Gene: ENSG00000143384 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000143384
Transcript Identifier
ENST00000369026
Gene Type
Coding gene
Location
1 : 150577375-150579530 : negative

Family Information

Homologous gene family
HOM02SEM028962
(3 genes in 1 species)
specific family

Descriptions

gene_descr
myeloid cell leukemia 1

Identifiers

Type Value
pidENSP00000358022
HGNC6943
UniprotQ07820
RefSeq_mRNANM_021960.4
EMBLCHEMBL4361
EMBLAF118124
EMBLAF118276
EMBLAF118277
EMBLAF118278
EMBLAF147742
EMBLAF162676
EMBLAF162677
EMBLAF198614
EMBLAF203373
EMBLAK312508
EMBLAL356356
EMBLBC017197
EMBLBC071897
EMBLBC107735
EMBLBT006640
EMBLCH471121
EMBLDQ088966
EMBLL08246

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001240
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240
IMP
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway in absence of ligand1
GO:2001020
IMP
Genome Projectregulation of response to DNA damage stimulus
GO:2001020
IMP
Gene Ontologyregulation of response to DNA damage stimulus2
GO:2000811
IMP
Genome Projectnegative regulation of anoikis
GO:2000811
IMP
Gene Ontologynegative regulation of anoikis3
GO:1903378
IGI
Genome Projectpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378
IGI
Gene Ontologypositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway4
GO:0097192
IMP
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097192
IMP
Gene Ontologyextrinsic apoptotic signaling pathway in absence of ligand5
GO:0071806
IEA
Genome Projectprotein transmembrane transport
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043066
IDA
Gene Ontologynegative regulation of apoptotic process6
GO:0034097
IDA
Genome Projectresponse to cytokine
GO:0034097
IDA
Gene Ontologyresponse to cytokine7
GO:0019725
NAS
Genome Projectcellular homeostasis
GO:0019725
NAS
Gene Ontologycellular homeostasis8
GO:0010507
IMP
Genome Projectnegative regulation of autophagy
GO:0010507
IMP
Gene Ontologynegative regulation of autophagy9
GO:0008637
IEA
Genome Projectapoptotic mitochondrial changes
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0007275
IEA
Genome Projectmulticellular organism development
GO:0001709
NAS
Genome Projectcell fate determination
GO:0001709
NAS
Gene Ontologycell fate determination8
GO:0019221
TAS
Gene Ontologycytokine-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051434
IPI
Genome ProjectBH3 domain binding
GO:0051434
IPI
Gene OntologyBH3 domain binding10
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0046982
IPI
Gene Ontologyprotein heterodimerization activity8
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34
GO:0008320
TAS
Gene Ontologyprotein transmembrane transporter activity8

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097136
IDA
Genome ProjectBcl-2 family protein complex
GO:0097136
IDA
Gene OntologyBcl-2 family protein complex24
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016020
IDA
ISS
Genome Projectmembrane
GO:0016020
IDA
ISS
Gene Ontologymembrane35
GO:0005829
ISS
TAS
Genome Projectcytosol
GO:0005829
ISS
TAS
Gene Ontologycytosol
GO:0005759
IEA
Genome Projectmitochondrial matrix
GO:0005741
TAS
Genome Projectmitochondrial outer membrane
GO:0005741
TAS
Gene Ontologymitochondrial outer membrane8
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion35
GO:0005737
TAS
Genome Projectcytoplasm
GO:0005737
TAS
Gene Ontologycytoplasm8
GO:0005654
IEA
Genome Projectnucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus2

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002475Bcl2-like
IPR013281Apoptosis regulator, Mcl-1
IPR020717Apoptosis regulator, Bcl-2, BH1 motif, conserved site
IPR020726Apoptosis regulator, Bcl-2, BH2 motif, conserved site
IPR020728Apoptosis regulator, Bcl-2, BH3 motif, conserved site
IPR026298Blc2 family

No MapMan annotations defined for this gene.
KeggID Description
K02539MCL1; myeloid leukemia cell differntiation protein MCL-1
No chloroplast target sequence found.