Gene: ENSG00000149295 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000149295
Transcript Identifier
ENST00000538967
Gene Type
Coding gene
Location
11 : 113410727-113424651 : negative

Family Information

Homologous gene family
HOM02SEM000364
(94 genes in 3 species)
specific family

Descriptions

gene_descr
dopamine receptor D2

Identifiers

Type Value
pidENSP00000438215
HGNC3023
UniprotP14416

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071880
IBA
Genome Projectadenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901386
IBA
Genome Projectnegative regulation of voltage-gated calcium channel activity
GO:1900273
IEA
Genome Projectpositive regulation of long-term synaptic potentiation
GO:1900168
IDA
Genome Projectpositive regulation of glial cell-derived neurotrophic factor secretion
GO:1900168
IDA
Gene Ontologypositive regulation of glial cell-derived neurotrophic factor secretion1
GO:0099565
NAS
Genome Projectchemical synaptic transmission, postsynaptic
GO:0090325
IEA
Genome Projectregulation of locomotion involved in locomotory behavior
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0060160
ISS
Genome Projectnegative regulation of dopamine receptor signaling pathway
GO:0060160
ISS
Gene Ontologynegative regulation of dopamine receptor signaling pathway
GO:0060158
IGI
Genome Projectphospholipase C-activating dopamine receptor signaling pathway
GO:0060158
IGI
Gene Ontologyphospholipase C-activating dopamine receptor signaling pathway2
GO:0060134
ISS
Genome Projectprepulse inhibition
GO:0060134
ISS
Gene Ontologyprepulse inhibition
GO:0060124
ISS
Genome Projectpositive regulation of growth hormone secretion
GO:0060124
ISS
Gene Ontologypositive regulation of growth hormone secretion
GO:0051967
ISS, IBA
Genome Projectnegative regulation of synaptic transmission, glutamatergic
GO:0051967
ISS
Gene Ontologynegative regulation of synaptic transmission, glutamatergic
GO:0051898
ISS
NAS
Genome Projectnegative regulation of protein kinase B signaling
GO:0051898
ISS
NAS
Gene Ontologynegative regulation of protein kinase B signaling3
GO:0051823
IEA
Genome Projectregulation of synapse structural plasticity
GO:0051586
ISS
Genome Projectpositive regulation of dopamine uptake involved in synaptic transmission
GO:0051586
ISS
Gene Ontologypositive regulation of dopamine uptake involved in synaptic transmission
GO:0051584
IC
Genome Projectregulation of dopamine uptake involved in synaptic transmission
GO:0051584
IC
Gene Ontologyregulation of dopamine uptake involved in synaptic transmission4
GO:0051481
IBA
Genome Projectnegative regulation of cytosolic calcium ion concentration
GO:0051209
ISS
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051209
ISS
Gene Ontologyrelease of sequestered calcium ion into cytosol
GO:0050709
IDA
Genome Projectnegative regulation of protein secretion
GO:0050709
IDA
Gene Ontologynegative regulation of protein secretion5
GO:0050482
IDA
Genome Projectarachidonic acid secretion
GO:0050482
IDA
Gene Ontologyarachidonic acid secretion4
GO:0048755
ISS
Genome Projectbranching morphogenesis of a nerve
GO:0048755
ISS
Gene Ontologybranching morphogenesis of a nerve
GO:0048678
IEA
Genome Projectresponse to axon injury
GO:0048169
ISS
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048169
ISS
Gene Ontologyregulation of long-term neuronal synaptic plasticity
GO:0048149
ISS, IBA
Genome Projectbehavioral response to ethanol
GO:0048149
ISS
Gene Ontologybehavioral response to ethanol
GO:0048148
ISS, IBA
Genome Projectbehavioral response to cocaine
GO:0048148
ISS
Gene Ontologybehavioral response to cocaine
GO:0046676
IEA
Genome Projectnegative regulation of insulin secretion
GO:0046488
ISS
Genome Projectphosphatidylinositol metabolic process
GO:0045944
IEA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045824
IEA
Genome Projectnegative regulation of innate immune response
GO:0045776
ISS
Genome Projectnegative regulation of blood pressure
GO:0045776
ISS
Gene Ontologynegative regulation of blood pressure
GO:0045745
IEA
Genome Projectpositive regulation of G protein-coupled receptor signaling pathway
GO:0043666
IEA
Genome Projectregulation of phosphoprotein phosphatase activity
GO:0043473
IEA
Genome Projectpigmentation
GO:0043278
ISS
Genome Projectresponse to morphine
GO:0043278
ISS
Gene Ontologyresponse to morphine
GO:0043266
ISS, IBA
Genome Projectregulation of potassium ion transport
GO:0043266
ISS
Gene Ontologyregulation of potassium ion transport
GO:0042493
ISS, IBA
Genome Projectresponse to drug
GO:0042493
ISS
Gene Ontologyresponse to drug
GO:0042417
IC
Genome Projectdopamine metabolic process
GO:0042417
IC
Gene Ontologydopamine metabolic process4
GO:0042321
IEA
Genome Projectnegative regulation of circadian sleep/wake cycle, sleep
GO:0042220
ISS
