Gene: ENSG00000153071 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000153071
Transcript Identifier
ENST00000320816
Gene Type
Coding gene
Location
5 : 39375019-39394320 : negative

Family Information

Homologous gene family
HOM02SEM029252
(3 genes in 2 species)
specific family

Descriptions

gene_descr
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Identifiers

Type Value
pidENSP00000313391
HGNC2662
UniprotP98082
UniprotA0A024R036
RefSeq_mRNANM_001343.3
EMBLCH471119

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007229
IMP
Genome Projectintegrin-mediated signaling pathway
GO:0007229
IMP
Gene Ontologyintegrin-mediated signaling pathway1
GO:2000643
IMP
Genome Projectpositive regulation of early endosome to late endosome transport
GO:2000643
IMP
Gene Ontologypositive regulation of early endosome to late endosome transport2
GO:2000370
IMP
Genome Projectpositive regulation of clathrin-dependent endocytosis
GO:2000370
IMP
Gene Ontologypositive regulation of clathrin-dependent endocytosis3
GO:2000096
IMP
Genome Projectpositive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000096
IMP
Gene Ontologypositive regulation of Wnt signaling pathway, planar cell polarity pathway4
GO:1903077
IMP
Genome Projectnegative regulation of protein localization to plasma membrane
GO:1903077
IMP
Gene Ontologynegative regulation of protein localization to plasma membrane1
GO:0090090
IMP
ISS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090090
IMP
ISS
Gene Ontologynegative regulation of canonical Wnt signaling pathway4
GO:0061024
TAS
Genome Projectmembrane organization
GO:0061024
TAS
Gene Ontologymembrane organization
GO:0060766
IMP
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0060766
IMP
Gene Ontologynegative regulation of androgen receptor signaling pathway5
GO:0060391
IDA
Genome Projectpositive regulation of SMAD protein signal transduction
GO:0060391
IDA
Gene Ontologypositive regulation of SMAD protein signal transduction6
GO:0045893
IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
IMP
Gene Ontologypositive regulation of transcription, DNA-templated4
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IMP
Gene Ontologynegative regulation of transcription, DNA-templated4
GO:0045807
IMP
Genome Projectpositive regulation of endocytosis
GO:0045807
IMP
Gene Ontologypositive regulation of endocytosis1 2
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043066
IDA
Gene Ontologynegative regulation of apoptotic process7
GO:0035026
IMP
Genome Projectleading edge cell differentiation
GO:0035026
IMP
Gene Ontologyleading edge cell differentiation1
GO:0032436
IMP
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
IMP
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process4
GO:0032091
IMP
Genome Projectnegative regulation of protein binding
GO:0032091
IMP
Gene Ontologynegative regulation of protein binding4
GO:0030511
IDA
Genome Projectpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0030511
IDA
Gene Ontologypositive regulation of transforming growth factor beta receptor signaling pathway6
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030335
IMP
Gene Ontologypositive regulation of cell migration1
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0015031
IEA
Genome Projectprotein transport
GO:0010862
IDA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010862
IDA
Gene Ontologypositive regulation of pathway-restricted SMAD protein phosphorylation6
GO:0010718
IDA
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0010718
IDA
Gene Ontologypositive regulation of epithelial to mesenchymal transition7
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008283
TAS
Gene Ontologycell proliferation8
GO:0007275
IEA
Genome Projectmulticellular organism development
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006898
IEA
