Gene: ENSG00000145632 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000145632
Transcript Identifier
ENST00000274289
Gene Type
Coding gene
Location
5 : 58454583-58459959 : negative

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
polo-like kinase 2

Identifiers

Type Value
pidENSP00000274289
HGNC19699
UniprotQ9NYY3
UniprotA0A024QZV1
RefSeq_mRNANM_006622.3
EMBLCHEMBL5938
EMBLAC008814
EMBLAF059617
EMBLAF223574
EMBLBC013879
EMBLCH471123
EMBLU85755

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061000
IEA
Genome Projectnegative regulation of dendritic spine development
GO:0060292
ISS
Genome Projectlong-term synaptic depression
GO:0060292
ISS
Gene Ontologylong-term synaptic depression
GO:0060291
ISS
Genome Projectlong-term synaptic potentiation
GO:0060291
ISS
Gene Ontologylong-term synaptic potentiation
GO:0048167
ISS
Genome Projectregulation of synaptic plasticity
GO:0048167
ISS
Gene Ontologyregulation of synaptic plasticity
GO:0046599
IDA, IMP
Genome Projectregulation of centriole replication
GO:0046599
IDA, IMP
Gene Ontologyregulation of centriole replication1 2 3 4
GO:0045732
IDA
Genome Projectpositive regulation of protein catabolic process
GO:0045732
IDA
Gene Ontologypositive regulation of protein catabolic process5
GO:0043123
IMP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling6
GO:0043066
ISS
Genome Projectnegative regulation of apoptotic process
GO:0043066
ISS
Gene Ontologynegative regulation of apoptotic process
GO:0032486
ISS
Genome ProjectRap protein signal transduction
GO:0032486
ISS
Gene OntologyRap protein signal transduction
GO:0032436
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092
IEA
Genome Projectpositive regulation of protein binding
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018105
IDA
Gene Ontologypeptidyl-serine phosphorylation5
GO:0010508
IDA
Genome Projectpositive regulation of autophagy
GO:0010508
IDA
Gene Ontologypositive regulation of autophagy5
GO:0007613
ISS
Genome Projectmemory
GO:0007613
ISS
Gene Ontologymemory
GO:0007265
ISS
Genome ProjectRas protein signal transduction
GO:0007265
ISS
Gene OntologyRas protein signal transduction
GO:0007093
ISS
Genome Projectmitotic cell cycle checkpoint
GO:0007093
ISS
Gene Ontologymitotic cell cycle checkpoint
GO:0007052
IDA
Genome Projectmitotic spindle organization
GO:0007052
IDA
Gene Ontologymitotic spindle organization2
GO:0006977
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006977
TAS
Gene OntologyDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0006468
IDA
Gene Ontologyprotein phosphorylation3
GO:0000082
IMP
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000082
IMP
Gene OntologyG1/S transition of mitotic cell cycle1
GO:0031122
IEA
PLAZA Integrative Orthologycytoplasmic microtubule organization ENSG00000173846
GO:0097435
IEA
PLAZA Integrative Orthologysupramolecular fiber organization ENSG00000173846
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process ENSG00000173846
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process ENSG00000173846
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000173846
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II ENSG00000173846
GO:0042886
IEA
PLAZA Integrative Orthologyamide transport ENSG00000173846
GO:0022411
IEA
PLAZA Integrative Orthologycellular component disassembly ENSG00000173846
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated ENSG00000173846
GO:1901576
IEA
PLAZA Integrative Orthologyorganic substance biosynthetic process ENSG00000173846
GO:0090087
IEA
PLAZA Integrative Orthologyregulation of peptide transport ENSG00000173846
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated ENSG00000173846
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process ENSG00000173846
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process ENSG00000173846
GO:0033157
IEA
PLAZA Integrative Orthologyregulation of intracellular protein transport ENSG00000173846
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization ENSG00000173846
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process ENSG00000173846
GO:0034248
IEA
PLAZA Integrative Orthologyregulation of cellular amide metabolic process ENSG00000173846
GO:0032465
IEA
PLAZA Integrative Orthologyregulation of cytokinesis ENSG00000173846
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process ENSG00000173846
GO:0051223
IEA
PLAZA Integrative Orthologyregulation of protein transport ENSG00000173846
GO:0000086
IEA
PLAZA Integrative OrthologyG2/M transition of mitotic cell cycle ENSG00000173846
GO:0051222
IEA
PLAZA Integrative Orthologypositive regulation of protein transport ENSG00000173846
GO:0006979
IEA
PLAZA Integrative Orthologyresponse to oxidative stress ENSG00000173846
GO:0000122
IEA
PLAZA Integrative Orthologynegative regulation of transcription by RNA polymerase II ENSG00000173846
GO:1904714
IEA
PLAZA Integrative Orthologyregulation of chaperone-mediated autophagy ENSG00000173846
GO:1903507
IEA
PLAZA Integrative Orthologynegative regulation of nucleic acid-templated transcription ENSG00000173846
GO:1904716
IEA
PLAZA Integrative Orthologypositive regulation of chaperone-mediated autophagy ENSG00000173846
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription ENSG00000173846
GO:0009058
IEA
PLAZA Integrative Orthologybiosynthetic process ENSG00000173846
GO:0009059
IEA
PLAZA Integrative Orthologymacromolecule biosynthetic process ENSG00000173846
GO:0000910
IEA
PLAZA Integrative Orthologycytokinesis ENSG00000173846
GO:0007030
IEA
PLAZA Integrative OrthologyGolgi organization ENSG00000173846
GO:1904951
IEA
PLAZA Integrative Orthologypositive regulation of establishment of protein localization ENSG00000173846
GO:0043603
IEA
PLAZA Integrative Orthologycellular amide metabolic process ENSG00000173846
GO:0034250
IEA
PLAZA Integrative Orthologypositive regulation of cellular amide metabolic process ENSG00000173846
GO:0060341
IEA
PLAZA Integrative Orthologyregulation of cellular localization ENSG00000173846
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process ENSG00000173846
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process ENSG00000173846
GO:0010467
IEA
PLAZA Integrative Orthologygene expression ENSG00000173846
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression ENSG00000173846
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization ENSG00000173846
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000173846
