Gene: ENSG00000143190 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000143190
Transcript Identifier
ENST00000367866
Gene Type
Coding gene
Location
1 : 167220898-167415810 : positive

Family Information

Homologous gene family
HOM02SEM002452
(29 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM004342
(19 genes in 3 species)
specific family

Descriptions

gene_descr
POU class 2 homeobox 1

Identifiers

Type Value
pidENSP00000356840
HGNC9212
UniprotP14859
RefSeq_mRNANM_002697.3
EMBLAK303201
EMBLAL136984
EMBLAL359962
EMBLAL451050
EMBLAY113189
EMBLBC001664
EMBLBC003571
EMBLBC007388
EMBLBC052274
EMBLCH471067
EMBLX13403

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0045944
IMP, IGI
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA, IMP, IGI
Gene Ontologypositive regulation of transcription by RNA polymerase II1 2
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA
Gene Ontologynegative regulation of transcription, DNA-templated3 4
GO:0042795
TAS
Genome ProjectsnRNA transcription by RNA polymerase II
GO:0042795
TAS
Gene OntologysnRNA transcription by RNA polymerase II
GO:0006357
IC
Genome Projectregulation of transcription by RNA polymerase II
GO:0019221
TAS
Gene Ontologycytokine-mediated signaling pathway
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process WBGene00000441
GO:0010721
IEA
PLAZA Integrative Orthologynegative regulation of cell development WBGene00000441
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium FBgn0085424
GO:0002787
IEA
PLAZA Integrative Orthologynegative regulation of antibacterial peptide production FBgn0085424
GO:0002786
IEA
PLAZA Integrative Orthologyregulation of antibacterial peptide production FBgn0085424
GO:0002785
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial peptide production FBgn0085424
GO:0048870
IEA
PLAZA Integrative Orthologycell motility WBGene00000441
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process WBGene00000441
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00000441
GO:0048864
IEA
PLAZA Integrative Orthologystem cell development FBgn0004394
GO:0048865
IEA
PLAZA Integrative Orthologystem cell fate commitment FBgn0085424
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0085424
GO:0048867
IEA
PLAZA Integrative Orthologystem cell fate determination FBgn0085424
GO:0060173
IEA
PLAZA Integrative Orthologylimb development FBgn0085424
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process WBGene00000441
GO:0034249
IEA
PLAZA Integrative Orthologynegative regulation of cellular amide metabolic process FBgn0085424
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00000441
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process ENSG00000137709
GO:0097549
IEA
PLAZA Integrative Orthologychromatin organization involved in negative regulation of transcription FBgn0085424
GO:0034248
IEA
PLAZA Integrative Orthologyregulation of cellular amide metabolic process FBgn0085424
GO:0016032
IEA
PLAZA Integrative Orthologyviral process ENSG00000137709
GO:0045596
IEA
PLAZA Integrative Orthologynegative regulation of cell differentiation WBGene00000441
GO:0048863
IEA
PLAZA Integrative Orthologystem cell differentiation FBgn0085424
GO:0002778
IEA
PLAZA Integrative Orthologyantibacterial peptide production FBgn0085424
GO:0045595
IEA
PLAZA Integrative Orthologyregulation of cell differentiation WBGene00000441
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0085424
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0085424
GO:0002777
IEA
PLAZA Integrative Orthologyantimicrobial peptide biosynthetic process FBgn0085424
GO:0052312
IEA
PLAZA Integrative Orthologymodulation of transcription in other organism involved in symbiotic interaction ENSG00000137709
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction WBGene00000441
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus FBgn0085424
GO:0002775
IEA
PLAZA Integrative Orthologyantimicrobial peptide production FBgn0085424
GO:0002784
IEA
PLAZA Integrative Orthologyregulation of antimicrobial peptide production FBgn0085424
GO:0048736
IEA
PLAZA Integrative Orthologyappendage development FBgn0085424
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0085424
GO:0002780
IEA
PLAZA Integrative Orthologyantibacterial peptide biosynthetic process FBgn0085424
GO:0006342
IEA
PLAZA Integrative Orthologychromatin silencing FBgn0085424
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development ENSG00000137709
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0085424
GO:1900194
IEA
PLAZA Integrative Orthologynegative regulation of oocyte maturation WBGene00000441
GO:1905880
IEA
PLAZA Integrative Orthologynegative regulation of oogenesis WBGene00000441
GO:0043603
IEA
PLAZA Integrative Orthologycellular amide metabolic process FBgn0085424
