Gene: ENSG00000149357 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000149357
Transcript Identifier
ENST00000278671
Gene Type
Coding gene
Location
11 : 72097822-72103224 : negative

Family Information

Homologous gene family
HOM02SEM031353
(2 genes in 2 species)
specific family
Orthologous gene family
ORTHO02SEM020037
(2 genes in 2 species)
specific family

Descriptions

gene_descr
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Identifiers

Type Value
pidENSP00000278671
HGNC26068
UniprotQ6IAA8
RefSeq_mRNANM_017907.2
EMBLAF289583
EMBLAK000632
EMBLBC001706
EMBLCR457247

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071230
IMP
Genome Projectcellular response to amino acid stimulus
GO:0071230
IMP
Gene Ontologycellular response to amino acid stimulus1
GO:0060620
IMP
Genome Projectregulation of cholesterol import
GO:0060620
IMP
Gene Ontologyregulation of cholesterol import2
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0043410
ISS
Genome Projectpositive regulation of MAPK cascade
GO:0043410
ISS
Gene Ontologypositive regulation of MAPK cascade
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0042632
IMP
Genome Projectcholesterol homeostasis
GO:0042632
IMP
Gene Ontologycholesterol homeostasis2
GO:0034613
IMP
Genome Projectcellular protein localization
GO:0034613
IMP
Gene Ontologycellular protein localization1
GO:0032418
ISS
Genome Projectlysosome localization
GO:0032418
ISS
Gene Ontologylysosome localization
GO:0032008
IMP
Genome Projectpositive regulation of TOR signaling
GO:0032008
IMP
Gene Ontologypositive regulation of TOR signaling1
GO:0016241
TAS
Genome Projectregulation of macroautophagy
GO:0016241
TAS
Gene Ontologyregulation of macroautophagy
GO:0016049
IMP
Genome Projectcell growth
GO:0010874
IMP
Genome Projectregulation of cholesterol efflux
GO:0010874
IMP
Gene Ontologyregulation of cholesterol efflux2
GO:0010872
IMP
Genome Projectregulation of cholesterol esterification
GO:0010872
IMP
Gene Ontologyregulation of cholesterol esterification2
GO:0007050
TAS
Genome Projectcell cycle arrest
GO:0007050
TAS
Gene Ontologycell cycle arrest
GO:0007040
ISS
Genome Projectlysosome organization
GO:0007040
ISS
Gene Ontologylysosome organization
GO:0007032
ISS
Genome Projectendosome organization
GO:0007032
ISS
Gene Ontologyendosome organization
GO:0001919
ISS
Genome Projectregulation of receptor recycling
GO:0001919
ISS
Gene Ontologyregulation of receptor recycling
GO:0016197
ISS
Gene Ontologyendosomal transport
GO:0001558
IMP
Gene Ontologyregulation of cell growth1
GO:0038202
IEA
PLAZA Integrative OrthologyTORC1 signaling FBgn0036932
GO:1904263
IEA
PLAZA Integrative Orthologypositive regulation of TORC1 signaling FBgn0036932
GO:1903432
IEA
PLAZA Integrative Orthologyregulation of TORC1 signaling FBgn0036932

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032947
IDA
Genome Projectprotein-containing complex scaffold activity
GO:0032947
IDA
Gene Ontologyprotein-containing complex scaffold activity3
GO:0005085
IDA
Genome Projectguanyl-nucleotide exchange factor activity
GO:0005085
IDA
Gene Ontologyguanyl-nucleotide exchange factor activity3
GO:0051020
IPI
Genome ProjectGTPase binding
GO:0051020
IPI
Gene OntologyGTPase binding4
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3 5 6

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0101003
TAS
Genome Projectficolin-1-rich granule membrane
GO:0101003
TAS
Gene Ontologyficolin-1-rich granule membrane
GO:0071986
IDA
Genome ProjectRagulator complex
GO:0071986
IDA
Gene OntologyRagulator complex1
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome7
GO:0045121
ISS
Genome Projectmembrane raft
GO:0045121
ISS
Gene Ontologymembrane raft
GO:0035579
TAS
Genome Projectspecific granule membrane
GO:0035579
TAS
Gene Ontologyspecific granule membrane
GO:0035577
TAS
Genome Projectazurophil granule membrane
GO:0035577
TAS
Gene Ontologyazurophil granule membrane
GO:0031902
ISS
Genome Projectlate endosome membrane
GO:0031902
ISS
Gene Ontologylate endosome membrane
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0005765
TAS
Genome Projectlysosomal membrane
GO:0005765
TAS
Gene Ontologylysosomal membrane
GO:0005764
IDA
Genome Projectlysosome
GO:0005764
IDA
Gene Ontologylysosome2

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR028209LAMTOR1/MEH1

No MapMan annotations defined for this gene.
No Kegg annotations defined for this gene.
No chloroplast target sequence found.