Genome Projectreceptor-mediated endocytosis
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0001934
IMP
Gene Ontologypositive regulation of protein phosphorylation4
GO:0019098
IEA
PLAZA Integrative Orthologyreproductive behavior WBGene00000894
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00000894
GO:0009306
IEA
PLAZA Integrative Orthologyprotein secretion WBGene00000894
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development ENSG00000173406
GO:0048468
IEA
PLAZA Integrative Orthologycell development ENSG00000173406
GO:0002790
IEA
PLAZA Integrative Orthologypeptide secretion WBGene00000894
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation ENSG00000173406
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00000894
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development ENSG00000173406
GO:0032940
IEA
PLAZA Integrative Orthologysecretion by cell WBGene00000894
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis ENSG00000173406
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus ENSG00000173406
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction WBGene00000894
GO:0006935
IEA
PLAZA Integrative Orthologychemotaxis ENSG00000173406
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis ENSG00000173406
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons ENSG00000173406
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development ENSG00000173406
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis ENSG00000173406
GO:0040010
IEA
PLAZA Integrative Orthologypositive regulation of growth rate WBGene00000894
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis ENSG00000173406
GO:0042395
IEA
PLAZA Integrative Orthologyecdysis, collagen and cuticulin-based cuticle WBGene00000894
GO:0042303
IEA
PLAZA Integrative Orthologymolting cycle WBGene00000894
GO:0040007
IEA
PLAZA Integrative Orthologygrowth WBGene00000894
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth WBGene00000894
GO:0040009
IEA
PLAZA Integrative Orthologyregulation of growth rate WBGene00000894
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis ENSG00000173406
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation ENSG00000173406
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation ENSG00000173406
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process WBGene00000894
GO:0046903
IEA
PLAZA Integrative Orthologysecretion WBGene00000894
GO:0061564
IEA
PLAZA Integrative Orthologyaxon development ENSG00000173406
GO:0018996
IEA
PLAZA Integrative Orthologymolting cycle, collagen and cuticulin-based cuticle WBGene00000894
GO:0018991
IEA
PLAZA Integrative Orthologyoviposition WBGene00000894
GO:0007409
IEA
PLAZA Integrative Orthologyaxonogenesis ENSG00000173406
GO:0002119
IEA
PLAZA Integrative Orthologynematode larval development WBGene00000894
GO:0097485
IEA
PLAZA Integrative Orthologyneuron projection guidance ENSG00000173406
GO:0007610
IEA
PLAZA Integrative Orthologybehavior WBGene00000894
GO:0002164
IEA
PLAZA Integrative Orthologylarval development WBGene00000894
GO:0022404
IEA
PLAZA Integrative Orthologymolting cycle process WBGene00000894
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis ENSG00000173406
GO:0007411
IEA
PLAZA Integrative Orthologyaxon guidance ENSG00000173406
GO:0042330
IEA
PLAZA Integrative Orthologytaxis ENSG00000173406
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development WBGene00000894
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization ENSG00000173406
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00000894
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis ENSG00000173406
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization ENSG00000173406
GO:0045927
IEA
PLAZA Integrative Orthologypositive regulation of growth WBGene00000894
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00000894