Genome Projectresponse to cocaine
GO:0042220
ISS
Gene Ontologyresponse to cocaine
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0035815
IEA
Genome Projectpositive regulation of renal sodium excretion
GO:0035810
IEA
Genome Projectpositive regulation of urine volume
GO:0035094
IEA
Genome Projectresponse to nicotine
GO:0034776
IDA
Genome Projectresponse to histamine
GO:0034776
IDA
Gene Ontologyresponse to histamine5
GO:0033602
IEA
Genome Projectnegative regulation of dopamine secretion
GO:0032922
ISS
Genome Projectcircadian regulation of gene expression
GO:0032922
ISS
Gene Ontologycircadian regulation of gene expression
GO:0032467
IMP
Genome Projectpositive regulation of cytokinesis
GO:0032467
IMP
Gene Ontologypositive regulation of cytokinesis6
GO:0032228
ISS
Genome Projectregulation of synaptic transmission, GABAergic
GO:0032228
ISS
Gene Ontologyregulation of synaptic transmission, GABAergic
GO:0032147
IEA
Genome Projectactivation of protein kinase activity
GO:0031223
IEA
Genome Projectauditory behavior
GO:0030432
ISS
Genome Projectperistalsis
GO:0030432
ISS
Gene Ontologyperistalsis
GO:0030336
ISS
Genome Projectnegative regulation of cell migration
GO:0030336
ISS
Gene Ontologynegative regulation of cell migration
GO:0021984
ISS
Genome Projectadenohypophysis development
GO:0021984
ISS
Gene Ontologyadenohypophysis development
GO:0021853
ISS
Genome Projectcerebral cortex GABAergic interneuron migration
GO:0021853
ISS
Gene Ontologycerebral cortex GABAergic interneuron migration
GO:0021769
IEA
Genome Projectorbitofrontal cortex development
GO:0021756
IEA
Genome Projectstriatum development
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0014854
IEA
Genome Projectresponse to inactivity
GO:0014059
IBA
Genome Projectregulation of dopamine secretion
GO:0010039
IEA
Genome Projectresponse to iron ion
GO:0009636
IBA
Genome Projectresponse to toxic substance
GO:0009416
ISS
Genome Projectresponse to light stimulus
GO:0009416
ISS
Gene Ontologyresponse to light stimulus
GO:0008542
ISS
Genome Projectvisual learning
GO:0008542
ISS
Gene Ontologyvisual learning
GO:0008306
ISS
Genome Projectassociative learning
GO:0008306
ISS
Gene Ontologyassociative learning
GO:0008285
ISS
Genome Projectnegative regulation of cell proliferation
GO:0008285
ISS
Gene Ontologynegative regulation of cell proliferation
GO:0008104
ISS
Genome Projectprotein localization
GO:0008104
ISS
Gene Ontologyprotein localization
GO:0007631
IEA
Genome Projectfeeding behavior
GO:0007628
ISS
Genome Projectadult walking behavior
GO:0007628
ISS
Gene Ontologyadult walking behavior
GO:0007626
ISS
Genome Projectlocomotory behavior
GO:0007626
ISS
Gene Ontologylocomotory behavior
GO:0007625
IEA
Genome Projectgrooming behavior
GO:0007616
IEA
Genome Projectlong-term memory
GO:0007608
ISS
Genome Projectsensory perception of smell
GO:0007608
ISS
Gene Ontologysensory perception of smell
GO:0007416
ISS
Genome Projectsynapse assembly
GO:0007416
ISS
Gene Ontologysynapse assembly
GO:0007409
ISS
Genome Projectaxonogenesis
GO:0007409
ISS
Gene Ontologyaxonogenesis
GO:0007270
ISS
Genome Projectneuron-neuron synaptic transmission
GO:0007270
ISS
Gene Ontologyneuron-neuron synaptic transmission
GO:0007195
IDA
Genome Projectadenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007195
IDA
Gene Ontologyadenylate cyclase-inhibiting dopamine receptor signaling pathway7 8
GO:0007194
IBA
Genome Projectnegative regulation of adenylate cyclase activity
GO:0002092
IEA
Genome Projectpositive regulation of receptor internalization
GO:0002052
ISS
Genome Projectpositive regulation of neuroblast proliferation
GO:0002052
ISS
Gene Ontologypositive regulation of neuroblast proliferation
GO:0002031
IEA
Genome ProjectG protein-coupled receptor internalization
GO:0002028
ISS
Genome Projectregulation of sodium ion transport
GO:0002028
ISS
Gene Ontologyregulation of sodium ion transport
GO:0002027
ISS
Genome Projectregulation of heart rate
GO:0002027
ISS
Gene Ontologyregulation of heart rate
GO:0001976
ISS
Genome Projectneurological system process involved in regulation of systemic arterial blood pressure
GO:0001976
ISS
Gene Ontologyneurological system process involved in regulation of systemic arterial blood pressure
GO:0001975
ISS
Genome Projectresponse to amphetamine
GO:0001975
ISS
Gene Ontologyresponse to amphetamine
GO:0001963
IBA
Genome Projectsynaptic transmission, dopaminergic
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001659
ISS
Genome Projecttemperature homeostasis
GO:0001659
ISS
Gene Ontologytemperature homeostasis
GO:0060079
NAS
Gene Ontologyexcitatory postsynaptic potential3
GO:0007186
TAS
Gene OntologyG protein-coupled receptor signaling pathway
GO:0007191
IEA
PLAZA Integrative Orthologyadenylate cyclase-activating dopamine receptor signaling pathway ENSG00000151577

