Gene: ENSG00000142405 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000142405
Transcript Identifier
ENST00000391773
Gene Type
Coding gene
Location
19 : 53794049-53824174 : negative

Family Information

Homologous gene family
HOM02SEM000951
(50 genes in 5 species)
specific family

Descriptions

gene_descr
NLR family, pyrin domain containing 12

Identifiers

Type Value
pidENSP00000375653
HGNC22938
UniprotP59046
RefSeq_mRNANM_001277126.1
EMBLAC008753
EMBLAF231021
EMBLAK095460
EMBLAY095146
EMBLAY116204
EMBLAY116205
EMBLAY116206
EMBLAY116207
EMBLAY154467
EMBLBC028069
EMBLCH471135

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1901223
IEA
Genome Projectnegative regulation of NIK/NF-kappaB signaling
GO:0071345
IEA
Genome Projectcellular response to cytokine stimulus
GO:0070373
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0050729
NAS
Genome Projectpositive regulation of inflammatory response
GO:0050729
NAS
Gene Ontologypositive regulation of inflammatory response1
GO:0050728
IMP
Genome Projectnegative regulation of inflammatory response
GO:0050728
IMP
Gene Ontologynegative regulation of inflammatory response2
GO:0050718
NAS
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050718
NAS
Gene Ontologypositive regulation of interleukin-1 beta secretion1
GO:0050711
IDA
Genome Projectnegative regulation of interleukin-1 secretion
GO:0050711
IDA
Gene Ontologynegative regulation of interleukin-1 secretion3
GO:0050710
IDA
Genome Projectnegative regulation of cytokine secretion
GO:0050710
IDA
Gene Ontologynegative regulation of cytokine secretion3
GO:0045751
IDA
Genome Projectnegative regulation of Toll signaling pathway
GO:0045751
IDA
Gene Ontologynegative regulation of Toll signaling pathway3
GO:0045409
IDA
Genome Projectnegative regulation of interleukin-6 biosynthetic process
GO:0045409
IDA
Gene Ontologynegative regulation of interleukin-6 biosynthetic process3
GO:0045381
NAS
Genome Projectregulation of interleukin-18 biosynthetic process
GO:0045381
NAS
Gene Ontologyregulation of interleukin-18 biosynthetic process1
GO:0045345
IDA
Genome Projectpositive regulation of MHC class I biosynthetic process
GO:0045345
IDA
Gene Ontologypositive regulation of MHC class I biosynthetic process4
GO:0043281
IDA
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281
IDA
Gene Ontologyregulation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IDA
Gene Ontologynegative regulation of I-kappaB kinase/NF-kappaB signaling3
GO:0043122
IDA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043122
IDA
Gene Ontologyregulation of I-kappaB kinase/NF-kappaB signaling1
GO:0036336
IEA
Genome Projectdendritic cell migration
GO:0032088
IDA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032088
IDA
Gene Ontologynegative regulation of NF-kappaB transcription factor activity2
GO:0031953
IDA
Genome Projectnegative regulation of protein autophosphorylation
GO:0031953
IDA
Gene Ontologynegative regulation of protein autophosphorylation3
GO:0009968
IDA
Genome Projectnegative regulation of signal transduction
GO:0009968
IDA
Gene Ontologynegative regulation of signal transduction3
GO:0007165
NAS
Genome Projectsignal transduction
GO:0007165
NAS
Gene Ontologysignal transduction1
GO:0006919
NAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
NAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:1901224
IDA
Gene Ontologypositive regulation of NIK/NF-kappaB signaling1
GO:0032610
IEA
PLAZA Integrative Orthologyinterleukin-1 alpha production ENSG00000276780
GO:0050705
IEA
PLAZA Integrative Orthologyregulation of interleukin-1 alpha secretion ENSG00000276780
GO:0050703
IEA
PLAZA Integrative Orthologyinterleukin-1 alpha secretion ENSG00000276780
GO:0032730
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-1 alpha production ENSG00000276780
GO:0071347
IEA
PLAZA Integrative Orthologycellular response to interleukin-1 ENSG00000277776
GO:0071222
IEA
PLAZA Integrative Orthologycellular response to lipopolysaccharide ENSG00000277776
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium ENSG00000277776
GO:0002674
IEA
PLAZA Integrative Orthologynegative regulation of acute inflammatory response ENSG00000162711
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation ENSG00000158077
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction ENSG00000158077
GO:0002673
IEA
PLAZA Integrative Orthologyregulation of acute inflammatory response ENSG00000162711
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process ENSG00000158077
GO:0035295
IEA
PLAZA Integrative Orthologytube development ENSG00000276230
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis ENSG00000158077
GO:0050829
IEA
PLAZA Integrative Orthologydefense response to Gram-negative bacterium ENSG00000276780
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process ENSG00000158077
GO:0072604
IEA
PLAZA Integrative Orthologyinterleukin-6 secretion ENSG00000276780
GO:0072606
IEA
PLAZA Integrative Orthologyinterleukin-8 secretion ENSG00000276780
GO:0010955
IEA
PLAZA Integrative Orthologynegative regulation of protein processing ENSG00000277776
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process ENSG00000276230
GO:0001568
IEA
PLAZA Integrative Orthologyblood vessel development ENSG00000276230
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction ENSG00000158077
GO:0051346
IEA
PLAZA Integrative Orthologynegative regulation of hydrolase activity ENSG00000277776
GO:0002534
IEA
PLAZA Integrative Orthologycytokine production involved in inflammatory response ENSG00000277776
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus ENSG00000277776
GO:0002532
IEA
PLAZA Integrative Orthologyproduction of molecular mediator involved in inflammatory response ENSG00000277776
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation ENSG00000158077
GO:0045861
IEA
PLAZA Integrative Orthologynegative regulation of proteolysis ENSG00000277776
GO:1905245
IEA
PLAZA Integrative Orthologyregulation of aspartic-type peptidase activity ENSG00000277776
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development ENSG00000276230
GO:1905246
IEA
PLAZA Integrative Orthologynegative regulation of aspartic-type peptidase activity ENSG00000277776
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development ENSG00000276230
GO:0032479
IEA
PLAZA Integrative Orthologyregulation of type I interferon production ENSG00000160505
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus ENSG00000277776
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000179709
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction ENSG00000158077
