Gene: ENSG00000143258 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000143258
Transcript Identifier
ENST00000289865
Gene Type
Coding gene
Location
1 : 161160641-161165447 : positive

Family Information

Homologous gene family
HOM02SEM000124
(197 genes in 26 species)
specific family

Descriptions

gene_descr
ubiquitin specific peptidase 21

Identifiers

Type Value
pidENSP00000289865
HGNC12620
UniprotQ9UK80
RefSeq_mRNANM_012475.4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0045893
ISS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
ISS
Gene Ontologypositive regulation of transcription, DNA-templated
GO:0031175
IEA
Genome Projectneuron projection development
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016579
TAS
Gene Ontologyprotein deubiquitination
GO:0016578
ISS
Genome Projecthistone deubiquitination
GO:0016578
ISS
Gene Ontologyhistone deubiquitination
GO:0006511
IEA
Genome Projectubiquitin-dependent protein catabolic process
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0071108
IEA
PLAZA Integrative Orthologyprotein K48-linked deubiquitination FBgn0031187
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process FBgn0031187
GO:0050821
IEA
PLAZA Integrative Orthologyprotein stabilization ENSG00000036672
GO:0045088
IEA
PLAZA Integrative Orthologyregulation of innate immune response FBgn0031187
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process ENSG00000036672
GO:0045087
IEA
PLAZA Integrative Orthologyinnate immune response FBgn0031187
GO:0002701
IEA
PLAZA Integrative Orthologynegative regulation of production of molecular mediator of immune response FBgn0031187
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization FBgn0031187
GO:0002700
IEA
PLAZA Integrative Orthologyregulation of production of molecular mediator of immune response FBgn0031187
GO:0031647
IEA
PLAZA Integrative Orthologyregulation of protein stability ENSG00000036672
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium FBgn0031187
GO:0002785
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial peptide production FBgn0031187
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II ENSG00000036672
GO:0007563
IEA
PLAZA Integrative Orthologyregulation of eclosion FBgn0031187
GO:0007562
IEA
PLAZA Integrative Orthologyeclosion FBgn0031187
GO:0030162
IEA
PLAZA Integrative Orthologyregulation of proteolysis FBgn0031187
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response FBgn0031187
GO:0050896
IEA
PLAZA Integrative Orthologyresponse to stimulus FBgn0031187
GO:0050777
IEA
PLAZA Integrative Orthologynegative regulation of immune response FBgn0031187
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus FBgn0031187
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process ENSG00000036672
GO:0032102
IEA
PLAZA Integrative Orthologynegative regulation of response to external stimulus FBgn0031187
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus FBgn0031187
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0031187
GO:0010959
IEA
PLAZA Integrative Orthologyregulation of metal ion transport FBgn0031187
GO:0002775
IEA
PLAZA Integrative Orthologyantimicrobial peptide production FBgn0031187
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus FBgn0031187
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus FBgn0031187
GO:0000122
IEA
PLAZA Integrative Orthologynegative regulation of transcription by RNA polymerase II ENSG00000036672
GO:0002784
IEA
PLAZA Integrative Orthologyregulation of antimicrobial peptide production FBgn0031187
GO:1903507
IEA
PLAZA Integrative Orthologynegative regulation of nucleic acid-templated transcription ENSG00000036672
GO:0045862
IEA
PLAZA Integrative Orthologypositive regulation of proteolysis FBgn0031187
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus FBgn0031187
GO:1903050
IEA
PLAZA Integrative Orthologyregulation of proteolysis involved in cellular protein catabolic process FBgn0031187
GO:0071684
IEA
PLAZA Integrative Orthologyorganism emergence from protective structure FBgn0031187
GO:0051179
IEA
PLAZA Integrative Orthologylocalization FBgn0031187
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization FBgn0031187
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression ENSG00000036672
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism FBgn0031187
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle ENSG00000036672
GO:0006810
IEA
PLAZA Integrative Orthologytransport FBgn0031187
GO:0042742
IEA
PLAZA Integrative Orthologydefense response to bacterium FBgn0031187
GO:0045732
IEA
PLAZA Integrative Orthologypositive regulation of protein catabolic process FBgn0031187
GO:1903052
IEA
PLAZA Integrative Orthologypositive regulation of proteolysis involved in cellular protein catabolic process FBgn0031187
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle ENSG00000036672
GO:0002832
IEA
PLAZA Integrative Orthologynegative regulation of response to biotic stimulus FBgn0031187
GO:0043271
IEA
PLAZA Integrative Orthologynegative regulation of ion transport FBgn0031187
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus FBgn0031187
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport FBgn0031187
GO:0043269
IEA
PLAZA Integrative Orthologyregulation of ion transport FBgn0031187
GO:0002683
IEA
PLAZA Integrative Orthologynegative regulation of immune system process FBgn0031187
GO:0002440
IEA
PLAZA Integrative Orthologyproduction of molecular mediator of immune response FBgn0031187
GO:0002682
IEA
PLAZA Integrative Orthologyregulation of immune system process FBgn0031187
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II ENSG00000036672
GO:0051051
IEA
PLAZA Integrative Orthologynegative regulation of transport FBgn0031187
GO:0042176
IEA