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression ENSG00000173846
GO:0045184
IEA
PLAZA Integrative Orthologyestablishment of protein localization ENSG00000173846
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process ENSG00000173846
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process ENSG00000173846
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000173846
GO:0044249
IEA
PLAZA Integrative Orthologycellular biosynthetic process ENSG00000173846
GO:0000302
IEA
PLAZA Integrative Orthologyresponse to reactive oxygen species ENSG00000173846
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical ENSG00000173846
GO:1901796
IEA
PLAZA Integrative Orthologyregulation of signal transduction by p53 class mediator ENSG00000173846
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization ENSG00000173846
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process ENSG00000173846
GO:0090304
IEA
PLAZA Integrative Orthologynucleic acid metabolic process ENSG00000173846
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus ENSG00000173846
GO:0071456
IEA
PLAZA Integrative Orthologycellular response to hypoxia ENSG00000173846
GO:0006518
IEA
PLAZA Integrative Orthologypeptide metabolic process ENSG00000173846
GO:0071453
IEA
PLAZA Integrative Orthologycellular response to oxygen levels ENSG00000173846
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus ENSG00000173846
GO:0070482
IEA
PLAZA Integrative Orthologyresponse to oxygen levels ENSG00000173846
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport ENSG00000173846
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound ENSG00000173846
GO:0006886
IEA
PLAZA Integrative Orthologyintracellular protein transport ENSG00000173846
GO:0036293
IEA
PLAZA Integrative Orthologyresponse to decreased oxygen levels ENSG00000173846
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport ENSG00000173846
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II ENSG00000173846
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process ENSG00000173846
GO:0036294
IEA
PLAZA Integrative Orthologycellular response to decreased oxygen levels ENSG00000173846
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process ENSG00000173846
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport ENSG00000173846
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process ENSG00000173846
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process ENSG00000173846
GO:0048313
IEA
PLAZA Integrative OrthologyGolgi inheritance ENSG00000173846
GO:1903827
IEA
PLAZA Integrative Orthologyregulation of cellular protein localization ENSG00000173846
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process ENSG00000173846
GO:1903829
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein localization ENSG00000173846
GO:0048308
IEA
PLAZA Integrative Orthologyorganelle inheritance ENSG00000173846
GO:0090166
IEA
PLAZA Integrative OrthologyGolgi disassembly ENSG00000173846
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport ENSG00000173846
GO:2000777
IEA
PLAZA Integrative Orthologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia ENSG00000173846
GO:0032386
IEA
PLAZA Integrative Orthologyregulation of intracellular transport ENSG00000173846
GO:0032388
IEA
PLAZA Integrative Orthologypositive regulation of intracellular transport ENSG00000173846
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process ENSG00000173846
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process ENSG00000173846
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process ENSG00000173846
GO:0051302
IEA
PLAZA Integrative Orthologyregulation of cell division ENSG00000173846
GO:0051301
IEA
PLAZA Integrative Orthologycell division ENSG00000173846
GO:0007113
IEA
PLAZA Integrative Orthologyendomitotic cell cycle ENSG00000173846
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process ENSG00000173846
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process ENSG00000173846
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process ENSG00000173846
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process ENSG00000173846
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process ENSG00000173846
GO:0090316
IEA
PLAZA Integrative Orthologypositive regulation of intracellular protein transport ENSG00000173846
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization ENSG00000173846
GO:0015833
IEA
PLAZA Integrative Orthologypeptide transport ENSG00000173846
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription ENSG00000173846
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process ENSG00000173846
GO:0051253
IEA
PLAZA Integrative Orthologynegative regulation of RNA metabolic process ENSG00000173846
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process ENSG00000173846
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process ENSG00000173846
GO:0006970
IEA
PLAZA Integrative Orthologyresponse to osmotic stress ENSG00000173846
GO:0046907
IEA
PLAZA Integrative Orthologyintracellular transport ENSG00000173846
GO:0061684
IEA
PLAZA Integrative Orthologychaperone-mediated autophagy ENSG00000173846
GO:0010256
IEA
PLAZA Integrative Orthologyendomembrane system organization ENSG00000173846
GO:0051649
IEA
PLAZA Integrative Orthologyestablishment of localization in cell ENSG00000173846
GO:0070201
IEA
PLAZA Integrative Orthologyregulation of establishment of protein localization ENSG00000173846
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process ENSG00000173846
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process ENSG00000173846
GO:0045892
IEA
PLAZA Integrative Orthologynegative regulation of transcription, DNA-templated ENSG00000173846
GO:0001666
IEA
PLAZA Integrative Orthologyresponse to hypoxia ENSG00000173846
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization ENSG00000173846
GO:1902679
IEA
PLAZA Integrative Orthologynegative regulation of RNA biosynthetic process ENSG00000173846
GO:1903008
IEA
PLAZA Integrative Orthologyorganelle disassembly ENSG00000173846
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation ENSG00000173846
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization ENSG00000173846
GO:0015031
IEA
PLAZA Integrative Orthologyprotein transport ENSG00000173846
GO:0044839
IEA
PLAZA Integrative Orthologycell cycle G2/M phase transition ENSG00000173846
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization ENSG00000173846