GO:0043604
IEA
PLAZA Integrative Orthologyamide biosynthetic process FBgn0085424
GO:0035220
IEA
PLAZA Integrative Orthologywing disc development FBgn0085424
GO:1900193
IEA
PLAZA Integrative Orthologyregulation of oocyte maturation WBGene00000441
GO:0060281
IEA
PLAZA Integrative Orthologyregulation of oocyte development WBGene00000441
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis FBgn0085424
GO:0035108
IEA
PLAZA Integrative Orthologylimb morphogenesis FBgn0085424
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization FBgn0085424
GO:0035107
IEA
PLAZA Integrative Orthologyappendage morphogenesis FBgn0085424
GO:0043043
IEA
PLAZA Integrative Orthologypeptide biosynthetic process FBgn0085424
GO:0006928
IEA
PLAZA Integrative Orthologymovement of cell or subcellular component WBGene00000441
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0085424
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism FBgn0085424
GO:0009888
IEA
PLAZA Integrative Orthologytissue development ENSG00000137709
GO:0042742
IEA
PLAZA Integrative Orthologydefense response to bacterium FBgn0085424
GO:1905879
IEA
PLAZA Integrative Orthologyregulation of oogenesis WBGene00000441
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process WBGene00000441
GO:0046782
IEA
PLAZA Integrative Orthologyregulation of viral transcription ENSG00000137709
GO:0002683
IEA
PLAZA Integrative Orthologynegative regulation of immune system process FBgn0085424
GO:0002682
IEA
PLAZA Integrative Orthologyregulation of immune system process FBgn0085424
GO:0002440
IEA
PLAZA Integrative Orthologyproduction of molecular mediator of immune response FBgn0085424
GO:0009994
IEA
PLAZA Integrative Orthologyoocyte differentiation WBGene00000441
GO:0008544
IEA
PLAZA Integrative Orthologyepidermis development ENSG00000137709
GO:0060284
IEA
PLAZA Integrative Orthologyregulation of cell development WBGene00000441
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0085424
GO:0060283
IEA
PLAZA Integrative Orthologynegative regulation of oocyte development WBGene00000441
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0085424
GO:0019730
IEA
PLAZA Integrative Orthologyantimicrobial humoral response FBgn0085424
GO:0019731
IEA
PLAZA Integrative Orthologyantibacterial humoral response FBgn0085424
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0085424
GO:0051276
IEA
PLAZA Integrative Orthologychromosome organization FBgn0085424
GO:0007402
IEA
PLAZA Integrative Orthologyganglion mother cell fate determination FBgn0085424
GO:0040029
IEA
PLAZA Integrative Orthologyregulation of gene expression, epigenetic FBgn0085424
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development FBgn0085424
GO:0048667
IEA
PLAZA Integrative Orthologycell morphogenesis involved in neuron differentiation FBgn0085424
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0085424
GO:0016458
IEA
PLAZA Integrative Orthologygene silencing FBgn0085424
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0085424
GO:0016477
IEA
PLAZA Integrative Orthologycell migration WBGene00000441
GO:0051702
IEA
PLAZA Integrative Orthologyinteraction with symbiont ENSG00000137709
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000137709
GO:0052472
IEA
PLAZA Integrative Orthologymodulation by host of symbiont transcription ENSG00000137709
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development FBgn0085424
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism FBgn0085424
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion WBGene00000441
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation FBgn0085424
GO:0007417
IEA
PLAZA Integrative Orthologycentral nervous system development FBgn0004394
GO:0001556
IEA
PLAZA Integrative Orthologyoocyte maturation WBGene00000441
GO:0061844
IEA
PLAZA Integrative Orthologyantimicrobial humoral immune response mediated by antimicrobial peptide FBgn0085424
GO:1900424
IEA
PLAZA Integrative Orthologyregulation of defense response to bacterium FBgn0085424
GO:1900425
IEA
PLAZA Integrative Orthologynegative regulation of defense response to bacterium FBgn0085424
GO:0021700
IEA
PLAZA Integrative Orthologydevelopmental maturation WBGene00000441
GO:0048525
IEA
PLAZA Integrative Orthologynegative regulation of viral process ENSG00000137709
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0085424
GO:0051817
IEA
PLAZA Integrative Orthologymodification of morphology or physiology of other organism involved in symbiotic interaction ENSG00000137709
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0085424
GO:0045814
IEA
PLAZA Integrative Orthologynegative regulation of gene expression, epigenetic FBgn0085424
GO:0002759
IEA
PLAZA Integrative Orthologyregulation of antimicrobial humoral response FBgn0085424
GO:0051241
IEA
