Gene: ENSG00000156709 (Homo sapiens)

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Gene Identifier
ENSG00000156709
Transcript Identifier
ENST00000287295
Gene Type
Coding gene
Location
X : 130129557-130165656 : negative

Family Information

Homologous gene family
HOM02SEM007530
(12 genes in 8 species)
specific family

Descriptions

gene_descr
apoptosis-inducing factor, mitochondrion-associated, 1

Identifiers

Type Value
pidENSP00000287295
HGNC8768
UniprotO95831
RefSeq_mRNANM_004208.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904045
IEA
Genome Projectcellular response to aldosterone
GO:1902510
IEA
Genome Projectregulation of apoptotic DNA fragmentation
GO:1902065
IEA
Genome Projectresponse to L-glutamate
GO:0090650
IEA
Genome Projectcellular response to oxygen-glucose deprivation
GO:0071732
IEA
Genome Projectcellular response to nitric oxide
GO:0071392
IEA
Genome Projectcellular response to estradiol stimulus
GO:0070301
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0070059
ISS
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070059
ISS
Gene Ontologyintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
TAS
Gene Ontologypositive regulation of apoptotic process1
GO:0030261
TAS
Genome Projectchromosome condensation
GO:0030261
TAS
Gene Ontologychromosome condensation1
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process2
GO:0006915
IMP
Genome Projectapoptotic process
GO:0006915
IMP
Gene Ontologyapoptotic process3
GO:0002931
IEA
Genome Projectresponse to ischemia
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport WBGene00006937
GO:0044070
IEA
PLAZA Integrative Orthologyregulation of anion transport WBGene00006937
GO:0032411
IEA
PLAZA Integrative Orthologypositive regulation of transporter activity WBGene00006937
GO:0019693
IEA
PLAZA Integrative Orthologyribose phosphate metabolic process FBgn0031392
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0031392
GO:0097035
IEA
PLAZA Integrative Orthologyregulation of membrane lipid distribution WBGene00006937
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization WBGene00006937
GO:0006753
IEA
PLAZA Integrative Orthologynucleoside phosphate metabolic process FBgn0031392
GO:0006869
IEA
PLAZA Integrative Orthologylipid transport WBGene00006937
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0031392
GO:0006796
IEA
PLAZA Integrative Orthologyphosphate-containing compound metabolic process FBgn0031392
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0031392
GO:0006952
IEA
PLAZA Integrative Orthologydefense response FBgn0031392
GO:0006793
IEA
PLAZA Integrative Orthologyphosphorus metabolic process FBgn0031392
GO:0009620
IEA
PLAZA Integrative Orthologyresponse to fungus FBgn0031392
GO:1903793
IEA
PLAZA Integrative Orthologypositive regulation of anion transport WBGene00006937
GO:1901135
IEA
PLAZA Integrative Orthologycarbohydrate derivative metabolic process FBgn0031392
GO:0009144
IEA
PLAZA Integrative Orthologypurine nucleoside triphosphate metabolic process FBgn0031392
GO:1900163
IEA
PLAZA Integrative Orthologypositive regulation of phospholipid scramblase activity WBGene00006937
GO:0055086
IEA
PLAZA Integrative Orthologynucleobase-containing small molecule metabolic process FBgn0031392
GO:0015980
IEA
PLAZA Integrative Orthologyenergy derivation by oxidation of organic compounds FBgn0031392
GO:1900161
IEA
PLAZA Integrative Orthologyregulation of phospholipid scramblase activity WBGene00006937
GO:0061024
IEA
PLAZA Integrative Orthologymembrane organization WBGene00006937
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0031392
GO:0009141
IEA
PLAZA Integrative Orthologynucleoside triphosphate metabolic process FBgn0031392
GO:0016310
IEA
PLAZA Integrative Orthologyphosphorylation FBgn0031392
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0031392
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization WBGene00006937
GO:0010876
IEA
PLAZA Integrative Orthologylipid localization WBGene00006937
GO:0017121
IEA
PLAZA Integrative Orthologyplasma membrane phospholipid scrambling WBGene00006937
GO:0034204
IEA
PLAZA Integrative Orthologylipid translocation WBGene00006937
GO:0070782
IEA
PLAZA Integrative Orthologyphosphatidylserine exposure on apoptotic cell surface WBGene00006937
GO:0072521
IEA
PLAZA Integrative Orthologypurine-containing compound metabolic process FBgn0031392
GO:0006811
IEA
PLAZA Integrative Orthologyion transport WBGene00006937
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus FBgn0031392
GO:0006820
IEA
PLAZA Integrative Orthologyanion transport WBGene00006937
GO:1900119
IEA
PLAZA Integrative Orthologypositive regulation of execution phase of apoptosis WBGene00006937
GO:0022900
IEA
PLAZA Integrative Orthologyelectron transport chain FBgn0031392
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0031392
GO:0022904
IEA