GO:0010466
IEA
PLAZA Integrative Orthologynegative regulation of peptidase activity ENSG00000277776
GO:0032755
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-6 production ENSG00000276780
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis ENSG00000091592
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization ENSG00000091592
GO:0048731
IEA
PLAZA Integrative Orthologysystem development ENSG00000276230
GO:0032637
IEA
PLAZA Integrative Orthologyinterleukin-8 production ENSG00000276780
GO:0032757
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-8 production ENSG00000276780
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression ENSG00000277776
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism ENSG00000276780
GO:0042742
IEA
PLAZA Integrative Orthologydefense response to bacterium ENSG00000276780
GO:1904784
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex assembly ENSG00000091592
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process ENSG00000158077
GO:0070646
IEA
PLAZA Integrative Orthologyprotein modification by small protein removal ENSG00000162711
GO:0071219
IEA
PLAZA Integrative Orthologycellular response to molecule of bacterial origin ENSG00000277776
GO:0070647
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation or removal ENSG00000162711
GO:0051604
IEA
PLAZA Integrative Orthologyprotein maturation ENSG00000277776
GO:0071216
IEA
PLAZA Integrative Orthologycellular response to biotic stimulus ENSG00000277776
GO:0051606
IEA
PLAZA Integrative Orthologydetection of stimulus ENSG00000162711
GO:0035239
IEA
PLAZA Integrative Orthologytube morphogenesis ENSG00000276230
GO:0002833
IEA
PLAZA Integrative Orthologypositive regulation of response to biotic stimulus ENSG00000276780
GO:0044085
IEA
PLAZA Integrative Orthologycellular component biogenesis ENSG00000091592
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus ENSG00000276780
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound ENSG00000277776
GO:1901701
IEA
PLAZA Integrative Orthologycellular response to oxygen-containing compound ENSG00000277776
GO:0022603
IEA
PLAZA Integrative Orthologyregulation of anatomical structure morphogenesis ENSG00000276230
GO:0022607
IEA
PLAZA Integrative Orthologycellular component assembly ENSG00000091592
GO:0009595
IEA
PLAZA Integrative Orthologydetection of biotic stimulus ENSG00000162711
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development ENSG00000276230
GO:0070613
IEA
PLAZA Integrative Orthologyregulation of protein processing ENSG00000277776
GO:0032650
IEA
PLAZA Integrative Orthologyregulation of interleukin-1 alpha production ENSG00000276780
GO:0032496
IEA
PLAZA Integrative Orthologyresponse to lipopolysaccharide ENSG00000277776
GO:0072358
IEA
PLAZA Integrative Orthologycardiovascular system development ENSG00000276230
GO:0072359
IEA
PLAZA Integrative Orthologycirculatory system development ENSG00000276230
GO:1903317
IEA
PLAZA Integrative Orthologyregulation of protein maturation ENSG00000277776
GO:1903318
IEA
PLAZA Integrative Orthologynegative regulation of protein maturation ENSG00000277776
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization ENSG00000091592
GO:0016579
IEA
PLAZA Integrative Orthologyprotein deubiquitination ENSG00000162711
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000277776
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid ENSG00000277776
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid ENSG00000277776
GO:0001525
IEA
PLAZA Integrative Orthologyangiogenesis ENSG00000276230
GO:2000778
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-6 secretion ENSG00000276780
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis ENSG00000276230
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism ENSG00000277776
GO:0032677
IEA
PLAZA Integrative Orthologyregulation of interleukin-8 production ENSG00000276780
GO:0051259
IEA
PLAZA Integrative Orthologyprotein complex oligomerization ENSG00000162711
GO:2000484
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-8 secretion ENSG00000276780
GO:0016485
IEA
PLAZA Integrative Orthologyprotein processing ENSG00000277776
GO:0070555
IEA
PLAZA Integrative Orthologyresponse to interleukin-1 ENSG00000277776
GO:0002526
IEA
PLAZA Integrative Orthologyacute inflammatory response ENSG00000162711
GO:0043086
IEA
PLAZA Integrative Orthologynegative regulation of catalytic activity ENSG00000277776
GO:1900426
IEA
PLAZA Integrative Orthologypositive regulation of defense response to bacterium ENSG00000276780
GO:1900424
IEA
PLAZA Integrative Orthologyregulation of defense response to bacterium ENSG00000276780
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis ENSG00000276230
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly ENSG00000091592
GO:0051402
IEA
PLAZA Integrative Orthologyneuron apoptotic process ENSG00000091592
GO:0050713
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-1 beta secretion ENSG00000277776
GO:0001944
IEA
PLAZA Integrative Orthologyvasculature development ENSG00000276230
GO:0002237
IEA
PLAZA Integrative Orthologyresponse to molecule of bacterial origin ENSG00000277776
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process ENSG00000276230
GO:0032606
IEA
PLAZA Integrative Orthologytype I interferon production ENSG00000160505
GO:0051092
IEA
PLAZA Integrative Orthologypositive regulation of NF-kappaB transcription factor activity ENSG00000162711
GO:0051091
IEA
PLAZA Integrative Orthologypositive regulation of DNA-binding transcription factor activity ENSG00000162711
GO:1900015
IEA
PLAZA Integrative Orthologyregulation of cytokine production involved in inflammatory response ENSG00000277776
GO:1900016
IEA
PLAZA Integrative Orthologynegative regulation of cytokine production involved in inflammatory response ENSG00000277776
GO:0048514
IEA
PLAZA Integrative Orthologyblood vessel morphogenesis ENSG00000276230
GO:0045765
IEA
PLAZA Integrative Orthologyregulation of angiogenesis ENSG00000276230
GO:0032691
IEA
PLAZA Integrative Orthologynegative regulation of interleukin-1 beta production ENSG00000277776
GO:1901342
IEA
PLAZA Integrative Orthologyregulation of vasculature development ENSG00000276230
GO:0050717
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-1 alpha secretion ENSG00000276780
GO:0043902
IEA
PLAZA Integrative Orthologypositive regulation of multi-organism process ENSG00000276780
GO:2000482
IEA
PLAZA Integrative Orthologyregulation of interleukin-8 secretion ENSG00000276780
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process ENSG00000276780

