Gene: ENSG00000138778 (Homo sapiens)

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Gene Identifier
ENSG00000138778
Transcript Identifier
ENST00000265148
Gene Type
Coding gene
Location
4 : 103106222-103198319 : negative

Family Information

Homologous gene family
HOM02SEM000008
(894 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000007
(797 genes in 26 species)
specific family

Descriptions

gene_descr
centromere protein E, 312kDa

Identifiers

Type Value
pidENSP00000265148
HGNC1856
UniprotQ02224
RefSeq_mRNANM_001813.2
EMBLCHEMBL5870
EMBLAB209996
EMBLAC079919
EMBLAK290362
EMBLCH471057
EMBLZ15005

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0099607
IMP
Genome Projectlateral attachment of mitotic spindle microtubules to kinetochore
GO:0099607
IMP
Gene Ontologylateral attachment of mitotic spindle microtubules to kinetochore1
GO:0051382
NAS
Genome Projectkinetochore assembly
GO:0051382
IDA
Gene Ontologykinetochore assembly2
GO:0051315
IMP
Genome Projectattachment of mitotic spindle microtubules to kinetochore
GO:0051315
IMP
Gene Ontologyattachment of mitotic spindle microtubules to kinetochore3
GO:0051310
IMP
Genome Projectmetaphase plate congression
GO:0051310
IMP
Gene Ontologymetaphase plate congression1 4 5 6
GO:0051301
IEA
Genome Projectcell division
GO:0045860
IMP
Genome Projectpositive regulation of protein kinase activity
GO:0045860
IMP
Gene Ontologypositive regulation of protein kinase activity7
GO:0030071
IMP
Genome Projectregulation of mitotic metaphase/anaphase transition
GO:0030071
IMP
Gene Ontologyregulation of mitotic metaphase/anaphase transition8
GO:0019886
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019886
TAS
Gene Ontologyantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0007275
IEA
Genome Projectmulticellular organism development
GO:0007080
IMP
Genome Projectmitotic metaphase plate congression
GO:0007080
IMP
Gene Ontologymitotic metaphase plate congression3
GO:0007079
TAS
Genome Projectmitotic chromosome movement towards spindle pole
GO:0007079
IDA
Gene Ontologymitotic chromosome movement towards spindle pole6
GO:0007062
TAS
Genome Projectsister chromatid cohesion
GO:0007059
IMP
Genome Projectchromosome segregation
GO:0007059
IMP
Gene Ontologychromosome segregation9
GO:0007018
TAS
Genome Projectmicrotubule-based movement
GO:0007018
TAS
Gene Ontologymicrotubule-based movement
GO:0006890
TAS
Genome Projectretrograde vesicle-mediated transport, Golgi to ER
GO:0006890
TAS
Gene Ontologyretrograde vesicle-mediated transport, Golgi to ER
GO:0000278
IMP
Genome Projectmitotic cell cycle
GO:0000278
IMP
Gene Ontologymitotic cell cycle9
GO:0099606
IDA
Gene Ontologymicrotubule plus-end directed mitotic chromosome migration6
GO:0007052
IMP
Gene Ontologymitotic spindle organization6
GO:0010245
IEA
PLAZA Integrative Orthologyradial microtubular system formation AT3G43210
GO:0033206
IEA
PLAZA Integrative Orthologymeiotic cytokinesis AT3G43210
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction AT3G43210
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response AT4G39050
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0040232
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0040232
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation AT3G43210
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism AT3G43210
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0040232
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction AT3G43210
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress AT4G39050
GO:0007349
IEA
PLAZA Integrative Orthologycellularization AT3G43210
GO:0006952
IEA
PLAZA Integrative Orthologydefense response AT4G39050
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process AT3G43210
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis AT3G43210
GO:0048229
IEA
PLAZA Integrative Orthologygametophyte development AT3G43210
GO:0009561
IEA
PLAZA Integrative Orthologymegagametogenesis AT3G43210
GO:0007140
IEA
PLAZA Integrative Orthologymale meiotic nuclear division AT3G43210
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process AT3G43210
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process AT3G43210
GO:0061640
IEA
PLAZA Integrative Orthologycytoskeleton-dependent cytokinesis AT3G43210
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division AT3G43210
GO:0050896
IEA
PLAZA Integrative Orthologyresponse to stimulus AT4G39050
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process AT3G43210
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction AT3G43210
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle AT3G43210
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus AT4G39050
GO:0009558
IEA
PLAZA Integrative Orthologyembryo sac cellularization AT3G43210
GO:0007112
IEA
PLAZA Integrative Orthologymale meiosis cytokinesis AT3G43210
GO:0009553
IEA
PLAZA Integrative Orthologyembryo sac development AT3G43210
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0040232
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis AT3G43210
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation AT3G43210
GO:0000910
IEA
PLAZA Integrative Orthologycytokinesis AT3G43210
GO:0009555
IEA
PLAZA Integrative Orthologypollen development AT3G43210
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0040232
GO:0000911
IEA
PLAZA Integrative Orthologycytokinesis by cell plate formation AT3G43210
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress AT4G39050
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process AT3G43210