PLAZA Integrative Orthologyrespiratory electron transport chain FBgn0031392
GO:0009259
IEA
PLAZA Integrative Orthologyribonucleotide metabolic process FBgn0031392
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism FBgn0031392
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus FBgn0031392
GO:0015711
IEA
PLAZA Integrative Orthologyorganic anion transport WBGene00006937
GO:0061091
IEA
PLAZA Integrative Orthologyregulation of phospholipid translocation WBGene00006937
GO:0010623
IEA
PLAZA Integrative Orthologyprogrammed cell death involved in cell development FBgn0031392
GO:2001138
IEA
PLAZA Integrative Orthologyregulation of phospholipid transport WBGene00006937
GO:0061092
IEA
PLAZA Integrative Orthologypositive regulation of phospholipid translocation WBGene00006937
GO:0015914
IEA
PLAZA Integrative Orthologyphospholipid transport WBGene00006937
GO:0046034
IEA
PLAZA Integrative OrthologyATP metabolic process FBgn0031392
GO:0051130
IEA
PLAZA Integrative Orthologypositive regulation of cellular component organization WBGene00006937
GO:1903729
IEA
PLAZA Integrative Orthologyregulation of plasma membrane organization WBGene00006937
GO:0110113
IEA
PLAZA Integrative Orthologypositive regulation of lipid transporter activity WBGene00006937
GO:0051179
IEA
PLAZA Integrative Orthologylocalization WBGene00006937
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization WBGene00006937
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism FBgn0031392
GO:0110112
IEA
PLAZA Integrative Orthologyregulation of lipid transporter activity WBGene00006937
GO:0009205
IEA
PLAZA Integrative Orthologypurine ribonucleoside triphosphate metabolic process FBgn0031392
GO:0006810
IEA
PLAZA Integrative Orthologytransport WBGene00006937
GO:1905954
IEA
PLAZA Integrative Orthologypositive regulation of lipid localization WBGene00006937
GO:0045333
IEA
PLAZA Integrative Orthologycellular respiration FBgn0031392
GO:0009126
IEA
PLAZA Integrative Orthologypurine nucleoside monophosphate metabolic process FBgn0031392
GO:0009123
IEA
PLAZA Integrative Orthologynucleoside monophosphate metabolic process FBgn0031392
GO:1905952
IEA
PLAZA Integrative Orthologyregulation of lipid localization WBGene00006937
GO:0009167
IEA
PLAZA Integrative Orthologypurine ribonucleoside monophosphate metabolic process FBgn0031392
GO:0006091
IEA
PLAZA Integrative Orthologygeneration of precursor metabolites and energy FBgn0031392
GO:0009161
IEA
PLAZA Integrative Orthologyribonucleoside monophosphate metabolic process FBgn0031392
GO:2001140
IEA
PLAZA Integrative Orthologypositive regulation of phospholipid transport WBGene00006937
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality WBGene00006937
GO:0010256
IEA
PLAZA Integrative Orthologyendomembrane system organization WBGene00006937
GO:0032368
IEA
PLAZA Integrative Orthologyregulation of lipid transport WBGene00006937
GO:0015748
IEA
PLAZA Integrative Orthologyorganophosphate ester transport WBGene00006937
GO:0050832
IEA
PLAZA Integrative Orthologydefense response to fungus FBgn0031392
GO:0017144
IEA
PLAZA Integrative Orthologydrug metabolic process FBgn0031392
GO:0032409
IEA
PLAZA Integrative Orthologyregulation of transporter activity WBGene00006937
GO:0006119
IEA
PLAZA Integrative Orthologyoxidative phosphorylation FBgn0031392
GO:0045332
IEA
PLAZA Integrative Orthologyphospholipid translocation WBGene00006937
GO:0043270
IEA
PLAZA Integrative Orthologypositive regulation of ion transport WBGene00006937
GO:0007009
IEA
PLAZA Integrative Orthologyplasma membrane organization WBGene00006937
GO:0044281
IEA
PLAZA Integrative Orthologysmall molecule metabolic process FBgn0031392
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport WBGene00006937
GO:0009117
IEA
PLAZA Integrative Orthologynucleotide metabolic process FBgn0031392
GO:0042775
IEA
PLAZA Integrative Orthologymitochondrial ATP synthesis coupled electron transport FBgn0031392
GO:0042773
IEA
PLAZA Integrative OrthologyATP synthesis coupled electron transport FBgn0031392
GO:0043269
IEA
PLAZA Integrative Orthologyregulation of ion transport WBGene00006937
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport WBGene00006937
GO:0009199
IEA
PLAZA Integrative Orthologyribonucleoside triphosphate metabolic process FBgn0031392
GO:1905780
IEA
PLAZA Integrative Orthologyregulation of phosphatidylserine exposure on apoptotic cell surface WBGene00006937
GO:0006163
IEA
PLAZA Integrative Orthologypurine nucleotide metabolic process FBgn0031392
GO:0009150
IEA
PLAZA Integrative Orthologypurine ribonucleotide metabolic process FBgn0031392
GO:0019637
IEA
PLAZA Integrative Orthologyorganophosphate metabolic process FBgn0031392
GO:1905782
IEA
PLAZA Integrative Orthologypositive regulation of phosphatidylserine exposure on apoptotic cell surface WBGene00006937
GO:0032370
IEA
PLAZA Integrative Orthologypositive regulation of lipid transport WBGene00006937