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008656
NAS
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
NAS
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process1
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3 5
GO:0016787
IEA
PLAZA Integrative Orthologyhydrolase activity ENSG00000276780
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000277776
GO:0017111
IEA
PLAZA Integrative Orthologynucleoside-triphosphatase activity ENSG00000276780
GO:0005539
IEA
PLAZA Integrative Orthologyglycosaminoglycan binding ENSG00000162711
GO:0016818
IEA
PLAZA Integrative Orthologyhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ENSG00000276780
GO:0016817
IEA
PLAZA Integrative Orthologyhydrolase activity, acting on acid anhydrides ENSG00000276780
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding ENSG00000162711
GO:0002020
IEA
PLAZA Integrative Orthologyprotease binding ENSG00000277776
GO:0019955
IEA
PLAZA Integrative Orthologycytokine binding ENSG00000277776
GO:0008428
IEA
PLAZA Integrative Orthologyribonuclease inhibitor activity ENSG00000276230
GO:0004866
IEA
PLAZA Integrative Orthologyendopeptidase inhibitor activity ENSG00000277776
GO:0019828
IEA
PLAZA Integrative Orthologyaspartic-type endopeptidase inhibitor activity ENSG00000277776
GO:0019966
IEA
PLAZA Integrative Orthologyinterleukin-1 binding ENSG00000277776
GO:0003924
IEA
PLAZA Integrative OrthologyGTPase activity ENSG00000276780
GO:0004857
IEA
PLAZA Integrative Orthologyenzyme inhibitor activity ENSG00000276230
GO:0032090
IEA
PLAZA Integrative OrthologyPyrin domain binding ENSG00000278789
GO:0061135
IEA
PLAZA Integrative Orthologyendopeptidase regulator activity ENSG00000277776
GO:0019838
IEA
PLAZA Integrative Orthologygrowth factor binding ENSG00000277776
GO:0016462
IEA
PLAZA Integrative Orthologypyrophosphatase activity ENSG00000276780
GO:0003676
IEA
PLAZA Integrative Orthologynucleic acid binding ENSG00000179873
GO:0003824
IEA
PLAZA Integrative Orthologycatalytic activity ENSG00000276780
GO:0089720
IEA
PLAZA Integrative Orthologycaspase binding ENSG00000277776
GO:0042834
IEA
PLAZA Integrative Orthologypeptidoglycan binding ENSG00000162711
GO:0030414
IEA
PLAZA Integrative Orthologypeptidase inhibitor activity ENSG00000277776
GO:0019904
IEA
PLAZA Integrative Orthologyprotein domain specific binding ENSG00000278789
GO:0003723
IEA
PLAZA Integrative OrthologyRNA binding ENSG00000179873
GO:0016887
IEA
PLAZA Integrative OrthologyATPase activity ENSG00000276780