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043515
IDA
Genome Projectkinetochore binding
GO:0043515
IDA
Gene Ontologykinetochore binding2
GO:0016887
IBA
Genome ProjectATPase activity
GO:0008017
IEA
Genome Projectmicrotubule binding
GO:0008017
IDA
Gene Ontologymicrotubule binding6
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 10 11 12
GO:0003777
IMP
Genome Projectmicrotubule motor activity
GO:0003777
IDA, IMP
Gene Ontologymicrotubule motor activity6 13

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000940
TAS
Genome Projectcondensed chromosome outer kinetochore
GO:1990023
IDA
Genome Projectmitotic spindle midzone
GO:1990023
IDA
Gene Ontologymitotic spindle midzone8
GO:0030496
IDA
Genome Projectmidbody
GO:0030496
IDA
Gene Ontologymidbody2 8
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane14
GO:0015630
IDA
Genome Projectmicrotubule cytoskeleton
GO:0015630
IDA
Gene Ontologymicrotubule cytoskeleton
GO:0005874
IDA
Genome Projectmicrotubule
GO:0005874
IDA
Gene Ontologymicrotubule13
GO:0005871
IBA
Genome Projectkinesin complex
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005694
IDA
Genome Projectchromosome
GO:0005694
IDA
Gene Ontologychromosome8
GO:0005634
IMP
Genome Projectnucleus
GO:0005634
IMP
Gene Ontologynucleus2
GO:0000779
IDA
Genome Projectcondensed chromosome, centromeric region
GO:0000779
IDA
Gene Ontologycondensed chromosome, centromeric region15
GO:0000776
IDA
Genome Projectkinetochore
GO:0000776
IDA
Gene Ontologykinetochore2 4 7 11 16
GO:0000775
IDA
Genome Projectchromosome, centromeric region
GO:0000775
IDA
Gene Ontologychromosome, centromeric region8 12 17
GO:0051233
IDA
Gene Ontologyspindle midzone2
GO:0005828
IDA
Gene Ontologykinetochore microtubule6
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery AT2G21300
GO:0030054
IEA
PLAZA Integrative Orthologycell junction AT5G66310
GO:0005911
IEA
PLAZA Integrative Orthologycell-cell junction AT5G66310
GO:0009524
IEA
PLAZA Integrative Orthologyphragmoplast AT1G18370
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane AT2G21300
GO:0055044
IEA
PLAZA Integrative Orthologysymplast AT5G66310
GO:0009506
IEA
PLAZA Integrative Orthologyplasmodesma AT5G66310

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001752Kinesin motor domain
IPR019821Kinesin motor domain, conserved site
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K11498CENPE; centromeric protein E
No chloroplast target sequence found.