Gene: ENSG00000143476 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000143476
Transcript Identifier
ENST00000366991
Gene Type
Coding gene
Location
1 : 212035891-212102940 : positive

Family Information

Homologous gene family
HOM02SEM006967
(12 genes in 11 species)
specific family
Orthologous gene family
ORTHO02SEM006667
(12 genes in 11 species)
specific family

Descriptions

gene_descr
denticleless E3 ubiquitin protein ligase homolog (Drosophila)

Identifiers

Type Value
pidENSP00000355958
HGNC30288
UniprotQ9NZJ0
RefSeq_mRNANM_016448.3
EMBLAC092814
EMBLAF195765
EMBLAF345896
EMBLAK000742
EMBLAK001206
EMBLAK001261
EMBLAK027651
EMBLAK292343
EMBLAL592297
EMBLAL606468
EMBLBC033297
EMBLBC033540
EMBLCH471100
EMBLDQ641253

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051726
IMP
Genome Projectregulation of cell cycle
GO:0051726
IMP
Gene Ontologyregulation of cell cycle1
GO:0043687
TAS
Genome Projectpost-translational protein modification
GO:0043687
TAS
Gene Ontologypost-translational protein modification
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0031572
IMP
Genome ProjectG2 DNA damage checkpoint
GO:0019985
IDA
Genome Projecttranslesion synthesis
GO:0019985
IDA
Gene Ontologytranslesion synthesis2
GO:0009411
IDA
Genome Projectresponse to UV
GO:0009411
IDA
Gene Ontologyresponse to UV3
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0006974
IDA, IMP
Gene Ontologycellular response to DNA damage stimulus2 4
GO:0006513
IDA
Genome Projectprotein monoubiquitination
GO:0006513
IDA
Gene Ontologyprotein monoubiquitination2
GO:0006511
IDA
TAS
Genome Projectubiquitin-dependent protein catabolic process
GO:0006511
IDA
TAS
Gene Ontologyubiquitin-dependent protein catabolic process1 3
GO:0006260
IEA
Genome ProjectDNA replication
GO:0000209
IDA
TAS
Genome Projectprotein polyubiquitination
GO:0000209
IDA
TAS
Gene Ontologyprotein polyubiquitination1 3
GO:0072425
IMP
Gene Ontologysignal transduction involved in G2 DNA damage checkpoint1
GO:0045732
IMP
Gene Ontologypositive regulation of protein catabolic process4
GO:0010971
IMP
Gene Ontologypositive regulation of G2/M transition of mitotic cell cycle4
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process SPAC17H9.19c
GO:1903050
IEA
PLAZA Integrative Orthologyregulation of proteolysis involved in cellular protein catabolic process SPAC17H9.19c
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0013548
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0013548
GO:0043161
IEA
PLAZA Integrative Orthologyproteasome-mediated ubiquitin-dependent protein catabolic process WBGene00011318
GO:0031329
IEA
PLAZA Integrative Orthologyregulation of cellular catabolic process SPAC17H9.19c
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0013548
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction SPAC17H9.19c
GO:0006279
IEA
PLAZA Integrative Orthologypremeiotic DNA replication SPAC17H9.19c
GO:0044786
IEA
PLAZA Integrative Orthologycell cycle DNA replication SPAC17H9.19c
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process SPAC17H9.19c
GO:0030162
IEA
PLAZA Integrative Orthologyregulation of proteolysis SPAC17H9.19c
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0013548
GO:0010498
IEA
PLAZA Integrative Orthologyproteasomal protein catabolic process WBGene00011318
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0013548
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process SPAC17H9.19c
GO:2000058
IEA
PLAZA Integrative Orthologyregulation of ubiquitin-dependent protein catabolic process SPAC17H9.19c
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle SPAC17H9.19c
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0013548
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0013548
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0013548
GO:0006261
IEA
PLAZA Integrative OrthologyDNA-dependent DNA replication SPAC17H9.19c
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process SPAC17H9.19c
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0013548
GO:0033260
IEA
PLAZA Integrative Orthologynuclear DNA replication SPAC17H9.19c
GO:1903362
IEA
PLAZA Integrative Orthologyregulation of cellular protein catabolic process SPAC17H9.19c

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IDA
Genome Projectubiquitin-protein transferase activity
GO:0004842
IDA
Gene Ontologyubiquitin-protein transferase activity2 3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 5
GO:0030674
IEA
PLAZA Integrative Orthologyprotein binding, bridging SPAC17H9.19c
GO:0060090
IEA
PLAZA Integrative Orthologymolecular adaptor activity SPAC17H9.19c
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding SPAC17H9.19c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031965
IEA
Genome Projectnuclear membrane
GO:0031465
IDA
Genome ProjectCul4B-RING E3 ubiquitin ligase complex
GO:0031465
IDA
Gene OntologyCul4B-RING E3 ubiquitin ligase complex3
GO:0031464
IDA
Genome ProjectCul4A-RING E3 ubiquitin ligase complex
GO:0031464
IDA
Gene OntologyCul4A-RING E3 ubiquitin ligase complex1 2 3 6
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol
GO:0005813
IDA
Genome Projectcentrosome
GO:0005813
IDA
Gene Ontologycentrosome7
GO:0005730
IDA
Genome Projectnucleolus
GO:0005730
IDA
Gene Ontologynucleolus
GO:0005694
IEA
Genome Projectchromosome
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus7
GO:0080008
IMP
Gene OntologyCul4-RING E3 ubiquitin ligase complex4

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001680WD40 repeat
IPR011042Six-bladed beta-propeller, TolB-like
IPR015943WD40/YVTN repeat-like-containing domain superfamily
IPR017986WD40-repeat-containing domain
IPR019775WD40 repeat, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K11790DTL, CDT2, DCAF2; denticleless
No chloroplast target sequence found.