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004935
IBA
Genome Projectadrenergic receptor activity
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding9
GO:0035255
IEA
Genome Projectionotropic glutamate receptor binding
GO:0035240
IBA
Genome Projectdopamine binding
GO:0008144
IDA
Genome Projectdrug binding
GO:0008144
IDA
Gene Ontologydrug binding10
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding11 12 13
GO:0001591
IDA
Genome Projectdopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001591
IDA
Gene Ontologydopamine neurotransmitter receptor activity, coupled via Gi/Go4

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097730
IDA
Genome Projectnon-motile cilium
GO:0097730
IDA
Gene Ontologynon-motile cilium14
GO:0060170
IDA
Genome Projectciliary membrane
GO:0060170
IDA
Gene Ontologyciliary membrane14
GO:0043679
IEA
Genome Projectaxon terminus
GO:0043204
IEA
Genome Projectperikaryon
GO:0043197
IEA
Genome Projectdendritic spine
GO:0036126
IEA
Genome Projectsperm flagellum
GO:0030672
IBA
Genome Projectsynaptic vesicle membrane
GO:0030425
ISS
Genome Projectdendrite
GO:0030425
ISS
Gene Ontologydendrite
GO:0030424
ISS
Genome Projectaxon
GO:0030424
ISS
Gene Ontologyaxon
GO:0030139
IEA
Genome Projectendocytic vesicle
GO:0016328
IEA
Genome Projectlateral plasma membrane
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0005887
IDA
Gene Ontologyintegral component of plasma membrane10
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005886
IDA
TAS
Gene Ontologyplasma membrane8
GO:0001669
IEA
Genome Projectacrosomal vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR000929Dopamine receptor family
IPR001922Dopamine D2 receptor
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.
KeggID Description
K04145DRD2; dopamine receptor D2
No chloroplast target sequence found.