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046332
IDA
Genome ProjectSMAD binding
GO:0046332
IDA
Gene OntologySMAD binding6
GO:0038024
IMP
Genome Projectcargo receptor activity
GO:0038024
IMP
Gene Ontologycargo receptor activity3
GO:0035615
IMP
Genome Projectclathrin adaptor activity
GO:0035615
IMP
Gene Ontologyclathrin adaptor activity3
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0008022
IPI
Gene Ontologyprotein C-terminus binding9
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 6 10 11 12 13 14
GO:0019904
IEA
PLAZA Integrative Orthologyprotein domain specific binding WBGene00000894
GO:0032050
IEA
PLAZA Integrative Orthologyclathrin heavy chain binding WBGene00000894

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle
GO:0030665
IEA
Genome Projectclathrin-coated vesicle membrane
GO:0030136
IDA
Genome Projectclathrin-coated vesicle
GO:0030136
IDA
Gene Ontologyclathrin-coated vesicle1
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005925
Gene Ontologyfocal adhesion15
GO:0005905
IDA
Genome Projectclathrin-coated pit
GO:0005905
IDA
Gene Ontologyclathrin-coated pit16
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005886
IDA
TAS
Gene Ontologyplasma membrane
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005765
TAS
Genome Projectlysosomal membrane
GO:0005765
TAS
Gene Ontologylysosomal membrane
GO:0005730
IDA
Genome Projectnucleolus
GO:0001650
IDA
Genome Projectfibrillar center
GO:0001650
IDA
Gene Ontologyfibrillar center
GO:0019897
IEA
PLAZA Integrative Orthologyextrinsic component of plasma membrane WBGene00000894
GO:0019898
IEA
PLAZA Integrative Orthologyextrinsic component of membrane WBGene00000894
GO:0048475
IEA
PLAZA Integrative Orthologycoated membrane WBGene00000894
GO:0005938
IEA
PLAZA Integrative Orthologycell cortex WBGene00000894
GO:0030119
IEA
PLAZA Integrative OrthologyAP-type membrane coat adaptor complex WBGene00000894
GO:0098562
IEA
PLAZA Integrative Orthologycytoplasmic side of membrane WBGene00000894
GO:0030117
IEA
PLAZA Integrative Orthologymembrane coat WBGene00000894
GO:0030118
IEA
PLAZA Integrative Orthologyclathrin coat WBGene00000894
GO:0030125
IEA
PLAZA Integrative Orthologyclathrin vesicle coat WBGene00000894
GO:0030122
IEA
PLAZA Integrative OrthologyAP-2 adaptor complex WBGene00000894
GO:0030120
IEA
PLAZA Integrative Orthologyvesicle coat WBGene00000894
GO:0030121
IEA
PLAZA Integrative OrthologyAP-1 adaptor complex WBGene00000894
GO:0099568
IEA
PLAZA Integrative Orthologycytoplasmic region WBGene00000894
GO:0098797
IEA
PLAZA Integrative Orthologyplasma membrane protein complex WBGene00000894
GO:0098552
IEA
PLAZA Integrative Orthologyside of membrane WBGene00000894
GO:0030128
IEA
PLAZA Integrative Orthologyclathrin coat of endocytic vesicle WBGene00000894
GO:0098796
IEA
PLAZA Integrative Orthologymembrane protein complex WBGene00000894
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part WBGene00000894
GO:0009898
IEA
PLAZA Integrative Orthologycytoplasmic side of plasma membrane WBGene00000894
GO:0030130
IEA
PLAZA Integrative Orthologyclathrin coat of trans-Golgi network vesicle WBGene00000894
GO:0030133
IEA
PLAZA Integrative Orthologytransport vesicle WBGene00000894
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex WBGene00000894
GO:0030131
IEA
PLAZA Integrative Orthologyclathrin adaptor complex WBGene00000894
GO:0030132
IEA
PLAZA Integrative Orthologyclathrin coat of coated pit WBGene00000894
GO:0030658
IEA
PLAZA Integrative Orthologytransport vesicle membrane WBGene00000894
GO:0030139
IEA
PLAZA Integrative Orthologyendocytic vesicle WBGene00000894
GO:0045334
IEA
PLAZA Integrative Orthologyclathrin-coated endocytic vesicle WBGene00000894
GO:0030140
IEA
PLAZA Integrative Orthologytrans-Golgi network transport vesicle WBGene00000894
GO:0012510
IEA
PLAZA Integrative Orthologytrans-Golgi network transport vesicle membrane WBGene00000894
GO:0030666
IEA
PLAZA Integrative Orthologyendocytic vesicle membrane WBGene00000894
GO:0031234
IEA
PLAZA Integrative Orthologyextrinsic component of cytoplasmic side of plasma membrane WBGene00000894
GO:0030660
IEA
PLAZA Integrative OrthologyGolgi-associated vesicle membrane WBGene00000894
GO:0030669
IEA
PLAZA Integrative Orthologyclathrin-coated endocytic vesicle membrane WBGene00000894
GO:0005798
IEA
PLAZA Integrative OrthologyGolgi-associated vesicle WBGene00000894
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus WBGene00000894
GO:0044431
IEA
PLAZA Integrative OrthologyGolgi apparatus part WBGene00000894

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006020PTB/PI domain
IPR011993PH-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K12475DAB2; disabled homolog 2
No chloroplast target sequence found.