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043008
IDA
Genome ProjectATP-dependent protein binding
GO:0043008
IDA
Gene OntologyATP-dependent protein binding5
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 7
GO:0004674
IDA
TAS
Genome Projectprotein serine/threonine kinase activity
GO:0004674
IDA
TAS
Gene Ontologyprotein serine/threonine kinase activity2 3 4 5
GO:0002039
IEA
PLAZA Integrative Orthologyp53 binding ENSG00000173846

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030425
ISS
Genome Projectdendrite
GO:0030425
ISS
Gene Ontologydendrite
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005814
IDA
Genome Projectcentriole
GO:0005814
IDA
Gene Ontologycentriole2
GO:0005813
IDA
Genome Projectcentrosome
GO:0005813
IDA
Gene Ontologycentrosome1
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm5
GO:0005622
ISS
Genome Projectintracellular
GO:0005622
ISS
Gene Ontologyintracellular
GO:0000785
IEA
Genome Projectchromatin
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000173846
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000173846
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000173846
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000173846
GO:0098791
IEA
PLAZA Integrative OrthologyGolgi subcompartment ENSG00000173846
GO:0005795
IEA
PLAZA Integrative OrthologyGolgi stack ENSG00000173846
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000173846
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000173846
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus ENSG00000173846
GO:0031984
IEA
PLAZA Integrative Orthologyorganelle subcompartment ENSG00000173846
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000173846
GO:0005634
IEA
PLAZA Integrative Orthologynucleus ENSG00000173846
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000173846
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle ENSG00000173846
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000173846
GO:0044431
IEA
PLAZA Integrative OrthologyGolgi apparatus part ENSG00000173846

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000959POLO box domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain superfamily
IPR017441Protein kinase, ATP binding site
IPR033695Second polo-box domain
IPR033701First polo-box domain

No MapMan annotations defined for this gene.
KeggID Description
K08861PLK2; polo-like kinase 2 [EC:2.7.11.21]
No chloroplast target sequence found.