Gene: ENSG00000154803 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000154803
Transcript Identifier
ENST00000285071
Gene Type
Coding gene
Location
17 : 17213655-17228137 : negative

Family Information

Homologous gene family
HOM02SEM017068
(5 genes in 4 species)
specific family
Orthologous gene family
ORTHO02SEM012036
(5 genes in 4 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
folliculin

Identifiers

Type Value
pidENSP00000285071
HGNC27310
UniprotQ8NFG4
RefSeq_mRNANM_144997.5
EMBLAC055811
EMBLAF517523
EMBLAK126951
EMBLAK127912
EMBLBC015687
EMBLBC015725
EMBLCH471196

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001170
ISS
Genome Projectnegative regulation of ATP biosynthetic process
GO:2001170
ISS
Gene Ontologynegative regulation of ATP biosynthetic process
GO:2000973
ISS
Genome Projectregulation of pro-B cell differentiation
GO:2000973
ISS
Gene Ontologyregulation of pro-B cell differentiation
GO:1901723
ISS
Genome Projectnegative regulation of cell proliferation involved in kidney development
GO:1901723
ISS
Gene Ontologynegative regulation of cell proliferation involved in kidney development
GO:1900181
IDA
Genome Projectnegative regulation of protein localization to nucleus
GO:1900181
IDA
Gene Ontologynegative regulation of protein localization to nucleus1
GO:0070373
ISS
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070373
ISS
Gene Ontologynegative regulation of ERK1 and ERK2 cascade
GO:0051898
ISS
Genome Projectnegative regulation of protein kinase B signaling
GO:0051898
ISS
Gene Ontologynegative regulation of protein kinase B signaling
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA, IMP
Gene Ontologypositive regulation of transcription by RNA polymerase II1 2
GO:0045785
IMP
Genome Projectpositive regulation of cell adhesion
GO:0045785
IMP
Gene Ontologypositive regulation of cell adhesion1
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0043065
ISS
Genome Projectpositive regulation of apoptotic process
GO:0043065
ISS
Gene Ontologypositive regulation of apoptotic process
GO:0035065
ISS
Genome Projectregulation of histone acetylation
GO:0035065
ISS
Gene Ontologyregulation of histone acetylation
GO:0035024
IMP
Genome Projectnegative regulation of Rho protein signal transduction
GO:0035024
IMP
Gene Ontologynegative regulation of Rho protein signal transduction3
GO:0032465
IMP
Genome Projectregulation of cytokinesis
GO:0032465
IMP
Gene Ontologyregulation of cytokinesis3
GO:0032008
ISS
Genome Projectpositive regulation of TOR signaling
GO:0032008
ISS
Gene Ontologypositive regulation of TOR signaling
GO:0032007
ISS
Genome Projectnegative regulation of TOR signaling
GO:0032007
ISS
Gene Ontologynegative regulation of TOR signaling
GO:0032006
ISS
Genome Projectregulation of TOR signaling
GO:0032006
ISS
Gene Ontologyregulation of TOR signaling
GO:0031929
IMP
Genome ProjectTOR signaling
GO:0031929
IMP
Gene OntologyTOR signaling4
GO:0030511
IDA
ISS
Genome Projectpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0030511
IDA
ISS
Gene Ontologypositive regulation of transforming growth factor beta receptor signaling pathway2
GO:0030336
IMP
Genome Projectnegative regulation of cell migration
GO:0030336
IMP
Gene Ontologynegative regulation of cell migration3
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0030308
IDA
Gene Ontologynegative regulation of cell growth2
GO:0030097
ISS
Genome Projecthemopoiesis
GO:0030097
ISS
Gene Ontologyhemopoiesis
GO:0010823
ISS
Genome Projectnegative regulation of mitochondrion organization
GO:0010823
ISS
Gene Ontologynegative regulation of mitochondrion organization
GO:0010629
ISS
Genome Projectnegative regulation of gene expression
GO:0010629
ISS
Gene Ontologynegative regulation of gene expression
GO:0010508
IMP
Genome Projectpositive regulation of autophagy
GO:0010508
IMP
Gene Ontologypositive regulation of autophagy5
GO:0007043
ISS
Genome Projectcell-cell junction assembly
GO:0007043
ISS
Gene Ontologycell-cell junction assembly
GO:0001934
ISS
Genome Projectpositive regulation of protein phosphorylation
GO:0001934
ISS
Gene Ontologypositive regulation of protein phosphorylation
GO:0001932
IDA
Genome Projectregulation of protein phosphorylation
GO:0001932
IDA