PLAZA Integrative Orthologyregulation of protein catabolic process FBgn0031187
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process ENSG00000036672
GO:0061136
IEA
PLAZA Integrative Orthologyregulation of proteasomal protein catabolic process FBgn0031187
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development FBgn0031187
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process ENSG00000036672
GO:0072511
IEA
PLAZA Integrative Orthologydivalent inorganic cation transport FBgn0031187
GO:0019730
IEA
PLAZA Integrative Orthologyantimicrobial humoral response FBgn0031187
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process ENSG00000036672
GO:0031329
IEA
PLAZA Integrative Orthologyregulation of cellular catabolic process FBgn0031187
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress FBgn0031187
GO:0006952
IEA
PLAZA Integrative Orthologydefense response FBgn0031187
GO:0030001
IEA
PLAZA Integrative Orthologymetal ion transport FBgn0031187
GO:0031331
IEA
PLAZA Integrative Orthologypositive regulation of cellular catabolic process FBgn0031187
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0031187
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process FBgn0031187
GO:0006816
IEA
PLAZA Integrative Orthologycalcium ion transport FBgn0031187
GO:0006812
IEA
PLAZA Integrative Orthologycation transport FBgn0031187
GO:0006811
IEA
PLAZA Integrative Orthologyion transport FBgn0031187
GO:0002698
IEA
PLAZA Integrative Orthologynegative regulation of immune effector process FBgn0031187
GO:0002697
IEA
PLAZA Integrative Orthologyregulation of immune effector process FBgn0031187
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle ENSG00000036672
GO:0045824
IEA
PLAZA Integrative Orthologynegative regulation of innate immune response FBgn0031187
GO:1901800
IEA
PLAZA Integrative Orthologypositive regulation of proteasomal protein catabolic process FBgn0031187
GO:0009894
IEA
PLAZA Integrative Orthologyregulation of catabolic process FBgn0031187
GO:0009896
IEA
PLAZA Integrative Orthologypositive regulation of catabolic process FBgn0031187
GO:0045787
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle ENSG00000036672
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process ENSG00000036672
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism FBgn0031187
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process ENSG00000036672
GO:0032270
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein metabolic process FBgn0031187
GO:0031348
IEA
PLAZA Integrative Orthologynegative regulation of defense response FBgn0031187
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response FBgn0031187
GO:0002921
IEA
PLAZA Integrative Orthologynegative regulation of humoral immune response FBgn0031187
GO:0051253
IEA
PLAZA Integrative Orthologynegative regulation of RNA metabolic process ENSG00000036672
GO:0002920
IEA
PLAZA Integrative Orthologyregulation of humoral immune response FBgn0031187
GO:0061844
IEA
PLAZA Integrative Orthologyantimicrobial humoral immune response mediated by antimicrobial peptide FBgn0031187
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process FBgn0031187
GO:0045931
IEA
PLAZA Integrative Orthologypositive regulation of mitotic cell cycle ENSG00000036672
GO:1900424
IEA
PLAZA Integrative Orthologyregulation of defense response to bacterium FBgn0031187
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process ENSG00000036672
GO:1900425
IEA
PLAZA Integrative Orthologynegative regulation of defense response to bacterium FBgn0031187
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process FBgn0031187
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process ENSG00000036672
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality ENSG00000036672
GO:0070838
IEA
PLAZA Integrative Orthologydivalent metal ion transport FBgn0031187
GO:0010498
IEA
PLAZA Integrative Orthologyproteasomal protein catabolic process FBgn0031187
GO:0051924
IEA
PLAZA Integrative Orthologyregulation of calcium ion transport FBgn0031187
GO:0051926
IEA
PLAZA Integrative Orthologynegative regulation of calcium ion transport FBgn0031187
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process ENSG00000036672
GO:0006959
IEA
PLAZA Integrative Orthologyhumoral immune response FBgn0031187
GO:0002759
IEA
PLAZA Integrative Orthologyregulation of antimicrobial humoral response FBgn0031187
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process FBgn0031187
GO:0045892
IEA
PLAZA Integrative Orthologynegative regulation of transcription, DNA-templated ENSG00000036672
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response FBgn0031187
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process FBgn0031187
GO:0051247
IEA
PLAZA Integrative Orthologypositive regulation of protein metabolic process FBgn0031187
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process FBgn0031187
GO:0008348
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial humoral response FBgn0031187
GO:1902679
IEA
PLAZA Integrative Orthologynegative regulation of RNA biosynthetic process ENSG00000036672
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process ENSG00000036672
GO:0051094
IEA
PLAZA Integrative Orthologypositive regulation of developmental process FBgn0031187
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress FBgn0031187
GO:1903364
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein catabolic process FBgn0031187
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process FBgn0031187
GO:1903362
IEA
PLAZA Integrative Orthologyregulation of cellular protein catabolic process FBgn0031187
GO:0043901
IEA
PLAZA Integrative Orthologynegative regulation of multi-organism process FBgn0031187
GO:0045805
IEA
PLAZA Integrative Orthologypositive regulation of eclosion FBgn0031187