PLAZA Integrative Orthologynegative regulation of multicellular organismal process WBGene00000441
GO:0019083
IEA
PLAZA Integrative Orthologyviral transcription ENSG00000137709
GO:0019080
IEA
PLAZA Integrative Orthologyviral gene expression ENSG00000137709
GO:0006325
IEA
PLAZA Integrative Orthologychromatin organization FBgn0085424
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0085424
GO:0048513
IEA
PLAZA Integrative Orthologyanimal organ development FBgn0085424
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress FBgn0085424
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation WBGene00000441
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis WBGene00000441
GO:0002701
IEA
PLAZA Integrative Orthologynegative regulation of production of molecular mediator of immune response FBgn0085424
GO:0048599
IEA
PLAZA Integrative Orthologyoocyte development WBGene00000441
GO:0002700
IEA
PLAZA Integrative Orthologyregulation of production of molecular mediator of immune response FBgn0085424
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism WBGene00000441
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation FBgn0085424
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization FBgn0085424
GO:0048468
IEA
PLAZA Integrative Orthologycell development WBGene00000441
GO:0048469
IEA
PLAZA Integrative Orthologycell maturation WBGene00000441
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00000441
GO:0036022
IEA
PLAZA Integrative Orthologylimb joint morphogenesis FBgn0085424
GO:0035295
IEA
PLAZA Integrative Orthologytube development FBgn0085424
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development WBGene00000441
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response FBgn0085424
GO:0050777
IEA
PLAZA Integrative Orthologynegative regulation of immune response FBgn0085424
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus FBgn0085424
GO:2000177
IEA
PLAZA Integrative Orthologyregulation of neural precursor cell proliferation FBgn0085424
GO:0034401
IEA
PLAZA Integrative Orthologychromatin organization involved in regulation of transcription FBgn0085424
GO:0032102
IEA
PLAZA Integrative Orthologynegative regulation of response to external stimulus FBgn0085424
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus FBgn0085424
GO:0030728
IEA
PLAZA Integrative Orthologyovulation WBGene00000441
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus FBgn0085424
GO:0007398
IEA
PLAZA Integrative Orthologyectoderm development FBgn0004394
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0085424
GO:1901566
IEA
PLAZA Integrative Orthologyorganonitrogen compound biosynthetic process FBgn0085424
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation WBGene00000441
GO:1901564
IEA
PLAZA Integrative Orthologyorganonitrogen compound metabolic process FBgn0085424
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0085424
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0085424
GO:0044419
IEA
PLAZA Integrative Orthologyinterspecies interaction between organisms ENSG00000137709
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus FBgn0085424
GO:0070828
IEA
PLAZA Integrative Orthologyheterochromatin organization FBgn0085424
GO:0050767
IEA
PLAZA Integrative Orthologyregulation of neurogenesis FBgn0085424
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction WBGene00000441
GO:0051179
IEA
PLAZA Integrative Orthologylocalization WBGene00000441
GO:0051851
IEA
PLAZA Integrative Orthologymodification by host of symbiont morphology or physiology ENSG00000137709
GO:0044403
IEA
PLAZA Integrative Orthologysymbiont process ENSG00000137709
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation FBgn0085424
GO:0014016
IEA
PLAZA Integrative Orthologyneuroblast differentiation FBgn0004394
GO:0014019
IEA
PLAZA Integrative Orthologyneuroblast development FBgn0004394
GO:0006518
IEA
PLAZA Integrative Orthologypeptide metabolic process FBgn0085424
GO:0071695
IEA
PLAZA Integrative Orthologyanatomical structure maturation WBGene00000441
GO:0051960
IEA
PLAZA Integrative Orthologyregulation of nervous system development FBgn0085424
GO:0002832
IEA
PLAZA Integrative Orthologynegative regulation of response to biotic stimulus FBgn0085424
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus FBgn0085424
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction WBGene00000441
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation WBGene00000441
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development FBgn0085424
GO:0032897
IEA
PLAZA Integrative Orthologynegative regulation of viral transcription ENSG00000137709
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell WBGene00000441
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress FBgn0085424
GO:0006952
IEA