Gene Ontologyregulation of protein phosphorylation6
GO:0001701
ISS
Genome Projectin utero embryonic development
GO:0001701
ISS
Gene Ontologyin utero embryonic development
GO:0000122
IDA, IMP
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
IDA, IMP
Gene Ontologynegative regulation of transcription by RNA polymerase II1 2
GO:0097009
ISS
Gene Ontologyenergy homeostasis
GO:0120163
ISS
Gene Ontologynegative regulation of cold-induced thermogenesis7
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function FBgn0261111
GO:0098727
IEA
PLAZA Integrative Orthologymaintenance of cell number FBgn0261111
GO:0051098
IEA
PLAZA Integrative Orthologyregulation of binding FBgn0261111
GO:0030718
IEA
PLAZA Integrative Orthologygerm-line stem cell population maintenance FBgn0261111
GO:0042790
IEA
PLAZA Integrative Orthologynucleolar large rRNA transcription by RNA polymerase I FBgn0261111
GO:0006356
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase I FBgn0261111
GO:0009303
IEA
PLAZA Integrative OrthologyrRNA transcription FBgn0261111
GO:0034660
IEA
PLAZA Integrative OrthologyncRNA metabolic process FBgn0261111
GO:0019827
IEA
PLAZA Integrative Orthologystem cell population maintenance FBgn0261111
GO:0016479
IEA
PLAZA Integrative Orthologynegative regulation of transcription by RNA polymerase I FBgn0261111
GO:2000678
IEA
PLAZA Integrative Orthologynegative regulation of transcription regulatory region DNA binding FBgn0261111
GO:2000677
IEA
PLAZA Integrative Orthologyregulation of transcription regulatory region DNA binding FBgn0261111
GO:0051100
IEA
PLAZA Integrative Orthologynegative regulation of binding FBgn0261111
GO:0016072
IEA
PLAZA Integrative OrthologyrRNA metabolic process FBgn0261111
GO:1901839
IEA
PLAZA Integrative Orthologyregulation of RNA polymerase I regulatory region sequence-specific DNA binding FBgn0261111
GO:0051101
IEA
PLAZA Integrative Orthologyregulation of DNA binding FBgn0261111
GO:0043392
IEA
PLAZA Integrative Orthologynegative regulation of DNA binding FBgn0261111
GO:1901836
IEA
PLAZA Integrative Orthologyregulation of transcription of nucleolar large rRNA by RNA polymerase I FBgn0261111
GO:1901837
IEA
PLAZA Integrative Orthologynegative regulation of transcription of nucleolar large rRNA by RNA polymerase I FBgn0261111
GO:0098781
IEA
PLAZA Integrative OrthologyncRNA transcription FBgn0261111
GO:1901840
IEA
PLAZA Integrative Orthologynegative regulation of RNA polymerase I regulatory region sequence-specific DNA binding FBgn0261111
GO:0006360
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase I FBgn0261111

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 5 6 8 9
GO:0005085
IEA
Genome Projectguanyl-nucleotide exchange factor activity
GO:0044877
IDA
Gene Ontologyprotein-containing complex binding4

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0044291
IDA
Genome Projectcell-cell contact zone
GO:0044291
IDA
Gene Ontologycell-cell contact zone3
GO:0030496
IDA
Genome Projectmidbody
GO:0030496
IDA
Gene Ontologymidbody3
GO:0005929
TAS
Genome Projectcilium
GO:0005929
TAS
Gene Ontologycilium5
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol
GO:0005764
TAS
Genome Projectlysosome
GO:0005764
TAS
Gene Ontologylysosome5
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm3 4 6
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4 6
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen FBgn0261111
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen FBgn0261111
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part FBgn0261111
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part FBgn0261111
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle FBgn0261111
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen FBgn0261111
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part FBgn0261111
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen FBgn0261111
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle FBgn0261111
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus FBgn0261111

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR021713Folliculin
IPR032035Folliculin, C-terminal

No MapMan annotations defined for this gene.
KeggID Description
K09594FLCN, BHD; folliculin
No chloroplast target sequence found.