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0036459
IDA
ISS
TAS
Genome Projectthiol-dependent ubiquitinyl hydrolase activity
GO:0036459
IDA
ISS
TAS
Gene Ontologythiol-dependent ubiquitinyl hydrolase activity1 2
GO:0019784
IDA
Genome ProjectNEDD8-specific protease activity
GO:0019784
IDA
Gene OntologyNEDD8-specific protease activity2
GO:0008234
IMP
ISS
Genome Projectcysteine-type peptidase activity
GO:0008234
IMP
ISS
Gene Ontologycysteine-type peptidase activity2
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4
GO:0004843
IDA, IMP
Genome Projectthiol-dependent ubiquitin-specific protease activity
GO:0004843
IDA, IMP
Gene Ontologythiol-dependent ubiquitin-specific protease activity2 4
GO:0003713
ISS
Genome Projecttranscription coactivator activity
GO:0003713
ISS
Gene Ontologytranscription coactivator activity
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000036672
GO:0044389
IEA
PLAZA Integrative Orthologyubiquitin-like protein ligase binding ENSG00000036672
GO:0004175
IEA
PLAZA Integrative Orthologyendopeptidase activity ENSG00000036672
GO:0030332
IEA
PLAZA Integrative Orthologycyclin binding ENSG00000036672
GO:0004197
IEA
PLAZA Integrative Orthologycysteine-type endopeptidase activity ENSG00000036672
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding FBgn0031187
GO:0070628
IEA
PLAZA Integrative Orthologyproteasome binding FBgn0031187
GO:0031625
IEA
PLAZA Integrative Orthologyubiquitin protein ligase binding ENSG00000036672
GO:1990380
IEA
PLAZA Integrative OrthologyLys48-specific deubiquitinase activity FBgn0031187

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005575
ND
Genome Projectcellular_component
GO:0005575
ND
Gene Ontologycellular_component

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001394Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR018200Ubiquitin specific protease, conserved site
IPR028889Ubiquitin specific protease domain

No MapMan annotations defined for this gene.
KeggID Description
K11833USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
No chloroplast target sequence found.