PLAZA Integrative Orthologydefense response FBgn0085424
GO:1903430
IEA
PLAZA Integrative Orthologynegative regulation of cell maturation WBGene00000441
GO:0070868
IEA
PLAZA Integrative Orthologyheterochromatin organization involved in chromatin silencing FBgn0085424
GO:0002698
IEA
PLAZA Integrative Orthologynegative regulation of immune effector process FBgn0085424
GO:0002697
IEA
PLAZA Integrative Orthologyregulation of immune effector process FBgn0085424
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0085424
GO:0043921
IEA
PLAZA Integrative Orthologymodulation by host of viral transcription ENSG00000137709
GO:1903429
IEA
PLAZA Integrative Orthologyregulation of cell maturation WBGene00000441
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0085424
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0085424
GO:0061351
IEA
PLAZA Integrative Orthologyneural precursor cell proliferation FBgn0085424
GO:0043922
IEA
PLAZA Integrative Orthologynegative regulation by host of viral transcription ENSG00000137709
GO:0035821
IEA
PLAZA Integrative Orthologymodification of morphology or physiology of other organism ENSG00000137709
GO:0031348
IEA
PLAZA Integrative Orthologynegative regulation of defense response FBgn0085424
GO:0002809
IEA
PLAZA Integrative Orthologynegative regulation of antibacterial peptide biosynthetic process FBgn0085424
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response FBgn0085424
GO:0002808
IEA
PLAZA Integrative Orthologyregulation of antibacterial peptide biosynthetic process FBgn0085424
GO:2000242
IEA
PLAZA Integrative Orthologynegative regulation of reproductive process WBGene00000441
GO:0002806
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial peptide biosynthetic process FBgn0085424
GO:0002805
IEA
PLAZA Integrative Orthologyregulation of antimicrobial peptide biosynthetic process FBgn0085424
GO:0002921
IEA
PLAZA Integrative Orthologynegative regulation of humoral immune response FBgn0085424
GO:0002920
IEA
PLAZA Integrative Orthologyregulation of humoral immune response FBgn0085424
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process FBgn0085424
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process FBgn0085424
GO:0008354
IEA
PLAZA Integrative Orthologygerm cell migration WBGene00000441
GO:0001709
IEA
PLAZA Integrative Orthologycell fate determination FBgn0085424
GO:0006959
IEA
PLAZA Integrative Orthologyhumoral immune response FBgn0085424
GO:0050792
IEA
PLAZA Integrative Orthologyregulation of viral process ENSG00000137709
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response FBgn0085424
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process WBGene00000441
GO:0008348
IEA
PLAZA Integrative Orthologynegative regulation of antimicrobial humoral response FBgn0085424
GO:0051093
IEA
PLAZA Integrative Orthologynegative regulation of developmental process WBGene00000441
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0085424
GO:2000241
IEA
PLAZA Integrative Orthologyregulation of reproductive process WBGene00000441
GO:0043903
IEA
PLAZA Integrative Orthologyregulation of symbiosis, encompassing mutualism through parasitism ENSG00000137709
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process ENSG00000137709
GO:0043901
IEA
PLAZA Integrative Orthologynegative regulation of multi-organism process ENSG00000137709

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043565
IDA
Genome Projectsequence-specific DNA binding
GO:0043565
IDA
Gene Ontologysequence-specific DNA binding4 5 6
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 7 8 9 10 11
GO:0003700
TAS
Genome ProjectDNA-binding transcription factor activity
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding12
GO:0000979
IMP
Genome ProjectRNA polymerase II core promoter sequence-specific DNA binding
GO:0000979
IMP
Gene OntologyRNA polymerase II core promoter sequence-specific DNA binding13
GO:0000981
ISA, ISM
NAS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific14
GO:0000978
IMP
Gene OntologyRNA polymerase II proximal promoter sequence-specific DNA binding1 13 15

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0090575
IMP
Genome ProjectRNA polymerase II transcription factor complex
GO:0090575
IMP
Gene OntologyRNA polymerase II transcription factor complex1 15
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus3 6

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000327POU-specific domain
IPR000972Octamer-binding transcription factor
IPR001356Homeobox domain
IPR009057Homeobox-like domain superfamily
IPR010982Lambda repressor-like, DNA-binding domain superfamily
IPR013847POU domain
IPR017970Homeobox, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K09364POU2F, OTF; POU domain transcription factor, class 2
No chloroplast target sequence found.