PLAZA Integrative Orthologydecapentaplegic signaling pathway FBgn0085450
GO:0090099
IEA
PLAZA Integrative Orthologynegative regulation of decapentaplegic signaling pathway FBgn0085450
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0085450
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0085450
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0085450
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0085450
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0085450

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070491
IPI
Genome Projectrepressing transcription factor binding
GO:0070491
IPI
Gene Ontologyrepressing transcription factor binding12
GO:0046811
ISS
Genome Projecthistone deacetylase inhibitor activity
GO:0046811
ISS
Gene Ontologyhistone deacetylase inhibitor activity
GO:0046332
IPI
Genome ProjectSMAD binding
GO:0046332
IPI
Gene OntologySMAD binding5 8
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding13
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0019904
IPI
Gene Ontologyprotein domain specific binding14
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding2
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0008270
IDA
Gene Ontologyzinc ion binding15
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 9 10 12 15 16 17 18 19 20 21 22 23 24 25 26 27
GO:0003714
IDA, IMP
Genome Projecttranscription corepressor activity
GO:0003714
IDA, IMP
Gene Ontologytranscription corepressor activity8 12
GO:0000981
ISM
NAS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific28
GO:1990837
IEA
PLAZA Integrative Orthologysequence-specific double-stranded DNA binding ENSG00000136603
GO:0097159
IEA
PLAZA Integrative Orthologyorganic cyclic compound binding ENSG00000136603
GO:0001067
IEA
PLAZA Integrative Orthologyregulatory region nucleic acid binding ENSG00000136603
GO:0003677
IEA
PLAZA Integrative OrthologyDNA binding ENSG00000136603
GO:0003676
IEA
PLAZA Integrative Orthologynucleic acid binding ENSG00000136603
GO:0000987
IEA
PLAZA Integrative Orthologyproximal promoter sequence-specific DNA binding ENSG00000136603
GO:0001012
IEA
PLAZA Integrative OrthologyRNA polymerase II regulatory region DNA binding ENSG00000136603
GO:0043565
IEA
PLAZA Integrative Orthologysequence-specific DNA binding ENSG00000136603
GO:0000976
IEA
PLAZA Integrative Orthologytranscription regulatory region sequence-specific DNA binding ENSG00000136603
GO:0044212
IEA
PLAZA Integrative Orthologytranscription regulatory region DNA binding ENSG00000136603
GO:0003690
IEA
PLAZA Integrative Orthologydouble-stranded DNA binding ENSG00000136603
GO:0000977
IEA
PLAZA Integrative OrthologyRNA polymerase II regulatory region sequence-specific DNA binding ENSG00000136603
GO:0000978
IEA
PLAZA Integrative OrthologyRNA polymerase II proximal promoter sequence-specific DNA binding ENSG00000136603
GO:1901363
IEA
PLAZA Integrative Orthologyheterocyclic compound binding ENSG00000136603

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0017053
ISS
Genome Projecttranscriptional repressor complex
GO:0017053
ISS
Gene Ontologytranscriptional repressor complex
GO:0016605
IDA
Genome ProjectPML body
GO:0016605
IDA
Gene OntologyPML body11
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body2
GO:0005813
IDA
Genome Projectcentrosome
GO:0005813
IDA
Gene Ontologycentrosome29
GO:0005737
ISS
Genome Projectcytoplasm
GO:0005737
ISS
Gene Ontologycytoplasm
GO:0005667
ISS
Genome Projecttranscription factor complex
GO:0005667
ISS
Gene Ontologytranscription factor complex
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus6 13
GO:0032991
IDA
Gene Ontologyprotein-containing complex25

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003380SKI/SNO/DAC domain
IPR009061Putative DNA-binding domain superfamily
IPR010919SAND-like domain superfamily
IPR014890c-SKI SMAD4-binding domain
IPR023216Transcription regulator SKI/SnoN
IPR028760Ski oncogene

No MapMan annotations defined for this gene.
No Kegg annotations defined for this gene.
No chloroplast target sequence found.