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus1
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm1
GO:0072559
IEA
PLAZA Integrative OrthologyNLRP3 inflammasome complex ENSG00000162711
GO:0019897
IEA
PLAZA Integrative Orthologyextrinsic component of plasma membrane ENSG00000276780
GO:0019898
IEA
PLAZA Integrative Orthologyextrinsic component of membrane ENSG00000276780
GO:0072558
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex ENSG00000091592
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000278789
GO:0016020
IEA
PLAZA Integrative Orthologymembrane ENSG00000276780
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000278789
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000276780
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part ENSG00000278789
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000278789
GO:0061702
IEA
PLAZA Integrative Orthologyinflammasome complex ENSG00000091592
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000276230
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000278789
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000276230
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000276230
GO:0000784
IEA
PLAZA Integrative Orthologynuclear chromosome, telomeric region ENSG00000278789
GO:0005829
IEA
PLAZA Integrative Orthologycytosol ENSG00000278789
GO:0000781
IEA
PLAZA Integrative Orthologychromosome, telomeric region ENSG00000278789
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000278789
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000276230
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery ENSG00000276780
GO:0098687
IEA
PLAZA Integrative Orthologychromosomal region ENSG00000278789
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000276230
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000278789
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000276230
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000276230
GO:0044459
IEA
PLAZA Integrative Orthologyplasma membrane part ENSG00000276780
GO:0005694
IEA
PLAZA Integrative Orthologychromosome ENSG00000278789
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part ENSG00000278789
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000276230
GO:0032311
IEA
PLAZA Integrative Orthologyangiogenin-PRI complex ENSG00000276230
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000278789
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane ENSG00000276780
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000278789
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part ENSG00000278789
GO:0044445
IEA
PLAZA Integrative Orthologycytosolic part ENSG00000091592
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000278789
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome ENSG00000278789
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000278789
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000276230
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000278789

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001611Leucine-rich repeat
IPR004020DAPIN domain
IPR007111NACHT nucleoside triphosphatase
IPR011029Death-like domain superfamily
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR029495NACHT-associated domain

No MapMan annotations defined for this gene.
No Kegg annotations defined for this gene.
No chloroplast target sequence found.