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071949
IEA
Genome ProjectFAD binding
GO:0046983
IEA
Genome Projectprotein dimerization activity
GO:0016651
IDA
Genome Projectoxidoreductase activity, acting on NAD(P)H
GO:0016651
IDA
Gene Ontologyoxidoreductase activity, acting on NAD(P)H3
GO:0016174
TAS
Genome ProjectNAD(P)H oxidase activity
GO:0016174
TAS
Gene OntologyNAD(P)H oxidase activity1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 4 5 6
GO:0003677
IEA
Genome ProjectDNA binding
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding WBGene00006937

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0005829
ISS
Genome Projectcytosol
GO:0005829
ISS
Gene Ontologycytosol
GO:0005758
IDA
Genome Projectmitochondrial intermembrane space
GO:0005758
IDA
Gene Ontologymitochondrial intermembrane space7
GO:0005743
TAS
Genome Projectmitochondrial inner membrane
GO:0005743
TAS
Gene Ontologymitochondrial inner membrane1
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
Gene Ontologymitochondrion8
GO:0005634
IDA
ISS
Genome Projectnucleus
GO:0005634
IDA
ISS
Gene Ontologynucleus3

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR016156FAD/NAD-linked reductase, dimerisation domain superfamily
IPR023753FAD/NAD(P)-binding domain
IPR029324Mitochondrial apoptosis-inducing factor, C-terminal domain

No MapMan annotations defined for this gene.
KeggID Description
K04727AIFM1, PDCD8; apoptosis-inducing factor 1
No chloroplast target sequence found.